Biseptol: composition, when prescribed

Compound

The drug contains a combined active substance Co-Trimoxazole , which in turn consists of the substances sulfamethoxazole (200 mg for suspension and 100 mg (400 mg) for tablets) and trimethoprim (40 mg for suspension and 20 mg (80 mg) for tablets ).

Additional funds

For suspension: purified water, macrogol, sodium carmellose, propylene glycol, propyl parahydroxybenzoate, aluminum magnesium silicate, sodium saccharin, citric acid monohydrate, maltitol, sodium hydrogen phosphate dodecahydrate, methyl parahydroxybenzoate.

For tablets: propylene glycol, potato starch, methyl parahydroxybenzoate, talc, propyl parahydroxybenzoate, magnesium stearate, polyvinyl alcohol.

Pharmacodynamics and pharmacokinetics

Combined antimicrobial drug. The main active ingredient is Co-Trimoxazole (trimethoprim + sulfamethoxazole). What is it used for? Biseptol has a double blocking effect on bacterial metabolism. Trimethoprim has an inhibitory effect on the enzyme involved in the metabolism of folic acid and converts dihydrofolate to tetrahydroflorate. Sulfamethoxazole has a bacteriostatic effect. In combination, the components of the drug Biseptol block the biosynthesis of purines and nucleic acids, without which the reproduction and growth of bacteria is impossible.

The active substances are actively absorbed from the gastrointestinal tract. They are excreted mainly through the kidneys.

Indications for use of Biseptol

What are these tablets and suspension for?

In general, the drug is prescribed for infectious lesions of the urinary tract: pyelitis, urethritis , prostatitis , pyelonephritis , gonorrhea , epididymitis, lymphogranuloma venereum, chancroid , inguinal granuloma. Let's look at what Biseptol helps with in different parts of the body.

Indications for the use of Biseptol for gastrointestinal infections: paratyphoid , cholera , typhoid fever , cholangitis, dysentery , gastroenteritis (E. coli), cholangitis, salmonella carriage.

Respiratory tract infections: lobar pneumonia, bronchiectasis, bronchitis (acute and chronic), Pneumocystis pneumonia, bronchopneumonia .

Infections of the ENT organs: tonsillitis , sinusitis , otitis media , scarlet fever , laryngitis .

Infections of soft tissues, skin: furunculosis, acne , wound infections, pyoderma . In complex therapy it is used to treat toxoplasmosis, malaria, South American blastomycosis, and acute brucellosis.

What does Biseptol help with and indications for use?

The drug is prescribed for infectious diseases of most organs and systems, namely:

• Diseases of the gastrointestinal tract: gastroenteritis, colitis, salmonellosis, cholera, typhoid fever and paratyphoid fever.
• Otorhinolaryngological pathology: laryngitis, sore throat, otitis, sinusitis.
• Infectious lesions of the lungs and respiratory tract: acute and chronic bronchitis, pneumonia, exacerbation of bronchiectasis.
• Diseases of the genitourinary system: urethritis, cystitis, prostatitis, pyelonephritis, gonorrhea.
• Dermatological pathology: acne, boils, pyoderma.

Side effects

Nervous system: dizziness, headaches, rarely depression, aseptic meningitis , tremor, apathy , peripheral neuritis.

Respiratory system: pulmonary infiltrates, bronchospasm.

Digestive system: dyspeptic disorders, cholestasis, diarrhea, vomiting, loss of appetite, glossitis, epigastric pain, gastritis, increased levels of liver transaminases, stomatitis, pseudomembranous enterocolitis, hepatonecrosis, hepatitis.

Hematopoietic organs: megaloblastic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia.

Side effects from the urinary system: crystalluria, interstitial nephritis, polyuria, toxic nephropathy with anuria , oliguria, increased urea levels, hematuria, impaired renal function.

Musculoskeletal system: myalgia, arthralgia. thrombophlebitis , hypoglycemia, allergies .

Instructions for use of Biseptol (Method and dosage)

The dose of the drug in each case is prescribed by the doctor.

Biseptol tablets, instructions for use

Adults: 960 mg once, or 480 mg in 2 doses. Severe infections: 480 mg three times. Course 1-2 weeks.

For acute brucellosis, the course of treatment is 3-4 weeks, for paratyphoid and typhoid fever - up to 3 months.

Chronic infections: twice 480 mg tablets.

Instructions for use for children

For children, Biseptol is prescribed twice a day, dose from 120 to 480 mg.

At the age of 3-5 years: 2 times 120 mg per 24 hours.

Biseptol suspension, instructions for use

The syrup is used in the same way as the tablets.

Instructions for use of Biseptol

The dosage and frequency of use are prescribed by the doctor.

On average, one course of treatment for an adult patient requires 960 mg of the drug in one or two doses. Complicated infectious diseases may require increasing the duration of therapy to 1-2 weeks.

The drug is approved for use in children.

The suspension can be prescribed to babies starting from 3 months at a dosage of 2.5 to 20 ml per dose, depending on the weight and age of the child.

Tablets can be used from 3 years of age. The dosage ranges from 120 to 480 mg per day.

Overdose

Intestinal colic, dyspeptic disorders, headaches, dizziness, drowsiness, vomiting, confusion, fever, depression, hematuria , fainting, visual impairment, leukopenia, fever, crystalluria . With prolonged overdose, jaundice, megaloblastic anemia, thrombocytopenia, and leukopenia are noted. It is necessary to administer trimethoprim, calcium folinate intramuscularly at a dose of 5-15 mg/day. If necessary, hemodialysis is prescribed. There is no specific antidote.

Side effects and overdose

Taking the drug may be accompanied by the development of many unwanted reactions. Most often, dizziness, loss of appetite, dyspeptic syndrome (nausea, vomiting, stool disorders), pain in muscles and joints occur.

More rare side effects are depression, apathy, insomnia, bronchospasm, gastritis, hepatitis, agranulocytosis, anemia, nephropathy, decreased plasma glucose levels.

It is also possible to develop various allergic reactions.

An overdose can be accompanied by all of the listed symptoms. The clinic is also supplemented by an increase in body temperature, abdominal pain, the appearance of a jaundiced coloration of the skin, and disturbances in vision and consciousness.

First aid: intramuscular injection of 5-15 mg of calcium folinate and trimetropim.

Interaction

Biseptol enhances the effect of hypoglycemic drugs, indirect anticoagulants, methotrexate. The drug reduces the effectiveness and reliability of oral contraception. The risk of developing megaloblastic anemia increases when taken concomitantly with pyrimethamine (more than 25 mg per week). Thiazides may cause thrombocytopenia. The effectiveness of Biseptol is reduced by procainamide , procaine , and benzocaine . The drug leads to the development of cross-allergy when taken simultaneously with oral hypoglycemic drugs. Lack of folic acid increases with the prescription of barbiturates, phenytoin, PAS . Crystalluria develops when taking hexamethylenetetramine , ascorbic acid.

Drug interactions

Biseptol interacts with a large number of drugs. It improves efficiency:

• hypoglycemic agents;
• methotrexate;
• indirect anticoagulants.

Reduces the effectiveness of oral contraceptives.

The simultaneous use of hypoglycemic drugs and Biseptol can provoke the development of cross-allergy. And treatment with benzocaine, procaine and procainamide blocks the effect of the drug.

The interaction with alcohol has not been fully studied at the moment, so it is recommended to abstain from drinking alcohol during therapy.

special instructions

Regular monitoring of the concentration of sulfamethoxazole in the blood is necessary. If the value is more than 150 mcg/ml, then treatment is stopped until the value reaches 120 mcg/ml or lower. If the course of treatment lasts a month or more, then regular monitoring of the blood condition is required. When folic acid , hematological changes are reversible. In patients with AIDS, side effects are more common and more pronounced. Biseptol is not recommended to be prescribed for pharyngitis and tonsillitis caused by beta-hemolytic streptococcus gr. A.

Biseptol - an antibiotic or not? According to the annotation, the drug is not an antibiotic.

The recipe in Latin may look something like this: Rp: “Biseptoli-420” Dtd No. 20 in tab.

There is no description of the drug on Wikipedia.

Biseptol®

The drug should be prescribed only in cases where the benefits of such combination therapy outweigh the possible risks compared to other antibacterial single drugs. Since the sensitivity of bacteria to antibacterial drugs in vitro

varies across different geographic areas and over time, local bacterial susceptibility data should be taken into account when selecting a drug. Sulfamethoxazole + trimethoprim is not recommended for use in tonsillitis and pharyngitis, which are caused by group A P-hemolytic streptococcus, due to widespread resistance of the strains.

Rare cases of life-threatening complications associated with the use of sulfonamides have been described, including liver necrosis, aplastic anemia, agranulocytosis, other blood disorders and hypersensitivity reactions in the respiratory system (pulmonary infiltrates).

Hypersensitivity and allergic reactions:

At the first appearance of skin rash or any other severe adverse reaction, the drug should be discontinued. Patients with a tendency to allergic reactions and bronchial asthma should prescribe Biseptol® with caution.

Infiltrates in the lungs

(like eosinophilic or allergic alveolitis) may present with symptoms such as cough or shortness of breath. If these symptoms appear or suddenly increase, it is necessary to re-examine the patient and consider stopping treatment with Biseptol®.

Kidney disorders:

sulfonamides, including Biseptol®, may increase diuresis, especially in patients with edema caused by heart failure.
Careful monitoring of renal function and potassium concentration in the blood serum is necessary for patients receiving high doses of Biseptol® (including during treatment of Pneumocystis pneumonia caused by P. jirovecii
), as well as the following groups: patients with a history of impaired potassium metabolism receiving standard doses drug; patients with renal failure; patients receiving drugs that contribute to the development of hyperkalemia.

Serious adverse reactions:

Fatalities, although rare, have been reported associated with adverse reactions such as blood disorders, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), drug rash with eosinophilia and systemic manifestations (DRESS syndrome), and fulminant hepatic necrosis . Patients should be informed of the signs and symptoms of skin reactions and the need to closely monitor their development. The greatest risk of developing Stevens-Johnson syndrome or toxic epidermal necrolysis is observed during the first weeks of treatment. Treatment with Biseptol® should be discontinued if signs of Stevens-Johnson syndrome or toxic epidermal necrolysis appear. The best results in the treatment of Stevens-Johnson syndrome or toxic epidermal necrolysis can be achieved if they are detected early and the drug that may be causing it is immediately stopped. If during treatment with Biseptol® the patient develops Stevens-Johnson syndrome or toxic epidermal necrolysis, treatment with this drug should not be resumed.

In patients with AIDS treated with sulfamethoxazole + trimethoprim due to infection with Pneumocystis jirovecii

, adverse events are more often observed, in particular, rash, increased body temperature, leukopenia, increased aminotransferase activity in the blood plasma, hyperkalemia and hyponatremia.

While taking sulfamethoxazole + trimethoprim (as with other antibacterial drugs), pseudomembranous colitis may develop.

In mild cases of pseudomembranous colitis, simply stopping the drug is sufficient. In moderate to severe cases, it is necessary to replace the loss of fluid, electrolytes and protein, and also use antibacterial agents that affect Clostridium difficile

(metronidazole or vancomycin). You should not take drugs that inhibit peristalsis, as well as other drugs with antidiarrheal effects.

Special patient groups:

in elderly and senile patients, as well as in patients with concomitant diseases, for example, impaired renal and/or liver function, or while taking other drugs, there is an increased risk of severe adverse reactions, which in these cases is related to the dose and duration therapy.

The most common severe adverse reactions in elderly patients are severe skin reactions, myelosuppression, and thrombocytopenia with or without purpura. Concomitant use of diuretics increases the risk of developing purpura.

The duration of treatment with Biseptol® should be as short as possible, especially in elderly and senile patients.

If renal function is impaired, the dose should be adjusted according to the instructions in the "Dosage and Administration" section. Patients with severe renal impairment (creatinine clearance 15-30 ml/min) receiving sulfamethoxazole + trimethoprim should be carefully monitored for the development of toxicity symptoms (nausea, vomiting, hyperkalemia).

For patients with severe hematological diseases, Biseptol® can be prescribed only in exceptional cases.

Elderly and senile patients, as well as patients with pre-existing folic acid deficiency or renal failure, may experience

hematological changes characteristic of folic acid deficiency. They disappear after administration of folic acid (3-6 mg/day).

Due to the risk of hemolysis, Biseptol® should not be prescribed to patients with glucose-6-phosphate dehydrogenase deficiency, except in cases of absolute indications, and should be used only in minimal doses.

As with any sulfonamides, caution should be exercised in patients with porphyria or thyroid dysfunction.

Patients whose metabolic processes are characterized by “slow acetylation” are more likely to develop idiosyncrasy to sulfonamides.

Long-term therapy:

with long-term use of the drug Biseptol®, it is necessary to regularly determine the number of blood cells. If there is a significant decrease in the number of any blood cells, Biseptol® should be discontinued.

Patients receiving long-term treatment with Biseptol® (especially with renal failure) should regularly undergo a general urine test and monitor kidney function. During treatment, it is necessary to ensure sufficient fluid intake and adequate diuresis to prevent crystalluria.

During treatment with Biseptol®, it is not recommended to consume foods containing large amounts of PABA - green vegetables (cauliflower, spinach, legumes), carrots, tomatoes.

Excessive sun and UV exposure should be avoided.

Biseptol for children

It is noted that the drug can be used from 3 months of life; naturally, the doses will vary. However, this should be done with caution and only as directed by a doctor. In some countries of the world, Biseptol for children is allowed to be used only from 12 years of age.

Usually they can prescribe a suspension from 3 months, tablets from 2 years.

Instructions for Biseptol for children

At the age of 3 to 6 months, 2.5 ml of syrup is prescribed 2 times a day. The interval between doses should be at least 12 hours. From six months to 3 years, take up to 5 ml of Biseptol suspension for children twice a day.

From 3 to 6 years, the dosage is made equal to 5-10 ml twice, 6-12 years - 10 ml 2 times a day. From 12 years of age, take 20 ml every 12 hours.

How to take pills for children?

At the age of 2-5 years: 2 times 120 mg per 24 hours. From 6 to 12 years, use 480 mg every 12 hours.

The course of treatment is 5-7 days. When using drugs for children, you should drink plenty of water.

BISEPTOL - an antibiotic or not?

Representative office of Polpharma SA

Antibiotics are drugs based on substances produced by microorganisms or obtained by semi-synthetic methods. There are also synthetic drugs - these are artificially created substances with a similar effect; they are combined under the general term “antibacterial drugs”.

In popular scientific literature, the term “antibiotic” is often used to refer to all antimicrobial agents.

Some people categorically do not use antibiotics; in others, the body responds to their use with allergic reactions. What should such patients do if they need to cope with an infection? There is one remedy that has been tested by time and the practice of pediatricians. This is BISEPTOL suspension.

The active component of BISEPTOL suspension is co-trimoxazole. This is a product that destroys pathogenic microflora. Co-trimaxozole consists of two components, which, on the one hand, disrupt important life processes occurring in the cells of harmful microbes, and on the other, activate the production of substances that suppress the proliferation of microbes.

BISEPTOL is an antibacterial drug, but not an antibiotic.

BISEPTOL suspension can help destroy pathogens such as staphylococci, streptococci, salmonella, Haemophilus influenzae, Shigella, Legionella, Proteus, Brucella, Neisseria, mycobacteria and many others.

A special form of BISEPTOL for children is produced in Poland, part of the pharmaceutical industry. This suspension has a strawberry flavor, does not contain sugar and can be used in children from the age of three months.

In what cases can children be prescribed BISEPTOL suspension?

BISEPTOL suspension is used for such infectious and inflammatory diseases as inflammation of the bronchi and lungs, inflammation of the middle ear, tonsils, paranasal sinuses, larynx, kidney disease, urinary tract and intestines. BISEPTOL will also help with infections localized in the digestive tract, as well as with infectious skin lesions, furunculosis and purulent wounds. BISEPTOL is effective even in case of infection that has settled deep in the bone tissue.

Who is not recommended to take BISEPTOL suspension?

If your child has an individual intolerance to a number of sulfonamides or very severe kidney and liver diseases, blood diseases or streptococcal tonsillitis, then BISEPTOL suspension should not be taken.

How to take BISEPTOL suspension?

BISEPTOL suspension is taken after meals in the morning and evening.

The dosage depends on the disease and the age of the patient.

One measuring cap holds 10 ml. with divisions into 2.5 ml 5 ml, 7.5 ml and 10 ml, which is very convenient for parents.

BISEPTOL suspension is prescribed to children starting from three months.

Warning!

It is not advisable to treat babies with BISEPTOL for less than three days. When all the manifestations of the disease completely disappear, you need to take BISEPTOL for two more days, that is, only 5-7 days, but the duration of therapy should always be determined only by the attending physician.

Special instructions

If your child takes BISEPTOL suspension, then it is advisable to adjust his diet. Try to give him more fluids and not give him a lot of green leafy vegetables, cabbage of all kinds, peas and beans, as well as tomatoes, carrots, desserts and baked goods. This is due to the fact that BISEPTOL improves the functioning of the kidneys and intestines.

During treatment with BISEPTOL, support the baby’s body with vitamins approved by the attending physician. For example, ascorbic acid in CEVICAP .

“CEVIKAP” is the only form of ascorbic acid in drops specially designed for children, has a pleasant taste and is accepted with pleasure by children.

Just a few drops a day, depending on age, will significantly strengthen your child’s immunity. "CEVIKAP" - with love and care for the baby.

For more information contact:

Representative office of Polpharma SA

Biseptol's analogs

Level 4 ATC code matches:
Biseptol 480

Co-trimoxazole

Bactrim

Analogues are the following drugs: Bactiseptol , Bactrim , Biseptazol , Biseptrim , Groseptol , Co-Trimoxazole , Oriprim , Raseptol , Solyuseptol , Sumetrolim , Triseptol .

Reviews of Biseptol

The product is very effective, especially for respiratory diseases. Has an excellent antibacterial effect. Among the disadvantages, it should be noted that there are sometimes side effects. Should not be used without the direction of the attending physician.

Biseptol for children, reviews

It is considered a very effective means of combating microbes. There are generally no negative reviews when treating children with Biseptol syrup.

Reviews of Biseptol for cystitis

The drug is effective against cystitis, but do not forget about the side effects.

For sore throat

Prescribed when it is impossible to take antibiotics. According to research, microorganisms that cause sore throat have begun to lose sensitivity to this drug.

Biseptol price

The price of Biseptol in 120 mg tablets is 35 rubles for 20 pieces. You can buy 480 mg tablets for 100 rubles per pack of 28 pieces.

The price of Biseptol syrup is approximately 130 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Biseptol Susp.
  for internal approx. 240mg/5ml 80mlMedana Pharma Terpol Group Joint Stock Company RUR 128 order
• Biseptol tab. 480 mg n28 JSC "Adamed Pharma"

  103 rub. order

• Biseptol tab. 120 mg n20 JSC "Adamed Pharma"

  34 RUR order

Pharmacy Dialogue

• Biseptol 120 tablets 120 mg No. 20Polfa

  37 RUR order

• Biseptol suspension (vial 240mg/5ml 80ml)Medana

  121 rub. order

• Biseptol 480 tablets 480 mg No. 28Polfa

  90 rub. order

• Biseptol 480 ampoules 5ml No. 10Polfa

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Pharmacy24

• Biseptol 480 No. 14 tablets Pub Yanitsky FZ, Polfa A.T., Poland
  76 UAH.order
• Biseptol 100/20 mg No. 20 tablets Pub Yanitsky FZ, Polfa A.T., Poland

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• Biseptol 480 N20 tablets Pub Yanitsky FZ, Polfa A.T., Poland

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PaniPharmacy

• Biseptol infusion Biseptol solution d/in. 480mg amp. 5ml No. 10 Poland, Warsaw Federal Law

  271 UAH order

• Biseptol liquid Biseptol suspension for oral use bottle 80ml Poland, Medana Pharma SA

  119 UAH order

• Biseptol tablets Biseptol tablets 480 mg No. 20 Poland, Pabianicki Federal Plant Polfa

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• Biseptol tablets Biseptol tablets 120 mg No. 20 Poland, Pabianicki Federal Plant Polfa

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• Biseptol tablets Biseptol tablets. 480 mg No. 14 Poland, Pabianicki Federal Plant Polfa

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