Pharmacodynamics and pharmacokinetics
The drug has an antispasmodic effect aimed at the smooth muscles of the gastrointestinal tract, gall bladder, and genitourinary organs. In addition, the secretion of food glands is reduced . In this case, the anticholinergic effect on the nervous system is not manifested.
Thanks to the presence of an additional substance - paracetamol , Buscopan Plus, in addition to its antispasmodic effect, eliminates the cause of pain, providing a muscle-relaxing effect exactly at the site of pain.
The active component, hyoscine butyl bromide, is characterized by insignificant absorption in the gastrointestinal tract. Once inside the body, it is absorbed by 8%, with an average absolute bioavailability of up to 1%. A single use of hyoscine butyl bromide at a dosage of 20-400 mg leads to maximum plasma concentrations after 2 hours.
The active component is predominantly distributed in the muscle cells of the abdominal cavity and pelvis. The interaction of the drug with the movement of choline in the epithelial cells of the human placenta was also noted. The bulk of metabolism is due to hydrolysis of the ester bond. The drug is excreted through urine and feces.
Composition and dosage form
The medicine contains the only active ingredient - hyoscine butyl bromide. This compound has a pronounced antispasmodic effect. It relaxes the contractions of smooth muscle fibers lining the walls of internal organs and blood vessels.
Buscopan is available for systemic use: in tablet form and in the form of suppositories.
- The tablets are white, sugar-coated, round, convex on both sides. In addition to the active substance, their composition includes: starch, magnesium stearate, MCC, calcium salts, hydrophobic.
- Buscopan Plus tablets are enhanced with paracetamol.
- Buscopan candles are fat-based: torpedo-shaped, white or milky in color, smooth texture, dissolve at temperatures above +36°C. In addition to the active ingredient, they contain auxiliary ones, including: soft paraffin, vegetable fats.
Indications for use of Buscopan
- spasm of the genitourinary and gastrointestinal tract , for example, with renal colic, pyloric spasms, cholecystitis and intestinal colic;
- exacerbation of gastric ulcer and duodenal ulcer;
- dyskinesia of the bile ducts and gallbladder;
- algodismenorrhea and so on.
In addition, indications for the use of Buscopan suppositories for patients before labor were noted.
Contraindications for use
It is not recommended to take tablets:
- patients under 6 years of age;
- if you have hypersensitivity to Buscopan and its components;
- for myasthenia gravis , megacolony , angle-closure glaucoma and pulmonary edema .
Additional contraindications for suppositories are:
- prostate adenoma;
- abnormalities in cardiac activity and cerebral vessels.
Mechanism of action of the drug
Butyl bromide is absorbed into the blood slowly. The maximum concentration is achieved within 2 hours after taking the tablet or placing the suppository rectally. Bioavailability of the active substance is about 8%. The drug does not accumulate in the body; metabolites are filtered by the kidneys and excreted in the urine. Partially their remains leave the body through the intestines.
Buscopan has a relaxing effect only on smooth muscles. As a result of its administration, a moderate decrease in secretion of the digestive tract is observed, although the antispasmodic has no anticholinergic effect on the nervous system. The most powerful antispasmodic property of the drug is manifested in the tissues of the organs and blood vessels of the abdominal cavity. Buscopan Plus eliminates not only the spasm itself, but also its immediate causes, reducing the release of painful and inflammatory prostaglandins.
The effectiveness of the medication and its duration directly depend on the size of the doses taken. Buscopan has no effect on the pathological process. Its purpose is to eliminate the symptoms of the disease and alleviate the physical condition, neutralizing spasms and pain.
Side effects
Taking Buscopan may be accompanied by unwanted effects caused by the anticholinergic properties of the drug. Therefore, they are usually mild in severity and pass quickly without additional intervention.
Patients are especially often concerned about:
- skin peeling , urticaria , itching , irritation;
- dry mouth;
- difficulty breathing;
- tachycardia , arrhythmia;
- problems with urination and so on.
Overdose
Cases of overdose with Buscopan have not been established, but the occurrence of the symptoms described in the list of side effects should not be excluded.
In such situations, the following treatment procedures are recommended:
- gastric lavage;
- taking activated carbon or other means of similar action;
- use of cholinomimetics intravenously or intramuscularly.
All other complications require symptomatic therapy.
Interaction
The simultaneous use of Buscopan and tricyclic antidepressants, Hindin, antihistamines, amantadine and disopyramide may enhance the anticholinergic effect.
Combined use with dopamine antagonists , for example, metoclopramide , weakens the effect of each drug on the gastrointestinal tract.
Complex treatment with Buscopan and beta-adrenergic drugs often increases tachycardia .
special instructions
Treatment with Buscopan requires special instructions. For example, you need to stop using the drug gradually, since rapid withdrawal can cause nausea , sweating and dizziness .
It is also recommended to refrain from overheating when performing physical activity, in the heat, in the bath and sauna. If dry mouth does not disappear for more than 2 weeks, then the risk of developing damage to tooth enamel, gums, and fungal infections . When treating with Buscopan, you should be careful when driving vehicles and other activities that require high attention.
Buscopan
Trade name: Buscopan International name: Hyoscine butylbromide Pharmacological group: m-anticholinergic drug Pharmacological group according to ATC: A03BB01. Hyoscine butylbromide Pharmacological action: m-anticholinergic, antiulcer, antispasmodic Pharmacodynamics: M-anticholinergic, reduces the tone of the smooth muscles of internal organs and their contractile activity, the secretion of the digestive glands, increases heart rate, intraocular pressure, causes mydriasis and paralysis of accommodation.
Pharmacokinetics: Poorly absorbed from the gastrointestinal tract. Plasma protein binding is low. It is found in the greatest quantities in the gastrointestinal tract, gall bladder and ducts, liver and kidneys.
Indications for use: Renal colic, biliary colic, spastic dyskinesia of the biliary tract and gallbladder, cholecystitis, intestinal colic, pylorospasm, peptic ulcer of the stomach and duodenum in the acute phase (as part of complex therapy), algodismenorrhea
Contraindications: Hypersensitivity to hyoscine butyl bromide, or any other component of the drug, myasthenia gravis, megacolon, children (up to 6 years). For dosage forms containing sucrose (additionally): hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency.
Dosage regimen: Inside, with a small amount of water, Inside (tablets), unless otherwise prescribed, adults and children over 6 years old, 1-2 tablets. 3-5 times a day, washed down with water. Rectally (suppositories), unless otherwise prescribed, adults and children over 6 years old, 1-2 supp. 3 times a day. Suppositories should be removed from the shell and inserted into the rectum with the pointed end first. The duration of use is determined by the doctor. For acute conditions subcutaneously, intramuscularly or intravenously: adults - 20-40 mg
Side effects: associated with the anticholinergic effect of the drug: dry mouth, dry skin, tachycardia, possible urinary retention (usually mild and resolves on its own). Allergic reactions: in rare cases - skin manifestations, anaphylaxis with episodes of difficulty breathing.
Overdose: Symptoms: dry mouth, urinary retention, skin flushing, tachycardia, depression of gastrointestinal motility, transient visual impairment, paralysis of the respiratory muscles. Treatment: administration of cholinomimetics (neostigmine IV or IM 0.5-2.5 mg), for paralysis of the respiratory muscles - intubation, mechanical ventilation, bladder catheterization, symptomatic and supportive therapy.
Interaction: Strengthens the anticholinergic effect of tricyclic antidepressants, antihistamines, quinidine, amantadine, disopyramide, and other anticholinergic drugs (including ipratropium bromide, tiotropium bromide). Dopamine antagonists (including metoclopramide) - weakening of the effect on the gastrointestinal tract of both drugs. May enhance tachycardia caused by beta stimulants.
Special instructions: Discontinuation of the drug should be carried out gradually (with rapid withdrawal, nausea, sweating, and dizziness may occur). It is prohibited to take ethanol during treatment. Overheating should be avoided during intense physical activity and hot weather, as well as hot baths and saunas. Dry mouth that persists for more than 2 weeks increases the risk of diseases of tooth enamel, gums, and the development of fungal infections. During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Update date 02/25/2010
Manufacturer: Delpharm Reims, France Marketing authorization holder: Boehringer Ingelheim International GmbH, Germany Release form: film-coated tablets 10 mg (blisters) Composition: hyoscine butyl bromide 10 mg Dispensed without a prescription Shelf life: 5 years Registration data: P N014393/01 dated 08/15/2008 Registration certificate status: valid HS codes: 3004 40 100 9
Analogues of Buscopan
In pharmacology there are no analogues of this drug for the active substance.
The list of analogues by pharmacological group includes: Atrovent, Atropine, Gastrocepin, Gastrozem, Driptan, belladonna extract, Midriacil, Novitropan, Spazmex, Trigan and others. Moreover, the price of analogues may vary depending on the manufacturer, the active substance and the number of doses in the package. To change treatment, you must consult a doctor.
How to use Buscopan: instructions
The drug is approved for use by patients over the age of 6 years. It can be used once: for spontaneous spasms of unknown origin, or in short courses: for exacerbations of pathologies, regular painful conditions.
The tablets are taken orally, without chewing, with plenty of clean still water. It is recommended to take 30 minutes before meals or 1.5 hours after, since food can slow down the absorption of the active substance and the development of the pharmacological effect. Daily doses depend on the severity and nature of the spasms:
- for moderately painful symptoms and in childhood, it is enough to take 1 tablet twice a day;
- for severe cramps, the dosage is increased to 6 tablets per day: 2 pcs. three times a day.
Suppositories are used rectally, inserted into the anus for similar symptoms and in appropriate doses:
- children under 12 years of age and adults with mild spasms: 1 suppository 2-3 times a day, keeping a break between administrations of 5-6 hours;
- in case of severe pain, double the dose, using 2 suppositories.
It is noted that the effect of suppositories for spasms in the pelvic organs occurs faster than after taking tablets. For diseases of the small intestine, gallbladder or stomach, it is best to use the oral form of the drug.
Reviews of Buscopan
Discussions of this drug are found on various thematic forums dedicated to pregnancy . As reviews of Buscopan show, suppositories are often prescribed before childbirth, which help prepare the cervix for labor. Most patients, leaving reviews of Buscopan suppositories during pregnancy, note that its effectiveness is not always evident. Some users know that suppositories are prescribed during childbirth, and are interested in what the pills help with. There are also reports that the use of medicine in the treatment of pain and colic can quickly eliminate the problem.
When is Buscopan indicated?
The drug is prescribed to eliminate painful spasms:
- with exacerbation of gastritis, ulcerative pathology of the stomach, duodenum, pancreatitis, cholecystitis, inflammation of the bile ducts, impaired liver function;
- colic in the intestines, kidneys;
- abdominal pain;
- with painful menstruation: at the first signs of cramps, during the period of discharge;
- in other conditions accompanied by painful muscle contractions.
In some cases, Buscopan is used to facilitate cervical dilatation during the prenatal period. Suppositories and tablets are also used in the complex treatment of complications of osteochondrosis.
Buscopan price, where to buy
On average, the price of Buscopan in Moscow pharmacies can vary from 275 to 369 rubles. At the same time, the price of Buscopan candles is higher.
In Ukrainian pharmacies, tablets or suppositories can be purchased for 225-263 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Buscopan rectal suppositories 10 mg 10 pcs. Boehringer/Instituto de Angeli Srl
446 RUR order - Buscopan tablets p.p.o. 10 mg 20 pcs Delpharm Reims
RUR 507 order
Pharmacy Dialogue
- Buscopan suppositories 10 mg No. 10 Boehringer Ingelheim
RUR 456 order
- Buscopan tablets 10 mg No. 20Boehringer Ingelheim
RUR 488 order
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Pharmacy24
- Buscopan 10 mg No. 6 suppositories Istituto de Angeli S.r.l., Italy
41 UAH.order - Buscopan 20 mg/ml 1 ml No. 5 solution Boehringer Ingelheim Espana, CA, Spain
90 UAH order
- Buscopan 10 mg No. 20 tablets Delpharm Reims, France
54 UAH order
PaniPharmacy
- Buscopan ampoule Buscopan solution d/in. 20mg amp. 1ml No. 5 Spain, Boehringer Ingelheim Espana
127 UAH order
- Buscopan suppository Supp. buscopan 10 mg No. 10 Italy, Instituto de Angeli
49 UAH order
- Buscopan tablets Buscopan etc. 10 mg No. 20 France, Delpharm Reims
62 UAH.order
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