Pharmacodynamics and pharmacokinetics
Reduces the flow of calcium into the cell, reduces the level of calcium in the plasmalemma depot, enhances the vasodilatory effect of carbon dioxide, reduces the tone of smooth muscle tissue of arterioles. Cinnarizine has a vasodilating effect and does not affect blood pressure.
The antihistamine activity of the drug is moderate, reduces the tone of the sympathetic nervous system, and moderately reduces the excitability of the vestibular apparatus.
Cinnarizine is effective in patients with a latent variant of cerebral circulatory insufficiency, with the initial form cerebral atherosclerosis a stroke . In persons with impaired peripheral circulation, it improves the nutrition of tissues, organs, myocardium, and increases post-ischemic dilation of the lumen of blood vessels. Cinnarizine reduces blood viscosity, moderately increases the ability of red blood cells to deform, and has a positive effect on the elasticity of their membranes.
Maximum absorption occurs within 1-3 hours. It is excreted in the form of metabolites in the urine by one third and in feces by two thirds. The half-life is 4-24 hours.
Pharmacological effects, pharmacodynamics and pharmacokinetics
According to the annotation, the drug has the following therapeutic effect:
- Cinnarizine dilates blood vessels without changing blood pressure levels.
- Improves blood supply to brain structures and peripheral organs.
- Shows moderate antihistamine activity.
- Somewhat suppresses the sensitivity of the vestibular apparatus (the organ responsible for coordination and balance).
- Helps reduce blood viscosity.
- Increases the elasticity of the cell membrane of red blood cells, facilitating their passage through small capillaries.
Absorption of the drug from the gastrointestinal tract into the systemic bloodstream and the onset of its action occurs within 1 to 3 hours, depending on the characteristics of metabolism. Most of the drug is excreted during the day with feces, about 25-30% leaves the body during urination.
Indications for use of Cinnarizine
What are the pills for? The drug is prescribed after an ischemic stroke , after suffering a brain injury, discirculatory encephalopathy , Minière's disease , vestibular disorders, for the prevention of kinetosis .
What other indications for the use of Cinnarizine exist? The medicine is effective for Raynaud's disease , thromboangiitis obliterans , senile dementia, migraine , sea and air sickness, atherosclerosis obliterans , thrombophlebitis , angiopathy , paresthesia , trophic disorders.
What does Cinnarizine help with?
The drug is prescribed for prophylactic and therapeutic purposes for a number of diseases and pathological conditions:
- The recovery period after an ischemic stroke.
- Disculatory encephalopathy.
- Raynaud's syndrome (vasospastic pathology).
- Minière's disease.
- Kinetoses of various origins.
- Condition after suffering traumatic injuries to the head and central nervous system.
- Obliterating atherosclerosis of cerebral vessels.
- Thromboangiitis and thrombophlebitis.
- Sea and mountain sickness.
Any condition accompanied by impaired blood circulation and nutrition of organs can cause the preventive or therapeutic use of Cinnarizine.
Side effects
Nervous system: increased fatigue, drowsiness, extrapyramidal disorders , depression , hyperkinesia , limb tremors, headaches.
Side effects from the digestive system: cholestatic jaundice , dyspeptic disorders, transient epigastric pain, dry mouth.
Rarely increased sweating , allergies , drop in blood pressure, lichen planus , and obesity .
Contraindications, side effects and overdose
The drug has a minimal number of contraindications for use, but they still exist. Cinnarizine is strictly prohibited during pregnancy and breastfeeding. It should also not be prescribed to children under 12 years of age.
A relative contraindication is Parkinson's disease. In this case, Cinnarizine can be used, but under the strict supervision of the attending physician.
Undesirable side reactions develop extremely rarely. Most often they are associated with individual intolerance to the main or auxiliary components of the drug. Some patients may experience weakness, fatigue, headaches, increased drowsiness, nausea, vomiting, stool disorders and dry mouth. It is extremely rare that taking Cinnarizine leads to hypotension and the development of depressive states.
The symptoms of overdose are similar to the manifestations of adverse reactions. If this condition develops, it is recommended to discontinue the drug, thoroughly rinse the stomach with clean water and take adsorbents (activated carbon or filtrum). There is currently no specific antidote.
Cinnarizine tablets, instructions for use (Method and dosage)
The drug is taken orally. There is no injection medicine.
If the blood supply to the brain is impaired: 25-50 milligrams three times a day.
If peripheral blood supply is impaired: 50-75 mg three times a day.
Prevention of sea and airborne illness: 30 minutes before the event, take 25 milligrams.
Labyrinthine disorders: 25 milligrams three times a day.
For children over 12 years of age, the dosage is halved. Age less than 12 years is a contraindication to using the drug.
The effect is achieved with continuous treatment.
Do not take more than 225 mg of medication per day.
Cinnarizine: instructions for use
The drug tablets are taken orally with a sufficient amount of water. The daily dosage and frequency depend on the type of underlying pathology:
- For ischemic stroke, it is recommended to take 1-2 tablets 3 times a day.
- For disorders of nutrition and blood supply to the peripheral parts - 2-3 tablets three times a day.
- For disorders of the vestibular apparatus - 1 tablet with the same dosage.
- To prevent various pathologies described in the “Indications” section, Cinnarizine is taken 1 tablet every 24 hours.
The maximum daily dose is 200-225 mg of the drug for adults and 100-125 mg for children aged 12 to 18 years.
To achieve a lasting therapeutic effect, continuous and long-term use of the drug is necessary. The duration of treatment is determined by a specialist.
special instructions
Cinnarizine may cause false positive doping tests in athletes. This effect is explained by the antihistamine effect of the drug. Long-term use requires monitoring the functioning of the liver, kidneys, and blood condition. It is acceptable to take the drug while breastfeeding. Affects transport management.
A combination of Cinnarizine and Piracetam for chronic cerebrovascular insufficiency. The interaction of these substances is described in detail on Wikipedia.
Cinnarizine analogs
Level 4 ATX code matches: Betagis
Stugeron
Betaserk
Betaver
Westinorm
Westicap
Betagistine
Tagista
Vestibo
An analogue of the drug is Stugeron .
Cinnarizine price, where to buy
The price of Cinnarizine tablets is about 60 rubles for 50 pieces.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Cinnarizine tab.
0.025 mg 50 pcs PAO Biosynthesis 45 rub. order - Cinnarizine Avexima tablets 25 mg 50 pcs. LLC Avexima Siberia
66 RUR order
- Cinnarizine tablets 25 mg 50 pcs. Pharma AD
53 RUR order
- Cinnarizine tablets 25 mg 56 pcs. AO Update PFC
96 RUR order
- Cinnarizine tablets 25 mg 50 pcs. OzonOzon LLC
68 RUR order
Pharmacy Dialogue
- Cinnarizine (tab. No. 50)Sopharma
70 rub. order
- Cinnarizine tablets No. 50Balkanpharma
78 RUR order
- Cinnarizine (tab. No. 50)Pharma AD
62 RUR order
- Cinnarizine (tab. No. 56)Update of PFC CJSC
93 RUR order
- Cinnarizine (tab. No. 50)Pharma AD
63 RUR order
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Pharmacy24
- Cinnarizine 25 mg N50 tablets AT "Lekhim-Kharkiv", Ukraine
13 UAH.order - Cinnarizine-KMP forte 75 mg N20 tablets PAT "Kievmedpreparat", Ukraine
33 UAH order
- Cinnarizine Sopharma 25 mg N50 tablets PAT "Vitamin" Ukraine
19 UAH order
PaniPharmacy
- Cinnarizine tablets Cinnarizine tablets. 25mg No. 50 Ukraine, Lekhim-Kharkov CJSC
12 UAH order
- Cinnarizine forte tablets Cinnarizine forte tablets. 75 mg No. 20 Ukraine, Kievmedpreparat OJSC
39 UAH order
- Cinnarizine tablets Cinnarizine tablets. 25 mg No. 50 Bulgaria, Sopharma
23 UAH order
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