Many skin diseases lead to thickening of the stratum corneum. This is due to an increased rate of cell division and a disruption in the process of their desquamation. To cope with various unpleasant symptoms, it is necessary to use topical external agents with high penetrating power. One of these drugs is Akriderm SK ointment, which has established itself as a potent remedy with a quick and long-lasting effect. This was achieved due to a unique combined composition, which delivers a powerful blow to the source of inflammation. The ointment has proven itself excellent in the treatment of chronic dermatoses accompanied by severe dryness, peeling and thickening of the skin. Our website will introduce you to the instructions for use of the drug, you will learn what Akriderm SK is used for and how to use the ointment.
Pharmacodynamics and pharmacokinetics
This combination drug combines the properties of a glucocorticosteroid and a keratolytic agent.
of leukocytes is inhibited , lysosomal enzymes and pro-inflammatory mediators are released in the area of inflammation, phagocytosis is inhibited, vascular-tissue permeability is reduced, and the development of inflammatory swelling is prevented.
Salicylic acid exhibits a keratolytic and antimicrobial effect, helping to eliminate horny deposits and deep penetration of GCS into tissues.
pharmachologic effect
"Akriderm SK" is a combined preparation for external use that has several effects:
- anti-inflammatory;
- antiallergic;
- antiseptic;
- keratolytic.
Betamethasone dipropionate is a glucocorticosteroid that has antiexudative, decongestant and antipruritic effects. It mainly affects leukocytes, slowing down their accumulation. It also inhibits the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema.
Keratolytic and antimicrobial effects are provided by salicylic acid, which also eliminates horny deposits.
Indications for use
As a rule, Akriderm SK ointment is prescribed for the local treatment of dermatoses accompanied by signs of hyperkeratosis , for example:
- psoriasis;
- neurodermatitis;
- lichen planus;
- eczema;
- dermatitis;
- ichthyosis and ichthyosiform changes.
Composition of the drug
"Akriderm SK" is an ointment that combines two active substances, namely: betamethasone dipropionate (0.064 g) and salicylic acid (3 g). These components endow the drug with excellent healing properties and complement each other perfectly. Betamethasone dipropionate is highly hydrophobic, quickly penetrates into the inflammatory focus and provides a good long-term therapeutic effect. Salicylic acid promotes deep penetration of betamethasone into the affected area of the skin.
The composition also contains liquid paraffin and petroleum jelly, thanks to which Akriderm SK ointment is capable of having an occlusive effect.
Contraindications
The drug is not prescribed for:
- hypersensitivity to it;
- skin tuberculosis;
- manifestation of syphilis on the skin;
- chicken pox;
- herpes simplex;
- skin post-vaccination reactions;
- open wounds;
- lactation;
- children under one year of age;
- perioral dermatitis.
Pharmacodynamics
The corticosteroid betamethasone dipropionate inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema.
Gentamicin is a broad-spectrum antibiotic from the aminoglycoside group. Has a bactericidal effect against pathogens of primary and secondary bacterial skin infections. Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp. (susceptible strains of group A beta- and alpha-hemolytic streptococcus), Staphytococcus spp. (coagulase-positive, coagulase-negative and some penicillinase-producing strains). Inactive against anaerobes, fungi and viruses.
Clotrimazole has an antifungal effect by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Active against: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furtur (Pityrosporum orbiculare).
Salicylic acid provides a keratolytic, antimicrobial effect, eliminates horny layers and promotes deeper penetration of GCS.
special instructions
The appearance of signs of high sensitivity, as well as skin irritation caused by the use of the drug, requires cessation of treatment and selection of adequate therapy.
Long-term treatment, application of ointment to large skin surfaces, use of occlusive dressings and therapy in children can lead to systemic absorption of GCS.
Treatment of children over one year of age should be carried out only according to indications, strict adherence to the regimen and dosage of the drug and under close medical supervision. This will prevent the development of systemic undesirable actions.
The use of an external agent on large surfaces, and especially under an occlusive dressing, can suppress the functioning of the hypothalamic-pituitary-adrenal system, cause symptoms of hypercortisolism, reduce the excretion of hormone and increase intracranial pressure.
Undesirable effects occur especially often when used on the face. For example, long-term treatment with GCS can lead to atrophic changes, so the therapeutic course should not exceed 5 days.
The use of ointment in ophthalmology is unacceptable; try to avoid its contact with mucous membranes and eyes.
After prolonged use, gradual withdrawal of the external agent is carried out.
Side effects
When using the glucocorticosteroid drug Akriderm SK, you must exercise caution and follow your doctor’s recommendations. Uncontrolled, prolonged application to large areas of skin can lead to the development of side effects such as:
- burning;
- irritation;
- dry skin;
- folliculitis;
- hypertrichosis;
- acne-like rashes;
- hypopigmentation;
- perioral dermatitis;
- allergic contact dermatitis.
Akriderm SK has an occlusive effect, so there is no need to use bandages: this can lead to maceration of the skin, secondary infection, skin atrophy, prickly heat, and purpura.
Analogues of Akriderm SK
Level 4 ATX code matches:
Rederm
Losterine
Akriderm
Akriderm GK
Akriderm Genta
Elokom S
Diprosalik
Belosalik
Triderm
Kanizon Plus
Betasalik
Triacutan
Momat-S
The main analogues of the drug: Triderm and Kanison.
Characteristic
Akriderm®
Glucocorticosteroid for local use.
Akriderm® GENTA
Combined drug for external use (glucocorticosteroid + antibiotic-aminoglycoside).
Akriderm® GK
Combined preparation for external use (glucocorticosteroid + antibiotic-aminoglycoside + antifungal agent).
Akriderm® SK
Combined preparation for external use (glucocorticosteroid + keratolytic agent).
Reviews about Akriderm SK
In most cases, reviews of Akriderm SK are confirmation of its high effectiveness. This drug can be prescribed to treat various skin diseases. Patients usually notice significant improvement within a few days.
As reviews of Akriderm SK show, in case of psoriasis its use helps to quickly eliminate the manifestation of symptoms, alleviating the general condition of the patient. This drug is also widely used in the treatment of other skin diseases; in almost every case its good effectiveness is noted.
However, along with positive reviews, users report the development of side effects associated with the use of this external remedy. Usually this is an exacerbation of the symptoms of the underlying disease.
In addition, patients often complain that after stopping treatment they notice a return of symptoms of the disease. People who have already been examined and know their diagnosis understand that in addition to medications that help quickly eliminate unwanted skin manifestations, basic therapy is necessary.
Those who encounter this for the first time can be advised to consult a doctor who can clarify the diagnosis and prescribe competent treatment.
In any case, you should not experiment with such drugs, since, in the end, the treatment may not only be useless, but even cause the development of serious complications.
Directions for use and dosage
The instructions provide information on the standard use of Akriderm SK. The drug is applied externally to the affected area of the skin using gentle circular movements and light rubbing. The recommended frequency of application is at least 2 times a day - in the morning and evening. In mild cases, a single use is allowed. In case of severe manifestations of the disease or localization of the lesion in areas from which the product can be easily washed off, more frequent application may be necessary.
Another treatment regimen can be established by the doctor, based on the severity of the disease. If improvement does not occur, it is necessary to clarify the diagnosis or adjust therapy.
Akriderm SK price, where to buy
The price of Akriderm SK in the form of an ointment for external application varies between 350-650 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Akriderm SK ointment 30gAO Akrikhin
RUB 413 order - Akriderm SK ointment 15gAO Akrikhin
RUB 263 order
Advantages of Akriderm SK ointment
First of all, it is worth noting the affordable price, convenient form of release of the drug "Akriderm SK" and packaging formats. Patients can purchase both 30 g and 15 g of the product. The drug is available to a wide range of consumers not only due to its attractive price. It has over-the-counter status.
But the main advantages of Akriderm SK are its unique combined composition and medicinal properties:
- the drug penetrates deeply into the site of inflammation;
- salicylic acid reduces the risk of side effects due to the action of the glucocorticosteroid betamethasone;
Indications of the drug Akriderm® SK
Akriderm®
Allergic skin diseases (including acute, subacute and chronic contact dermatitis, occupational dermatitis, seborrheic dermatitis, atopic dermatitis, solar dermatitis, neurodermatitis, pruritus, dyshidrotic dermatitis, eczema); acute and chronic forms of non-allergic dermatitis; psoriasis.
Akriderm® GENTA
Dermatitis (simple and allergic), especially secondarily infected, eczema (atopic, childhood, coin-shaped), atopic dermatitis (diffuse neurodermatitis), simple chronic lichen (limited neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, diaper rash, psoriasis, itching.
Akriderm® GK
Treatment of dermatoses complicated by primary and/or secondary infection, pityriasis versicolor, limited and diffuse neurodermatitis, dermatomycosis (including inguinal, foot) caused by pathogens sensitive to the drug.
Akriderm® SK
Local treatment of dermatoses accompanied by hyperkeratosis: psoriasis, limited and diffuse neurodermatitis, lichen planus, eczema, dyshidrotic dermatitis, ichthyosis and ichthyosiform changes.
