Even with a varied diet, a person, unfortunately, does not receive the norm of vitamins and microelements. This is especially felt in regions with a sharp and cold climate and food seasonality. For example, in our region, only 3 months a year we can eat clean, fresh vegetables and berries. The sun also doesn’t spoil us all year round, like in the south, for example. Therefore, a lack of vitamin D, poor absorption of calcium, and a lack of omega-3 and 6 are the costs of living in the northern and northeastern parts of Russia, for example, in the Irkutsk region. Taking vitamins becomes a necessity.
Today we’ll talk about magnesium - the main building block for a strong nervous system, the deficiency of which is becoming very common. Which drug is better, what is their feature, how to take magnesium correctly and when a positive effect is achieved.
Magnesium for health
Magnesium is an essential trace element that is directly involved in the functioning of the nervous system. Regulates cellular metabolism, ensures the transmission of nerve impulses between muscles and the brain. A sufficient amount of this element in the body helps to more easily endure stress and shock, not experience muscle tone and spasms, and regulate mood and emotions.
Magnesium is extremely important for women's health during pregnancy. Regulates endocrine functions. Magnesium is best absorbed only in combination with vitamin B6 or pyridoxine. Therefore, it is required to be present in magnesium preparations.
The main symptoms of magnesium deficiency in the body:
- headache;
- tachycardia;
- arrhythmia;
- muscle cramps;
- irritability;
- insomnia;
- premenstrual syndrome;
- "lazy bowel" syndrome;
- anxiety and neurasthenic disorders;
- photosensitivity and sensitivity to noise;
- hypertension;
- increased level of platelets in the blood.
Magnesium B6 forte, 30 pcs., 100 mg, film-coated tablets
Magnesium takes part in more than 300 enzymatic reactions. It is needed for the production of protein, DNA, for the breakdown of glucose, the removal of toxins from the body, for the absorption of vitamin C, thiamine (B1) and pyridoxine (B6). Magnesium contributes to the stability of the cell structure during growth, takes part in the process of regeneration of body cells, has a beneficial effect on the functioning of internal organs, reduces irritability and protects against radiation. Vitamin B2 (riboflavin) helps convert vitamin B6 into its active form. With a lack of Vitamin B2, the absorption of iron decreases and the activity of the thyroid gland worsens. It has antioxidant properties, participates in metabolic processes and has a positive effect on the immune system, the state of the cardiovascular and nervous systems, skin and mucous membranes, liver function, stimulates hematopoiesis, and is responsible for the health of hair and nails. Vitamin B6 (pyridoxine hydrochloride) improves the absorption of magnesium from the gastrointestinal tract and its penetration into body cells, participates in the synthesis of hormones, as well as nucleic acids, which increase immunity and prevent the aging process. Magnesium and the female body Magnesium will help eliminate PMS symptoms. Premenstrual passion for chocolate is explained by a lack of magnesium in the body. "Magnesium B6 FORTE VITAMIR®" will help compensate for the lack of magnesium without adding calories to you.
Effect of Magnesium on the human body:
Magnesium and bones Today it has been proven that consuming the required amount of magnesium significantly increases bone mineral density. Moreover, as it turns out, magnesium is much more important than calcium for the health of our bones. Bone health depends not only on calcium, but it is clear that it depends just as much on magnesium. With the help of magnesium, cartilage and bone tissue grow, calcium and vitamins B, C, E are absorbed.
Magnesium and muscles Magnesium increases endurance. An experiment was conducted for a group of American athletes: before important competitions, they took magnesium. The results exceeded all expectations. In addition, complaints of chest pain that arose during intense training earlier have practically disappeared.
Magnesium and memory, emotions If you have increased anxiety, magnesium will help cope with stress. This trace element increases interest in new things, relieves some types of migraines, and improves memory.
Magnesium and the Heart Most patients with cardiovascular disease are deficient in magnesium. Patients who are being prepared for heart surgery are recommended to be prescribed magnesium to normalize blood pressure and minimize the possibility of heart rhythm disturbances and arrhythmias. Taking magnesium-containing medications as a preventive measure will help reduce the risk of cardiovascular disease.
Magnesium and figure Magnesium improves digestion, helps move food through the intestines, utilize proteins and fats, and stabilizes genes responsible for obesity. If your family has a tendency to be overweight, then in the presence of magnesium these genes will not open up. Magnesium reduces the level of “stress” hormones, saving you from overeating
Magne B6 and Magnelis B6 comparison
Let's try to answer the question of what is better Magne B6 or Magnelis B6
As can be seen from the table, both drugs have the same indications, the same recommendations for side effects and, judging by consumer reviews, are generally equally well tolerated if all conditions of administration are met.
But some indicators, as well as the composition of the drugs, are different. The form of the active substance, magnesium, and the excipients differ. The form of magnesium in Magna B6 is lactate dihydrate, in Magnelis it is lactate.
Magnesium lactate is a magnesium salt of natural lactic acid. A dihydrate is a form of a substance (i.e. magnesium lactate) that contains two water molecules attached. Thus, the dihydrate provides the greatest bioavailability and better absorption. In fact, this form allows the molecules of the active substance to separate faster and more easily, attach to transporter substances, reach their destination intact and be absorbed there. But even this fact does not deprive the related drug Magnelis B6 of its beneficial properties and effectiveness.
Moreover, in the line of Magnelis products there is a drug Magnelis Express Calm, which in addition to magnesium contains extracts of hops, valerian, passionflower and folic acid. It has a more pronounced calming effect and helps regulate sleep and wakefulness. In turn, Magne B6 has a solution form that can be given to children from 1 year of age in the presence of hypertension, increased excitability and nervous tension during the adaptation period. Magnelis is acceptable for use by children over 6 years of age. However, before using magnesium in children, you should consult a specialist.
Both drugs in tablet form should be used with caution if you have diabetes, since the tablet shells contain sugar.
When are magnesium supplements prescribed?
- when restoring the nervous system, in the event of any, even seemingly minor, disorders, ranging from mild irritability to severe forms of vegetative-vascular dystonia and cardioneurosis.
- to normalize blood pressure in hypertension.
- to eliminate heart pain and heart rhythm disturbances. If the cause of heart ailments lies not in a functional disorder, but in a serious heart disease, then the supplement is prescribed in combination with other medications.
- for the treatment of muscle cramps, including in children
- with poor and imaginative nutrition, diets, increased physical activity.
Benefits of magnesium
- Helps absorb calcium, activates vitamin D in the kidneys, which is necessary for the health of the skeletal system.
- Metabolizes carbohydrates and glucose, therefore reduces the risk of type 2 diabetes.
- Reduces fat deposits on artery walls, reduces the risk of coronary artery calcification.
- Magnesium therapy reduces the likelihood of developing migraines.
- Reduces premenstrual symptoms.
- Promotes weight loss due to its influence on hormonal levels and its participation in the synthesis of female hormones.
- The presence of magnesium in the body can change the types of bacteria present in the intestines.
Magne B6 oral solution in ampoules 10ml No. 10
Magne B6 solution.
Release forms
Solution.
INN
Magnesium lactate + magnesium pidolate + pyridoxine hydrochloride.
FTG
Magnesium preparation.
Description
Transparent brown liquid with a caramel odor.
Compound
One ampoule (10 ml) contains: Active substances: magnesium lactate dihydrate – 186 mg, magnesium pidolate – 936 mg (total magnesium content (Mg2+) is 100 mg (4.11 mmol)), pyridoxine hydrochloride – 10 mg. Excipients: sodium disulfite (E223), sodium saccharinate (E954), cherry-caramel flavor, purified water. Composition of cherry-caramel flavoring: alcoholates and alcohol tinctures of raspberry, orange, cocoa, black currant, extracts of coffee, Tonka beans, hemanthus and fenugreek, vanillin, ethylvanillin, maltol (E 636), piperonal, oxyphenylone, acetylmethylcarbinol, diacetyl, isoamyl acetate, gamma-nonalactone, ionones, methylisoeugenol, benzoic aldehyde, caramel (E 150), propylene glycol (E 1520). Pharmacotherapeutic group Mineral supplements. Magnesium-based products. ATX code: A12CC.
Pharmacological properties
Pharmacodynamics Physiological aspects: Magnesium is predominantly an intracellular cation. It reduces the excitability of neurons and neuromuscular transmission of excitation, and takes part in many enzymatic processes. Magnesium is an essential element of organs and tissues: bone tissue contains half of the total amount of magnesium contained in the human body. Clinical aspects: Serum magnesium levels: - between 12 and 17 mg/L (1-1.4 mEq/L or 0.5-0.7 mmol/L): indicate mild magnesium deficiency - below 12 mg/L ( 1 mEq/L or 0.5 mmol/L): indicates severe magnesium deficiency. Deficiency can be: - primary, due to a congenital abnormality of magnesium metabolism, - secondary, due to • inadequate intake (severe malnutrition, alcoholism, total parenteral nutrition), • gastrointestinal absorption disorders (chronic diarrhea, gastrointestinal fistula, hypoparathyroidism), • excessive losses at the renal level (tubular disease, significant polyuria, diuretic abuse, chronic pyelonephritis, primary hyperaldosteronism, treatment with cisplatin). Pyridoxine (vitamin B6) is involved in many metabolic processes in the body and in the regulation of nervous system metabolism. The biological properties of pyridoxine are provided by pyridoxal-5-phosphate, which is formed in the body with the participation of the enzyme pyridoxal kinase. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells, which determines the effectiveness of the combination of these substances. Pharmacokinetics Gastrointestinal absorption of magnesium salts occurs partly through a passive mechanism in which the solubility of the salt plays a determining role. The degree of this absorption does not exceed 50%. Excretion occurs primarily through urine.
Indications for use
This medicine contains magnesium and is used to correct a deficiency of this element in the body. A combination of a certain number of the following symptoms may indicate a magnesium deficiency: - Nervousness, irritability, mild anxiety, transient fatigue, mild sleep disturbances, - Signs of anxiety such as gastrointestinal cramps or rapid heartbeat (if the heart is healthy), - Muscle cramps, tingling sensation Prescribing magnesium may help relieve these symptoms. If no improvement is observed after one month of treatment, continuation of monotherapy with this drug is not advisable.
Contraindications
The use of the drug is contraindicated in the following cases: - hypersensitivity to one of the components - severe renal failure with creatinine clearance less than 30 ml/minute - co-administration with levodopa.
Precautionary measures
In case of concomitant calcium deficiency, the magnesium deficiency must be corrected before the calcium deficiency is corrected, i.e. before starting to take calcium supplements. In cases of severe magnesium deficiency and malabsorption, the intravenous route of drug administration should be chosen for treatment. This drug is indicated for oral administration. IT CANNOT BE INJECTED! In moderate renal impairment, caution should be exercised to avoid the risk associated with hypermagnesemia. Due to the presence of sucrose, the drug is contraindicated in cases of fructose intolerance, impaired absorption of glucose or galactose, or sucrase-isomaltase deficiency. Use with caution for gastric and duodenal ulcers and coronary heart disease. In case of severe liver damage, pyridoxine in high doses can cause deterioration of liver function. When pyridoxine is used in high doses (> 200 mg/day) for a long time (several months or in some cases years), sensory neuropathy may develop, which is accompanied by symptoms such as numbness and vestibular disturbances, tremors of the distal extremities and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after discontinuation of high doses of vitamin B6. The ampoules contain sulfite, which may cause or worsen allergic-type reactions, including anaphylactic reactions, in patients at risk. Interaction with other medicinal products and other forms of interaction You must systematically inform your doctor about all the medications you are taking. Magnesium, not recommended combinations ■ Phosphorus or calcium salts These drugs inhibit the absorption of magnesium from the intestines. Combinations to consider ■ Oral tetracyclines An interval of at least 3 hours should be maintained between oral tetracyclines and magnesium due to reduced absorption of tetracyclines in the gastrointestinal tract. ■ Oral thrombolytic agents Magnesium weakens their effect. Magnesium reduces iron absorption. Vitamin B6, not recommended combinations ■ Levodopa When used simultaneously with levodopa, the effects of levodopa are reduced or completely inhibited. Vitamin B6, combinations that should be taken into account ■ Hormonal contraceptives When used simultaneously with hormonal contraceptives, the concentration of pyridoxine in the blood plasma may increase. ■ Diuretics When used simultaneously, the effect of diuretics is potentiated. ■ Isonicotin hydrazide, penicillamine, cycloserine When used simultaneously with isonicotin hydrazide, penicillamine, cycloserine, the effectiveness of pyridoxine may be reduced. ■ Phenytoin, phenobarbital When used simultaneously with phenytoin, phenobarbital, a decrease in the concentrations of phenytoin and phenobarbital in the blood plasma is possible.
Pregnancy and breastfeeding
Pregnancy This medicine, if necessary, can be used at any stage of pregnancy. If, during treatment with the drug, you discover that you are pregnant, consult your doctor, who will decide whether you need to continue treatment. Breastfeeding period The use of magnesium and vitamin B6 contained in the drug is considered compatible with the lactation period. Data on this issue are limited by the maximum daily dose of vitamin B6. The recommended dose of vitamin B6 during breastfeeding is no more than 20 mg per day.
Impact on the ability to drive vehicles or other machinery
There are no special recommendations.
Directions for use and doses
This drug is indicated for oral administration. IT CANNOT BE INJECTED! The contents of the ampoules should be diluted in half a glass of water. Adults: 3-4 ampoules per day, divided into 2-3 doses with meals. Children weighing over 10 kg (about 1 year of age and older): 10-30 mg/kg/day (0.4-1.2 mmol/kg/day), that is, 1-4 ampoules per day, divided into 2 -3 doses during meals. If you forget to take Magne B6, do not take a double dose to make up for the missed dose! Treatment should be stopped after normalization of magnesium levels in the blood. ATTENTION: THE AMPOULES ARE SELF-PRESSING, DO NOT REQUIRE THE USE OF A NAILFISH! To open the ampoule, take it by the tip (you can first cover it with a piece of cloth) and break off the tip with a sharp movement. Follow the instructions shown in the picture!
Overdose
Oral overdose of magnesium usually does not cause toxic reactions if the kidneys are functioning normally. However, magnesium poisoning can develop in cases of kidney failure. Toxic effects depend on the level of magnesium in the blood, and their symptoms are as follows: - drop in blood pressure, - nausea, vomiting, - central nervous system depression, impaired reflexes, - ECG changes, - respiratory depression, coma, cardiac arrest and respiratory paralysis, - anuric syndrome . When taking a large dose, there is a risk of anuric syndrome. Treatment: rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.
Side effects
Like all medicines, this drug may cause varying degrees of side effects in some people. - diarrhea - abdominal pain - skin reactions - allergic reactions Due to the presence of sodium disulfite (E 223) in this form of the drug (oral solution), there is a risk of allergic reactions, including anaphylactic reactions, and bronchospasm. Reporting Adverse Reactions If you experience any adverse reactions, consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the Adverse Drug Events Information Database, including reports of drug failure. By reporting side effects, you can help provide more information about the safety of the drug.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C. Keep out of the reach of children.
Best before date
3 years. Do not take after the expiration date stated on the package.
Conditions for dispensing from pharmacies
Available without a prescription.
Package
10 ampoules of yellow glass type III, 10 ml capacity, with two or one break line at each of the two ends of the ampoule, along with instructions for use, in a cardboard box.
Buy Magne B6 solution d/pr. ext. in amp. 10 ml in pack No. 10 in the pharmacy
Price for Magne B6 solution d/pr. ext. in amp. 10 ml in pack No. 10
Instructions for use for Magne B6 solution d/pr. ext. in amp. 10 ml in pack No. 10
Special recommendations for taking magnesium supplements
Taking magnesium and other medications together
Concomitant use of the drug with tetracycline antibiotics or calcium supplements is not recommended. Magnesium interferes with the full absorption of antibiotics, reducing its effectiveness. Calcium, in turn, interferes with the absorption of magnesium. If there is an urgent need to take magnesium along with the listed drugs, you need to ensure that an interval of at least 3 hours is maintained between doses.
Magnesium during pregnancy
Only a doctor can prescribe taking the drug during pregnancy, taking into account the balance of benefit and harm for the expectant mother and fetus. However, the prescription of magnesium during pregnancy is common, because during this period there is most often a deficiency of vital magnesium. It helps relieve uterine hypertonicity, regulate mood and sleep in a pregnant woman against the background of hormonal changes. But magnesium is contraindicated during breastfeeding, since the drug passes into breast milk. So, during the feeding period, magnesium supplements should be discontinued.
Magnesium intake and kidneys
The kidneys play a critical role in magnesium balance. They control the retention and excretion of minerals. Magnesium is not harmful to healthy, normally functioning kidneys. In fact, adequate magnesium levels reduce the risk of cardiovascular and kidney disease. Research has shown that chronic kidney disease causes magnesium depletion, and reduced magnesium levels cause calcification of blood vessels. Therefore, special attention should be paid to the use of magnesium if there are kidney diseases. This results in hypermagnesemia.
Hypermagnesemia
Normally, the human body contains about 70 g of magnesium, of which a large proportion (60%) is in bone tissue, the rest is contained in muscles, soft tissues and liquid media. It is present in large quantities in brain cells and in the heart. An excess of the element provokes an imbalance in the functioning of internal organs.
The reason for this may be insufficient excretion of magnesium in the urine and impaired renal function.
