Resorcinol

RESORCIN: instructions for use of solution and paste, price and analogues

Dermatologist of the highest category Petr Viktorovich
29650

Update date: April 2019

The drug Resorcinol belongs to the group of antiseptic medications. It has an antimicrobial and antiseborrheic effect. The medicine is actively used in the treatment of dermatological diseases in order to disinfect the skin and improve its general condition.

Composition and release form

Resorcinol is available in several forms

A drug with antiseptic properties is available in several forms. Under this name, powder for dilution, solution and ointment are presented in pharmacies. There is also a preparation in the form of a paste, which is also used in medical practice. The resorcinol-formalin therapy method involves the use of this composition.

Resorcinol, produced in powder form, has a crystalline form. It is characterized by a pronounced odor. This product can be easily dissolved in ethanol, water or oil.

The solution has a concentration of 1-5%. It is prepared on a water or alcohol basis. It goes on sale in 25 ml bottles made of dark glass.

The ointment contains from 5% to 20% of the active substance. It is packaged in tubes of 15 g.

The main active ingredient of Resorcinol is meta-dioxybenzene. If you study the composition of the drug in detail, you can find in it a number of auxiliary components that support its dosage form.

Pharmacological properties

All basic requirements for the medicinal use of the drug Resorcinol are contained in its instructions. It also describes the pharmacological properties that this medication has.

The drug has a pronounced healing and epithelializing effect. Thanks to its use, the restoration of affected tissues is stimulated. The product also copes with the activity of the inflammatory process in problem areas. Resorcinol is characterized by astringent and antiseptic properties.

The medication is actively used not only in medicine, but also in cosmetology, since it is able to exfoliate problem areas of the skin and cauterize them. Cosmetologists use it as a powerful scrub that promotes deep cleansing of contaminated pores.

It is recommended to use the medicinal composition as a disinfectant in minimal dosages. The concentration of the active substance should not exceed 0.25-1.5%. This condition is brought forward by the resorcinol-formalin method of therapy.

Indications for use

Acne and neurodermatitis are indications for the use of Resorcinol

A patient who plans to use Resorcinol should be primarily interested in the instructions for the drug. It indicates the main indications for which treatment with this composition is appropriate and effective. Doctors and cosmetologists prescribe the use of the drug in various forms to eliminate the following pathological conditions:

1. Seborrheic dermatitis.
2. Skin itching.
3. Acne.
4. Neurodermatitis.
5. Eczema.
6. Skin fungus.
7. Alopecia.

The resorcinol-formalin treatment method should be prescribed by a competent specialist. Using it for other purposes may result in serious skin damage.

Contraindications and restrictions

For burns, the drug Resorcinol is not used

Antiseptic belongs to the group of safe medicines. Therefore, its use is permitted for most patients who have such a need. Resorcinol manages to suppress the activity of pathogenic microflora in a short time.

However, such therapy will only be harmful to a person who cannot use the resorcinol-formalin method due to the following contraindications:

• burns, regardless of the nature of their occurrence;
• deep damage to the epidermis;
• individual intolerance to the active substance;
• renal or liver failure;
• childhood;
• carrying out hormonal therapy.

It is highly not recommended to use the drug for patients who have overly sensitive skin. She may react negatively to interaction with Resorcinol, which will only complicate the course of the disease.

Use during pregnancy and lactation

If you are breastfeeding, you should avoid using Resorcinol.

According to most experts, women should not use antiseptics during pregnancy or breastfeeding. This is due to the fact that the drug has toxic properties.

Its active substance in a certain amount can penetrate the human body and biological fluids.

As a result, the likelihood of negative effects of the medication on the fetus or newborn child increases.

Side effects

Headache and dizziness indicate side effects

Resorcinol is highly toxic. For this reason, its use may lead to side effects. This phenomenon is due to the large amount of phenol contained in the drug. The patient should be informed about this by his attending physician; he is obliged to warn the patient about the possible development of negative reactions.

External use of the drug can lead to the following adverse reactions:

• burns;
• spasms;
• convulsions;
• headache;
• dizziness.

The development of allergic reactions and loss of consciousness as a result of poisoning with the active substance Resorcinol cannot be ruled out.

Drug interactions

An antiseptic in powder form cannot be used simultaneously with products such as phenol, menthol and salicylic acid. This combination leads to the formation of eutectic (low-melting) compounds and liquefaction of the listed substances.

Drugs that give an alkaline reaction should not be used simultaneously with Resorcinol. An antiseptic is capable of oxidizing them. It is highly not recommended to add even minimal doses of the composition to ready-made ointments.

Instructions for use

Resorcinol ointment should be used as prescribed by a doctor.

Resorcinol must be used as indicated in the instructions for use. Only if this condition is met can successful completion of the course of treatment be guaranteed, as well as the absence of side effects.

Solution

Resorcinol solution must be applied externally to the affected areas. It is best to do this with a clean cotton swab. The dosage regimen of the drug is selected for each patient separately.

If a patient is diagnosed with red acne, he is prescribed skin treatment with a 1% alcohol-based solution. 1-2% product is suitable for the treatment of oily seborrhea, dermatitis and eczema.

Ointment

10-15% ointment is recommended to be applied in a thin layer to areas that are covered with acne and need exfoliation. If a person is sick with seborrheic eczema, then he should combine the drug with sulfur.

Powder

Local skin lesions with genital warts can be conveniently treated with Resorcinol powder. It does not contain unnecessary impurities and acts directly on the problem area of ​​the body.

Paste

The resorcinol-formalin treatment method involves the use of the drug in the form of a paste. For a long time, dentists used it when filling teeth, if the procedure involved incomplete extirpation of the pulp. The paste was used often, since this method of therapy was low cost.

At the moment, dentists are trying not to use paste, replacing it with better and safer products.

Overdose

An overdose of the drug may manifest itself as general weakness

The patient may experience an overdose of Resorcinol if he uses it in large doses. This condition is accompanied by severe weakness, difficulty breathing, tachycardia, headaches and fainting. In case of overdose, seek medical help immediately.

Price and analogues

Fukortsin solution is one of the analogues of Resorcinol

The medicine can be found on sale in any pharmacy, as it is quite common and cheap. You can purchase a bottle of Resorcinol solution for about 80-100 rubles. The ointment costs patients a little more. Its cost is in the range of 270-400 rubles.

If the patient is not satisfied with treatment with Resorcinol, he can use its analogues in the fight against the disease. The drug has a huge number of them. Fukortsin and Fukaseptol are replacing the medication in the form of a solution. Analogues of the ointment are Azulene, Viosept and Hexadreps.

All questions regarding the replacement of a drug with its analogue must be discussed with your doctor.

Pharmacological properties of Resorcinol

The use of Resorcinol as a disinfectant must be carried out in low concentrations - 0.25-1.5%. The drug solution has an epithelializing and healing effect, and also stimulates tissue regeneration and eliminates the inflammatory process. The solution also acts as an astringent and antiseptic on areas of inflammation.

In cosmetology, Resorcinol is used as a product with exfoliating and cauterizing properties, acting as a scrub for deep cleansing of the skin.

According to pharmacology, Resorcinol is incompatible with hydrogen peroxide, camphor, menthol and alkaline substances.

Resorcinol

Resorcinol is a pharmacological drug from the group of antiseptic drugs that has a pronounced antifungal effect. International name: Resorcinol. It also has antiseborrheic and dermatoprotective effects on the human body.

Resorcinol is used primarily for disinfection in the treatment of dermatological diseases.

With its properties and pungent odor, Resorcinol is similar to phenol. This drug should not be used on the mucous membranes of the body.

Contraindications

Resorcinol has some contraindications for its use. These include:

• individual intolerance or hypersensitivity to any of the components that make up this drug;
• thermal and chemical burns;
• deep skin lesions;
• pregnancy period;
• breastfeeding period;
• children and adolescents up to eighteen years of age.

Caution is necessary when prescribing this drug to patients who have sensitive skin or are in adolescence with increased hormonal development.

Storage conditions and periods

This drug must be stored in a place protected from light, moisture and children. The shelf life of Resorcinol powder or ointment is three years from the date of release of the medicine indicated on the package. The optimal temperature for storing ointment is from ten to eighteen degrees Celsius, for powder – up to thirty degrees Celsius.

After the expiration date, the drug cannot be used in any form.

external links

• International Chemical Safety Card 1033
• NIOSH Pocket Guide to Chemical Hazards
• IARC monograph: “Resorcinol”
• Blue Book
  online version )

This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Resorcinol". Encyclopedia Britannica

.
23
(11th ed.). Cambridge University Press. pp. 183–184.

Buy resorcinol in any quantity

An organic chemical compound with a specific odor. Identical composition with pyrocatechol and hydroquinone, the difference is in the relative placement of hydroxyl groups.

Easily dissolves in aqueous and alcoholic solutions, diethyl ether, acetone, water, poorly soluble in organic solvents (cs2 benzene in 100 g 2.2 g at 20 degrees), when reacting with picric acid it gives picrate, mp. 89-90 °C.

Resorcinol is used:

• In the chemical industry it is used in the synthesis of dyes and some polymers (resoraldehyde resins), in the production of plasticizers and as an ultraviolet absorber in polymers
• In petrochemistry - as a biocide in inhibitory compositions
• In medicine - as an antiseptic for the treatment of skin diseases
• In analytics as a reagent for the colorimetric determination of various elements

Safety:

Dust and resorcinol vapors irritate the skin and mucous membranes of the eyes and respiratory tract, cause coughing, and irritate the mucous membranes upon contact. Caution is also required when using multicomponent formulations if resorcinol is indicated as an active ingredient.

Storage and transportation:

Resiorcin should be stored exclusively in tightly sealed manufacturer's containers out of reach of direct sunlight and away from heat sources. Transportation is carried out by all types of transport.

Buy resorcinol

The Interauto lubricant company offers to buy resorcinol at the best price with shipment to any city in Russia and the CIS. To receive a commercial offer with prices for resorcinol, simply send a request to our mail.

To place an order or consultation, you can email or call +7 (3412) 56-92-49

In pharmacology, resorcinol is used to create alcohol solutions and formaldehyde ointments for the treatment of skin diseases. Good antiseptic properties are the reason for the use of Resorcinol in medicine, including as an independent remedy, but much more often it is used as a component of other drugs.

For example, resorcinol is included in ointments for cleansing the skin, liquids for the treatment of mycoses, in rectal suppositories; its use is known in antibacterial lotions and shampoos to combat dandruff. The industrial method of production is the sulfonation of benzene.

When used as a bactericide in the manufacture of aqueous coloring solutions, synthetic coolants are used in the fur industry, metalworking and others.

Synonym: Resorcinol, meta-dihydroxybenzene

International name: RESORCINOL

Resorcinol is a simple diatomic phenol, also found under the name resorcinol or 1,3-dihydroxybenzene and is a transparent crystals or white powder with a sharp, specific, characteristic odor. Depending on the batch and manufacturer, it may have a pink or yellowish tint.

If stored incorrectly, the powder becomes dark in color - i.e. oxidizes, with the modification above it is applicable in coloring solutions.

Resorcinol has a wide range of applications, it is easily soluble in oils (14.1 g at 60 degrees), therefore in industry and petrochemistry it can be used as an antiseptic that protects petroleum products from biological damage by fungi or bacteria.

When added to lubricating or washing liquids, it should be taken into account that suspensions of resorcinol in the air can cause irritation of the skin and mucous membranes, irritation of the respiratory tract, and for example, derivatives are not safe, for example, resorcinol dimethyl ether is more toxic than resorcinol.

Store the product in a hermetically sealed container from the manufacturer away from exposure to light and direct sunlight; it should be noted that resorcinol is a fire hazard.

Properties of resorcinol

• Widely in demand in the chemical industry as a component in the synthesis of artificial dyes, polymers, and plastics.
• In the fur industry, as a component of coloring compositions for fur processing.

Quality guarantees

All batches are accompanied by the necessary certificates, the quality meets the requirements of GOST.

The products have a declaration of conformity and State Registration Certificate.

Resorcinol-resorcinol is a chemical substance of the phenol class, formula - C6H4(OH)2, meta-dihydroxybenzene. Colorless crystals, up to 70.8°C exist in the a-modification, higher in the p-modification, soluble in ethanol, diethyl ether, acetone, water, sparingly soluble in CHCl3 cs2 benzene in 100 g 2.2 g at 20 c 14.1 g at 60 c .

• In the chemical industry it is used in the synthesis of dyes and some polymers (resoraldehyde resins), in the production of plasticizers and as an ultraviolet absorber in polymers
• In petrochemistry - as a biocide in inhibitory compounds and for the synthesis of resorcinol-formaldehyde resins
• In medicine - as an antiseptic for the treatment of skin diseases
• In analytics as a reagent for the colorimetric determination of various elements
• reagent for colorimetry in laboratory research;
• component for the production of polymers, aldehyde resins, dyes, rubber and explosives;
• a medical antiseptic drug, included in medications used in the treatment of dermatological diseases, resorcinol should not be used in conjunction with salicylic acid

Production of resorcinol

After 1945, large-scale production of resorcinol was organized for the first time in the Soviet Union on the basis of one of the then operating factories for aniline dyeing of sheepskin. Sulfonation was carried out in one stage according to the Shestov method with a solution of sulfuric acid at a concentration of 65% in the presence of Na2SO4.

The production process is quite difficult both from the technological and hardware side.

Thus, during the production process, up to sixteen tons of waste are generated per ton of the finished product; during the sulfonation reaction of benzene, there is a severe impact on the technological equipment - the working part of the mixer must be replaced once every two years, stainless pipes - once every three years.

During the reaction, the consistency of the reagent changes several times; when the components are loaded in powder form and melted at a temperature above two hundred degrees, a stretchy, consistent mass is formed, which, with further heating, gains viscosity to an almost dough-like state, and so on several times. All this places special demands on the hardware of the technological process for producing resorcinol and its reliability. Reagent removal is carried out in ethanol, diethyl ether, acetone, benzene, and carbon disulfide. Has a specific smell. The mutual influence of two OH groups ensures that resorcinol easily enters into electrophilic substitution reactions, for example, it easily enters into azo coupling reactions, for example, with diazotized sulfanilic acid it gives resorcinol yellow dye. Derivatives are used as stabilizers and plasticizers of polymers in the production of resorcinol-aldehyde resins.

Related compounds

Resazurin, C12HAS7No4, obtained by the action of nitrous acid on resorcinol,[17] forms small dark red crystals with a greenish metallic tint. When dissolved in concentrated sulfuric acid and heated to 210 ° C, the solution, when poured into water, gives a precipitate of resorufin, C.12H7Net3, oxyphenoxazone, which is insoluble in water, but readily dissolves in hot concentrated hydrochloric acid and in solutions of caustic alkalis. Alkaline solutions have a pink-red color and cinnabar-red fluorescence. Tetrabromoresorufin is used as a dye called fluorescent resorcinol blue.

Thioresorcinol is obtained by the action of zinc and hydrochloric acid on benzene metadisulfonic acid chloride. It melts at 27 °C and boils at 243 °C. Resorcinol disulfonic acid, (HO)2C6HAS2(HSO3)2, is a deliquescent mass produced by the action of sulfuric acid on resorcinol.[18] It dissolves well in water and ethanol.

Resorcinol is also a common scaffolding that is in the class of anticancer agents, several of which (luminespib, ganetespib, KW-2478 and onalespib) were in clinical trials as of 2014.[19][20] Part of the resorcinol structure binds to and inhibits the N-terminal domain of heat shock protein 90, which is a drug target for anticancer treatment.[19]

RESORCIN: instructions for use, price, composition and analogues

Dermatologist of the highest category Inna Vladimirovna

34049

Update date: April 2019

Resorcinol is an antiseptic that has a powerful antimicrobial effect and has antiseborrheic and dermatoprotective properties. Most often used for disinfection in the treatment of skin diseases.

Side effects

Just like phenol, resorcinol formaldehyde, if used incorrectly, can cause a number of undesirable reactions from the body. The most common effects that occur are:

• nausea;
• vomit;
• severe headaches;
• dizziness;
• increased sweating;
• cyanosis;
• increased heart rate;
• spasms and cramps;
• loss of consciousness.

In rare cases, after taking Resorcinol formaldehyde, allergic reactions such as dermatitis, itching and redness of the skin, urticaria, bronchospasm and angioedema may develop.

Drug interactions

Before you start taking Resorcinol, you should carefully read the instructions for drug interactions with other drugs.

Formalin resorcinol is absolutely incompatible with the following drugs:

• Antipyrine.
• Camphor.
• Salicylic acid.
• Menthol.
• Phenyl salicylate phenol.

If we are talking about an alcohol solution or a powder form of the product, then it is incompatible with substances that have an alkaline reaction. In the form of an ointment, the product cannot be used together with yellow mercuric oxide, since the latter completely loses its effectiveness.

Analogs and cost of Resorcinol

There are several drugs that have a similar effect to Resorcinol. The most popular of them is Resorcinol. This remedy has the same active ingredient and has a similar effect.

The average price of Resorcinol in powder form is 200 rubles per package.

Reviews

Reviews about Resorcinol are mostly positive. Here are some of them.

Olga, Saratov

“I used Resorcinol in the treatment of acne vulgaris. The doctor prescribed me a 15% ointment, which I applied to the affected area twice a day. As a result, the acne began to dry out slowly and then disappeared completely. A year passed and I completely forgot about my acne problems.”

Valery, Nizhny Novgorod

“A 14-year-old child was prescribed formalin resorcinol for eczema. They applied it several times a day - it didn’t help. In the end, the doctor suggested choosing a different medicine.”

Igor, St. Petersburg

“Used Resorcinol in powder form as powders. As a result, irritation developed and the treatment had to be canceled. I do not recommend this drug to anyone.”

Maxim, St. Petersburg

“Great product! The doctor prescribed me resorcinol alcohol to cauterize papillomas. Since there were only two, he said that a local remedy would be most effective. And I turned out to be right - I eventually got rid of papillomas once and for all!”

References

1. ^ a b
   "Front matter."
   Organic Chemistry Nomenclature: IUPAC Recommendations and Preferred Names 2013 (Blue Book)
   . Cambridge: Royal Society of Chemistry. 2014. p. 691. Doi:10.1039 / 9781849733069-FP001. ISBN 978-0-85404-182-4.
2. ^ a b c d f g h Chemical
   Hazards. "#0543". National Institute of Occupational Safety and Health (NIOSH).
3. Gawron, O.; Duggan, M.; Greleci, K. (1952). "Manometric determination of dissociation constants of phenols." Analytical chemistry
   .
   24
   (6):969–970. doi:10.1021/ac60066a013.
4. Lander, John J.; Swirbely, John J. Lander, W. J. (1945). "Dipole moments of catechol, resorcinol and hydroquinone". Journal of the American Chemical Society
   .
   67
   (2):322–324. Doi:10.1021/ja01218a051.
5. ^ a b c
   K. V. Schmiedel, D. Dekker (2012).
   "Resorcinol". Ullman Encyclopedia of Industrial Chemistry
   . Weinheim: Wiley-VCH. Doi:10.1002 / 14356007.a23_111.pub2.CS1 maint: uses the authors parameter (link to site)
6. Wood Adhesives, Pizzi and Mittal, 2010
7. Meyer, J (1897). “Notiz über die Umwandlung von Aminen in Phenole.” Berichte der Deutschen Chemischen Gesellschaft
   .
   30
   (3):2568–2569. Doi:10.1002/cber.18970300334.
8. Nencki, M.; Sieber, N. (1881). “Über die Verbindungen der ein- und zweibasischen Fettsäuren mit Phenolen.” Journal für Praktische Chemie
   .
   23
   (1): 147–156. Doi:10.1002/prac.18810230111.
9. A. Seewitz, Bull. Soc. Chins., 1890, 3, p. 811
10. Traub, M. S.; Hawk, C. (1884). "Ueber ein Lakmoid". Berichte der Chemischen Gesellschaft
    .
    17
    (2):2615–2617. Doi:10.1002/cber.188401702192.
11. J. T. Hewitt and F. G. Pope, Jour. S/thorn. Soc., 1897, 75, p. 1084
12. Michael, Arthur (1888). "Ueber das Verhalten von Natriummalonäther gegen Resorcinol." Journal für Praktische Chemie
    .
    37
    (1):469–471. Doi:10.1002/prac.18880370144.
13. Boer, J; Jamek, G. B. (2010). "Resorcinol peels as a possible self-treatment of painful nodules in hidradenitis suppurativa." Clinical and Experimental Dermatology
    .
    35
    (1): 36–40. Doi:10.1111/j.1365-2230.2009.03377.x. PMID 19549239. S2CID 1794323.
14. Euresol, PubChem
15. Vipperman, J; Bragg, D. A.; Litzner, B. (November 1, 2021). "Hidradenitis Suppurativa: Rapid Evidence Review". American family physician
    .
    100
    (9):562–569. PMID 31674740.
16. "Military Explosives," Department of the Army Technical Manual, TM-9-1300-214 (Washington, DC: Department of the Army, September 1984), pp. 7-12.
17. Veselsky, P (1871). "Neue Derivate des Resorcins" [New resorcinol derivatives]. Berichte der Deutschen Chemischen Gesellschaft
    .
    4
    : 32–33. Doi:10.1002/cber.18710040114.
18. Piccard, J.; Humbert, A. (1876). "Ueber eine Resorcindisulfosäure" [On the disulfonic acid of resorcinol]. Berichte der Deutschen Chemischen Gesellschaft
    .
    9
    (2):1479–1483. Doi:10.1002/cber.187600902133.
19. ^ a b
    Sidera, K.;
    Patsavudi, E. (January 2014). "HSP90 inhibitors: current developments and potential in cancer therapy." Latest Patents for Anti-Cancer Drug Discovery
    .
    9
    (1): 1–20. Doi:10.2174/15748928113089990031. PMID 23312026.
20. Biamonte, M. A.; Van de Water, R.; Arndt, J. W.; Scannevin, R.H.; Perret, D.; Lee, W.-C. (January 2010). "Heat shock protein 90: inhibitors in clinical trials". Journal of Medicinal Chemistry
    .
    53
    (1): 3–17. Doi:10.1021/jm9004708. PMID 20055425.
21. Raj B. Durairaj. Resorcinol: chemistry, technology and application.
    Springer Science & Business Media, 2005 ISBN 9783540280903
22. McConnell, Virginia F. (1953). “Hlasivec and Bart are pioneers in the structural aspects of plant foods.” Journal of Chemical Education
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    30
    (8): 380. Bibcode:1953JChEd..30..380M. Doi:10.1021/ed030p380.
23. Panico, R.; & Powell, W. H. (eds.) (1994). 1992 IUPAC Manual of Nomenclature for Organic Compounds
    . Oxford: Blackwell Science. ISBN 978-0-632-03488-8 .CS1 maint: multiple names: list of authors (link to website) CS1 maint: additional text: list of authors (link to website)
24. H. Hlasivec and L. Barth (1864) “Ueber einen neuen, dem Orcin homologen Körper” (On a new substance homologous to Orcin), Annalen der Chemie
    ,
    130
    (3): 354-359.
    Resorcinol is named on page 358: "Wir nennen den neuen Körper, da wir gefunden haben, dass er auch aus dem Ammoniakgummiharz erhalten werden kann,
    Resorcinol
    , um an seine Entstehung aus Harzen und seine Beziehung zum Orcin zu erinnern."
    (We call the new substance because we discovered that it can be obtained from ammoniated gum
    resorcinol
    , to recall its creation from the resin and its relationship with orcinol [i.e. orcinol].)

Does resorcinol help with fungus - instructions for use

The skin of every person is exposed to the negative effects of external and internal factors, the consequences of which “Resorcinol” (international name “Resorcinol”) helps to remove.

A substance from the group of antiseptics that has antimicrobial, antiseborrheic, and also dermatoprotective effects .

It has a pungent odor and, like phenolic acid, has a negative effect on mucous membranes, so the substance should not be allowed to come into contact with their surface.

The Latin name of the drug is resorcinol, as stated in Wikipedia.

Compound

The medicine contains the following components:

1. Resorcinol (active ingredient).
2. Benzene.
3. Formalin ointment.
4. Dioxybenzene.
5. Antibiotic.

Generics can be used instead of the original drug, but the original substance is much more effective. Therefore, it is necessary to check the authenticity of the product before using it.

Release form

"Resorcinol" is produced in the form of a solution, powder and ointment. All these products are intended for external use.

pharmachologic effect

The use of this medication is carried out with the aim of providing a healing and epithelializing effect, as well as improving the restoration of the epidermis.

It is used as an antiseptic and astringent for the active regeneration of skin areas affected by dermatological pathologies.

Pharmacodynamics and pharmacokinetics

"Resorcinol" is a phenol derivative. “Resorcinol” forms compounds with polysaccharides in the walls of microorganisms, destroying their properties.

In a small dosage, it provides an epithelializing effect , eliminates foci of inflammation and activates tissue regeneration.

And increased doses have a cauterizing and keratolytic effect.

The pharmacokinetics of the drug has not been studied.

within the framework of the “Health of the Nation” program

Resorcinol, benzoyl peroxide, glycolic acid, sulfur - the use of topical drugs in the treatment of acne

Directions for use and dosage

To cure a disease caused by an infection, resorcinol alcohol or ointment must strictly follow the instructions:

• for acne, the drug with the addition of a few drops of “Resorcinol” is applied before bedtime;
• obtaining the desired result is only possible when treating thoroughly cleansed skin ;
• if the concentrated substance gets on the mucous membranes or in the eyes, they are washed with plenty of running water;
• The healing properties of the ointment are better manifested if you add it to a solution of water and ethyl alcohol.

Interaction

In cosmetology and medicine, “Resorcinol” is prohibited from being used with products that contain alkalis and hydrogen peroxide , as well as Hb products.

When planning, it is taken into account that when combining “Resorcin” with the following agents, melting mixtures are formed:

1. Phenol.
2. Antipyrine.
3. Terpinhydrate.
4. Fenadon.
5. Hexamethylenetetramine.
6. Camphor.
7. Aminophenazole.
8. ASK.
9. Chloral hydrate.
10. Benzonafthol.
11. Bromocamphor.
12. Metamizo.
13. Phenyl salicylate.
14. Menthol.
15. Benzocaine.

Therefore, complex treatment must be extremely careful.

Storage conditions

The instructions for using the substance indicate that the alcohol solution and ointment are stored in a well-ventilated place.

Reliably protected from direct sunlight and high humidity .

The optimal air temperature is up to +18 degrees Celsius.

Otherwise, the substance may oxidize and lose its properties.

Best before date

The cream can be stored for 3 years.

The shelf life of the lotion solution is 2 years.

Analogs

Some people are not suitable for the medicine due to contraindications or adverse reactions. In this case, the alcohol solution or ointment should be replaced with analogues.

Drugs with similar effects include:

• "Amukin";
• "Adgisept";
• "Aquazan";
• "Amol";
• "Amident";
• "Arenarine";
• "Aseptolin";
• "Aseptinol spray";
• "Antisept-Angin";
• "Ankerplast";
• "Arenarine."

Important! Each product (ointments, drops, lotions) must be selected by the attending physician. After all, self-medication leads to complications that require serious treatment to eliminate.

Price

The solution can be purchased at a price of 120 to 250 rubles per 200 ml bottle. Resorcinol ointment will cost 200 rubles. The powder costs 150-270 rubles. A doctor's prescription is not required to purchase the products.

The chemical properties of the drug make it possible to use it to treat a number of skin diseases.

The medication effectively copes with the manifestations of infection, but before use it is necessary to consult a dermatologist in order to prevent the development of complications in case of contraindications.

Numerous patient reviews show that the drug rarely causes side effects, so it is suitable for almost every person.

Reactions

This reduces Fehling's Solution and ammonia solutions of silver. Does not form a precipitate with lead acetate solution, like isomeric pyrocatechol. Iron (III) chloride colors its aqueous solution dark purple, and bromine water precipitates tribromoresorcinol. These properties allow it to be used as a dye. chromatography experiments.

Sodium amalgam reduces it to dihydroresorcinol, which when heated to 150-160 °C with concentrated barium hydroxide solution gives γ-acetylbutyric acid

When combined with potassium hydroxide, resorcinol gives phloroglucinol, pyrocatechol and Diresorcin. This condenses with acids or acid chlorides, in the presence of dehydrating agents, onto oxyketones, for example with zinc chloride and glacial acetic acid at 145 °C to form resacetophenone (HO)2C6H3~CO.CH3.[8] With dibasic acid anhydrides, it gives fluoresceins. When heated with calcium chloride-ammonia to 200 °C it gives meta-dioxydiphenylamine.[9]

With the participation of sodium nitrate, it forms a water-soluble blue dye that turns red when exposed to acids and is used as an indicator called lakmoid.[10] Easily condenses with aldehydes, yielding to formaldehyde, when adding catalytic hydrochloric acid, methylene direxorcinol [(HO) C6HAC3(O)]2• CH2. Reaction with chloral hydrate in the presence of potassium bisulfate gives tetra-oxydiphenylmethanecarboxylic acid lactone.[11] In alcohol solution, it condenses with sodium acetoacetate to form 4-methylumbelliferone.[12]

In addition to electrophilic aromatic addition, resorcinol (and other polyols) undergo nucleophilic substitution via the Enone tautomer.

Nitration of concentrated nitric acid in the presence of cold with concentrated sulfuric acid gives trinitro-resorcinol (styphic acid), an explosive.

Resorcinol in cosmetics

Resorcinol, also known as resorcinol, is a well-known and powerful ingredient that should be used with extreme caution. Resorcinol is used to treat many skin problems, and also in skin or hair cosmetics as... an enhancer that improves the color of the product.

Synonyms: Resorcinol, Phenylethyl Resorcinol, (E)-5-(p-Hydroxystyryl)resorcinol, 2-Methyl Resorcinol, 4-Chloro Resorcinol, 4-n-Buryl Resorcinol.

Patented formulas: Jarocol RL, PromaCare® PS, Wilshire Technologies Resveratrol, Vivinol, MultiSal™ Triple-Action Anti-Aging (TAAA), SymWhite® 377, Hentowhite.

Essentially, resorcinol is an antiseptic (it coagulates proteins, which causes the death of vegetative forms of microorganisms, although it has a weak effect on spores), however, the effects of this substance are so diverse that in cosmetology it is used to solve a huge number of problems.

For example, resorcinol inhibits melanin pigmentation, thereby blocking the appearance of freckles; reduces ultraviolet-induced pigmentation by quickly and deeply penetrating the skin: this is an extremely active component, which can also be dangerous.

Resorcinol effectively prevents melanin synthesis, improves skin texture by smoothing out unevenness, and reduces pigmentation caused by ultraviolet radiation. Resorcinol acts not only as an antibacterial or whitening agent, but also as an antioxidant and anti-wrinkle agent.

Some resorcinol derivatives (Phenylethyl Resorcinol) have shown to be one of the most active tyrosinase inhibitors with a 22-fold effect of kojic acid. This ingredient reduces the formation of melanin at a very early stage of melanin synthesis and melanosome transfer to keratinocytes.

Promotes desquamation of the superficial stratum corneum and the melanin pigment residues contained in them.

As you can see, the properties of resorcinol and its effect on the skin are very diverse, but they are, so to speak, highly specialized, and it is better to use cosmetics with these components under the supervision of a dermatologist.

Who is resorcinol indicated for?

Resorcinol is a serious therapeutic substance that is used for the following problems and diseases:

• eczema;
• neurodermatitis;
• seborrheic dermatitis;
• chronic inflammation of hair follicles;
• hyperpigmentation;
• severe itching of the facial skin;
• pathological hair loss, which can lead to thinning or complete baldness (alopecia).

Western manufacturers, using resorcinol, rely mainly on the fact that it provides active skin lightening, whitening and removal of age spots. Cosmetics based on it are used for whitening, treating signs of chronological aging, photoaging, lightening the skin of the face, hands and bikini area, as well as for caring for aging skin.

In some cases (decorative cosmetics, hair dyes) this component has no indication, since it is an auxiliary substance (dye).

For whom is resorcinol contraindicated?

Resorcinol is one of those substances whose use in cosmetology is surrounded by many legends.

Its medicinal properties are quite interesting, but it is almost impossible to find facial skin preparations based on this compound on sale. The main reason is the very high risk of side effects.

These include: swelling; hives; severe irritation of facial skin; increased sweating, cyanosis, or other change in facial skin tone.

Important: resorcinol is incompatible with menthol, phenyl salicylate, phenol, camphor, antipyrine and salicylic acid. This component should not be used during treatment with drugs that have an alkaline reaction.

When using it as a medicine, it should be taken into account that dust or vapors of resorcinol irritate the skin and mucous membranes of the eyes and respiratory tract and cause coughing.

Strict contraindications include individual hypersensitivity reactions, extensive lesions of the skin and mucous membranes, violations of the integrity of the skin, as well as pregnancy and lactation.

At the same time, hypoallergenic, free of toxic additives and safe to use forms of resorcinol have been developed (for example, 4-n-Buryl Resorcinol).

This compound, based on a derivative of the resorcinol molecule, has outstanding results in reducing the appearance of dark spots on the skin and whitening the skin, without exhibiting any of the irritating effects associated with standard resorcinol.

Cosmetics containing resorcinol

Resorcinol is used to treat many skin problems, as well as in cosmetics for the skin and hair (including hair dye compositions), and in decorative cosmetics. According to the European Union Regulation, the maximum permissible concentration of this component in finished cosmetic skin care products is 0.5%.

History, etymology and nomenclature

Austrian chemist Heinrich Glasivec (1825–1875) is famous for his chemical analysis of resorcinol and his involvement in the first preparation of resorcinol, along with Ludwig Barth, which was published in 1864.[21]:10[22]

Benzene-1,3-diol is the name recommended by the International Union of Pure and Applied Chemistry (IUPAC) in its 1993 Recommendation on Nomenclature of Organic Chemistry.

.[23]

Resorcinol is so named because it is formed from an ammoniated resin and also because of its association with the chemical. orcin.[24]

Jessner peel protocol Salicylicpeel JS Medic Control Peel

Stage I. Pre-peeling preparation

For 14–21 days, the patient should apply Prepeel Active cream to skin previously cleansed with CleanserMousse. In the morning, you must apply MediScreen sunscreen.

Stage II. Chemical peeling

1 step.

Cleansing.
Apply Cleanser Mousse to the skin, distribute with light massage movements and leave for 15-20 seconds. Rinse with water. Step 2.
Degrease the skin with Prepeel Lotion.
Step 3.
Apply Salicylicpeel JS with cotton pads with quick movements (the cotton pad is moistened directly from the bottle) onto the entire facial skin in the following sequence: forehead, temples, chin, cheeks, nose, eyelids.
During application of the drug, the patient feels a burning sensation. After 2-3 minutes, the liquid fraction evaporates and a white coating formed by salicylic acid crystals appears on the skin. By the homogeneity of the plaque, one can judge the uniformity of application of the peeling composition to all treated areas. Do not rinse off. Then you can apply the next layer. The number of layers is determined by the individual characteristics of the patient’s skin, indications, as well as the desired depth of penetration. Leave for 4 hours. Step 4
Ask the patient to wash.
If the aggressive effect is pronounced, the peeling composition can be washed off earlier.
Step 5 Apply Vegefarma cream to the skin.

Stage III. Post-peeling care

for 5-7 days after the Jessner peel procedure.

Vegefarma cream and in the morning protect from ultraviolet radiation by applying MediScreen sunscreen.

Expected reactions after peeling

Immediately after applying the peeling composition, a pronounced burning sensation is noted, erythema is observed, on days 2–4 the skin becomes parchment-like, on days 3–4 severe peeling begins, which continues until days 6–7. 2 days after the procedure, desquamation begins, which lasts 5-7 days. It is necessary to warn the patient about the inadmissibility of forcible removal of crusts or film that have appeared.