pharmachologic effect
This product contains the active ingredient oxolin , which demonstrates antiviral activity against herpes , herpes zoster , and influenza (mainly type A2). Sensitivity to oxolin of adenoviruses, molluscum contagiosum and warts of infectious origin has been noted.
This remedy is used externally and has an antiviral effect. The mechanism of influence of the active substance is based on its ability to block the binding sites of the influenza virus with the cell membrane. The product blocks viruses on the surface of membranes, preventing the virus from entering cells.
Pharmacodynamics and pharmacokinetics
Oxolin ointment, in its external and nasal form, is an antiviral therapeutic agent, the activity of which is aimed at blocking the connection of the cell membrane with the virus affecting it and protecting the cell itself from its penetration. Oxolin nasal ointment in the nasal mucous membranes is characterized by its virucidal effect, which prevents the reproduction of the virus. The effectiveness of the drug is manifested against influenza , adenoviruses zoster and herpes simplex viruses , molluscum contagiosum and viral warts .
Application of the drug to the nasal mucous membranes leads to partial absorption of its active ingredient into the systemic bloodstream. The volume of drug absorbed in this way can reach up to 20%. At the same time, it does not cause local effects or resorptive toxicity. Oxoline accumulate in the body. Excretion is carried out mainly by the kidneys over a 24-hour period.
Pharmacokinetics and pharmacodynamics
It is not toxic, there is no systemic effect if it is applied topically. The active substance does not accumulate in the body. If the drug is applied to the mucous membranes, only 20% of the drug is absorbed. After application to the skin, only 5% of the product is absorbed. It is not irritating if the required amount and concentration have been applied and the skin at the application site has not been damaged.
Does not accumulate. Excretion occurs through the kidneys within one day.
Therapeutic effect
Oxolin has a local antimicrobial and antiviral effect. Weaken herpes simplex viruses, adenoviruses, influenza pathogens, molluscum contagiosum and some others.
The drug is easily applied, distributed over the skin and mucous membranes, forming a thin, breathable, transparent film.
- Being on the surface, oxolinic ointment prevents the penetration of pathogens from the outside into the epithelial cells.
- By acting on the membranes of viral shells, the drug destroys their nucleic acids, blocking functionality and accelerating the death of pathogens.
- It has a softening effect, reduces irritation and pain in the affected areas.
After application, the drug is partially absorbed through capillary vessels into the bloodstream. Inside the body it is completely neutral. Does not have a systemic effect, does not cause intoxication, does not accumulate in the blood and tissues. Oxoline particles are metabolized by the liver and are completely excreted in intestinal contents and urine within 24 hours.
Indications for use of Oxolinic ointment
The following indications for the use of Oxolinic ointment are noted:
- viral diseases of the skin and eyes;
- rhinitis of viral origin (inflammatory processes of the nasal mucosa);
- lichen squamosus , vesicular and herpes zoster ;
- molluscum contagiosum;
- the appearance of warts ;
- Dühring's dermatitis herpetiformis .
It is also used to prevent influenza, for which oxolinic ointment is applied during epidemics to prevent infection with the virus.
0.25% Oxolin is also used for stomatitis . This remedy is effective for stomatitis of herpes origin.
Side effects and interactions
Oksolin is well tolerated when used by children and adults. Negative reactions are extremely rare. In the first days of applying the drug, there may be a slight burning sensation of the mucous membranes and skin, a short-term increase in nasal discharge, decreased visual acuity, and increased lacrimation. In most cases, the discomfort gradually disappears on its own. Sometimes the ointment causes a bluish coating to appear, which is easily washed off with water.
When used together, oxolinic ointment and intranasal vasoconstrictor drops are likely to increase dryness of the mucous membranes. The problem can be solved by additional use of moisturizers.
Treatment and prevention of diseases with ointment does not cause disturbances in the speed of psychomotor reactions, concentration of attention, and does not affect the emotional state of patients. Using the drug does not require giving up work with high mental stress or driving.
Oxolinic ointment, instructions for use (Method and dosage)
If Oxolinic ointment is used, the instructions for use must be followed.
When treating viral keratitis , as well as adenoviral keratoconjunctivitis, it is necessary to apply 0.25% ointment behind the eyelid 1-3 times a day. Treatment is carried out for 3-4 days. If treatment is necessary for infants, you should definitely consult a specialist.
In order to treat viral rhinitis, you need to thoroughly lubricate the nasal mucosa 2-3 times a day for 3-4 days. For this, 0.25% ointment is used. The ointment is used similarly for children and adults to prevent influenza and ARVI . During a flu epidemic, it is necessary to practice lubrication for several weeks, and be sure to use the ointment when in contact with someone who has the flu.
Patients with different types of lichen and molluscum contagiosum should use a 3 percent ointment, which is applied 2-3 times a day to the affected areas. Treatment lasts from 2 weeks to 2 months, depending on the patient’s condition. Use during pregnancy for treatment and prevention should only be carried out after a doctor's prescription.
Use 3% Oxolinic ointment for warts . Apply to skin affected by warts. Reviews indicate that the medicine sometimes allows you to completely get rid of warts.
Application
In the treatment of eye pathologies, lesions of the mucous membranes of the nasal cavity and mouth, as well as for the prevention of influenza, the drug is used in a concentration of 0.25%:
- for keratitis and conjunctivitis, a thin strip of ointment is placed behind the lower eyelids 1–3 times a day;
- intranasally: for the treatment of rhinitis and for the prevention of viral respiratory infections, a thin layer of the drug is lubricated in the nasal cavity;
- for stomatitis: a small amount of ointment is distributed onto the affected areas, covering them from saliva with cotton swabs.
The drug in a 3% concentration is used in the treatment of skin diseases. It is applied in a thin layer or pointwise to areas affected by lichen, dermatitis or warts up to 4 times a day. If necessary, the skin is covered with sterile fabric breathable bandages.
The medicinal product does not require subsequent special rinsing from the skin and mucous membranes. The course of treatment depends on the severity of the disease and lasts from 2 to 10 weeks. For prevention, the product can be used once or periodically.
Oxolinic ointment is approved for use in children over 2 years of age. In some cases, in low concentrations under the supervision of a pediatrician, it can be used before this age.
Since a small part of the drug penetrates into the body, exceeding doses for external use does not lead to negative health consequences. If the ointment is accidentally swallowed, life-threatening situations also do not arise. To avoid disturbances from the digestive system, it is recommended to rinse the stomach with plenty of water and take enterosorbents. No antidotes are required.
Analogs
Level 4 ATC code matches:
Florenal
Oftalmoferon
Oksolin
Zirgan
Oftan I'm coming
Poludan
You can find many different drugs that have similar effects. Analogues of Oxolinic ointment 3 percent - Alpizarin , Atsigerpin , Vartek , Virolex , Amiksin , Gerperax , Vivorax , Zovirax and many others. At the same time, there are no medicines containing a similar active ingredient on the market.
Reviews of Oxolinic ointment
As a rule, users leave positive reviews about this product. Basically, the ointment is considered to be a good preventive measure, as well as an effective drug for the treatment of the common cold.
If Oxolinic ointment is used for papillomas , the reviews are also in most cases positive, but there are not so many such opinions. Sometimes they say that with long-term use the drug actually helps get rid of warts. As a positive point, the low price of the product is noted. The lack of a pronounced effect of treatment is mentioned as a negative.
Reviews
Patients' opinions about the effectiveness of topically applied Oxolin were divided. Some consider this ointment to be quite effective, use it successfully and recommend it to all their friends, even for the treatment of pregnant, lactating women and infants. Others, on the contrary, are confident in the complete uselessness of this medicinal drug and provide examples from their own negative experience of using it as proof.
It is worth noting that there is practically no mention of the side effects of the ointment, with the exception of a temporary burning sensation, so even if Oksolin is ineffective, there will be no harm from its use.
Price of Oxolinic ointment, where to buy
The price of Oxolinic ointment 3% ranges from 30 to 90 rubles per tube, depending on the manufacturer. You can buy Oxolinic ointment 3 percent at any pharmacy. Oksolin 0.25% costs approximately 30-40 rubles. for 10 g
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Oxolinic ointment 0.25% 10g OzonOzon LLC
83 rub. order
Pharmacy Dialogue
- Oxolinic ointment 0.25% 10gNizhpharm JSC
51 RUR order
- Oxolinic ointment 0.25% 10g Sintez (Kurgan) OJSC
69 RUR order
- Oxolinic ointment 0.25% 10gOzon LLC
70 rub. order
- Oxolinic ointment 0.25% 10g Altaivitamins
21 rub. order
- Oxolinic ointment 0.25% 10gMuromsky PZ
58 RUR order
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