Pharmacodynamics and pharmacokinetics
The medication stimulates the process of platelet release from the bone marrow and enhances their formation. The drug has antiplatelet and angioprotective effects. The drug helps stop bleeding, increases the rate of formation of the primary thrombus , etamsylate enhances retraction, has no effect on prothrombin time , fibrinogen concentration. With repeated use of the drug, thrombus formation increases. Dicynone reduces diapedesis of formed and blood elements from the vascular bed, reduces fluid output, and has a positive effect on microcirculation . The drug does not affect the normal indicators and parameters of the hemostasis system. Dicynone is able to restore altered bleeding time in various diseases.
The hemostatic effect is felt after 10-15 minutes. The peak level of the active substance is reached an hour after administration. It is excreted unchanged on the first day almost entirely in the urine.
How does Dicynon work?
The active substance, when introduced into the body, stimulates the production of platelets and their release into the blood from the bone marrow. The medication does not increase fibrin concentration and does not affect the normal prothrombin index. Dicinone eliminates pathological changes in blood clotting, promotes the formation of primary blood clots, has an antiplatelet and angioprotective effect, improves fluid circulation, and restores normal homeostasis during bleeding.
The effect of the drug in tablets develops within 15 minutes after it is dissolved in the stomach cavity and enters the blood. Injections work from the first minutes of being in the body. To stop massive bleeding, the medication needs 20 to 40 minutes.
1 hour after administration, the pharmacological effect of Dicinone reaches its maximum. The drug does not accumulate in the body. It is excreted completely unchanged through the kidneys within 24 hours.
Indications for use of Dicinone
What is Dicynon in tablets and ampoules for?
The medicine is prescribed to stop bleeding and prevent it: capillary, parenchymal bleeding (postoperative, traumatic, after dental interventions, intestinal, renal, pulmonary bleeding). The drug is prescribed for secondary bleeding due to thrombocytopathy , thromphocytopenia, hematuria, hypocoagulation, intracranial hemorrhage, hemorrhagic vasculitis , drug-induced bleeding, hemorrhagic diathesis . Indications for the use of Dicinon are repeated retinal hemorrhages, diabetic retinopathy, Werlhof's disease. Dicinone for menstruation is prescribed for heavy menstruation.
When is Dicinon indicated: instructions
All forms of the drug are prescribed to stop or prevent various types of bleeding, external and internal:
- capillary;
- dental;
- parenchymal;
- intestinal and gastric;
- uterine;
- pulmonary;
- renal.
Dicynone is used to normalize homeostasis during primary bleeding due to tissue damage, as well as for vascular diseases, the endocrine system and their consequences:
- with hemorrhages in the brain and retina of the eye;
- for diabetic retinopathy;
- with hemorrhagic vasculitis, diathesis;
- with pathologically reduced blood clotting;
- for hematuria, thrombocytopathy;
- with heavy menstrual blood loss;
- with Werlhof's disease.
The drug can be used to eliminate the consequences of overdoses of anticoagulant medications: with caution, under medical supervision.
Instructions for use of Dicinone (Method and dosage)
The medicine is taken orally, administered intramuscularly, intravenously. In ophthalmology it is used retrobulbarly. Single dose – 0.5 grams (tablets), 0.25 grams (parenteral). To prevent bleeding during surgical interventions, Etamzilat is administered one hour before surgery. Dicynone for menstruation, pulmonary, intestinal bleeding: 0.5 grams daily, course of treatment for 5-10 days. For diseases of the blood system, hemorrhagic diathesis, diabetic angiopathy, take 0.75 grams, duration of therapy is up to two weeks. To prevent postoperative bleeding, Dicynon is taken in an amount of 8 mg/kg.
Hemorrhagic syndrome: three times a day, 6-8 mg/kg, duration of administration up to two weeks, if necessary, repeat the course after a week.
Diabetic microangiopathy (hemorrhages): intramuscularly 0.25 grams three times a day, injections are given for 3 months. A sterile swab soaked in ethamsylate can be applied to the wound surface to stop bleeding.
Dicinon tablets, instructions for use
Usually take about 15 mg/kg per day. That is, 1-2 tablets at a time, 3 times every 24 hours.
Children aged three to twelve years take half the adult dose.
Dicinon injections, instructions for use
Dicynon is administered intravenously or intramuscularly. Usually 1-2 ampoules 3 times a day.
Instructions for use of Dicinon during menstruation
Used only with the permission of the attending physician. For heavy periods, 2 tablets are prescribed 3 times a day 3-5 days before menstruation and for five days after their onset. It is recommended to repeat the course at the next menstruation to consolidate.
It is not recommended to use the drug to stop menstruation.
How to take Dicinon for uterine bleeding
Only under the supervision of a doctor. For uterine bleeding, it is recommended to take Dicinon by injection, 1-2 ampoules every 6 hours until the bleeding stops or the risk of its recurrence disappears.
Side effects
While using the medication, the following reactions from the body are likely:
- redness of the facial skin, feeling of heat;
- changes in the sensitivity of the lower extremities, their numbness;
- decreased blood pressure;
- headache;
- dizziness;
- drowsiness, muscle weakness;
- for diseases of the gastrointestinal tract: epigastric pain, heartburn, nausea, loss of appetite, heaviness in the abdomen.
Dicynon's analogs
Level 4 ATC code matches:
Water pepper extract
Etamzilat
The main analogue is a drug that has the same name as the main active ingredient - Etamzilat .
Which is better: Dicynon or Tranexam?
Tranexam is considered a more effective drug for stopping bleeding.
How to use Dicynon tablets
The drug is taken orally with water, regardless of the time of meal. Treatment regimens depend on the physical condition and type of pathology.
- For heavy periods, the daily dose is 6 tablets, divided into 2 times. The course must be started a week before menstruation and continued until its end. Repeated administration is possible until the intensity of discharge normalizes.
- For low blood clotting, capillary bleeding, hemorrhagic diathesis, take 1-2 tablets up to 4 times a day.
Children under 12 years of age are prescribed the drug at a reduced dose - ½ of the adult dose.
Reviews of Dicynon
Reviews of Dicinone in tablets and ampoules indicate that the drug is a very effective remedy for stopping bleeding. It tastes bitter.
Reviews for menstruation
They perfectly help with heavy menstruation, for which they are often taken.
Reviews during pregnancy
Recommended with caution, but generally no side effects have been reported. Expectant mothers take this drug, pregnancy is successful.
For uterine bleeding
Used under the supervision of a physician. Helps stop uterine bleeding. However, the effect may not last long.
Contraindications
It is necessary to stop using the drug in case of chronic pathologies of the hematopoietic and circulatory system:
- acute form of porphyria;
- thrombosis;
- thromboembolism.
Another contraindication is an allergic reaction to any of the components of the drug. It can be expressed by skin manifestations, swelling of the mucous membranes, and itching.
Pregnancy is not an absolute contraindication. But caution is required during this period. Prescribing the drug during gestation is permitted in the absence of risks of premature termination in individually specified cases. It is necessary to exclude Dicynon in the first trimester, as it can negatively affect the formation of the fetus.
Dicinon price, where to buy
The price of Dicinon in tablets is approximately 380 rubles per package of 100 pieces. How much do tablets cost in Ukraine? You can buy a package for 320-340 UAH.
The price of Dicinon ampoules is 530 rubles for 50 pieces. The cost in Ukraine is 350-380 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Dicynone amp.
250 mg 2 ml (125 mg/ml) No. 10 RUB 1,290 order
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- Dicynon tablets 250 mg 100 pcs. Lek dd
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Pharmacy24
- Dicynon 250 mg 2 ml No. 50 injection solution Lek pharmaceutical company d.d., Slovenia
435 UAH.order - Dicynon 250 mg No. 100 tablets Lek pharmaceutical company d.d., Slovenia
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- Dicynone tablets Dicynone tablets 250 mg No. 100 Slovenia, Lek
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- Dicinone ampoule Dicinone solution d/in. 250mg amp. 2ml No. 50 Slovenia, Lek
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Composition and pharmaceutical forms
The drug is available for systemic use: orally and parenterally. The active component is the substance etamsylate, which has a hemostatic effect. Existing dosage forms of Dicynon:
- tablets: with a dosage of 250 mg of the active ingredient and the presence of auxiliary components: starch, citric acid, magnesium stearate, lactose;
- injection solution: in glass ampoules of 2 ml, the dose of etamsylate in each is 250 mg, other components: distilled water and sodium salts.
How to use Dicinon injections
The drug solution is administered intramuscularly or intravenously, without diluting or mixing with other medications in the same syringe.
- To prevent postoperative complications, the injection is given 1 hour before surgery.
- To stop massive uterine, pulmonary, and intestinal bleeding, Dicynone is administered intravenously, 1–3 ampoules per day.
- If there is a threat of developing hemorrhagic syndrome, intramuscular injections are given: 1–2 ampoules daily.
The course of taking the injection form of the drug is 5–10 days.
To stop moderate external bleeding, local use of the medication is allowed. Sterile swabs moistened with liquid can be applied to lesions on the skin and mucous membranes, covering them with bandages if necessary.
It is undesirable to combine Dicinone with the use of anticoagulant agents. Concomitant treatment with aminocaproic acid and sodium bisulfate is acceptable.
