Indications and contraindications for the use of Rosuvastatin
There are two main indications for taking this drug:
- Hypercholesterolemia.
- Hypertriglyceridemia.
It should be noted that, together with treatment with Rosuvastatin, strict adherence to the diet prescribed by the doctor is mandatory. Otherwise, the effectiveness of the drug is sharply reduced.
The use of the drug is limited if patients have the following conditions:
- The presence of individual hypersensitivity to the main or additional ingredients of the drug.
- Acute and chronic liver diseases.
- Myopathy.
- Chronic kidney disease.
- Pregnancy and breastfeeding period.
- Sepsis.
- Severe injuries.
If there are serious indications, Rosuvastatin can be prescribed with extreme caution to patients with endocrine pathology, as well as to patients under the age of 18 and over 60 years of age.
Rosuvastatin Tablets, box, 90 pcs., 10 mg, for oral administration, film-coated
special instructions
Before starting therapy and throughout the entire period of treatment, the patient should follow a standard lipid-lowering diet. During treatment, the lipid profile should be monitored every 2-4 weeks and, according to the results, the dose of the drug should be adjusted if necessary.; When using rosuvastatin at all doses, and especially at doses exceeding 20 mg, short-term proteinuria may occur. In patients taking the drug at a dose of 40 mg, it is recommended to monitor renal function indicators.; Patients taking rosuvastatin at a dose exceeding 20 mg may experience myalgia, myopathy, and rarely rhabdomyolysis. Determination of CPK activity should not be carried out after intense physical activity or in the presence of other possible reasons for the increase in CPK, which may lead to incorrect interpretation of the results obtained. If CPK increases 5 times above ULN, a repeat measurement should be taken after 5-7 days. Therapy should not be started if a repeat test confirms the initial increased CPK activity by more than 5 times compared to the ULN.; In patients at risk of developing myopathy/rhabdomyolysis, it is necessary to consider the balance of risk and possible benefit of therapy and carry out clinical monitoring throughout the course of treatment.; The patient should be informed to immediately report to the doctor in cases of unexpected onset of muscle pain, muscle weakness or spasms, especially in combination with malaise and fever. In such patients, CPK activity should be monitored. Therapy should be discontinued if CPK activity is increased by more than 5 times the ULN, or if muscle symptoms are severe and cause daily discomfort (even if CPK activity is 5 times less than the ULN). If symptoms disappear and CPK activity returns to normal, re-use of the drug or other HMG-CoA reductase inhibitors in lower doses should be considered under close medical supervision. Routine monitoring of CPK in the absence of symptoms of rhabdomyolysis is not advisable.; An increase in the number of cases of myositis and myopathy has been reported in patients taking other HMG-CoA reductase inhibitors in combination with fibric acid derivatives, including gemfibrozil, cyclosporine, nicotinic acid in lipid-lowering doses, azole antifungals, HIV protease inhibitors and antibiotics macrolides. Gemfibrozil increases the risk of myopathy when combined with certain HMG-CoA reductase inhibitors. Therefore, concomitant use of rosuvastatin and gemfibrozil is not recommended. The balance of risk and possible benefit should be carefully weighed when using rosuvastatin and fibrates or nicotinic acid in lipid-lowering doses together; It is recommended to determine liver function indicators before starting therapy and 3 months after starting therapy. If the activity of hepatic transaminases in the blood serum is 3 times higher than the ULN, the dose of the drug should be reduced or discontinued.; When hypercholesterolemia is combined with hypothyroidism or nephrotic syndrome, treatment of underlying diseases should be carried out before starting treatment with rosuvastatin.; There was an increase in the plasma concentration of rosuvastatin in patients of the Asian race compared to patients of the Caucasian race.; In patients with blood glucose concentrations from 5.6 to 6.9 mmol/l, rosuvastatin therapy was associated with an increased risk of developing type 2 diabetes mellitus; Women of reproductive age should use adequate methods of contraception; Impact on the ability to drive vehicles and operate machinery; During the treatment period, dizziness and weakness may occur, so care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Adverse reactions and symptoms of overdose
Taking the drug may be accompanied by a large number of side effects. Most often, patients develop the following conditions:
- From the musculoskeletal system: arthritis, myositis, myopathies.
- CNS: headaches, dizziness, sleep disturbances, anxiety, depressive thoughts.
- From the respiratory system: cough, bronchial asthma, rhinitis, pharyngitis, tracheitis, bronchitis and pneumonia.
- Urinary tract infections.
- Gastrointestinal tract: dyspeptic syndrome, bloating, gastritis.
- From the cardiovascular system: tachycardia or angina.
- Allergic reactions.
An overdose of the drug is currently not described.
Instructions for use of Rosuvastatin
The dosage is selected by the attending physician depending on the severity of the lipid profile disorder and the presence of cardiovascular risk.
The starting dose is 10 mg per day. If necessary, it is possible to increase the amount of the drug taken to 20 or 40 milligrams, but not earlier than after the start of treatment.
Increasing the daily dosage is possible only under the strict supervision of a specialist.
The drug should be taken whole, without chewing and with a sufficient amount of water. It is advisable to take the medication before meals.
Analogues of the drug
The drug has a fairly large number of analogues. Their cost can be both higher and lower and varies from 100 to 1000 rubles.
The most well-known analogues of Rosuvastatin include: Pravastatin, Lipitor, Simvastol, Lovastatin, Rozulip, Simvastatin, Atoris, Roxera, Crestor and a number of other drugs.
It is not recommended to change one medicine to another without the consent of a specialist. If necessary, the doctor himself will adjust the treatment, change the dosage and prescribe another drug.
Rosuvastatin price
On average, the price of this drug ranges from 500 to 1000 rubles.
The price of Rosuvastatin 10 mg differs from the same medicine with a dosage of 20 mg per tablet by approximately 200-300 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Crestor (Rosuvastatin) tablet.
p/o 40 mg 28 pcs 3600 rub. order
ZdravCity
- Rosuvastatin-SZ tab. p/o captivity. 0.02g 90pcsNAO Northern Star
RUB 896 order
- Rosuvastatin-Akrikhin tablets. p/o captivity. 10 mg No. 30 Polpharma JSC
RUR 459 order
- Rosuvastatin-SZ tab. p/o captivity. 10 mg No. 60NAO Northern Star
RUR 538 order
- Rosuvastatin tablets p.p.o. 20 mg 30 pcs. Ozone LLC
RUR 504 order
- Rosuvastatin-SZ tab. p/o captivity. 0.01g 90pcsNAO Northern Star
RUR 697 order
Pharmacy Dialogue
- Rosuvastatin (tab.pl.vol. 10 mg No. 30)Polpharma Pharmaceutical Works SA
RUR 488 order
- Rosuvastatin (tab.pl.vol. 20 mg No. 30)Polpharma Pharmaceutical Works SA
580 rub. order
- Rosuvastatin Canon (tab.pl.vol. 20mg No. 90)Canonpharma Production
RUB 837 order
- Rosuvastatin-SZ tablets 10 mg No. 90Northern Star ZAO
RUR 548 order
- Rosuvastatin-Teva (tab.p.pl.vol. 20 mg No. 90) Teva LLC
RUB 1,772 order
show more
Pharmacy24
- Rosuvastatin Sandoz 5 mg No. 28 tablets Lek pharmaceutical company d.d., Slovenia
96 UAH. order - Rosuvastatin Sandoz 10 mg No. 28 tablets Lek pharmaceutical company d.d., Slovenia
130 UAH order
- Rosuvastatin Teva 10 mg No. 30 tablets TEVA Pharmaceutical Industries Ltd., Israel
101 UAH order
- Rosuvastatin Teva 5 mg No. 30 tablets TEVA Pharmaceutical Industries Ltd., Israel
73 UAH order
- Rosuvastatin IC 5 mg No. 30 tablets INTERCHEM Partnership with additional coverage, Ukraine
67 UAH order
