What it is?
Noofen is a nootropic drug for the treatment of disorders of the nervous system and memory.
Nootropics belong to a group of drugs that stimulate metabolic processes in nerve cells. As a result of their influence, the brain works better and tolerates heavy loads well.
Noofen helps solve several problems:
- relieves tension;
- eliminates anxiety and fear;
- improves memory;
- promotes good sleep;
- increases physical activity.
Noofen contains the main active substance – aminophenylbutyric acid hydrochloride (phenibut). If the drug is released in the form of tablets or capsules, each of them contains 0.25 g of phenibut. And one sachet of Noofen powder contains 100 or 500 mg of the active ingredient.
The medicine contains excipients: lactose, calcium stearate and potato starch.
The manufacturer of the drug is the Latvian pharmaceutical company. There are also analogues from other companies.
Action
Aminophenylbutyric acid, which is part of Noofen, has the following effects on the human body:
- calming – removes irritability, neutralizes anxiety and fear, relieves emotional stress;
- nootropic – increases mental abilities, improves memory, enhances physical capabilities;
- psychomotor – increases the speed of reactions, enhances attention;
- physical – eliminates headache severity;
- has a positive effect on the quality and duration of sleep.
An important quality of the drug is the absence of drowsiness during its use, and after stopping use, the absence of withdrawal syndrome.
Pharmacological properties
Pharmacodynamics.
Noofen is a derivative of GABA and phenylethylamine. Its dominant antihypoxic and antiamnestic effect is. Noofen stimulates learning processes, improves memory, and increases physical and mental activity. Noofen also has tranquilizing properties: eliminates psycho-emotional stress, anxiety, fear, emotional lability, irritability, improves sleep; prolongs and enhances the effect of sleeping pills, narcotics, neuroleptics and anticonvulsants. Unlike tranquilizers, under the influence of Noofen, indicators of higher nervous activity (attention, memory, speed and accuracy of sensory-motor reactions) improve. The drug lengthens the latent period and reduces the duration and severity of nystagmus, and has an antiepileptic effect. Does not affect cholinergic and adrenergic receptors. Noofen significantly reduces the manifestations of asthenia and vasovegetative symptoms, including headache, a feeling of heaviness in the head. In patients with asthenia and in emotionally labile patients, from the first days of therapy with the drug, their well-being improves, interest and initiative increase, and motivation for vigorous activity without sedation or agitation. It has been established that when taking Noofen for traumatic brain injury, the number of mitochondria in the cells of perifocal tissues increases and bioenergetic processes in the brain improve. In the presence of disturbances in the activity of the heart and stomach, it normalizes the processes of lipid peroxidation.
Pharmacokinetics. The drug is well absorbed after oral administration and penetrates well into all tissues of the body, penetrating the BBB. It is distributed evenly in the liver and kidneys, and unevenly in the brain and blood. After 3 hours, a moderate amount of administered Noofen is detected in the urine, at the same time the concentration of the drug in the brain tissue does not decrease, it is detected in the brain after another 6 hours. The next day after taking Noofen, it can only be detected in the urine; it is determined in urine 2 days after use, but the detectable amount is 5% of the administered dose. The greatest binding of Noofen occurs in the liver (80%), it is not specific. With repeated administration, cumulation is not noted.
What is it prescribed for?
Noofen is prescribed for the treatment of various neurological diseases. These can be neuroses, psychopathy, chronic fatigue syndrome, obsessive and anxiety-neurotic conditions. Noofen helps children solve problems with stuttering, enuresis, and tics. For elderly patients, the drug is prescribed for insomnia.
Noofen is prescribed as a prophylactic before operations or unpleasant diagnostic procedures. It calms the nervous system and helps the patient to better tolerate them.
The medicine is used in the complex treatment of alcoholism in combination with other medications to relieve toxicity. It helps relieve mental and somatic disorders during withdrawal syndrome.
The drug is prescribed for the treatment of Meniere's disease, dizziness and problems of the vestibular system.
Noofen is prescribed to women for the treatment of cervicothoracic osteochondrosis and disorders during menopause.
Alcohol compatibility
Despite the fact that Noofen is used in complex treatment for alcoholism, its compatibility with alcohol is zero. It is not recommended to drink alcohol during treatment with Noofen. This is fraught with unpleasant consequences:
- The drug enhances the effect of alcohol and can cause severe intoxication of the body even with a small dose of alcohol.
- The main substance included in Noofen can cause gastrointestinal disorders and disruption of the functioning of other organs.
- There is also an option for the body to develop tolerance to the medicine, when the usual dosage no longer helps. We have to raise it.
- The most severe situations that arise as a result of the simultaneous use of medication and alcohol are delirium and deep fainting, turning into a coma.
Treatment of alcoholism with Noofen is possible only as prescribed by a doctor, with the correct dosage. It is not safe to take this drug on your own. This can lead to the following conditions:
- nausea, vomiting;
- severe gastrointestinal disorders;
- dizziness, severe headaches;
- skin allergic reactions;
- increased anxiety;
- panic attacks;
- drowsiness and loss of consciousness.
Overdose
Noofen is low-toxic; only in a daily dose of 7–14 g, with long-term use, it can have a hepatotoxic effect. the indicated doses significantly exceed the recommended (average therapeutic daily dose - 0.5–2.5 g). Only at the highest dose used, eosinophilia and fatty liver were sometimes noted. There were no such changes when using the drug at lower doses.
Symptoms: drowsiness, nausea, vomiting, possible development of arterial hypotension, acute renal failure.
Treatment: gastric lavage, symptomatic therapy. In case of complications (arterial hypotension, renal failure), additional therapy is carried out.
Instructions for use
Noofen should be taken according to the instructions for use of the drug. The dosage and regimen depends on the patient’s age and type of disease. It is necessary to know the indications for use of this drug. You should also pay attention to the maximum permissible dosage indicated in the instructions.
- For mild symptoms of the disease, a reduced or medium dosage is prescribed. If the symptoms worsen, the dose of the medicine is also increased. According to the instructions, the daily dose of Noofen for adults is 0.25-0.5 g 3 times a day. A single dose is no more than 0.75 g, for patients over 60 years old – no more than 0.5 g.
- For serious diseases, such as Meniere's syndrome, and for disorders of the vestibular system, the medicine is started to be taken at an increased dose: 0.75 g 3 times a day. After a week, they switch to the usual three times a day.
- Relief from alcohol withdrawal syndrome begins according to the following scheme: 3 times a day, 0.25-0.5 g + 0.75 g at night. After a few days, they switch to the usual regimen and dosage.
- If you suffer from seasickness or air sickness, you need to take 0.25-0.5 g of medication one hour before travel. During an attack it is ineffective.
- The course of treatment for cervicothoracic osteochondrosis and pathologies of menopause in women is one month. For two weeks, the medicine is taken 3 times a day, no more than 0.75 g per day. Then another two weeks - 2 times a day, no more than 0.5 g per day.
To the question “when to take pills, before meals or after?” The instructions answer unequivocally: “before meals, wash down with water.” But how long you can take it is decided by your attending physician.
special instructions
Caution should be exercised when prescribing to patients with pathologies of the digestive tract due to the irritating effect of Noofen. these patients are prescribed the drug in reduced doses. with long-term use, the cellular composition of the blood and indicators of functional liver tests are monitored.
Use during pregnancy and breastfeeding is undesirable, since there is insufficient data confirming the safety of the drug during this period.
Children
Tablets 250 mg. The drug can be used in children over 8 years of age.
Capsules 250 mg. The drug can be used in children over 11 years of age.
Capsules 500 mg. The drug in this dosage is not used in children.
Powder for oral solution 100 mg. The experience of using the drug in children under 3 years of age has not been studied.
Powder for oral solution 500 mg. The use of the drug in children is contraindicated.
The ability to influence reaction speed when driving vehicles or working with other mechanisms. Patients who experience drowsiness, dizziness or other central nervous system disorders should not drive vehicles or operate other machinery during treatment.
Side effects
Noofen generally does not cause serious side effects in adults. The exception is patients with individual intolerance to the drug. Therefore, it is better to familiarize yourself with possible side effects in advance. These include:
- headache, dizziness;
- drowsiness;
- state of strong emotional arousal;
- loss of appetite, nausea;
- change in stool;
- stomach pain, liver dysfunction;
- increased activity of liver transminases;
- itching, rash, urticaria;
- angioedema, anaphylactic shock (rare).
Side effects such as drowsiness and nausea sometimes appear at the beginning of treatment with Noofen and disappear over time.
Reviews
Reviews from patients who took the drug Noofen are quite different. Among them there are those who received excellent results, while for others the course of treatment did not help at all. Many agreed that the medicine is completely useless in the treatment of vegetative-vascular dystonia. There are cases of addiction to this drug.
There are many positive reviews from adults after using the product by children, especially in the first year of life. Mothers note that children have become calmer, move more adequately, sleep and eat better.
Doctors note that many take Noofen without a prescription on their own to relieve stress or improve memory, which is completely contraindicated.
Note!
Description of the drug Noofen table. 250 mg No. 20 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
