When is Zovirax ointment prescribed?

Compound

• 1 tablet of Zovirax contains 200 mg of acyclovir . Additional components: povidone K30, lactose monohydrate, sodium starch glycolate, microcrystalline cellulose, magnesium stearate.
• 1 gram of Zovirax cream contains 50 mg of acyclovir . Auxiliary components: dimethicone, white paraffin, propylene glycol, cetostearyl alcohol, poloxamer 407, liquid paraffin, sodium lauryl sulfate, macrogol stearate, glycerol monostearate, water.
• 1 gram of Zovirax ointment contains 30 mg of acyclovir . Auxiliary components: white Vaseline.
• 1 bottle of lyophilisate for preparing Zovirax injections contains 250 mg of acyclovir . Auxiliary components: sodium hydroxide.

Release form

White, biconvex, round tablets, engraved with “GXCL3”.

• 5 tablets in a contour pack, 5 packs in a paper pack.

White homogeneous cream 5% for external use.

• 2 grams of cream in a plastic bottle with a dispenser; one bottle in a paper pack.
• 2, 5 or 10 grams of cream in an aluminum tube, 1 tube in a paper pack.

White, translucent, homogeneous, oily ointment, with a slight odor, containing no lumps, grains or foreign inclusions.

• 4.5 grams of cream in a tube with a plastic nozzle, 1 tube in a paper pack.

The lyophilisate for the preparation of injections is a white powder (hygroscopic or in the form of a sintered mass).

• 250 mg powder in a glass bottle, 5 bottles in a plastic tray; one tray in a cardboard box.

Description of the dosage form

Tablets: blue, flat, shield-shaped (irregular polygonal) tablets; On one side there is the inscription “ZOVIRAX” and on the other there is a triangle. Minor inclusions may be visible on the surface of the tablet.

Powder for the preparation of solution for injection: sintered mass (porous cake) or lyophilized powder of white or almost white color. The drug is hygroscopic.

Eye ointment: soft, homogeneous, white or almost white, translucent oily mass with a weak characteristic odor, free of grains, lumps and foreign particles.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Antiviral drug , an artificial analogue of a purine-type nucleoside , which has the ability to inhibit the replication of herpes simplex viruses (HSV) of all types, Varicella zoster, cytomegalovirus and Epstein-Barr . Acyclovir has the most pronounced antiviral properties against the herpes virus type 1 .

The effect of the drug on viruses is highly selective. Thymidine kinase of cells infected with these viruses converts acyclovir into monophosphate , then successively into diphosphate and triphosphate under the influence of cell enzymes. The inclusion of triphosphate in the DNA and the subsequent termination of this chain blocks the copying of viral DNA .

In patients with severe immunodeficiency , prolonged or repeated courses of treatment with acyclovir can lead to the emergence of strains resistant to the drug. Many strains with reduced sensitivity to Zovirax had low concentrations of viral thymidine kinase .

Pharmacokinetics of Zovirax tablets and injections

When taken orally, the active substance is only partially absorbed from the intestine. The content in the cerebrospinal fluid is approximately half of its plasma concentration. Bounds to blood proteins to a small extent (10-33%).

The main metabolite is 9-carboxymethoxy-methylguanine . The half-life is 2.7-3.3 hours. Most of the drug is excreted by the kidneys in unchanged form. It is excreted not only through glomerular filtration, but also through tubular secretion.

In individuals with chronic renal failure, the half-life of acyclovir approaches 19.5 hours. In elderly patients, the clearance of acyclovir decreases with age, but the half-life changes slightly.

Pharmacokinetics of Zovirax ointment

After applying the eye ointment, the active substance is quickly absorbed by the periocular tissues and the corneal epithelium, after which the concentration of the drug necessary to suppress the virus is created in the fluid inside the eye. Acyclovir with this method of administration is determined in the urine in a very low concentration, which has no clinical significance.

Pharmacokinetics of Zovirax cream

With repeated use of acyclovir , systemic absorption is minimal.

Pharmacological properties

Zovirax eye ointment is an antiviral drug that is highly active against Varicella zoster and Herpes simplex viruses (types 1, 2).

Penetrating into infected cells, acyclovir is phosphorylated under the influence of viral thymidine kinase to acyclovir triphosphate. Acyclovir triphosphate inhibits viral DNA synthesis but does not damage host cells.

After instillation of the ointment into the eye, acyclovir is absorbed by the corneal epithelium, as well as by the periocular tissues, after which its concentration necessary to neutralize the virus is created in the aqueous humor.

Indications for use

Indications for use of the tablet form of the drug:

• therapy for infectious lesions of Varicella zoster ( herpes zoster and chickenpox virus );
• therapy for infectious lesions of the skin and mucous membranes of HSV of all types, including genital herpes in primary and recurrent forms ;
• HSV infections of all types, in persons with normal immunity or immunodeficiency ;
• therapy of patients with severe forms of immunodeficiency , mainly with HIV infection (with CD4+ less than 200 cells/μl with early manifestations of HIV infection and AIDS ) or after bone marrow transplantation.

Indications for use of Zovirax ointment:

• keratitis caused by HSV of all types.

Indications for use of Zovirax cream:

• infectious lesions of HSV of all types of skin and mucous membranes, including herpes lips.

Indications for the use of Zovirax lyophilisate for the preparation of injections:

• HSV infections of all types;
• prevention of infectious lesions of HSV of all types of skin and mucous membranes in persons with immunodeficiency ;
• therapy for infectious lesions of Varicella zoster;
• HSV infections of all types in newborns;
• prevention of cytomegalovirus infection after bone marrow transplantation.

Indications for Zovirax®

Powder for solution for injection:

treatment of infections caused by the herpes simplex virus;

prevention of infections caused by the herpes simplex virus in patients with immunodeficiency;

treatment of infections caused by the varicella zoster virus and herpes zoster;

treatment of infections caused by the herpes simplex virus in newborns;

prevention of CMV infections in bone marrow transplant recipients.

Pills:

treatment of skin and mucous membrane infections caused by the herpes simplex virus, including primary and recurrent genital herpes;

prevention of relapses of infections caused by the herpes simplex virus in patients with normal immune status;

prevention of infections caused by the herpes simplex virus in patients with immunodeficiency;

treatment of chickenpox and herpes zoster;

treatment of patients with severe immunodeficiency, mainly with HIV infection (CD4+ cell count < 200/mm3, early clinical manifestations of HIV infection and stage of AIDS) and who have undergone bone marrow transplantation.

Eye ointment: treatment of keratitis caused by the herpes simplex virus.

Contraindications

• Allergy to acyclovir or valacyclovir or components of the drug.
• Contraindications for intravenous administration of the drug: renal failure, dehydration , reactions to intravenous administration of cytotoxic drugs (including in the past), neurological disorders, pregnancy.
• Contraindications for oral administration of the drug: renal failure, dehydration .

Side effects

Side effects when using tablets and lyophilisate

• Digestive reactions: vomiting, nausea, diarrhea and abdominal (if taken orally).
• Hematopoietic reactions: leukopenia, anemia and thrombocytopenia .
• Hypersensitivity reactions: rash, fever , itching, shortness of breath, angioedema , anaphylaxis , urticaria , photosensitivity, severe inflammatory reactions at the site of parenteral administration.
• Reactions from the kidneys: increased concentrations of creatinine and urea in the blood. To avoid such phenomena, instead of a single-stage intravenous injection, it is necessary to prescribe a slower administration over 1 hour. Renal failure caused by intravenous administration of Zovirax is usually relieved by rehydration or reducing the dosage of the drug.
• Liver reactions: temporary increase in bilirubin and liver enzymes, hepatitis and jaundice (rarely with parenteral administration).
• Reactions from nervous activity: psychosis , confusion, tremor , nervous agitation, drowsiness, convulsions , hallucinations , coma , headache (if taken orally).
• Other reactions: fatigue, hair loss.

Side effects when using eye ointment

• Immune reactions: hypersensitivity reactions up to angioedema .
• Visual reactions: punctate keratopathy (passes without consequences and does not require stopping treatment), mild temporary burning sensation, conjunctivitis , blepharitis.

Side effects when using the cream

• Local reactions: temporary itching, redness, burning, peeling, tingling in the area of ​​application.
• Allergic reactions: dermatitis , Quincke's edema .

Instructions for use of Zovirax (Method and dosage)

Zovirax tablets, instructions for use

Zovirax tablets are taken orally with 200 ml of water during meals.

When treating infectious lesions of HSV , 200 mg of the drug is prescribed every 4 hours, five times a day. The standard course of treatment is 5 days, but for severe infections it is allowed to be extended. In the presence of severe immunodeficiency or in cases of intestinal absorption disorders, the dosage of Zovirax can be increased to 400 mg while maintaining the same frequency of administration. It is recommended to begin treatment as quickly as possible after the infection develops; in case of relapses, it is recommended to take the medicine when the first symptoms appear.

To prevent relapses of HSV infections in persons with normal immunity, 200 mg of the drug is recommended four times a day at regular intervals. For many, a more convenient dosage schedule is suitable - 400 mg twice a day. In some cases, low dosages of the drug are effective - 200 mg 3-2 times a day. In some patients, the progression of infection may be interrupted when taking a total dose of 800 mg per day.

Zovirax therapy should be stopped periodically for 6–12 months in order to detect changes in the course of the infection.

HSV infections in people with immunodeficiency , 200 mg of the drug is prescribed four times a day. In the presence of severe immunodeficiency or in case of impaired absorption from the intestine, the dosage can be increased to five times 400 mg of the drug per day. The time of preventive treatment is determined by the duration of the infectious period.

When treating herpes zoster and chickenpox, a five-time dose of 800 mg of the drug per day is prescribed (except during night sleep). The duration of such treatment is one week. The drug should be prescribed as quickly as possible after the onset of infection, because in this case the therapy is most effective.

For the treatment of patients with severe forms of immunodeficiency , four doses of 800 mg of the drug per day are prescribed at regular intervals. Persons who have undergone a bone marrow transplant are usually advised to undergo a month's course of parenteral therapy with Zovirax before taking Zovirax tablets. The maximum duration of treatment after bone marrow transplantation was 6 months. In patients with advanced clinical HIV infection, the duration of treatment was 1 year.

For patients with severe forms of renal failure, the dosage of Zovirax is recommended to be reduced to 200 mg twice a day.

In the treatment of herpes zoster and chickenpox , as well as in the treatment of persons with severe immunodeficiency , standard dosages are:

• severe renal failure - 800 mg twice a day;
• moderate form of renal failure - 800 mg three times a day.

Zovirax eye ointment, instructions for use

Zovirax eye ointment is placed into the conjunctival sac in a 10 mm strip up to 5 times a day. It is recommended to continue treatment after recovery for at least another 3 days.

Zovirax cream, instructions for use

Zovirax cream is applied with a cotton swab or pre-washed hands to avoid reinfection of the affected areas.

A small amount of the medicine is applied to the affected and adjacent areas of the skin and mucous membranes up to 5 times a day.

The duration of treatment is usually 4 days. If there is no healing, it can be extended up to 10 days. If symptoms of the disease persist after 10 days of treatment, you should consult your doctor.

Lyophilisate Zovirax for the preparation of injections, instructions for use

The prepared solution is administered intravenously. In obese individuals, the same dosages are used as in individuals of normal weight.

For the treatment of infectious lesions of HSV and herpes zoster virus , the drug is administered intravenously three times a day at a dose of 5 mg/kg body weight.

For the treatment of infectious lesions with the herpes zoster virus and herpetic encephalitis in people with immunodeficiency , the drug is administered intravenously three times a day at a dose of 10 mg/kg body weight.

To prevent cytomegalovirus infection during bone marrow transplantation, the drug is administered intravenously three times a day at a dose of 500 mg/m2 body area. Therapy begins 5 days before transplantation and continues until 30 days after transplantation.

Pay special attention to reducing Zovirax dosages in elderly people with reduced creatinine clearance .

In people with renal failure, intravenous administration of Zovirax should be prescribed with caution. The dosage will be changed depending on the severity of the deficiency.

The course of therapy with Zovirax in the form of intravenous infusions is usually 5 days, but can be adjusted depending on the patient’s condition and response to therapy. The duration of preventive treatment is determined by the duration of the infectious-dangerous period.

Preparation of solution and method of administration

Zovirax must be administered intravenously, slowly, over 1 hour.

To prepare a solution of the drug with a concentration of the active substance of 25 mg/ml, you need to add 10 ml of water or saline solution into the ampoule with powder and shake gently until the contents are completely dissolved.

Another method of infusion administration is possible: the prepared solution is diluted further to a concentration of 5 mg/ml. To do this, add the prepared solution to one of the infusion solutions and shake to completely mix the solutions. For adults, it is recommended to use infusion solutions in 100 ml bags, despite obtaining a dilution of acyclovir of less than 0.5%. Zovirax for intravenous administration is compatible with the following solutions and remains stable for 12 hours at a temperature of 15-24 °C:

• 0.18% sodium chloride and 4% glucose ;
• 0.45% sodium chloride and 2.5% glucose ;
• 0.45% or 0.9% sodium chloride ;
• Hartmann's solution.

Pharmacokinetics

After oral administration, acyclovir is only partially absorbed from the intestine. When taking 200 mg of acyclovir every 4 hours, the mean maximum steady-state plasma concentration (Cssmax) was 3.1 µmol (0.7 µg/ml), and the mean steady-state minimum plasma concentration (Cssmin) was 1.8 µmol (0.4 µg/ml). When taking 400 and 800 mg of acyclovir every 4 hours, Cssmax was 5.3 µmol (1.2 µg/ml) and 8 µmol (1.8 µg/ml), respectively, and Cssmin was 2.7 µmol (0.6 µg/ml ) and 4 µmol (0.9 µg/ml), respectively.

After intravenous administration of acyclovir to adults, the mean Cmax values ​​1 hour after infusion at doses of 2.5 mg/kg, 5 mg/kg, 10 mg/kg and 15 mg/kg were 22.7 µmol (5.1 µg/ml ); 43.6 µmol (9.8 µg/ml); 92 µmol (20.7 µg/ml) and 105 µmol (23.6 µg/ml), respectively. Cmin 7 hours after infusion was respectively equal to 2.2 µmol (0.5 µg/ml); 3.1 µmol (0.7 µg/ml); 10.2 µmol (2.3 µg/ml) and 8.8 µmol (2.0 µg/ml). In children over 1 year of age, similar Cmax and Cmin were observed when administered at a dose of 250 mg/m2 instead of 5 mg/kg (adult dose) and at a dose of 500 mg/m2 instead of 10 mg/kg (adult dose). In neonates (0 to 3 months) who received acyclovir as an infusion over 1 hour every 8 hours, Cmax was 61.2 µmol (13.8 µg/ml) and Cmin was 10.1 µmol (2.3 µg/ml). Their T1/2 was 3.8 hours.

T1/2 in adults is 2.5–3.3 hours. Most of the drug is excreted unchanged by the kidneys. The renal clearance of acyclovir significantly exceeds the clearance of creatinine, which indicates that acyclovir is eliminated through not only glomerular filtration, but also tubular secretion. The main metabolite of acyclovir is 9-carboxymethoxy-methylguanine, which accounts for about 10–15% of the administered dose in the urine. When acyclovir was administered 1 hour after taking 1 g of probenecid, the T1/2 of acyclovir and the area under the plasma concentration-time curve increased by 18 and 40%, respectively.

In elderly people, the clearance of acyclovir decreases with age in parallel with a decrease in creatinine clearance, but the T1/2 of acyclovir changes slightly.

In patients with chronic renal failure, T1/2 of acyclovir averaged 19.5 hours, and during hemodialysis, the average T1/2 of acyclovir was 5.7 hours, and the concentration of acyclovir in plasma decreased by approximately 60%.

The concentration of acyclovir in the cerebrospinal fluid is approximately 50% of its plasma concentration. Acyclovir binds to plasma proteins to a small extent (9–33%), so drug interactions due to displacement from protein binding sites are unlikely.

When acyclovir and zidovudine were administered simultaneously to HIV-infected patients, the pharmacokinetic characteristics of both drugs remained virtually unchanged.

After applying ophthalmic ointment, acyclovir is quickly absorbed by the corneal epithelium and periocular tissues, resulting in the concentration of the drug necessary to suppress the virus in the intraocular fluid. After using Zovirax ophthalmic ointment, acyclovir is detected only in the urine, and in small quantities.

Overdose

There is no information about an overdose of the drug in the form of a cream or eye ointment.

Overdose of pills

With a single random oral dose of up to 20 grams, no undesirable effects are recorded.

Signs of overdose: nausea, vomiting, headache, shortness of breath, confusion, renal dysfunction, diarrhea , convulsions , lethargy , coma .

Careful observation is necessary in order to timely identify possible signs of intoxication. of hemodialysis cannot be ruled out .

Overdose with solution

Signs of overdose: increased levels of urea nitrogen and creatinine in the blood, hallucinations, renal failure , confusion, convulsions , agitation, coma .

Hemodialysis is recommended , which significantly enhances the evacuation of acyclovir from the body and is the optimal method of treatment for overdose of injectable forms of Zovirax.

Use during pregnancy and breastfeeding

An analysis of acyclovir treatment of women during pregnancy did not reveal an increase in the number of birth defects in their children compared to the general population. However, caution should be exercised when prescribing Zovirax to women during pregnancy and assess the expected benefit to the mother and the possible risk to the fetus.

After taking Zovirax orally at a dose of 200 mg 5 times a day, acyclovir was detected in breast milk in concentrations ranging from 0.6 to 4.1 of plasma concentrations. At such concentrations in breast milk, breastfed children can receive acyclovir at a dose of up to 0.3 mg/kg/day. Given this fact, caution should be exercised when prescribing Zovirax to nursing women.

Interaction

No significant drug interactions were detected when using the drug.

Acyclovir is excreted unchanged into the urine due to tubular secretion . All drugs with a similar method of elimination can increase the concentration of acyclovir in the blood.

Caution should be exercised in combining intravenous administration of Zovirax with drugs that interfere with kidney function ( Ciclosporin , Tacrolimus and others).

special instructions

Patients taking the drug orally in large doses should drink sufficient fluid.

It is possible that a burning sensation may occur immediately after applying the eye ointment, which usually goes away spontaneously.

During drug therapy, wearing contact lenses is prohibited.

In order for the therapeutic effect to be maximum, it is necessary to start using the drug already at the initial symptoms of the disease (tingling, itching, burning, redness).

If you have severe symptoms of herpes , you should definitely consult a doctor.

When treating genital herpes , it is advised to abstain from sexual intercourse or use condoms, since the use of acyclovir does not protect against contracting the disease through sexual contact.

It is not recommended to apply the cream to the mucous membranes of the mouth and eyes due to the fact that local inflammation may occur.

Patients with immunodeficiency should adhere to the recommendations of the attending physician when treating any infectious lesions.

In persons with herpetic encephalitis , taking Zovirax in large dosages, it is necessary to constantly monitor kidney function.

The finished solution of the drug has a pH of 11, so it is prohibited for oral use.

Precautionary measures

In case of renal failure, Zovirax doses should be adjusted according to its degree to prevent the accumulation of acyclovir in the body.

In patients receiving IV Zovirax in high doses for herpetic encephalitis, it is necessary to monitor renal function, especially if it is initially impaired or there is dehydration.

Patients taking high doses of Zovirax by mouth should receive sufficient fluids.

The prepared Zovirax solution has a pH of 11.0 and cannot be used orally.

Patients should be informed of the possibility of a transient mild burning sensation after application of Zovirax ophthalmic ointment. During treatment with the drug, patients should not wear contact lenses.

Zovirax analogs

Level 4 ATX code matches:
Aldara

Viru-Merz Serol

Zovirax Duo-Active

Acyclovir

Fenistil Pencivir

Bonafton

Atsik

Alpizarin

Herpferon

Epigen Intim

Lysozyme

Gerpevir

Kondilin

Virolex

Gevisosh

Cheaper analogues of Zovirax are listed below: Acigerpin (lip analogue), Acyclovir (cream, eye ointment, tablets), Herperax (ointment), Acyclovir Belupo (tablets, cream), Acyclovir Sandoz (tablets, cream), Acyclovir-Acri (tablets , ointment), Acyclovir-Akrikhin (tablets, ointment), Acyclostad (cream), Vivorax (cream), Virolex (cream, lyophilisate, eye ointment, tablets), Medovir (lyophilisate), Acivir (cream), Herpetad (cream), Provirsan (tablets), Zovirax Duo (cream).

For children

Zovirax tablets

Treatment and prevention of infectious lesions caused by the common herpes virus in pediatric patients with immunodeficiency :

• up to the age of 2 years, use half the dosage for adults;
• over 2 years of age, use adult doses described in the section “Instructions for use of Zovirax” .

For the treatment of chickenpox in children, the following dosages are used:

• children under 2 years of age are prescribed 200 mg four times a day;
• children 2-6 years old are prescribed 400 mg four times a day;
• Children over 6 years old are prescribed 800 mg four times a day.

More accurately, the dosage can be determined based on the child’s weight: 20 mg/kg body weight four times a day. The course of therapy is 5 days.

According to the limited information currently available, adult dosages of Zovirax are permitted immunodeficiency “Instructions for use of Zovirax” ).

Zovirax eye ointment and cream

Zovirax eye ointment and cream are used by aunts according to the same scheme and in the same doses as adults (described in the section “Instructions for use of Zovirax”).

Lyophilisate for the preparation of injections

Dosages for intravenous administration in children 3 (months) - 12 (years) are calculated based on body area.

When treating infectious lesions associated with the herpes simplex virus (excluding herpetic encephalitis ) and herpes zoster virus , doses of intravenous infusions are calculated according to the scheme 250 mg/m2 three times a day.

In the treatment of infectious lesions associated with the herpes zoster virus and herpetic encephalitis in sick children with immunodeficiency doses are calculated according to the regimen of 500 mg/m2 three times a day.

It is suggested that children 2 years of age and older who have received a bone marrow transplant can be given adult doses of Zovirax.

Clinical pharmacology

In patients with severe immunodeficiency, long-term or repeated courses of acyclovir therapy may lead to the emergence of resistant strains, and therefore further treatment with acyclovir may be ineffective. The majority of isolated strains with reduced sensitivity to acyclovir had a relatively low content of viral thymidine kinase and a disorder in the structure of viral thymidine kinase or DNA polymerase. The effect of acyclovir on HSV strains in vitro can also lead to the formation of strains that are less sensitive to it. A correlation has not been established between the sensitivity of HSV strains to acyclovir in vitro and the clinical effectiveness of the drug.

It has been shown that intravenous administration of Zovirax in high doses reduces the incidence and delays the development of CMV infection. If, after infusion therapy with Zovirax in a high dose, treatment with Zovirax for oral administration in a high dose is carried out for 6 months, then mortality and the incidence of viremia are reduced.

Reviews of Zovirax

Almost all reviews of Zovirax ointment and reviews of other forms of release of this drug perfectly characterize the therapeutic effectiveness of the drug. Zovirax is most often used for herpes . Reports of side effects and ineffectiveness of the drug are extremely rare. The greatest dissatisfaction of patients is the high price of the drug.

Which is better: Zovirax or Acyclovir?

Acyclovir and Zovirax have the same active substance and release forms. Based on reviews, when used for herpes , there is no difference in effect, given that the latter costs almost 20 times more. The choice between drugs should be made based on economic considerations and individual characteristics.

Zovirax price, where to buy

Zovirax price in tablets

A package of the drug 200 mg No. 25 in Russia costs from 500 to 850 rubles. In Ukraine, its average price is 90 hryvnia.

How much does the ointment cost?

The price of Zovirax ointment in Russia is 270-380 rubles. There are no data on the price of ointment in Ukraine.

Cream price

The price of Zovirax cream (5 g), used for colds on the lips, in Russia ranges from 180-195 rubles. In Ukraine, a tube of cream (2 g) will cost approximately 55-75 hryvnia.

Zovirax lyophilisate price

The price of a package of lyophilisate 250 mg No. 5 in Russian pharmacies costs 1590-1750 rubles. In Ukraine, such packaging can be purchased for 670-740 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Zovirax tablets 200 mg 25 pcs. Glaxo Wellcome S.A./GlaxoSmithKline Pharmaceuticals S.A.
  RUB 233 order
• Zovirax Zovirax for colds on the lips, cream 5%, 5gGlaxo Welcome Operations

  RUB 193 order

Pharmacy Dialogue

• Zovirax DUO-ACTIVE for colds on the lips, cream 5% 2gGlaxo-Wellcome

  RUB 390 order

• Zovirax (lyof. d/p. solution d/inf. 250 mg No. 5)GlaxoSmithKline

  RUB 1,242 order

• Zovirax for cold lips, cream 5% 5gGlaxo-Wellcome

  182 RUR order

• Zovirax tablets 200 mg No. 25GlaxoSmithKline Pharmaceuticals CA

  RUB 228 order

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Pharmacy24

• Zovirax 200 mg No. 25 tablets Glaxo Wellcome S.A.
  Spain/GlaxoSmith Klein Pharmaceuticals S.A., Poland 96 UAH order
• Zovirax 250 mg No. 5 lyophilisate for the preparation of solution for infusion GlaxoSmithKline Manufacturing S.p.A., Italy

  801 UAH order

• Zovirax 5% 2 g cream Glaxo Operations UK Limited, Great Britain

  50 UAH order

• Zovirax Duo 2 g cream Glaxo Operations UK Limited, Great Britain

  68 UAH order

PaniPharmacy

• Zovirax infusion Zovirax lyophilisate for solution for infusion 250 mg No. 5 Italy, GlaxoSmithKline Manufacturing

  924 UAH. order

• Zovirax cream Zovirax cream 5% 2g UK, Glaxo Operations UK

  52 UAH order

• Zovirax tablets Zovirax tablets 200 mg No. 25 Poland, GlaxoSmithKline Pharmaceuticals

  101 UAH order

• Zovirax ointment Zovirax ointment for eyes. 3% 4.5g Canada, Jubilant HollisterStier General Partnership

  248 UAH order

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