Andipal: instructions for use, prices and reviews. Indications for use of the drug

Pharmacodynamics and pharmacokinetics

This is a combined drug that has a vasodilator, analgesic and analgesic effect. A good antispasmodic, which determines the use of Andipal for blood pressure.

Metamizole sodium, which is part of the composition, reduces body temperature and relieves pain. Once in the gastrointestinal tract, the substance is well and quickly absorbed and blocks the prostaglandin system of arachidonic acid, increasing the sensitivity threshold of pain centers in the hypothalamus .

Papaverine hydrochloride dilates blood vessels (reduces the level of calcium in cells) located on the periphery and significantly reduces the overall tone of the smooth muscles of the surface of internal organs.

Bendazole is an antispasmodic, dilates blood vessels, stimulates the spinal cord, and restores nerve endings in the periphery.

Phenobarbital exhibits its sedative properties and enhances the effects of other components of the drug.

Pharmadynamics and pharmacokinetics

Andipal begins to act 15 minutes after administration. This is due to the fact that the active components of the drug are quickly absorbed into the blood. The condition of a person with high blood pressure is normalized by improving cerebral circulation and stopping the release of adrenaline.

Analgin, entering the body, helps reduce the pain symptoms of migraines. The substance also reduces the severity of swelling in soft tissues, which provokes an increase in body temperature.

Papaverine eliminates spasms of smooth muscles in the digestive organs and in the walls of blood vessels. By dilating the arteries, blood flow improves.

Dibazol reduces heart rate and normalizes breathing. Phenobarbital in the drug has a sedative effect on the cells of the central nervous system.

Indications for use of Andipal. What does it help with?

Andipal tablets, what are they for?

Indications for the use of the drug are migraines of various types.
Pain associated with spasms of cerebral vessels in the head.
The medicine helps against pain caused by spasms of smooth muscles or internal organs of the gastrointestinal tract.
For mild forms of hypertension, it can be used as blood pressure pills.

What blood pressure should I take the medicine for? For primary or secondary hypertension, Andipal can be taken for high blood pressure.

Admission rules

In order to get the maximum effect from the drug, you must adhere to some rules during treatment:

Take the drug once when signs of hypotension appear. Take 1-2 tablets at a time.
Use the drug for long-term therapy only with the permission of a cardiologist. The duration of therapy does not exceed 10 days
Take the drug with food. A tablet taken before meals causes irritation of the mucous membranes of the stomach and intestines.
For long-term use, do not take more than 4 tablets per day.

The dosage of the medication may vary depending on the therapeutic goals:

to relieve headaches, Andipal is taken in 2 doses with an interval of 1 hour;
for hypertension, drink the drug 2 times a day for 3 days.

In the initial stages of hypertension, Andipal is taken only in extreme cases. Failure to comply with the dosages prescribed by the doctor may lead to the appearance of a collaptoid state.

For blood pressure, the drug is indicated for children from 8 years of age. For hypertension, they are allowed to take 2-3 tablets per day.

Contraindications

Acute increased sensitivity to the constituent substances of the drug (especially pyrazolone).
For glucose-6-phosphate dehydrogenase deficiency, various blood diseases, porphyria.
Severe dysfunction of the kidneys and liver, tachyarrhythmia , angina pectoris, intestinal obstruction .

The use of the drug is contraindicated for children under 8 years of age during lactation.

Andipal No. 10 tab.

Instructions for medical use of the drug andipal Trade name Andipal International nonproprietary name No Dosage form Tablets Composition One tablet contains active substances: analgin 0.250 g, phenobarbital 0.020 g, dibazol 0.020 g, papaverine hydrochloride 0.020 g, excipients: potato starch, talc, acid stearic Description Tablets are white or white with a slight yellow tint, flat-cylindrical with a score and a bevel. Pharmacotherapeutic group: Other analgesics-antipyretics. Pyrazolones. ATC code N02BB72 Pharmacological properties Pharmacokinetics After oral administration, metamizole sodium is rapidly hydrolyzed in gastric juice to form the active metabolite 4-methyl-amino-antipyrine, which, after absorption, is metabolized into 4-formyl-amino-antipyrine and other metabolites. Metabolites do not bind to plasma proteins. Most of the drug is excreted in the urine in the form of metabolites. Metabolites are also excreted in breast milk. Pharmacodynamics Analgin has analgesic and antipyretic effects. Dibazole and papaverine hydrochloride reduce the tone of the smooth muscles of the gastrointestinal tract and cause dilatation of peripheral vessels. Phenobarbital has a sedative effect. Andipal is a combined drug that has a vasodilator, analgesic, antispasmodic and sedative effect. Indications for use - pain associated with spasm of peripheral arteries - spasm of cerebral vessels. Method of administration and dosage: Orally, after meals, 1-2 tablets 2-3 times a day, depending on the clinical picture. The course of treatment is 7-10 days. Side effects - allergic reactions - drowsiness - decreased speed of psychomotor reactions - nausea, constipation - decreased blood pressure - leukopenia, agranulocytosis - impaired liver/kidney function - Lyell and Stephen-Johnson syndrome - hypothermia - hepatotoxicity Contraindications - hypersensitivity to the components of the drug - hepatic and/or renal failure - hematopoietic disorders - tachyarrhythmia, severe angina, decompensated CHF - closed-angle glaucoma - prostatic hyperplasia - intestinal obstruction, megacolon - glucose-6-phosphate dehydrogenase deficiency - pregnancy, breastfeeding - children and adolescents under 18 years of age Drug interactions Andipal enhances the hypotensive effect of nitrates, calcium antagonists, beta-blockers, ganglion blockers, diuretics (including furosemide, hypothiazide), myotropic antispasmodics. There is a mutual increase in the risk of side effects when used simultaneously with narcotic analgesics. Andipal may enhance the effect of drugs that have a depressant effect on the central nervous system, including ethanol and ethanol-containing drugs. Adsorbents, astringents, and enveloping drugs reduce the absorption of the drug in the gastrointestinal tract. Anaprilin, H2-histamine receptor blockers enhance the effects of Andipal. Andipal increases the hypoglycemic effect of oral antidiabetic drugs. The combination of the active components of the drug phenobarbital and analgin increases the risk of developing Lyell and Steven-Johnson syndrome. The combination of analgin with dibazole and papaverine, as a result of the synergism of their antipyretic effect and increased heat transfer, can lead to hypothermia. Special instructions During long-term administration of Andipal, peripheral blood patterns should be regularly monitored. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms During treatment, you should avoid engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions Overdose Symptoms - increased side effects Treatment - symptomatic Release form and packaging 10 tablets per contour cellless packaging made of polyethylene-coated paper. Contour cellless packages with instructions for medical use in the state and Russian languages are placed in group packaging. Storage conditions Store in a dry place, protected from light at a temperature of 15 ° C to 25 ° C. Keep out of the reach of children! Shelf life 2 years 6 months Do not use after the expiration date Conditions for dispensing from pharmacies Without a prescription, 623856, Russia, Sverdlovsk region, Irbit, st. Kirova, 172 Tel/fax (34355) 3-60-90 Owner of the registration certificate OJSC “Irbitsky Chemical-Pharmaceutical Plant”, Russia Address of the organization that accepts claims from consumers on the quality of products of OJSC “Irbitsky Chemical-Pharmaceutical Plant” on the territory of the Republic of Kazakhstan 623856, Russia, Sverdlovsk region, Irbit, st. Kirova, 172 Tel/fax (34355) 3-60-90 Email address

Side effects

According to the annotation: constipation , nausea , various allergic reactions ( conjunctivitis , urticaria, Quincke's edema ), nephritis , red urine , drowsiness , increased sweating .

With long-term use, agranulocytosis , leukopenia , and thrombocytopenia .

Before use, you should consult your doctor.

Andipal

The frequency of these side effects is indicated in accordance with the WHO classification: very often - more than 10%; often - more than 1% and less than 10%; infrequently - more than 0.1% and less than 1%; rarely - more than 0.01% and less than 0.1%; very rarely - less than 0.01%, including isolated cases: frequency unknown - based on available data, it was not possible to establish the frequency of occurrence.

For Andipal:

To date, no side effects have been reported with this combination. The incidence of the following possible side effects is unknown.

From the central nervous system

: drowsiness, decreased speed of psychomotor reactions.

From the digestive system

: nausea, constipation.

From the cardiovascular system

: arterial hypotension.

Allergic reactions

With long-term use

: leukopenia, agranulocytosis, impaired liver and kidney function.

For Metamizole sodium:

From the skin

: uncommon - persistent drug rash; rarely - rash (for example, maculopapular); very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis.

From the urinary system

: very rarely - acute renal dysfunction, which in very rare cases can lead to proteinuria, oligo- or anuria and acute renal failure, acute interstitial nephritis.

From the hematopoietic organs

: rarely - leukopenia; very rarely - agranulocytosis, including fatal cases, thrombocytopenia; frequency unknown - aplastic anemia, pancytopenia, including fatal cases.*

*These reactions can occur even if metamizole sodium has not previously caused complications. There are a number of signs of an increased risk of agranulocytosis if metamizole sodium is used for more than one week. This reaction is dose-independent and can occur at any time during treatment. It is manifested by high fever, chills, sore throat, pain when swallowing, inflammation of the mucous membranes of the mouth, nose, throat, genital and anal area. However, when antibiotics are used, these phenomena may be mild. There is a slight enlargement of the lymph nodes and spleen or no enlargement at all. The erythrocyte sedimentation rate increases significantly, the content of granulocytes is sharply reduced or they are not detected. As a rule, but not always, normal levels of hemoglobin, red blood cells and platelets are maintained. Treatment tactics involve immediate discontinuation of the drug, i.e. the drug should be discontinued immediately, without waiting for laboratory results, if there is an unexpected deterioration in the general condition, the fever does not subside, or new or painful ulcerations appear on the mucous membranes, especially in the mouth, nose or throat. If pancytopenia occurs, the drug should be discontinued immediately and a complete blood count should be monitored until its values return to normal.

From the cardiovascular system

: uncommon - isolated decrease in blood pressure (possibly pharmacologically caused and not accompanied by other manifestations of anaphylactic/anaphylactoid reactions). The decrease in blood pressure can be pronounced. During fever, a dose-dependent sharp decrease in blood pressure without other signs of a hypersensitivity reaction is also possible.

Allergic reactions

: rarely - anaphylactoid or anaphylactic reactions; ** very rarely - analgesic bronchial asthma. In patients with analgesic bronchial asthma, intolerance usually manifests itself as attacks of bronchial asthma; frequency unknown - anaphylactic shock. **

**These reactions are especially common with parenteral administration of metamizole sodium and can be severe and life-threatening, in some cases leading to death. These reactions can occur even if metamizole sodium has not previously caused complications. These reactions may occur during administration or immediately after ingestion, or develop several hours later. However, they predominantly occur within the first hour after application. In milder cases, they manifest as rashes on the skin and mucous membranes (eg, itching, burning, redness, blistering and swelling), shortness of breath and, less commonly, gastrointestinal disorders. In severe cases, these mild reactions can develop into generalized urticaria, severe angioedema (including of the larynx), severe bronchospasm, cardiac arrhythmia, arterial hypotension (in some cases preceded by an increase in blood pressure), shock. In this regard, at the first signs of skin reactions, the drug should be discontinued.

Others

: Not known - Red urine has been reported and may be due to the presence of low concentrations of rubazonic acid (a metabolite of metamizole sodium).

For Phenobarbital:

From the central nervous system

: frequency unknown - asthenia, dizziness, general weakness, ataxia, nystagmus, paradoxical reaction (especially in elderly and weakened patients - agitation), hallucinations, depression, nightmares, syncope.

From the digestive system

: frequency unknown - vomiting, liver dysfunction with long-term use.

From the hematopoietic organs

: frequency unknown - agranulocytosis, megaloblastic anemia, thrombocytopenia.

Allergic reactions

: frequency unknown - skin rash, urticaria, swelling of the eyelids, face and lips, difficulty breathing, rarely - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome).

Others

: frequency unknown - with long-term use drug dependence.

For Bendazole:

The listed effects appear when used in large doses. When the dose is reduced or the drug is discontinued, these side effects quickly disappear.

From the central nervous system

: frequency unknown - dizziness, headache.

From the skin:

frequency unknown - increased sweating.

From the digestive system

: frequency unknown - nausea.

For Papaverine hydrochloride:

From the central nervous system

: often - drowsiness.

From the skin

: often - skin rash (usually erythematous, urticaria), infrequently - itching, rarely - increased sweating.

From the digestive system

: often - nausea, constipation, infrequently - increased activity of liver transaminases.

From the cardiovascular system:

often - decreased blood pressure, infrequently - ventricular extrasystole.

From the hematopoietic organs

: very rarely - eosinophilia.

Instructions for use of Andipal (Method and dosage)

How to use the drug? Inside. Adults should take 1-2 tablets 2-3 times a day. The full course of treatment should take 7-10 days.

Before taking the medicine, consult your doctor. The course of treatment should be prescribed by a specialist, depending on the nature of the disease and its course. It is not recommended to take the drug for more than 10 days.

How to take if you have high blood pressure? Does Andipal increase or decrease blood pressure?

The drug has a hypotensive effect and is used for high blood pressure. Cannot be used for hypotension, this can lead to harmful changes in the brain.

At what pressure is the drug used?

Andipal can only be taken with high blood pressure. The drug does not treat hypotension and does not eliminate the causes of the pathology. The main effect of consuming the drug is a decrease in the intensity of symptoms accompanying high blood pressure. For this reason, Andipal is considered as an emergency drug.

The maximum level at which taking the medication is justified is 160 mmHg. At higher levels, it is not recommended to consume Andipal. This is due to the effect of bendazole in the tablets. The substance first increases blood pressure and then lowers it.

Interaction

The use of astringents, enveloping agents and activated carbon reduces absorption in the gastrointestinal tract.

When combined with other antispasmodics and sedatives, the hypotensive effect of the drug is enhanced. diabetes medications increases . Enhances the effect of glucocorticosteroids , Indomethacin and ethanol . Reduces the concentration of cyclosporine in the blood.

Inducers of microsomal liver enzymes ( barbiturate , phenylbutazone ), analeptics ( camphor , Cordiamin ), tonics ( Eleutherococcus , ginseng root) reduce the effectiveness of the drug.

special instructions

With long-term use of Andipal, the overall picture of peripheral blood should be monitored.

It is recommended to be careful and vigilant when working with mechanisms, due to the fact that the drug significantly affects the change in the reaction rate.

Does the medicine lower or increase blood pressure?

The medicine lowers blood pressure.

At what pressure should Andipal be taken?

With high blood pressure.

Andipal should be used as a medicine for blood pressure after consulting a doctor.

Analogues and substitutes

Level 4 ATC code matches:
Analdim

Reopirin

Tempalgin

Spazgan

Benalgin

Pentalgin ICN

Pentalgin N

Pentalgin

Analgin

Renalgan

Tetralgin

Spasmalin

Maxigan

Sedal-M

Piralgin

Baralgin M

Sedalgin Plus

Baralgetas

Revalgin

The drug has no analogues in terms of its main active ingredient.

Analogs for antispasmodic effect:

Nomigren
Papazol-UBF
Papazole
Urolesan
No-Shpalgin
Unispaz
Teodibaverin

Price for Andipal

Andipal tablets in Russia will cost about 40 rubles per pack of 20 pieces.

In Kyiv pharmacies the price of tablets will be about 20 UAH. for 10 pcs.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Andipal Renewal tab.
10pcs ZAO PFK Update 57 RUR order
Andipal Avexima tablets 10 pcs. Avexima Siberia LLC
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Andipal (tab. No. 10) FS.-Leksredstva
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Pharmacy24

Andipal forte No. 100 tablets PAT Monfarm, Ukraine
154 UAH.order
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PaniPharmacy

Andipal tablets Andipal B tablet. No. 10 Ukraine, Monfarm JSC
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Andipal-Forte tablets Andipal-Forte tablets. No. 100 Ukraine, Monfarm JSC
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Andipal-Forte tablets Andipal-Forte tablets. No. 10 Ukraine, Monfarm JSC
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Composition and release form

Andipal is available in the form of round tablets of white or yellowish color. There are distinctive marks on the surface of the tablets. At the pharmacy, the drug is sold in cardboard or paper packages containing 10 tablets of the drug.

1 pill contains the following active ingredients:

analgin – 0.25g;
dibazol – 0.02 g;
papaverine – 0.02 g;
Phenobarbital – 0.02 g.

Among the auxiliary components of the medication are:

potato starch – 47.7 mg;
talc – 9.25 mg;
stearic acid – 2.9 mg.