Pharmacodynamics and pharmacokinetics
Mebhydrolin contained in this drug is an antihistamine that blocks histamine H1 receptors. It significantly reduces the spasmogenic effect of histamine on the smooth muscles of the intestines and bronchi. It also affects vascular permeability . If we compare this drug with first-generation antihistamines, such as suprastin or diphenhydramine , then its sedative and hypnotic effects are much less pronounced. Diazolin also has anesthetic properties, but they are weak.
Absorption of the drug occurs very quickly, and after 15-30 minutes it begins to act. The maximum effect in patients is observed after 1-2 hours, while its duration is up to two days. It is excreted from the body through the kidneys.
Description:
Dragee is white or white with a yellowish tint, spherical in shape. On a cross section, the dragee is white or white with a slightly brownish or slightly greenish tint. The surface of the dragee must be flat, smooth, and uniform in color.
Pharmacotherapeutic group:
Antiallergic agent – H1-histamine receptor blocker.
ATX code:
[R06AX15]
Pharmacological properties
Pharmachologic effect:
H1-histamine receptor blocker. It has an antiallergic effect, reduces swelling of the mucous membranes. Weakens the effect of histamine on the smooth muscles of the bronchi, uterus and intestines, reduces the severity of the decrease in blood pressure and increase in vascular permeability. Penetrating slightly into the central nervous system, unlike first-generation antihistamines, it does not have a pronounced sedative and hypnotic effect. It has mild M-cholinergic and anesthetic properties. The therapeutic effect develops 15-30 minutes after administration, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 2 days.
Pharmacokinetics:
It is quickly absorbed from the gastrointestinal tract, can cause irritation of the gastric mucosa, and penetrates into all tissues of the body. Bioavailability ranges from 40-60%. The half-life from plasma is about 4 hours. The drug practically does not penetrate the blood-brain barrier. Metabolized in the liver by methylation, induces microsomal liver enzymes, and is excreted by the kidneys.
Indications for use of Diazolin
Medicine Diazolin, what does it help with? The drug is successfully used for the prevention and treatment of manifestations of both seasonal and allergic rhinitis. The drug is prescribed to patients with hay fever , urticaria, food and drug allergies. What other indications for the use of Diazolin? It is taken in the presence of noticeable skin reactions due to bites of various insects, as well as for dermatoses that are accompanied by itching.
Overdose
Cases of overdose are possible, manifested in the form of: confusion of thinking, drowsiness, problems with coordination, depression of the central nervous system (can even lead to coma). In children, a stimulating effect on the central nervous system is more often observed. An overdose also has the following symptoms: dry mouth, dilated pupils, vomiting, nausea, pain in the stomach.
If such reactions occur, you should immediately stop taking the medication, induce vomiting (you can take activated charcoal) and contact a specialist who will prescribe symptomatic treatment.
Contraindications
Patients who are highly sensitive to the components of diazolin should not take the drug. The drug is not prescribed to people with exacerbation of gastric and duodenal ulcers or any other inflammatory diseases of the gastrointestinal tract. A contraindication to the use of Diazolin is pyloric stenosis.
This drug should be prescribed with extreme caution if the patient has severe liver and kidney failure. In this case, you need to individually adjust the dose of the drug, as well as the number of doses. It is not recommended to prescribe Diazolin for epilepsy , angle-closure glaucoma, or for various heart rhythm disorders.
special instructions
After taking the medicine, you should stop driving vehicles and operating other mechanisms that require increased concentration.
You should not take the drug with alcohol, as the effect of the drug will be several times less.
The composition contains sucrose, which should be taken into account by people with hereditary fructose intolerance. Also use with caution in case of renal and liver failure.
Diazolin enhances the effect of sedative-hypnotics when used simultaneously, as well as other medications. Having a depressant effect on the central nervous system.
Shelf life – 3.5 years from the date of production. It should be stored in a dark and dry place, at a temperature not exceeding 25 degrees.
Side effects
According to the annotation, the following side effects may occur while taking the drug.
In the digestive system: possible irritation of the mucous membranes of the gastrointestinal tract, dyspeptic symptoms - nausea, heartburn , pain in the epigastric region.
In the work of the central nervous system: possible dizziness, paresthesia , high level of fatigue, increased drowsiness, slow reaction, blurred visual perception.
Also, when taking the drug, you may experience dry mouth, problematic urination, and allergic reactions. Granulocytopenia and agranulocytosis occur very rarely . The risk of side effects increases significantly with an overdose.
Paradoxical reactions are possible when children take the drug: they may experience irritability, insomnia, and tremor .
Adverse reactions
From the gastrointestinal tract: irritation of the mucous membrane, vomiting, nausea, heartburn.
From the nervous system: dizziness, weakness, drowsiness, slow perception of the environment.
Other adverse reactions may include tremors, a feeling of dry mouth, problems with urination, allergies to ingredients, and disturbed sleep.
The child may experience excessive excitability and insomnia.
Isolated cases have been recorded in which angioedema and headache occurred.
Instructions for use of Diazolin (Method and dosage)
Dragees and Diazolin tablets, instructions for use
The drug in tablets and dragees is used after meals.
How to take for adults? Children from twelve years of age, as well as adults, use the drug once or twice a day at a dose of 100-200 mg. The maximum single dose for adults should be 300 mg; adults can take 600 mg of Diazolin per day. Children five to twelve years old can take 50 mg two to three times daily. Children aged three to five years can take 50 mg of the drug 1-2 times a day. How long the treatment should last should be determined by a specialist in each specific case.
Instructions for use of Diazolin for children
Children's Diazolin is used as follows: 100 ml of warm boiled water is added to the bottle containing the granules. The contents must be mixed very thoroughly, for which you need to stir for several minutes. After this, the suspension is given to children in doses that can be easily determined using the supplied graduated glass. Dosages of children's Diazolin should be as follows: 2.5 ml - children 2-3 years old; 5 ml - children 4-6 years old; 7.5 ml – children 7-10 years old. The drug should be taken two or three times after meals for 5-7 days. The suspension must be shaken before use.
Analogues of Diazolin
Level 4 ATX code matches:
Dezal
Histaphene
Clarisens
Telfast
Erius
Claridol
Claritin
Loratadine
Fexofast
Peritol
Desloratadine
LauraHEXAL
Clarotadine
Rupafin
Ciel
Dramamine
Lordestin
Lomilan
Fenkarol
Kestin
There are no direct analogues. Unpatented synonyms: Dialin , Mebhydrolin , Omeril. Diprazin , Tavegil , Suprastin , Diphenhydramine are similar in action .
Diazolin price, where to buy
The price of Diazolin in tablets is 50 rubles for 10 pieces of 50 mg of active ingredient. The cost of the pills is 70 rubles for 10 pieces of 50 mg of mebhydrolin, and 80 rubles for 10 pieces of 100 mg.
How much do tablets cost in Kharkov? Around 5-10 UAH.
The price of children's Diazolin is about 95 rubles.
The ointment of this drug is not for sale.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
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