Treatment of squamous cell carcinoma in Israel with effective innovative methods

Squamous cell skin cancer is a malignant tumor that consists of atypical epithelial cells that are similar in appearance to spiny keratinocytes. The disease has a tendency to quickly metastasize to lymph nodes and internal organs. The neoplasm can develop on any part of the skin, but more often - near natural openings: on the lower lip, in the genital area.

• Causes and risk factors
• Classification
• Localization options
• Clinical manifestations
• Diagnostic methods
• Treatment
• Forecast
• Prevention

Causes and risk factors

Currently, several factors have been identified that may predispose to the development of squamous cell carcinoma. These include:

• Age. The disease almost never occurs in young people. The majority of patients are elderly people over 65 years of age.
• Light skin color and presence of freckles.
• Increased insolation. The conclusion about the influence of this factor was made due to the fact that this form of malignant tumor always appears on open areas of the body that are constantly exposed to sunlight. In addition, squamous cell skin cancer can occur at the site of severe sunburn.
• Mutation of the TP53 gene, which is responsible for suppressing tumor growth.
• The presence of precancerous formations and other pathological conditions of the skin (scar atrophy, radiation damage, tuberculous lupus, occupational diseases, lichen planus, etc.).
• The effect of carcinogens on the skin (arsenic, paraffin, kerosene, coal tar, etc.), which leads to inflammation and atrophy. As a result, the formation of focal proliferations occurs, which over time can degenerate into a malignant formation.
• Prolonged mechanical irritation or damage to the skin.
• The patient is immunosuppressed.
• Infection with human papillomavirus. The role of some of its types in the occurrence of skin cancer of the penis, anus, and vulva has been proven.
• There is scientific evidence of the development of this tumor in patients with psoriasis after receiving courses of PUVA therapy and photochemotherapy, as well as in patients after radiation therapy.

Determining the cause of squamous cell skin cancer is critical to assessing the risk of recurrence and metastatic spread. Thus, a malignant tumor that developed at the site of skin lesions by actinic keratosis metastasizes only in 0.5% of cases. At the same time, cancer that occurs on the scar has a much higher risk of spreading - up to 30%.

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What does melanoma look like in a photo?

1. Nodal.

Nodular (diminutive from the Latin “nodus” - node) formation is less common (14-30%). The most aggressive form. Melanoma cancer is characterized by rapid growth (from 4 months to 2 years). Develops on objectively unchanged skin without visible damage or from a pigmented nevus. Growth is vertical. The color is uniform, dark blue or black. In rare cases, such a tumor, which resembles a nodule or papule, may not be pigmented.

1. Malignant lentigo.

The disease affects older people (after 60 years) and is detected in 5-10% of cases. Open areas of the skin (face, neck, hands) are covered by dark blue, dark or light brown nodules with a diameter of up to 3 mm. Slow radial growth of the tumor in the upper parts of the skin (20 years or longer before vertical invasion into the deep layers of the dermis) can involve the hair follicles.

Classification

There are several principles for classifying squamous cell skin cancer. According to the histological structure, there are 4 types of this neoplasm, and according to TNM staging - 4 stages, each of which reflects the prevalence of the process in the body.

According to histological classification, the following options are distinguished:

1. The spindle cell type has a poor prognosis due to its rapid invasive growth as well as its tendency to metastasize and recur.
2. Acantholytic type. Appears on skin affected by actinic keratosis.
3. Verrucous squamous cell skin cancer is accompanied by symptoms of severe hyperkeratosis, which is clinically manifested by the formation of a horny growth (skin horn).
4. The lymphoepithelial type consists of poorly differentiated cells. It is believed that this neoplasm is a tumor of the skin appendages, and not true squamous cell carcinoma.

The stage of development of this type of cancer is determined by the size of the primary tumor, the degree of invasion into the underlying tissue and the presence of distant metastases. The first stage corresponds to a formation less than 2 cm in size, the second and third - larger tumors with spread to nearby tissues, and the fourth - a lesion of any size with the presence of metastatic lesions.

Esophageal cancer symptoms

Early forms of cancer are asymptomatic, since for difficulty swallowing food (dysphagia) to occur, a narrowing of the lumen of the esophagus of less than 15 mm is necessary.

Unfortunately, more than half of patients (60%) have an advanced stage of the disease at the time of diagnosis.

The main symptoms of esophageal cancer are:

• Dysphagia.
• Pain when swallowing food.
• Jumping off eaten food (regurgitation).
• Pain and discomfort in the chest.
• Feeling of a foreign body in the esophagus.
• Hoarseness of voice (if the recurrent laryngeal nerve is involved in the process).
• The appearance of enlarged lymph nodes in the neck.
• Loss of body weight.

Squamous cell carcinoma is characterized by the development of a locally widespread process involving adjacent vital anatomical structures, such as the aorta, trachea, main bronchi, and heart.

Metastasis of squamous cell carcinoma of the esophagus occurs through the lymphogenous route with the development of distant metastases in the liver, lungs, and bones.

Localization options

Squamous cell skin cancer most often presents as a single lesion, much less often as multiple lesions. In the vast majority of cases, the skin of the face (nose, ears, periorbital area) is affected. Favorite localization is the transitions between the mucous membrane and squamous epithelium, which are observed on the red border of the lips, in the perianal region, and on the external genitalia.

In the oral cavity, this type of cancer is often located on the mucous membrane of the palate and tongue. This tumor is characterized by a long asymptomatic course. It gradually turns into a hard nodule or over time acquires the appearance of a peritonsillar abscess.

Squamous cell carcinoma on the lower lip occurs against the background of such precancerous formations as leukoplakia, actinic and abrasive cheilitis. Initially, it appears as tightly fitting scales, under which a small growing compaction forms. Less commonly, the disease begins with erosion, which has a dense base. As the tumor grows, the lip may become deformed or thicken.

For localization of cancer in the vulva area, localization is characteristic of the transitional fold of the labia majora and minora, and the clitoris. The disease has an unfavorable prognosis and is characterized by rapid metastasis. The formation of squamous cell skin cancer of this localization may be preceded by lichen sclerosus, Bowen's disease, and erythroplakia.

Penile skin cancer usually occurs in men over 40 years of age. Its typical location is the posterior surface of the body of the penis, the area of ​​the preputial sac and coronary sulcus. Predisposing factors to the formation of this tumor are chronic inflammatory processes, balanitis with congenital phimosis, and accumulation of smegma. This is why penile cancer almost never occurs in men who have undergone circumcision.

Anatomy of the esophagus

The esophagus is a hollow muscular tube that connects the pharynx and oral cavity to the stomach. The wall of the esophagus is built from the mucous membrane, submucosa, muscular and adventitial membranes. The muscular lining of the esophagus consists of two layers: the outer longitudinal and the inner circular. In the upper part of the esophagus, the muscular layer is formed by transverse muscle fibers. At approximately the level of one third of the esophagus (counting from the top), striated muscle fibers are gradually replaced by smooth muscle fibers. In the lower part, the muscular layer consists only of smooth muscle tissue.

The mucous membrane is covered with stratified squamous epithelium; the submucosa contains mucous glands that open into the lumen of the organ.

In the esophagus there is a skin-type mucous membrane. The epithelium is multilayered squamous, non-keratinizing, lying on fine-fibrous connective tissue - its own layer of the mucous membrane, consisting of thin bundles of collagen fibers; also contains reticulin fibers and connective tissue cells. The own layer of the mucous membrane protrudes into the epithelium in the form of papillae.

A special feature of the esophagus is the absence of a serous membrane; the outer layer is represented by adventitia, loose connective tissue. Only in the lower third of the esophagus, more precisely its abdominal section, is covered with serosa.

Clinical manifestations

There are two forms of growth of squamous cell carcinoma: exophytic and endophytic. Each of them is characterized by certain clinical manifestations.

Exophytic (papillary) form

The primary nodule in this type of tumor gradually increases in size and rises above the skin level. A large amount of horny mass accumulates on the surface of the lesion. Over time, its color becomes red or brownish with a large number of dilated vessels on the surface (telangiectasia). Sometimes retraction is detected in the center of formation.

The base of the neoplasm is wide. The lesion itself and the surrounding tissues are inactive due to tumor growth. In later stages, necrosis and ulceration occur.

A type of exophytic squamous cell skin cancer is its verrucous form, which is characterized by a yellow or red-brown color of the lesion, an uneven surface with warty growths. This type of tumor, in turn, also has several clinical variants depending on the location:

• Oral papillomatosis - neoplasms on the mucous membrane of the tongue, cheeks, and gums. Usually seen in people who chew tobacco.
• Anogenital carcinoma. It is located on the skin of the glans penis, scrotum, vulva, and perianal area.
• The plantar type is typical for older men.
• Squamous cell verrucous cancer of other areas of the skin (extremities, torso).

The verrucous form is characterized by slow growth and a low risk of metastasis. On the skin, this type of cancer forms most often in places that are subject to constant mechanical stress and may have the appearance of a cutaneous horn.

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Endophytic (ulcerative-infiltrative) form

With endophytic tumor growth, the primary element is a nodule, which over time turns into a dense node. The lesion is closely fused with the underlying tissues. After a few months, it ulcerates. The ulcer has an irregular shape, a dense bottom, a whitish film on the surface and crater-shaped edges. It may be covered with a brownish crust, which, when removed, releases a bloody exudate. The ulcer increases in depth and to the sides, quickly spreading to the underlying tissue. This form of squamous cell skin cancer is characterized by frequent recurrence and the formation of metastases.

Diagnostic methods

Since the direct dependence of the effectiveness of the treatment on the stage of the malignant neoplasm at which it was discovered has long been proven, there are two levels of diagnosis of squamous cell skin cancer: early and late.

An early diagnosis is considered to be made at stages I-II. In this case, complete recovery of the patient is possible, provided that the correct treatment tactics are chosen. Late detection means diagnosis at stages III and IV. The prognosis is usually unfavorable due to the complexity or impossibility of surgical treatment.

The “gold standard” for diagnosing squamous cell skin cancer is a biopsy followed by histological examination. The immunohistochemical method is considered especially informative. Since the tumor is external and it is not difficult to obtain biomaterial for histology, the tumor is verified in 99% of cases.

The dermatoscopy method is also widely used. In this case, the presence of central keratin plugs, dilated and branched vessels on the surface speaks in favor of skin cancer.

For any form of squamous cell carcinoma, along with a thorough history and physical examination, a specialist must evaluate the condition of the lymph nodes. If the presence of metastatic foci is suspected, the main diagnostic method is fine-needle aspiration. It is also possible to prescribe additional imaging methods (ultrasound, radiography, CT, angiography) to identify regional and distant metastases.

Advantages of Sofia Cancer Center

One of the key advantages of oncology is the high professionalism of qualified oncologists. Comfortable conditions have been created, we have a cozy and warm interior - patients do not feel like they are in a hospital. Excellent equipment allows you to make a diagnosis in the shortest possible time and begin treatment procedures, focusing on the latest achievements of world medicine.

Oncological benefits:

• everything in one place: hospital, outpatient department and own laboratory;
• experienced oncologists and other specialists, leaders of Russian medicine in squamous cell cancer;
• individual support around the clinic;
• treatment according to world protocols and the most effective methods;
• a full range of diagnostic and therapeutic procedures;
• increased comfort: inviting interior, there is a cafe and a rooftop restaurant with panoramic views;
• numerous certificates and awards, including JCI;
• the equipment is among the best in Moscow;
• 30 years of unique experience and impeccable reputation;
• plenty of parking spaces.

Treatment

Today, there are many ways to help patients with squamous cell skin cancer. These include both classical methods (removal with a scalpel, cryodestruction, laser therapy) and modern technologies, for example, photodynamic therapy.

Surgical removal

Surgical treatment consists of removing the tumor with an indentation of 1-2 cm towards healthy tissue. Surgical excision is indicated for low-risk skin cancer and a low probability of tumor recurrence.

Low risk criteria:

• Localization of cancer in open areas of the body (excluding lips and ears).
• Size up to 2 cm.
• There is no invasion into the dermis.
• Highly differentiated tumor.
• The immune status is normal.

Surgical treatment is not used in the following cases:

• High-risk squamous cell skin cancer (localized on the lips, ears, closed areas; development against the background of precancer; large tumor).
• Multiple metastases.
• Increased operational risk (drug intolerance, advanced age of the patient).
• Localization in which complete removal of the lesion is impossible (periorbital region, nose).

Surgical removal of cancer in the early stages in a large percentage of cases leads to the patient’s recovery. However, the disadvantage of this method is that it is not always possible to achieve a satisfactory aesthetic and functional result.

An effective option for surgical treatment of squamous cell skin cancer is the Mosch operation, during which the tumor is removed layer by layer with immediate histological examination of each layer. This approach allows for maximum preservation of healthy tissue.

Surgical removal according to Mosch can be used for high-risk skin cancer, multiple lesions, and tumor localization in cosmetically important areas. However, applying this method requires a lot of time and money.

Small tumors can be removed using curettage or electrocoagulation, including 5-6 mm of healthy skin. These methods are simple, but long-term results are disappointing: the risk of cancer recurrence is high.

Cryodestruction

For squamous cell skin cancer, cryodestruction is carried out in several cycles. Depending on the location and clinical signs of the lesion, the exposure time is selected. The procedure is performed by capturing 2-2.5 cm of healthy skin around the tumor. Removal using cryodestruction is possible only for low-risk tumors.

This method is good because it can be performed on an outpatient basis. In addition, it is characterized by low pain. The main disadvantage is the impossibility of histological control.

Laser therapy

This type of treatment uses a carbon or neodymium laser. The use of this method leads to good cosmetic results.

Laser therapy is indicated for patients who suffer from bleeding disorders or are taking anticoagulants. The disadvantages of this method are limited indications (can only be used for low-risk cancer) and the lack of the possibility of histological examination of a remote lesion.

Radiation therapy

Due to the fact that squamous cell skin cancer is a tumor with a relatively high sensitivity to radiation therapy, it is widely used as monotherapy and in combination with other methods. Small lesions are treated using close-focus X-ray radiation, large tumors without metastasis are treated with external gamma therapy. In the presence of regional metastases, combined treatment is performed, which includes the use of preoperative radiation therapy and excision of the formation along with the affected lymph nodes.

At the first and second stages of skin cancer, this method can be used as an independent method, at the third and fourth stages it can be used as pre- and postoperative treatment. For inoperable forms, it is an option for palliative care for patients.

The use of radiation therapy is contraindicated for recurrent cancer, verrucous carcinoma, connective tissue diseases (scleroderma, lupus erythematosus). Negative consequences of the method may be the development of periostitis, perichondritis, cataracts, and serious cicatricial deformities on the skin.

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Chemotherapy

Local and systemic chemotherapy can be used to treat squamous cell carcinoma. Fluorouracil, prospidin, and glyciphone ointments are used as local remedies. It should be noted that this type of therapy is rather low in effectiveness, and the risk of tumor recurrence with external treatment is high. In addition, such ointments can cause intoxication, which interferes with healing.

Also, cytostatic drugs (5-fluorouracil) are introduced into the lesion using intradermal or subcutaneous injections. Systemic chemotherapy with cisplatin, bleomycin, carboplatin is used in the presence of inoperable formation, metastatic tumor, or as preoperative preparation.

Thus, the indications for chemotherapy are:

• Recurrent skin cancer.
• Multiple lesions.
• Impossibility of surgical removal.
• Metastatic tumor.
• Squamous cell skin cancer in elderly patients who have contraindications to the use of other methods.

The use of cytotoxic drugs is contraindicated in case of severe concomitant pathology. This method is also not suitable for treating weakened patients with immunodeficiency conditions.

Interferon therapy

Local and systemic immunomodulators can be used to treat skin cancer. These include: imiquimod (cream), Viferon, intron A.

The indication for using the method is the presence of a large inoperable tumor. Treatment with interferons is contraindicated for autoimmune diseases, leukopenia, severe concomitant diseases in the stage of decompensation.

The frequent development of side symptoms is a significant drawback of immunomodulator therapy. In addition, the cost of the course of treatment is quite high with its relatively low effectiveness.

Photodynamic therapy

This method is a modern minimally invasive method for treating squamous cell skin cancer. It is based on the introduction of a photosensitizer into the body, followed by irradiation with a laser with a certain wavelength, resulting in the destruction of tumor cell membranes without damaging healthy tissue.

The photosensitizer can be administered systemically (intravenously, orally) or locally (by application). As a rule, the intravenous route of administration is used. Our clinic uses the drug Photoditazine.

Indications for systemic photodynamic therapy:

• Initial stages of squamous cell carcinoma without tissue invasion.
• Resistance to standard treatments.
• Severe concomitant pathology, which makes surgery impossible.
• Hard-to-reach localization of formation.
• Multiple and recurrent skin cancer.

Among the local photosensitizers, methylaminolevulinic acid (MALA) in the form of a cream is the most effective. When using this product, the cosmetic result is more acceptable than with surgical excision and cryodestruction.

The first signs of melanoma

Melanoma is the acquisition by cells of unfavorable signs of malignancy (malignancy properties), expressed by various symptoms.

To make it easier to remember the signs of melanoma, use the “FIGARO” rule:

Shape – swollen above the surface;

And changes - accelerated growth;

Borders are openwork, irregular, indented;

And symmetry is the absence of mirror similarity between the two halves of the formation;

P size – a formation with a diameter of more than 6 mm is considered a critical value;

About paint - uneven color, inclusion of random spots of black, blue, pink, red.

In widespread practice, the English version is also popular, summarizing the main, most typical features - the “ABCDE rule”:

A symmetry is an asymmetry in which, if you draw an imaginary line dividing the formation in half, one half will not be similar to the other.

B order irregularity – the edge is uneven, scalloped.

Color is a color that is different from other pigment formations. Interspersed areas of blue, white, and red colors are possible.

D iameter – diameter. Any lesion larger than 6 mm requires additional observation.

E volution – variability, development: density, structure, size.

Without special studies, it is difficult to determine the type of nevus, but timely changes in the nature of the spot will help detect malignancy.

Forecast

When squamous cell skin cancer measuring less than 2 cm is detected and adequate treatment is provided, the 5-year survival rate reaches 90%. If the tumor is larger and there is growth into the tissue, then this figure is reduced to 50%.

Tumors located on the skin of the periorbital region, external auditory canal, and nasolabial fold have a particularly unfavorable prognosis. With this localization, the tumor can grow into muscles and bones and can cause bleeding due to vascular damage, complicated by infections.

Prevention

The main measure for preventing squamous cell skin cancer is the timely detection and treatment of precancerous conditions. In this regard, young people are recommended to be examined by a dermatologist every 3 years, and people over 40 years old - every year. If you detect any changes in the skin, you should also contact a specialist.

Foci of chronic inflammation on the skin must undergo adequate sanitation. You should also avoid repeated damage to the same skin area (rubbing, compression by tight clothing and shoes, injury during monotonous manual work).

It is important to maintain a sun regime and use a cream with a sunscreen component, and avoid visiting a solarium. When working with chemical reagents that are sources of occupational hazard, it is necessary to use personal skin protection.

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When to see a doctor

You should see a doctor if you notice the following symptoms:

• the appearance of suspicious growths on the skin;
• non-healing ulcers;
• itching, bleeding, swelling in areas of the skin.

At the Sofia Oncology Center, patients can make an appointment with an oncologist. The Sofia Oncology Center is located at 2nd Tverskoy-Yamskaya Lane 10. All diagnostic measures are carried out using modern equipment, which allows us to obtain the most accurate research results.