HYDROXYZINE CANON film-coated tablets 25 mg No. 25

Hydroxyzine tablet p/o 25 mg N25 (Canonpharma)

Pharmacotherapeutic group: anxiolytic agent (tranquilizer) ATX code: [N05BB01] Pharmacological properties Pharmacodynamics Hydroxyzine is a first-generation H1-histamine receptor blocker, a derivative of phenothiazine with antimuscarinic and sedative properties and diphenylmethane, which helps inhibit the activity of certain subcortical zones. It has H1-histamine blocking, bronchodilating and antiemetic effects, and has a moderate inhibitory effect on gastric secretion. Hydroxyzine significantly reduces itching in patients with urticaria, eczema and dermatitis. Hydroxyzine has a positive effect on cognitive abilities, improves attention and memory. Hydroxyzine does not cause addiction or mental dependence; with prolonged use, no withdrawal syndrome has been observed. Hydroxyzine is capable of depressing the central nervous system, and also has anticholinergic, antihistamine, antispasmodic, local anesthetic, sympatholetic effects, and has muscle relaxant activity. In case of liver failure, the H1-histamine blocking effect can be prolonged up to 96 hours after a single dose. Has moderate anxiolytic activity. Polysomnography in patients with insomnia and anxiety demonstrates an increase in sleep duration and a decrease in the frequency of night awakenings after single or repeated administration of hydroxyzine at a dose of 50 mg. A decrease in muscle tension in patients with anxiety was noted when taking the drug at a dose of 50 mg 3 times a day. The H1-histamine blocking effect occurs approximately 1 hour after taking the tablets orally. The sedative effect appears after 30-45 minutes. Pharmacokinetics. Absorption: Absorption is high. The time to reach maximum concentration (TCmax) after oral administration is 2 hours. After taking an average dose of 50 mg, the Tmax in adults is 70 mg/ml. Distribution: The distribution coefficient is 7-16 l/kg in adults. Hydroxyzine penetrates the blood-brain barrier and the placenta, concentrating more in fetal than maternal tissues. After oral administration, hydroxyzine penetrates well into the skin, with hydroxyzine concentrations in the skin far exceeding serum concentrations after both single and multiple doses. Plasma concentration of hydroxyzine does not necessarily reflect its tissue binding or distribution at skin receptors. It has an effect on skin inflammation depending on serum concentration. Metabolism: Hydroxyzine is metabolized in the liver. Cetirizine - the main metabolite (45%) is a blocker of H1-histamine receptors. Metabolites are found in breast milk. Elimination: Half-life (T1/2) in adults is 14 hours (range: 7-20 hours). The total clearance of hydroxyzine is 13 ml/min/kg. About 0.8% of hydroxyzine is excreted unchanged through the kidneys. The main metabolite cetirizine is excreted mainly in the urine, also unchanged (25% of the dose of hydroxyzine). Pharmacokinetics in special groups of patients. In elderly patients In elderly patients T1/2 was 29 hours. The volume of distribution is 22.5 l/kg. It is recommended to reduce the daily dose of hydroxyzine when prescribed to elderly patients. Children under 1 year In children, the total clearance is 2.5 times higher than in adults. The dose must be adjusted. The half-life is 4 hours. Children from 1 year to 14 years The half-life is 11 hours. In patients with liver failure In patients with liver dysfunction secondary to primary biliary cirrhosis, the total clearance was approximately 66% of the value recorded in healthy volunteers. In patients with liver diseases, T1/2 increased to 37 hours, the concentration of metabolites in the blood serum was higher than in young patients with normal liver function. For patients with liver failure, a reduction in the daily dose or frequency of administration is recommended. In patients with renal failure The pharmacokinetics of hydroxyzine was studied in 8 patients with severe renal failure (creatinine clearance 24+7 ml/min). The duration of exposure to hydroxyzine did not change significantly, while the duration of exposure to cetirizine was increased. To avoid any significant accumulation of cetirizine metabolite after repeated use of hydroxyzine in patients with impaired renal function, the daily dose of hydroxyzine should be reduced.

Dosage form

Hydroxyzine is available in the form of round white tablets, which are packaged in cellular contour blisters. The records are placed in cardboard boxes. Also, there is Hydroxyzine in the form of a solution for intramuscular injection.

In addition to blocking histamine receptors, Hydroxyzine inhibits the high activity of subcortical zones. The drug does not have the ability to cause addiction in the patient. The therapeutic effect occurs 15-20 minutes after taking the medicine orally.

Reviews about the use of Hydroxyzine

Dehar M.G., psychiatrist: “I prescribe hydroxyzine to patients with sleep disturbances, increased irritability and anxiety. The drug quickly relieves negative symptoms. My drug addiction colleagues use Hydroxyzine to relieve withdrawal symptoms.”

Grigory, 56 years old: “I have a bad habit – alcohol addiction. I'm a binge alcoholic. I have binges 2-3 times a year, but for 1-2 weeks I cannot stop. During this period, as part of complex therapy, the doctor prescribes Hydroxyzine to me. After 2-3 days of this treatment, I am already back to normal and can work.”

Maria, 38 years old: “I periodically experience attacks of increased anxiety, nervous overexcitation and irritability. At this moment I take Hydroxyzine, which after 3-4 days brings my nervous and mental state back to normal. I also noticed that my mood improves.”

Hydroxyzine is the most effective anti-anxiety drug with an antihistamine effect. Medication is often prescribed to relieve symptoms of severe allergies and withdrawal symptoms. The medication is only prescribed by a doctor, who prescribes the dosages required for treatment. It is prohibited to use Hydroxyzine for self-medication.

Pharmacological group

The drug Hydroxyzine belongs to the category of sedative, anxiolytic pharmacological agents. It is a histamine H1 receptor blocker. Hydroxyzine is a derivative of hyperazine. Moderation is characterized by the ability to m-choline blocking. Also has an antiemetic effect.

The medication has a positive effect on mental abilities, develops memory function and improves the ability to concentrate. It has a relaxing effect on skeletal muscles and provokes a bronchodilator effect. It has a slight blocking effect on the secretory ability of the stomach and an analgesic effect.

General information about the drug

In addition to blocking histamine receptors, Hydroxyzine inhibits the high activity of subcortical zones. The drug does not have the ability to cause addiction in the patient. The therapeutic effect occurs 15-20 minutes after taking the medicine orally.

See the full list of structural analogues of Hydroxyzine, which are cheaper.

Drug group, INN

The medication has a positive effect on human cognitive functions - significantly improves the quality of memory and increases attentiveness. The active components quickly relax smooth muscle fibers, which contributes to an effective bronchodilator effect. Analgesic properties reduce tension and pain in eczema and urticaria.

Description of the drug

Hydroxyzine belongs to the pharmacological group of medications that act on the centers of the nervous system - anxiolytics. INN – Hydroxyzine. The drug is used for severe symptoms of anxiety, as well as for emotional stress and allergic reactions.

Release forms and prices for the drug, average in Russia

Hydroxyzine is produced in white, round tablets with an existing score. The tablets on the break are also white. The tablets are packaged in blisters of 10 pieces each and in cardboard boxes of 2, 3, 5 blisters. The manufacturer includes an annotation on the use of the medication in each box.

The price of Hydroxyzine in the Russian Federation is presented in the table.

Contraindications

The main indications for the use of the tableted pharmacological agent Hydroxyzine are the following patient conditions:

1. The need to eliminate excessive anxiety and increased excitability of the nervous system.
2. As a means to alleviate the patient's condition in case of alcohol withdrawal.
3. If the patient has a number of psychoneurotic disorders.
4. As part of complex therapy after surgical interventions and a number of injuries.
5. As a premedication.
6. With accumulated internal stress, disorders of adaptive abilities, somatic diseases and generalized anxiety.
7. To eliminate symptoms in the case of itchy dermatosis, atopic dermatitis, eczema and urticaria.
8. Indicated as an antiemetic drug.

Hydroxyzine has a certain number of contraindications, in the presence of which it is not recommended to use the drug:

• if the patient has glaucoma;
• in case of prostate hypertrophy;
• with increased convulsive activity of the patient;
• in case of myasthenia gravis;
• with kidney failure;
• in case of liver failure;
• during pregnancy;
• during lactation;
• for dementia;
• in case of porphyria;
• in case of an allergic reaction to the components of the medication;
• during labor.

Hydroxyzine is prescribed as an antihistamine, as well as an analgesic and sedative. The main use of the drug for the following pathologies:

• anxiety;
• psychomotor overexcitement;
• internal overvoltage;
• disruption of the adaptation process;
• irritability and increased nervousness;
• withdrawal syndrome of alcohol etiology;
• premedication after surgical treatment;
• allergic etiology itching;
• dermatitis;
• skin eczema.

Eczema
The drug is not prescribed for the following pathologies in the patient:

• allergy to components in the medicine;
• porphyria;
• lactose intolerance;
• Lapp deficiency.

Also, Hydroxyzine is not prescribed in pediatrics under 3 years of age, or for women during lactation and pregnancy. Hydroxyzine passes through the placenta barrier and is also detected in breast milk. Its concentration is higher in the fetus than in the body of a pregnant woman.

Hydroxyzine is used with great caution in the following concomitant diseases in the patient:

• myasthenia gravis;
• heart failure;
• arrhythmia;
• dementia;
• difficulty urinating and constant constipation;
• epilepsy and hypertension;
• hypokalemia and hypomagnesemia;
• glaucoma;
• hyperthyroidism;
• pathologies of the gastrointestinal tract.

special instructions

The drug in the form of a solution is intended exclusively for intramuscular injections; administration subcutaneously or the drug entering large vessels can lead to tissue damage.

Therapy with the drug can distort the results of allergy tests. Therapy must be suspended at least 5 days before the test. After using the drug, driving complex mechanisms or vehicles is prohibited.

It is prohibited to combine the drug with alcohol-containing products.