Nystatin ointment for external use approx. 100000 units/g 25g tube No. 1

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

What is nystatin ? This is a polyene antibiotic with antifungal activity. Shows activity against yeast-like fungi Candida . against bacteria . Has a fungistatic effect. Resistance of fungi to the drug develops slowly.

The structure of nystatin contains double bonds, which determine its affinity for the formation of the cell membrane of fungi - the substance molecule is embedded in the membrane and forms channels for the transport of electrolytes into the cell. An increase in osmolarity inside it leads to death. The cell lyses, losing its resistance to external osmotic forces.

Pharmacokinetics

When taken orally, it is almost not absorbed into the gastrointestinal tract. Does not accumulate with repeated doses. Excreted through the intestines.

The active substance of ointments and suppositories when applied externally is not absorbed through the mucous membrane and skin.

Indications for use

For vaginal suppositories

• candidiasis of the vulvo-vaginal area ;
• prevention of fungal diseases with local antibiotic .

For tablets

• prevention of fungal diseases in the postoperative period during operations on the gastrointestinal tract ;
• candidiasis of internal organs of the skin and mucous membranes ;
• prevention of gastrointestinal candidiasis during long-term antibiotic therapy .

Indications for use of ointment

Candidiasis of the skin and mucous membranes .

Instructions for use of Nystatin (Method and dosage)

The drug has several forms of release, so we will consider the instructions for use of all dosage forms.

Nystatin tablets, instructions for use

How to take the pills? The tablets are taken orally, regardless of food intake. They are swallowed without chewing. Nystatin tablets are prescribed to adults for candidiasis of internal organs , 500,000 units 6-8 times a day. Duration of treatment is up to 14 days. The average daily dose is 1,500,000 - 3,000,000 units. For generalized candidiasis - up to 6,000,000 units per day, repeated courses are given after 2 weeks.

For children under 1 year of age, the dose is 125,000 units, from 1 to 5 years - 250,000 units, over 13 years - 500,000 units, dosage frequency 3-4 times a day. Duration of treatment is up to 14 days.

Nystatin ointment, instructions for use

Nystatin ointment is intended for external use; it is applied in a thin layer to the skin or mucous membranes 2 times a day for 10 days. Often combined with oral tablets. For stomatitis in a child, apply ointment to the affected areas 3 times a day after meals, treatment continues for at least a week.

If local irritation , skin rash or urticaria , the drug is discontinued.

Nystatin suppositories, instructions for use

Vaginal suppositories Nystatin are inserted deep into the vagina. The dosage regimen is individual. Usually 1 candle in the morning and evening. The duration of treatment is 14 days. During menstruation, treatment is not interrupted. During the treatment period, avoid sexual intercourse. Treatment of the sexual partner is necessary. During pregnancy, suppositories with Nystatin are used as prescribed by a doctor in case of urgent need.

Nystatin ointment for external use approx. 100000 units/g 25g tube No. 1

Trade name: Nystatin. International nonproprietary name: Nystatin. Description: yellow or brownish-yellow ointment. Composition per tube: active substance - nystatin 2,500,000 units; excipients: lanolin, white petrolatum.

Dosage form: ointment for external use 100,000 units/g.

Pharmacotherapeutic group: Antifungal antibiotics for external use. Nystatin.

Pharmacological properties Pharmacodynamics Polyene antifungal antibiotic, highly active against yeast-like fungi of the genus Candida. The structure of the antibiotic contains double bonds that are highly tropic to the sterol structures of the fungal cell membrane, which facilitates the incorporation of the drug molecule into the cell membrane and the formation of a large number of channels through which uncontrolled transport of electrolytes occurs; An increase in osmolarity inside the cell leads to its death. Resistance develops very slowly. Pharmacokinetics: When applied externally and locally, it penetrates poorly through intact skin or mucous membranes; as a result, when the ointment is applied topically, the drug has virtually no resorptive effect.

Indications for use Nystatin ointment is used for candidiasis of the skin and mucous membranes.

Method of administration and dosage Externally, the ointment is applied to the affected surface 1-2 times a day. The course of treatment is 10-14 days.

Side effects Allergic reactions: skin itching, rashes, hyperemia at the site of application of the ointment. In these cases, the drug is discontinued and symptomatic therapy is carried out.

Contraindications Hypersensitivity.

Overdose To date, the phenomena of overdose when using nystatin ointment have not been described.

Features of use For fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During treatment, sexual intercourse should be avoided. Do not allow the ointment to get into your eyes. In case of accidental contact, rinse eyes with plenty of water. Do not use the ointment for tuberculosis, viral skin lesions, as well as staphylococcal pyoderma. Use in children. Data on the safety of use in children are limited. Use during pregnancy and lactation. Prescription of Nystatin during pregnancy is possible if the expected benefit to the mother outweighs the potential risk to the fetus. Although the drug is absorbed in small quantities, it is not known whether it is excreted in breast milk, therefore, if it is necessary to prescribe Nystatin during lactation, the issue of stopping breastfeeding should be considered.

Precautionary measures Impact on the ability to drive vehicles and other potentially dangerous mechanisms. Does not affect. Interaction with other drugs When Nystatin is used simultaneously with Clotrimazole, the activity of the latter decreases. Cross-resistance is observed with a number of polyene antibiotics, for example, Amphotericin B. The activity of the drug is reduced in the presence of divalent ions and fatty acids.

Storage conditions: at temperatures from 2C to 8C. Keep out of the reach of children. Shelf life: 3 years. Do not use after the expiration date stated on the package. Packaging: 25 g in tubes. Each tube, along with instructions for use, is placed in a pack. Dispensed from pharmacies: by prescription.

Nystatin during pregnancy

Pregnancy is a predisposing factor for the development of vulvovaginitis . The main thing in this situation is the safety of treatment. The instructions include contraindications for the use of nystatin during pregnancy, since there is no information about their safety for the fetus. Nystatin suppositories can be used during pregnancy only in exceptional cases when the benefit to the mother outweighs the risk to the fetus. Reviews from forum visitors confirm that the drug in this form is sometimes prescribed to pregnant women for short courses of treatment.

The use of ointment is contraindicated during pregnancy. However, it has been proven that the active substance is not excreted in milk when used externally, so breastfeeding can be continued during treatment with the ointment. Do not apply the ointment to the area of ​​the mammary gland and nipple.

Analogues of Nystatin ointment

Analogues of the drug in action are a variety of antimycotic drugs. The following products are sold in the form of ointment and solution for external treatment:

An overdose with proper (external) use is almost impossible.

If the medicine gets inside, you may experience nausea, abdominal pain, swelling of the mouth, chills, and vomiting. Such phenomena occur especially often in children, which must be taken into account if there is ointment in the house.

Nystatin for thrush

Candidiasis of the genital mucosa and oral cavity is called thrush . The main method of treating mild and moderate oral thrush is local treatment in the form of mouth rinses and treatment of the affected areas with a solution of this drug.

Women often experience candidal vulvitis or vulvovaginitis . Vaginal cream or ointment is recommended for the treatment of vulvitis, and tablets and suppositories for vaginitis. For mild vulvovaginitis, local treatment is sufficient - vaginal tablets or suppositories: micogal, clotrimazole, Klion-D. Suppositories with nystatin for thrush have recently been rarely used, since most strains of the Candida fungus have become insensitive to it. The drug has a mycostatic effect, not mycocidal. This provides temporary relief, making you feel better, but leads to relapse. Reviews from forum visitors also speak about this.

If there is no other choice, or the woman has an individual intolerance to the above drugs, then Nystatin is prescribed.

How to take Nystatin suppositories for thrush? They are inserted deep into the vagina 2 times a day. It is very important that the sexual partner also treats with antifungal tablets. If treatment is not carried out, there is a possibility of re-infection of the woman. For mild cases of the disease, drugs for local treatment can be replaced with a single dose of Fluconazole .

For recurrent candidiasis , which tends to exacerbate more than 4 times a year, a combination of local and systemic administration of drugs with one active ingredient is necessary. So, ointment and tablets for thrush are applied topically orally. The following treatment regimen is also possible: a suppository with Nystatin 250,000–500,000 units at night for 14 days, a thin layer of ointment on the mucous membrane of the vulva and vagina 2 times a day for 14-21 days, and tablets of 500,000 units 4 times a day for up to 10 days.

If there is a combined infection (yeast-like fungi and various bacteria), then complex drugs are used, which include nystatin: Macmiror , Terzhinan , Mikozhinaks , Polizhinaks .

Contraindications, negative effects

There are fewer contraindications for external application of ointment than for tablets and powder. But, according to the instructions, the prohibitions are:

• severe liver disease;
• stomach ulcer in the acute stage;
• decompensated heart and kidney failure;
• acute pancreatitis;
• staphylococcal pyoderma;
• active tuberculosis.

Contraindications must be observed especially carefully if it is intended to use a drug for stomatitis (the drug is taken orally and can have a number of systemic effects). In case of hypersensitivity or allergic reactions to nystatin, treatment will also have to be abandoned.

During pregnancy, the drug in the form of an ointment may be allowed, but only under the supervision of a doctor, and tablets and powder are prohibited for use.

When breastfeeding

It is better to exclude therapy - there is no exact data on the penetration of nystatin into breast milk. As a last resort, it should be applied pointwise, not covering large areas of the body and not using it on the mammary glands.

Side effects are rare; Nystatin ointment is usually well tolerated. Only occasionally are itching, urticaria, rash, and irritation of the epidermis observed.

Nystatin analogues

Level 4 ATC code matches:
Ecofucin

Primafungin

Clindacin

Polygynax Virgo

Polygynax

Analogs of the polyene series: Levoy , Natamycin ; imidazoles: Ketoconazole , Miconazole , Clotrimazole ; triazoles: Fluconazole , Intraconazole .

Reviews about Nystatin

Nystatin tablets, what are they for? This is an antifungal drug used to treat candidiasis , a fungal disease that can occur with damage to the skin, nail plates, mucous membranes and internal organs ( generalized candidiasis ). Candidiasis of the genital mucosa and oral cavity is called thrush. The main method of treating mild to moderate oral thrush is local treatment. Adults can dissolve the tablet after meals 3-4 times a day or lubricate the affected areas of the oral mucosa with ointment. For newborns, a tablet of nystatin 250,000 units is crushed and dissolved in a small amount of water. Drops of the resulting solution are applied to a gauze swab and the areas are treated 3-4 times a day. Children from 2 years of age can be given the drug orally, 1/4 tablet three times a day, and the oral mucosa can be treated with the drug “ Candide ”.

Reviews of Nystatin suppositories for thrush are associated with side effects: increased urination, irritation, burning sensation in the vagina. Women often stopped treatment immediately after the symptoms disappeared, while the pathogen was not eliminated and the symptoms returned after a while. According to many women, these suppositories are not very effective; they believe that the drug is “outdated” and prefer modern antimycotic drugs. There are also reviews that these suppositories were prescribed during pregnancy to treat thrush.

Reviews of Nystatin tablets are most often associated with its prescription for the prevention of dysbacteriosis during long-term use of antibiotics. From the first days of antibiotic treatment, many patients were prescribed 250,000 units 4 times a day. It is effective only for the prevention of intestinal candidiasis, since its systemic absorption is 3–5% and it does not affect fungi outside the intestine. When taking the tablets, side effects were observed in the form of nausea and stool upset. In order to prevent candidiasis infections, this drug is immediately introduced into tablets containing an antibiotic. Thus, Tetracycline with nystatin are used for bronchitis , tonsillitis , furunculosis , tracheitis , cholecystitis , purulent skin infections and acne .

Nystatin ointment was used to treat superficial candidomycosis of the skin and in cases of mild disease, good results were noted. For severe fungal skin infections, local application of ointment alone was not enough and systemic antimycotics ( Fluconazole ) were prescribed.

Nystatin price, where to buy

You can buy nystatin preparations for thrush at any pharmacy, they are available for free sale and you do not need a prescription in Latin, written out by a doctor. Their cost is reasonable. Thus, the price of Nystatin in suppositories ranges from 84-92 rubles, the price of Nystatin in tablets No. 20, 500,000 units. is 20-28 rubles, and the price of Nystatin ointment 30 g is 49-75 rubles.

• Online pharmacies in RussiaRussia
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Description of the drug

Nystatin is an antimycotic agent

, a polyene antibiotic with antifungal action. The drug is widely used in gynecology, dermatology, dentistry, most often it is recommended for candidiasis, including in the vagina (thrush).

The composition of the local drug is as follows:

• nystatin;
• lanolin anhydrous;
• soft white paraffin.

A gram of ointment contains 100 thousand units. main active ingredient. Nystatin is almost insoluble in water and alcohol and has a very bitter taste. Anti-fungal ointment is available in aluminum tubes; sometimes you can find the product on sale in glass jars. The amount of the drug is 10, 15, 30 g. Nystatin ointment is inexpensive - about 60 rubles / 15 ml.

The drug must be kept out of the reach of children - if consumed orally, it can cause unpleasant effects.

In appearance, the product has a yellow-brown color and has a characteristic odor. It should be stored at a temperature no higher than 5 degrees - the ointment should only be placed in the refrigerator.

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