Pharmacological properties of the drug Nemozol™
Pharmacodynamics. Albendazole is a broad-spectrum anthelmintic agent that is also active against pathogenic protozoa. Acts on intestinal and tissue forms of parasites; active against eggs, larvae and adult helminths. The antihelminthic effect of the drug is due to inhibition of tubulin polymerization, which leads to metabolic disturbances and death of the helminth. Albendazole is active against intestinal parasites, including nematodes (Ascaris lumbricoides, Triсhiurus triсhiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongiloides stercoralis, Cutaneous Larva Migrans) , cestodes (Hymenolepsis nana, Taenia solium, Taenia saginata) , trematodes ( Opisthorhis viverrini, Clonorchis sinensis) , protozoa ( Giardia lamblia (intestinalis and duodenalis) . Albendazole is effective against tissue parasites, including cystic echinococcosis and alveolar echinococcosis, caused by invasion of Echinococcus granulosus and Echinococcus multilocularis , respectively. The drug is also effective in the treatment of neurocysticercosis, caused by nogo invasion larvae of the pork tapeworm T. solium, capillariasis caused by invasion of Gnatostoma spinigerum . Albendazole destroys cysts or significantly reduces their size in patients with cysts of granular echinococcus. Pharmacokinetics. After oral administration, the drug is poorly absorbed (up to 5%) in the gastrointestinal tract. Simultaneous use of fatty foods approx. increases drug absorption 5 times. Albendazole is 70% bound to blood plasma proteins and is freely distributed in the body; determined in urine, bile, liver, cyst wall and cyst fluid, CSF. Albendazole sulfoxide is rapidly converted in the liver to albendazole sulfone (a secondary metabolite) and other oxidized products. The half-life of albendazole sulfoxide from blood plasma lasts 8–12 hours. Albendazole sulfoxide and other metabolites are excreted primarily in the bile, and only a small amount is excreted in the urine. Since the renal excretion of albendazole and its primary metabolite, albendazole sulfoxide, is insignificant, clearance in patients with impaired renal function does not change. In patients with biliary obstruction, systemic bioavailability may be increased and the half-life of albendazole sulfoxide may be prolonged.
Reviews of Nemozole
Reviews from doctors about the drug Nemozol allow us to conclude that this medicine for worms is one of the best today. The drug disrupts the flow of biochemical processes in the body of parasites, causes destruction of their cell membranes and, as a result, leads to the death of helminths.
The effect of the drug applies to tapeworm larvae (armed, canine), Giardia, whipworm, pinworms, opisthorchia, roundworm, necator americanus, intestinal eels, microsporidia, toxocara. Nemozol is also effective for polyhelminthiasis.
The manufacturer produces it in the form of tablets and suspensions: tablets are the optimal dosage form for adults, a suspension is prescribed for children over 12 months of age.
Most people leave good reviews about Nemozole on forums. Since helminthic infestations most often occur in childhood, these are mainly reviews of Nemozol for children. Almost all mothers note the speed of the drug and its effectiveness, however, they emphasize that some patients may experience side effects.
Use of the drug Nemozol™
Use internally during meals. The oral bioavailability of albendazole is increased if the drug is taken with a fatty meal. Adults and children over 2 years of age are prescribed:
- for enterobiasis, hookworm, necatoriasis, ascariasis, trichinosis, 400 mg (1 tablet) or 20 ml of suspension once. When treating enterobiasis, it is recommended to carry out simultaneous treatment of all persons living together;
- for strongyloidiasis and taeniasis - 400 mg (1 tablet) or 20 ml suspension 1 time per day for 3 days;
- for toxocariasis - 400 mg (1 tablet) or 20 ml suspension 1 time per day for 10 days;
- for mixed infestations caused by Opisthorchis viverrini and Clonorchis sinensis - 400 mg (1 tablet) 2 times a day for 3 days.
Children aged 2–12 years with giardiasis are prescribed 400 mg (1 tablet) or 20 ml of suspension once a day for 5 days. For cystic echinococcosis, patients weighing more than 60 kg are prescribed Nemozol at a dose of 400 mg (1 tablet) or 20 ml of suspension 2 times a day for 28 days. For patients weighing less than 60 kg, albendazole preparations are used in a daily dose of 15 mg/kg, divided equally, in 2 doses. The maximum daily dose is 800 mg. The course of treatment can be repeated after a 14-day break; if necessary, 3 courses of treatment can be carried out. For alveolar echinococcosis, patients weighing more than 60 kg are prescribed Nemozol at a dose of 400 mg (1 tablet) or 20 ml of suspension 2 times a day for 3 courses of 28 days with 14-day breaks between courses. For patients weighing less than 60 kg, albendazole preparations are used in a daily dose of 15 mg/kg, divided equally, in 2 doses. The maximum daily dose is 800 mg. For neurocysticercosis, patients weighing more than 60 kg Nemozol are prescribed at a dose of 400 mg (1 tablet) or 20 ml of suspension 2 times a day for 7–30 days, depending on the clinical effect. For patients weighing less than 60 kg, albendazole preparations are used in a daily dose of 15 mg/kg, divided equally, in 2 doses. The maximum daily dose is 800 mg. The course of treatment is 7–30 days, a second course can be carried out after a 14-day break. For cutaneous larva migrans syndrome, 400 mg (1 tablet) or 20 ml of suspension is prescribed once a day for 1–3 days.
Compound
Nemozol tablets in p/o contain 0.4 g of albendazole , corn starch, povidone-30, purified talc, sodium lauryl sulfate, gelatin, silicon dioxide (in colloidal form), sodium starch glycolate, methyl and propyl paraben, magnesium stearate.
Composition p/o: titanium dioxide, hydroxypropyl methylcellulose, propylene glycol; methylene chloride and isopropanol (evaporate when dried). Nemozol chewable tablets contain 0.4 g of albendazole , corn starch, povidone-30, purified talc, sodium lauryl sulfate, silicon dioxide (in colloidal form), gelatin, citric acid, methyl and propyl paraben, sodium starch glycolate, aspartame, magnesium stearate, flavorings (pineapple/mint).
The Nemozol suspension albendazole at a concentration of 20 mg/ml. Auxiliary components: MCC, sodium carboxymethylcellulose, sorbitol , benzoic and sorbic acids, glycerin (glycerol), potassium hydrochloride, polysorbate-80, flavorings (ice cream essences/mixed fruit flavor), purified water.
Side effects of the drug Nemozol™
from the gastrointestinal tract: stomatitis, dry mouth, heartburn, nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation; from the cardiovascular system: arterial hypertension; from the central and peripheral nervous system: insomnia or drowsiness, headache, dizziness, confusion, disorientation, hallucinations, convulsions, decreased visual acuity; from the hematopoietic system: leukopenia, thrombocytopenia, pancytopenia; from the skin and its appendages: alopecia; from the urinary system: impaired renal function, acute renal failure; allergic reactions: itching, urticaria, pemphigus, dermatitis, chills; laboratory indicators: increased activity of liver enzymes.
Special instructions for the use of Nemozol™
During use of the drug, it is necessary to monitor the activity of liver enzymes before the start of each treatment cycle. If the indicators exceed the upper limit of normal by more than 2 times, the use of Nemozol must be stopped until the indicators are completely normalized. It is necessary to monitor the number of leukocytes at the beginning and every 2 weeks of the 28-day cycle of drug use. The use of Nemozol for leukopenia can be continued if the degree of reduction is insignificant and the leukopenia does not progress. Patients with neurocysticercosis should receive appropriate therapy with steroids and anticonvulsants. Special security measures. In order to prevent the use of Nemozol in the early stages of an unknown pregnancy, women of childbearing age can begin taking the drug only after receiving a negative pregnancy test result or at the beginning of menstruation. During the treatment period, with breaks between courses inclusive, it is necessary to ensure reliable contraception. Use during pregnancy or breastfeeding. Taking Nemozol during pregnancy is contraindicated. During treatment, breastfeeding should be stopped (the safety of the drug has not been established). Children. The drug is used in children over 2 years of age. Influence on reaction speed when driving vehicles or working with other mechanisms. During the treatment period, you should refrain from driving vehicles and performing work that requires increased attention and quick reaction.
Nemozol price
The price for Nemozol tablets in Russian pharmacies varies from 176 to 206 rubles. The cost of chewable tablets 400 mg is 200-210 rubles. The price of Nemozol suspension is 160-205 rubles.
The average price in Ukraine for Nemozol (albendazole) in the form of tablets in p/o is 200 UAH, chewable tablets are 250 UAH. You can buy a suspension for oral administration for 220 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Cream Nemozol 15 mlLaboratoriya Emansi/Proba LLC
121 rub.order - Nemozol tablets p.p.o. 400 mg 1 piece Ipca Laboratories Ltd
RUB 204 order
- Nemozol chewable tablets. 400 mg 1 piece Ipca Laboratories Ltd
RUB 202 order
- Nemozol susp. for internal approx. 100mg/5ml 20mlIpca Laboratories Ltd
RUB 218 order
- Nemozol tablets p.p.o. 400 mg 5 pcs. Ipka Laboratories Limited
RUB 812 order
Pharmacy Dialogue
- Nemozol suspension bottle 100mg/5ml 20ml for oral administrationIpka Laboratoris
200 rub. order
- Nemozol tablets 400 mg No. 5Ipka Laboratoris
RUR 788 order
- Nemozol chewable tablets 400 mg No. 1Ipka Laboratoris
RUB 187 order
- Nemozol (15g) Emansi Laboratory JSC
RUB 173 order
- Nemozol tablets 400 mg No. 1Ipka Laboratoris
186 RUR order
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