Decaris: instructions for use

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Wikipedia defines Dekaris as an anthelmintic with an immunomodulatory effect. The drug depolarizes the muscle membranes of helminths, inhibits the enzymatic activity of fumarate reductase and succinate dehydrogenase, and suppresses bioenergetic processes. Paralyzed nematodes are removed from the body by intestinal peristalsis within 24 hours after taking the drug.

The immunomodulatory effect of the drug is manifested by increased production of antibodies to antigens and T-cell response, activation of T-lymphocytes, increased function of macrophages, monocytes and neutrophils (phagocytosis, chemotaxis and adhesion).

Pharmacokinetics

When taken orally, the drug is quickly absorbed from the gastrointestinal tract. Blood levels after taking the drug are achieved within 1.5-2 hours. Levamisole is metabolized in the liver; its metabolites are glucuronide and hydroxy-levamisole. The half-life is 3-6 hours. Excreted in the form of metabolites in urine and feces.

Adverse reactions

Treatment with Decaris causes negative symptoms. During the procedures the following may occur:

• sleep problems;
• convulsive syndrome;
• dizziness with cephalgia;
• signs of encephalopathy;
• dyspepsia;
• dermatological rash;
• involuntary muscle tremors;
• feeling of heartbeat.

An anthelmintic agent can provoke the development of agranulocytosis and a decrease in the number of leukocytes in the blood.

Dekaris tablets, instructions for use (Method and dosage)

For adults, take orally with meals in the following dosage:

• For toxoplasmosis : once at a time, 150 mg per day for three days. If necessary, the course of treatment can be repeated at intervals of one week.
• For helminthiasis : once, before bedtime, at a dose of 150 mg for adults and at a rate of 2.5 mg/kg for children. If necessary, the course can be repeated again after 1-2 weeks.

Instructions for use of Dekaris indicate the need to study peripheral blood before starting treatment, and during the treatment period - to monitor the number of leukocytes. While taking the drug and after, for one day, it is strictly forbidden to drink alcoholic beverages.

Who is Dekaris indicated and contraindicated for?

The drug is prescribed for infection with certain types of helminths:

• with ascariasis;
• hookworm;
• necatorosa;
• trichostongilosis;
• trichocephalosis;
• enterobiasis;
• strongyloidiasis;
• toxoplasmosis.

Contraindications to therapy are:

• individual intolerance to individual components;
• development of agranulocytosis during treatment with other medications.

Decaris is not used to combat parasitic organisms for pregnant and nursing mothers, children under three years of age.

Increased caution and monitoring by a physician is needed when treating patients with kidney failure, liver failure, and suppressed hematopoiesis in the bone marrow.

Decaris for children

Decaris for children, given the significant number of possible side effects in the treatment of helminthiasis, can be taken only after consultation with a doctor. Tablets for children are available in a dose of 50 mg of levamisole.

How should children take the drug? One tablet (50 mg) is designed for 10 kg of child weight. The instructions for the drug contain dosage calculations for children. Approximate dosages for children from 3 to 6 years old are 25-50 mg; from 6 to 10 —50-75 mg; from 10 to 14 years - 75-100 mg. However, calculating the dosage based on the child’s weight is more accurate and reduces the likelihood of side effects.

Decaris to boost immunity

It is practically not used to increase immunity in children. There are many modern, highly effective and relatively safe immunomodulators that your doctor will prescribe for your child if necessary. Reviews of taking Decaris in children are in most cases positive. Judging by them, side effects occur less frequently in children than in adults. This is probably explained by the fact that parents, when giving Decaris for worms to a child, strictly adhere to the dosage of the drug prescribed by the doctor. Reviews note the good anthelmintic effect of Dekaris and the convenience of a single dose.

Component composition of Dekaris

The instructions describe in detail the components contained in the tablets. The composition of Dekaris is presented:

• levamisole hydrochloride;
• corn starch;
• sodium saccharinate;
• talc;
• povidone;
• apricot flavoring;
• magnesium stearate;
• yellow dye.

The medicine is made in pale orange tablets, packaged in blisters and cardboard packaging.

Analogs

Level 4 ATC code matches:
Levamisole

Analogues of Dekaris for the active substance - Levamisole . Drugs with similar therapeutic effects include: Pirantel , Vermox , Helmintox , Piperazine , Mebendazole , Vormin , Medamin , Biltricid , Telmox , Nemozol , Tansy flowers , Pumpkin seeds and others.

Side effects of the drug Dekaris

When taken once as an anthelmintic, levamisole is usually well tolerated; headache, insomnia, dizziness, palpitations, convulsions, and dyspeptic symptoms such as nausea, vomiting, abdominal pain, and diarrhea may rarely occur. These phenomena are usually mild, short-lived and go away on their own. There are reports of the development of encephalopathy 2–5 weeks after taking the drug. When using the drug in high doses or with long-term therapy, leukopenia and agranulocytosis may occur.

Reviews about Dekaris

Reviews about the drug vary quite a bit. Many patients, taking Decaris tablets for worms, note strong side effects in the form of an unpleasant odor, severe nausea, headaches, dizziness, vomiting and skin rashes. Because of this, some parents are afraid to give it to their children. But in most cases, there are no complaints about the ineffectiveness of the drug, both for adults and for children, in the treatment of helminthic infestations.

Many website visitors are interested in how worms after using the drug. Helminths that die from paralysis are eliminated from the body within 24 hours after taking the drug in a natural way (through the intestines with feces). Some people ask why Dekaris tablets are prescribed, meaning what types of worms it acts on. The drug is effective against nematodes (roundworms), which include roundworms, pinworms, Trichinella, Toxocara, and whipworms.

Dekaris, reviews from doctors

Doctors, for the most part, speak favorably of Dekaris, noting its high effectiveness:

• “... in my practice as a doctor at a rural outpatient clinic, I use Dekaris quite often. Many patients, having read negative reviews on the Internet, are afraid to take the drug. Sometimes it takes a long time to dissuade them. In my personal, almost ten-year practice, there have been only a few cases of moderate consequences. Most people tolerate the recommended doses of the drug completely normally. I personally and my family have been taking Decaris for preventive purposes (3 cats and a dog live at home) for almost 7 years. And no serious complications were observed. It should be remembered that the phenomena of headache and nausea are a consequence of intoxication of the body, resulting from difficulties in bowel movement. For this purpose, you can take a laxative drug, and the drug must be taken at night, then the patient practically does not notice the side effects.”

Reviews

Opinions on forums about the drug vary greatly. Some patients are dissatisfied with the side effects that have arisen, while others are afraid to give it to children. In other cases, there are no complaints about the effectiveness of Dekaris in the fight against helminths.

Doctors believe that accidental and intentional overdoses are the main cause of problems with therapy. Incorrect calculation of the required amount of medication becomes a predisposing factor for the development of cephalalgia, diarrhea and dizziness. Symptoms of intoxication occur less frequently with the exact dose of the drug and taken before bedtime.

Dekaris price, where to buy

The price of Dekaris tablets 50 mg No. 2 varies between 68 -75 rubles per pack; 150 mg No. 1 - 88-92 rubles. The price of Dekaris in Ukraine in a dosage of 50 mg No. 1 is 28-35 hryvnia; 150 mg No. 1 - 40-44 hryvnia. You can buy the drug in most pharmacies in Moscow and the pharmacy chain of Ukraine.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Dekaris tablets 50 mg 2 pcs. JSC Gedeon Richter
  71 rub. order
• Dekaris tablets 150 mg 1 pc. JSC Gedeon Richter

  73 rub. order

Pharmacy Dialogue

• Dekaris (table 150 mg No. 1) Gedeon-Richter

  68 RUR order

• Dekaris (table 150 mg No. 1)Gedeon-Richter/Gedeon-Richter-RUS ZAO

  78 RUR order

• Decaris (table 50 mg No. 2)Gedeon-Richter

  65 rub. order

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Pharmacy24

• Decaris 50 mg N2 tablets Gedeon Richter Rumunia A.T., Rumunia
  79 UAH.order

PaniPharmacy

• Dekaris tablets Dekaris tablets. 50 mg No. 2 Hungary, Gedeon Richter

  86 UAH order

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Overdose symptoms and interaction features

Consumption of large amounts of Decaris, in a volume of more than 600 mg, causes the development of acute poisoning. Intoxication manifests itself:

• dyspeptic disorders;
• cephalalgia with dizziness;
• constant drowsiness;
• diarrhea;
• convulsive syndrome;
• impaired clarity of consciousness.

The patient needs symptomatic therapy to suppress signs of poisoning.

The instructions focus on the following nuances:

• the drug is incompatible with agents that reduce the number of leukocytes, alcohol and lipophilic compounds;
• the medicine may increase the effects of phenytoin and medications related to indirect coagulants.

Decaris is not intended to normalize the immune system in childhood.

Interactions of the drug Dekaris

When taking Decaris simultaneously with alcoholic drinks, disulfiram-like symptoms may develop. Caution is required when using Decaris with drugs that affect hematopoiesis. When taking Decaris simultaneously with coumarin anticoagulants, the prothrombin time may increase, so it is necessary to adjust the dose of the oral anticoagulant. Decaris increases the concentration of phenytoin in the blood, therefore, when using these drugs simultaneously, it is necessary to monitor the level of phenytoin in the blood serum. Do not use simultaneously with lipophilic drugs (chloroform, ether), as the toxicity of levamisole may increase.