Validol: features of taking the drug

Compound

According to Wikipedia, the INN (international nonproprietary name) of Validol is levomenthol solution in menthylisovalerate , chemical formula is C15H28O2.
Composition of Validol tablets: 60 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional components: calcium stearate, sucrose.

Composition of Validol in capsules: 50 mg or 100 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional ingredients: pharmaceutical gelatin, methyl parahydroxybenzoate, glycerol , propyl parahydroxybenzoate, purified water.

Directions for use and doses

Release forms of Validol

The frequency of administration depends on the patient’s condition and the characteristics of individual tolerance of Validol. Although the harm from an overdose is not fatal, you should not abuse the drug.

Clinical studies on the use of this drug in children have not been conducted.

Pharmacodynamics and pharmacokinetics

Validol is a complex substance obtained during the process of dissolving menthol (levomenthol) in menthylisovalerate (menthyl ester of isovaleric acid). In the case of sublingual use of validol , for which tablets or capsules of the drug should be placed under the tongue, its pharmacological effect is manifested due to the influence of its two active ingredients - menthol and menthylisovalerate .

The action of menthol in the oral cavity is aimed at irritating the nerve endings located on the mucous membrane. It has been proven that such irritation leads to a reflex dilation of blood vessels (including coronary vessels).

The effect of menthylisovalerate is manifested due to its ability to stimulate in the central nervous system the production and further release of peptides ( dynorphin , endorphin , kinin , enkephalin ) and the mediator histamine , which are regulators of pain and vascular permeability . In this case, the combined effect of these substances acts as an analgesic and sedative compound.

As a result of the general effect of the active ingredients of validol, the observed pain sensations , peripheral blood circulation , and a calming (sedative) effect is manifested, from which validol helps with various painful conditions associated with the cardiovascular system.

Absorption of the active ingredients of the drug in the oral cavity occurs very quickly and within a few minutes their maximum concentrations circulate in the systemic bloodstream. The effect of validol , in the case of its sublingual use, is felt within 3-5 minutes.

Partial transformation of validol occurs in the liver with the formation of products ( glucuronides ) excreted in bile and urine, as well as in the air exhaled by a person.

Pharmacology and pharmacodynamics

As already mentioned, Validol has a sedative and vasodilator effect. Thanks to the influence of the active components, there is an improvement in peripheral blood circulation, pain and discomfort disappear, and a calming effect on the central nervous system is exerted. The drug is actively used for various diseases of the heart and blood vessels.

The active elements are very quickly absorbed in the oral cavity and after 3-5 minutes their highest content is noted in the general bloodstream. The effect of taking it can be observed within 5-7 minutes.

Indications for use of Validol

Indications for use of Validol are:

• states of hysteria ;
• functional cardialgia ;
• various neuroses ;
• sensations of headaches ,
• arising during nitrate ;
• motion sickness syndrome (including symptoms of nausea / vomiting due to air and/or seasickness ).

Contraindications

Before taking Validol tablets or capsules, you must familiarize yourself with the contraindications to their use, which include personal hypersensitivity to the ingredients of the dosage form of the drug and the pathology of sugar intolerance (if they are present in the dosage form).

sucrose as an additional component , which is why Validol tablets should be taken with caution by people suffering from diabetes .

Side effects

allergic manifestations may occur , including itching / rash on the skin, Quincke's edema and urticaria .

The use of validol in large dosages and over a long period of time can lead to lacrimation , dizziness and nausea . These manifestations usually disappear when dosages are reduced or therapy is temporarily discontinued.

Adverse reactions and overdose

Due to individual intolerance to the components, an allergic reaction may occur, manifested by a rash, itching or hives.

If you take the medicine in excessive doses over a long period, there may be a deterioration in the condition, accompanied by nausea, dizziness, and watery eyes. Such signs are not dangerous and disappear immediately as soon as the dose is reduced to an acceptable value. Or you can stop taking it for a while.

An overdose may lower blood pressure or increase the likelihood of unwanted reactions.

An overdose can enhance the good and bad effects of taking the drug. There may be deterioration in heart function, severe pain in the head, nausea followed by vomiting, agitation, and suppression of the functions of the central nervous system.

In this case, it is advisable to begin symptomatic therapy.

Instructions for use of Validol

Before starting therapy with Validol, it is advised to establish the body’s personal sensitivity to its ingredients and, depending on their tolerance, determine how many tablets or capsules can be taken in 24 hours and whether taking large dosages is harmful in this particular case.

Capsules and tablets Validol, instructions for use

Instructions for use of Validol in capsules and tablets recommend their sublingual (under the tongue) use. Any form of the drug should be placed in the oral cavity under the tongue and kept there until it is completely absorbed. A single dose is considered to be one tablet (60 mg) or one capsule (50 mg or 100 mg). The average number of daily doses is 2-4 times, the maximum allowable dosage in 24 hours is 600 mg (10 tablets; 12 capsules of 50 mg or 6 capsules of 100 mg). It is better to limit the duration of alternating courses of therapy to 7 days. If the drug has zero or insufficient effectiveness 5-10 minutes after its complete absorption, the possibility of using other drugs should be considered.

Instructions for using Validol with glucose are identical to the above description.

How to take Validol correctly

Before using the drug, you need to make sure that there are no contraindications and that allergies will not appear.

Capsules and tablets should be placed under the tongue and held until the medicine is completely absorbed. You can take 1 tablet or 1 capsule at a time. 3-4 doses per day are allowed. The maximum permissible dose per day is 12 capsules or 10 tablets. The duration of the treatment course should not exceed 10 days. If no result is observed after taking it, then you should consider taking other medications.

Overdose

Taking large doses of the drug leads to Validol lowering blood pressure or increasing the risk of side effects and their severity.

Overdose, that is, the use of an excessive number of tablets or capsules at a time, enhances both the positive and negative effects of the drug and can lead to a sharp decrease cardiac function , , the formation of severe headaches and severe nausea leading to vomiting , overexcitation and even depression functionality of the central nervous system.

In this case, depending on the observed manifestations and their intensity, symptomatic treatment .

special instructions

Shelf life – 24-36 months (depending on the manufacturer). It should be stored in a dark place at a temperature of 9-16 degrees.

It is not recommended to take the drug in parallel with alcoholic beverages, since alcohol can have a suppressive effect on the central nervous system, which can lead to more severe adverse reactions.

If you use Validol together with psychotropic drugs, the effectiveness of the latter will increase.

After taking it, you should stop driving for a while.

Interaction

Parallel use with opioid analgesics , psychotropic drugs , ethanol-containing drugs and anesthesia drugs increases their effects.

Combined use with nitrates reduces the feeling of headache that occurs during their use.

Combined use with antihypertensive drugs may potentiate their effectiveness.

Pharmacological properties of the drug Validol

The drug has a calming effect on the central nervous system, and also has a moderate reflex vasodilator (coronary lytic) effect due to reflex irritation of sensitive nerve (“cold”) receptors of the oral mucosa. Stimulation of receptors is accompanied by the induction of the release of endorphins, enkephalins, dynorphins and other opioid peptides, which play an important role in reducing pain, normalizing vascular permeability and regulating other important mechanisms of functioning of the cardiovascular and nervous systems. Under the influence of the drug, physiologically active substances are released - histamines, kinins, etc. When administered sublingually, the drug is absorbed from the oral mucosa. The therapeutic effect occurs in approximately 5 minutes. After absorption, it is biotransformed in the liver and excreted in the urine in the form of glucuronides.

Analogs

Level 4 ATC code matches:
Eltacin

Tonginal

Tricardin

Instenon

Pumpan

Barboval

Corvalment

If for some reason the use of Validol is impossible, doctors can recommend the following analogues:

• Advocard;
• Gulidol;
• Cardiolin;
• Dystonin;
• Cardiofit;
• Cormenthol;
• Kratal;
• Pumpan;
• Barboval;
• Tonginal;
• Instenon;
• Rhythmocore;
• Tricardin , etc.

Validol during pregnancy and lactation

The question of whether pregnant or breastfeeding women can take sedatives should be considered on a case-by-case basis, with the understanding that even when a single dose of a minimal dose of a sedative is completely normal, continued use may cause harm to the fetus, mother or breastfeeding child. to kid. In this regard, deciding whether Validol can be taken during pregnancy and breastfeeding should be left to the consideration of the attending physician.

How to take Validol tablets

Before using the medicine, you should conduct a test that will help determine the body's reaction to the constituent substances. This will also allow you to determine how many tablets you can take per day without harm to the body.

The instructions indicate that the tablets should be placed under the tongue. They do not need to be swallowed or split, but kept until completely absorbed. The maximum dose is 10 tablets per day. The average duration of treatment is a week. If after taking it for 7-10 minutes no effect is achieved, then you should think about taking other medications.

Reviews about Validol

The vast majority of people leave purely positive reviews about Validol, especially when this drug is used occasionally to relieve various anxiety , stress or other similar conditions. Also, this medicine copes well with headaches nitrate therapy , and is a weak hypnotic and hypotonic .

Validol price, where to buy

The price of Validol, depending on the manufacturer and the number of tablets or capsules in secondary packaging, varies slightly, but still remains affordable for any consumer, since you can buy 10 tablets or capsules of the drug for 30-40 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Validol tablets 60 mg 16 pcs. AO Update PFK
  83 rub. order
• Validol with isomalt sublingual tablets. 60 mg 10 pcs. JSC Irbitsky Chemical Plant

  35 rub. order

• Validol capsules roach. 50 mg 20 pcs. ZAO FP Meligen

  31 rub. order

• Validol sublingual tablets 60 mg 10 pcs Usolye-Sibirsky chemical farm plant OJSC

  41 rub. order

• Validol sublingual tablets 60 mg 10 pcs. JSC Tatkhimfarmpreparaty

  39 RUR order

Pharmacy Dialogue

• Validol (caps. 50 mg No. 20) Meligen FP CJSC

  35 rub. order

• Validol Avexima (tab. 60 mg No. 20) Irbitsky HFZ

  54 RUR order

• Validol (tablet. 60 mg No. 8)Update of PFC CJSC

  62 RUR order

  Read also:  Why and how to take Pantogam for the treatment of children and adults
• Validol (caps. 50 mg No. 40) Meligen FP CJSC

  53 RUR order

• Validol with glucose (tab. 60 mg No. 10) FS.-Leksredstva

  42 RUR order

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Pharmacy24

• Validol 0.06 g N10 tablets PAT "Lubnipharm", Ukraine
  3 UAH. order
• Validol Darnitsa No. 10 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine

  4 UAH order

• Validol 0.06 g No. 10 tablets PAT "Farmak", Ukraine

  4 UAH order

• Validol Darnitsa No. 6 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine

  3 UAH order

PaniPharmacy

• Validol tablets Validol tablets. 0.06g No. 10 Ukraine, Darnitsa ChAO

  5 UAH order

• Validol tablets 0.06g No. 10 Ukraine, Farmak

  4 UAH order

• Validol tablets Validol tablets. 6mg No. 10 Ukraine, Lubnyfarm PJSC

  4 UAH order

• Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Darnitsa ChAO

  3 UAH order

• Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Lubnyfarm PJSC

  2 UAH order

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Use of the drug Validol

Tablets Adults are prescribed 1 tablet under the tongue until completely absorbed. The frequency and duration of taking the drug are determined taking into account the therapeutic effectiveness. Drops 4-5 drops of Validol solution are applied to a piece of sugar and kept in the mouth until completely absorbed. Locally, 5–10% alcohol solution of Validol is used for itchy skin. Capsules Adults are prescribed sublingual 1 capsule (100 mg). The capsule is kept under the tongue until completely dissolved. To speed up the effect, the capsule can be bitten. The dose and duration of use are determined depending on the therapeutic effect. The maximum daily dose is 600 mg. In the absence or insufficient severity of the therapeutic effect within 5–10 minutes after administration, it is necessary to prescribe another therapy.