Trade name of the drug: Amiksin®
International nonproprietary name: Tiloron
Chemical name: 2,7-bis-[2(diethylamino)-ethoxy]-fluoren-9-one dihydrochloride
Dosage form of the drug: film-coated tablets
Description Composition per tablet Pharmacological properties Indications for use Contraindications Use during pregnancy and breastfeeding Method of administration and dosage Side effects Overdose Interaction with other drugs Effect on the ability to drive vehicles and machinery Release form Expiration date Storage conditions Dispensing conditions from pharmacies Name and address of the manufacturer/organization receiving consumer complaints
Composition per tablet
Tiloron - 60 mg or 125 mg.
Excipients: core: potato starch - 25,500 mg or 46,000 mg, microcrystalline cellulose - 60,000 mg or 120,000 mg, povidone-K30 (kollidon 30) - 1,500 mg or 3,000 mg, calcium stearate - 1,500 mg or 3,000 mg, croscarmellose sodium ( primellose ) – 1,500 mg or 3,000 mg; shell: hypromellose (hydroxypropyl methylcellulose) – 3.4050 mg or 6.8100 mg, titanium dioxide – 1.7815 mg or 3.5630 mg, macrogol-4000 (polyethylene glycol-4000) – 0.4565 mg or 0.9130 mg, polysorbate -80 (Tween-80) – 0.0570 mg or 0.1140 mg, quinoline yellow dye (E 104) – 0.1235 mg or 0.2470 mg, sunset yellow dye (E 110) – 0.1765 mg or 0.3530 mg.
Pharmacotherapeutic group: antiviral immunostimulating agent – inducer of interferon formation.
ATX code: J05AX
Composition and release form
Film-coated tablets - 1 tablet.
tilorone - 0.06 g excipients: basic magnesium carbonate; PVP; calcium stearate; Aerosil; Vaseline oil; sugar; talc; tropeolin O; titanium dioxide; gelatin; beeswax in polymer jars of 6 or 10 pcs.; in a cardboard pack 1 jar. Film-coated tablets - 1 tablet. tilorone - 0.125 g excipients: basic magnesium carbonate; PVP; calcium stearate; Aerosil; Vaseline oil; sugar; talc; tropeolin O; titanium dioxide; gelatin; beeswax in polymer jars of 6 or 10 pcs.; in a cardboard pack 1 jar.
Pharmacological properties
Pharmacodynamics. A low-molecular-weight synthetic interferon inducer that stimulates the formation of all types of interferons in the body (alpha, beta, gamma and lambda). The main producers of interferon in response to the administration of tilorone are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After taking the drug orally, the maximum production of interferon is determined in the sequence intestines - liver - blood after 4-24 hours. Amiksin® has an immunomodulatory and antiviral effect. In human leukocytes it induces the synthesis of interferon. It also stimulates bone marrow stem cells, depending on the dose, enhances antibody formation, reduces the degree of immunosuppression, and restores the ratio of T-suppressors and T-helpers. The drug is effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpes viruses. The mechanism of antiviral action is associated with inhibition of the translation of virus-specific proteins in infected cells, as a result of which viral reproduction is suppressed.
Pharmacokinetics. After oral administration, Amiksin® is rapidly absorbed from the gastrointestinal tract. Bioavailability – 60%. About 80% of the drug binds to plasma proteins. The drug is excreted almost unchanged through the intestines (70%) and through the kidneys (9%). Half-life (T1/2) – 48 hours. The drug does not undergo biotransformation and does not accumulate in the body.
special instructions
Amiksin can be purchased at a pharmacy without a doctor's prescription. Should be stored at temperatures up to 25 degrees away from children. Avoid exposure to light.
Shelf life – 36 months.
Many people are interested in the question of whether Amiksin is an antibiotic. The medicine does not belong to the group of antibiotics, but is an immunomodulatory drug.
Before taking the medicine, you should consider its compatibility with alcohol. The drug should not be taken in parallel with alcohol, since the latter reduces the effect of the active substances, which is why the desired result will not be achieved.
Does not affect the ability to drive vehicles and other dangerous machinery.
The drug can be used in parallel with antimicrobial agents and antibiotics.
Directions for use and doses
Amiksin® is taken orally after meals.
For children from 7 to 18 years: For uncomplicated forms of influenza and other acute respiratory viral infections - 60 mg 1 time per day on the 1st, 2nd and 4th day from the start of treatment. The course dose is 180 mg (3 tablets).
For adults (over 18 years old). For the treatment of influenza and other acute respiratory viral infections - 125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. The course dose of Amiksin® is 750 mg (6 tablets).
For the prevention of influenza and other acute respiratory viral infections - 125 mg once a week for 6 weeks. Per course - 750 mg (6 tablets).
For the treatment of herpes, cytomegalovirus infections - the first two days, 125 mg, then after 48 hours, 125 mg. Course dose – 1.25–2.5 g (10–20 tablets).
When treating influenza and other acute respiratory viral infections, if symptoms of the disease persist for more than 4 days, you should consult a doctor
Analogs
Good analogues of Amiksin are:
Lavomax is a drug that has antiviral and immunomodulatory effects. Prescribed for various forms of hepatitis, herpes, pulmonary tuberculosis, ARVI, influenza, chlamydia. Prescribed for complex therapy. Contraindicated in pregnant women, during lactation, and persons under 18 years of age.
Tiloram is a drug that has an antiviral effect. Taken for hepatitis A, B, C, influenza, ARVI. Contraindicated for pregnant women and children under 18 years of age.
Tiloron is an antiviral drug that has a stimulating effect on the human immune system. Effective in the treatment and prevention of influenza and acute respiratory viral diseases. Also helps with tuberculosis, hepatitis and multiple sclerosis. Do not take during pregnancy, breastfeeding or children under 7 years of age.
Indications for use of Amiksin
Amiksin is indicated for use in adult patients in the following cases:
- for the purpose of prevention, as well as therapy of acute respiratory viral infections and influenza ;
- for the treatment of viral hepatitis A , B and C ;
- for the treatment of cytomegalovirus infection ;
- for the purpose of treating herpes ;
- as a drug in the complex therapy of encephalomyelitis of allergic and viral origin;
- as a drug in the complex treatment of chlamydia , respiratory and urogenital;
- as a medicine for tuberculosis as part of complex treatment.
Indications for the use of Amiksin for children over 7 years of age are determined - the treatment of colds and flu.
Precautionary measures
If you follow the dosage and course duration recommendations specified in the description of the drug Amiksin®, the likelihood of side effects (short-term chills, nausea and other symptoms of dyspepsia) is low. Treatment with Amiksin® is contraindicated during pregnancy and lactation; it should not be given to children under 7 years of age or in case of hypersensitivity to tilorone or the auxiliary components of the drug.
1. Instructions for medical use of the drug Amiksin
Amiksin's analogs
Level 4 ATC code matches:
Vekluri
Remdeform
Areplivir
Coronavirus
Avifavir
Triazavirin
Arpeflu
Yodantipyrine
Flavoside
Amizon
Altabor
Lavomax
Hyporamine
Anaferon for children
Anaferon
Arbidol
Ferrovir
Tiloron
Kagocel
Isoprinosine
Analogs of Amiksin are the drugs Actaviron , Lavomax , Tilaxin , Tiloron , Tiloram . The optimal drug should be chosen by the treating specialist.
Pharmacokinetics and pharmacodynamics
After the tablets have been taken orally, maximum production of interferon occurs in the following sequence: initially in the intestines, then in the liver and in the blood after 4-24 hours.
It is absorbed quickly from the digestive system, its bioavailability level is approximately 60%. Communication with blood proteins is approximately 80%.
It does not accumulate in the body and does not undergo biotransformation.
The active substance is excreted from the body almost unchanged. Excretion passes through the intestines and kidneys. The half-life is 48 hours.
Amiksin price, where to buy
You can buy the drug at any pharmacy. The price of Amiksin tablets depends on the packaging. On average, purchase a package of 10 pcs. 60 mg tablets are available for 600 rubles, pack of 10 pcs. 125 mg - priced from 1000 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Amiksin tablets 125 mg 6 pcs. Pharmstandard-Tomskkhimpharm/Pharmstandard-Leksredstva OJSC RUR
595 order - Amiksin tablets 60 mg 10 pcs. Pharmstandard-Leksredstva OJSC
600 rub. order
- Amiksin tab. p/o captivity. 125 mg 10 pcs. (blister) Pharmstandard-Leksredstva OJSC
RUB 1,139 order
Pharmacy Dialogue
- Amiksin tablets 125 mg No. 10FS.-Leksredstva
RUB 1,043 order
- Amiksin tablets 60 mg No. 10FS.-Leksredstva
RUR 616 order
- Amiksin tablets 125 mg No. 6FS.-Leksredstva
RUR 604 order
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Pharmacy24
- Amiksin IC 0.125 g No. 6 tablets INTERCHEM Partnership with additional coverage, Ukraine
176 UAH order - Amiksin IC 0.125 g No. 3 tablets INTERCHEM Partnership with additional distribution, Ukraine
100 UAH order
- Amiksin IC 0.06 g No. 6 tablets INTERCHEM Partnership with additional coverage, Ukraine
94 UAH order
- Amiksin IC 0.06 g No. 10 tablets INTERCHEM Partnership with additional distribution, Ukraine
117 UAH. order
- Amiksin IC 0.125 g N10 tablets INTERCHEM Partnership with additional distribution, Ukraine
282 UAH order
Dosage of Amiksin
Amiksin is taken orally after meals, for prophylactic purposes - 125 mg once a week for 4-6 weeks, for therapeutic purposes - 125-250 mg/day for 1-2 days, then 125 mg every 48 hours. Course treatment: influenza and other acute respiratory viral infections in adults - 1 week; hepatitis A-2-3 weeks; hepatitis B-3-4 weeks; herpetic, CMV and chlamydial infections and their combinations - 4 weeks. Chronic viral hepatitis B and C, mixed hepatitis - 250 mg 2 times a week, course of treatment - 2-4 weeks. Secondary immunodeficiencies and interferon status disorders - 125 mg 2 times a week. The course of treatment is 2-4 weeks. Multiple sclerosis - 125 mg every 48 hours (10 tablets in total). Treatment of influenza and other acute respiratory viral infections in children over 7 years of age - 60 mg per day in the first 2 days, then 60 mg after 48 hours (3-4 tablets in total). For children over 7 years of age, Amiksin is prescribed in a dosage of 60 mg.
