Arginine - description and instructions for use

Manufacturer: Nittany Pharmaceuticals Inc.
Active ingredients

• Not indicated. See instructions

Pharmacological action

• Not indicated. See instructions

• Description of the pharmacological action of Arginine
• Composition Arginine
• Release form of the drug Arginine
• Method of administration and dosage of the drug Arginine
• Storage conditions for the drug Arginine
• Shelf life of the drug Arginine

Benefits for the body

L-arginine participates in important vital processes of the body and activates the production of creatine, a source of energy for cells. Supplements based on this substance are included in the diet of athletes, especially those involved in bodybuilding. The drugs help restore muscle tissue after training and build it up, accelerate the healing of injuries, activate the production of growth hormone and collagen, and increase endurance. But not only athletes benefit from taking supplements with this substance. Preparations based on it also help you lose weight.

The benefits of arginine will be discussed in more detail in the video:

Arginine and its meaning Live Healthy with Elena Malysheva

Arginine benefits blood vessels, heart, kidneys, liver and gastrointestinal tract. It has the following beneficial properties:

• reduces blood pressure and cholesterol levels;
• normalizes the functioning of the heart and digestive tract;
• promotes the removal of toxins from the body;
• strengthens the walls of blood vessels;
• participates in the production of the happiness hormone, therefore improves mood;
• eliminates erectile dysfunction;
• slows down the growth of tumors.

This substance also produces a mild psychotropic effect and helps women stabilize their emotional background. It also normalizes the growth of nails and hair.

What is L-arginine for?

Not a single metabolic process taking place in the body can do without arginine. In addition to participating in the synthesis of protein, peptides, creatine, it:

• regulates vascular tone, preventing thrombus formation;
• normalizes the functioning of the security (immune) system (increases antipathogenic reactions, creates antitumor protection), promotes rapid healing of wounds;
• removes residual nitrogen (urea, ammonia), cleansing the liver of toxins;
• “thin” the blood, reducing its viscosity;
• affects the development and building of muscle mass, without increasing the fat layer;
• activates the healing process of wounds, sprains, fractures.

It is also a good fat burner that controls blood glucose levels.

Arginine preparations are used for the prevention and treatment of hypertension, atherosclerosis, liver cirrhosis, arthritis and kidney disease.

The substance also has the ability to stimulate sexually. Relaxation of smooth muscles leads to an increase in blood supply to the cavernous bodies and contributes to a strong and lasting erection.

As long as the cells of the inner layer of blood vessels are able to use arginine in sufficient quantities, everything is fine. But, if for some reason the endothelium is not able to secrete the required amount of NO (exhausting training, stress, illness), then blood pressure rises, memory weakens, and then hypertension, diabetes, obesity, and sexual dysfunction will not take long to come.

Indications for use

L-arginine can be taken by athletes and people who want to lose weight, as well as for cardiovascular diseases and reduced immunity. But the main indications for use are:

• protein deficiency due to physical and emotional fatigue;
• immunodeficiency;
• chronic fatigue syndrome;
• anemia;
• diabetes;
• joint diseases;
• recovery after infectious diseases or surgery;
• infertility;
• pathologies of physical development;
• tumors.

Amino acid-based supplements are also recommended for elderly people. The substance normalizes the functioning of organs and systems in an aging body.

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To strengthen the cardiovascular system

L-arginine should be taken for cardiovascular diseases, high blood pressure, hypertension, atherosclerosis, and ischemia. The substance dilates and tones the blood vessels of the heart, strengthens its muscles, and also:

• prevents the formation of blood clots and plaques;
• reduces cholesterol levels;
• saturates the blood with oxygen.

Attention! Arginine reduces the number of angina attacks.

To improve the functioning of the reproductive system

Amino acid supplements improve the functioning of the reproductive system in men and women. Dietary supplements help in the treatment of infertility, normalize blood circulation in the pelvic organs, and also:

• eliminate inflammatory processes;
• increase libido;
• increase sperm activity.

Taking medications also increases the likelihood of conception.

Interesting! Seminal fluid consists of 80% arginine.

To strengthen the immune system and increase vitality

The amino acid has an immunostimulating effect, increases strength, endurance, and mood. To improve vitality, it should be taken in combination with vitamin complexes.

For weight loss

L-arginine can also be taken for weight loss. The amino acid supplies nitric oxide, accelerates metabolic processes, and promotes the burning of fat deposits. With its help you can lose weight without risk to your health.

But you need to take arginine correctly. The following recommendations for use must be observed:

• drink the supplement on an empty stomach 1 hour before training or before bedtime;
• follow a protein diet.

To increase muscle mass, you can drink lysine and arginine at the same time. The daily norm is 1.5 g.

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To fight inflammation and infections

The amino acid helps to recover from infectious diseases, as it improves immunity. It also inhibits the multiplication of the virus during exacerbation of herpes.

Attention! A treatment regimen for herpes infection should be developed by a doctor, since incorrect use of the amino acid can lead to the opposite effect.

For edema

Preparations containing the amino acid normalize the functioning of the heart and kidneys and, accordingly, relieve edema.

Description of pharmacological action

Arginine is an amino acid that can be synthesized in the body independently from other amino acids, but with various diseases or protein deficiency in the diet, its synthesis sharply decreases; age is also one of the factors reducing arginine synthesis. Participation in the body This amino acid is necessary for the synthesis of a number of proteins. The biological participation of L-arginine in the human body is associated with the synthesis of nitric oxide (NO). Most of the effects attributed to arginine are performed by its metabolite, nitric oxide. L-arginine is a precursor to this important substance. What's so great about nitric oxide? NO - Nitric oxide is a substance formed in the body's cells during the oxidation of L-arginine. which then acts as the initiator of a variety of ordered biochemical reactions leading to various biological effects without which the human body could not exist. The role of L-arginine in the body: - Participation in the work of the cardiovascular system - Participation in the work of the nervous system - Participation in the detoxification function of the liver - Participation in the work of the immune system - Structural component of connective tissue - Participation in the work of the reproductive system - Participation in the work of the gastrointestinal tract , gastroprotective effect Participation in the work of the cardiovascular system Scientists have given the name Endothelial Relaxing Factor to nitric oxide; it is no coincidence that it is the most important regulator of the vascular system. Its main effect is the ability to influence the tone of blood vessels, or more precisely, to relax them (relieve spasms). The work of the heart muscle improves. L-arginine, like other NO donors, can not only prevent, but also stop an attack of angina. Due to the relaxation of blood vessels, the flow of blood, and therefore oxygen, to the heart muscle increases. The heart is again able to “breathe” in accordance with its load. In some countries (Japan, Greece), in case of an acute attack of angina, L-arginine is used as an emergency drug, in the form of injections. Participation in other vessels Improves blood circulation and oxygen delivery to the vessels of the brain, peripheral vessels (extremities). Increases blood flow to the external genitalia. According to the authors [1], it improves microcirculation of the vessels of the eye and reduces intraocular pressure. Taking L-arginine is accompanied by improved dynamics in patients with diabetes due to improved endothelial function [2, 3]. A decrease in NO is one of the prerequisites for the occurrence and progression of atherosclerosis. The authors suggest using L-arginine and antioxidants together to lower cholesterol levels and reduce the progression of atherosclerosis [4]. Participation in the functioning of the nervous system L-arginine is involved in communication between nerve cells. Promotes synaptic plasticity and improves memory, and is also a mediator (pulse transmitter), causing relaxation of smooth muscle cells of the digestive tract, bronchi, etc. Participation in the detoxification function of the liver. With arginine deficiency, the system responsible for removing ammonia from the body primarily suffers. and its neutralization. This system involves the liver and kidneys, and the chain of biochemical reactions is called the ornithine cycle. The ornithine cycle or, in other words, the urea cycle is a cyclic enzymatic process of successive transformations of the amino acid ornithine, leading to the synthesis of urea. The ornithine cycle is the most important way to neutralize ammonia; if it fails, the entire body suffers, primarily the liver and kidneys, because a high concentration of urea leads to their damage. Arginine and the immune system NO synthesized in macrophages and monocytes ensures their cytotoxic and cytostatic activity towards foreign cells, including microbial ones, activates T-lymphocytes and immunoglobulin E. Arginine and connective tissue L-arginine is part of collagen, which strengthens the framework of muscles and cartilage. Arginine and the reproductive system Not only erectile function, but also spermatogenesis depends on the normal level of L-arginine in the body. It is known that against the background of L-arginine deficiency, the composition of sperm changes. Arginine – to whom and when is it useful? As a general tonic for the prevention of diseases of the cardiovascular system and liver. A diet low in nutrients, the recovery period after taking hepatotoxic drugs and previous intoxications, during periods of increased physical activity.

Contraindications

Contraindications to taking arginine:

• pregnancy and lactation;
• children under 3 years old;
• teenagers during puberty;
• hypotension;
• asthma;
• individual intolerance to the components in the composition;
• severe diseases of the liver, kidneys, gastrointestinal tract;
• mental disorders.

Supplements should be prescribed with caution for endocrine pathologies, electrolyte metabolism disorders, and renal failure.

Attention! Before taking dietary supplements, you need to consult a specialist.

What is arginine?

Arginine
is a conditionally essential amino acid that was first isolated in 1886. In the human body, arginine is produced in sufficient quantities for normal functioning, but it should be noted that its production occurs only in the body of adult, healthy people. After 35 years, the body begins to produce less of this acid. Additionally, under conditions of stress or illness, the need for this substance increases, so in such cases it is advisable to consider obtaining this important amino acid through supplementation, especially over the age of 35.

Dosage and rules of administration

According to the instructions, you should start using arginine in small doses, this reduces the risk of side effects. You need to increase the rate gradually. The daily dose of arginine is 6.1 g. Bodybuilders can take up to 9 g. The dosage of arginine in children depends on age:

• 3-12 years – 3-10 mg 2 times a day;
• over 12 years old – 12-15 mg.

When and how best to take arginine depends on the purpose of use. To activate growth hormone, children need to drink the supplement before bedtime, since this is when the child grows. To achieve better results in sports, you should take dietary supplements 30-60 minutes before training. For other purposes, arginine can be taken at night, as well as 1 hour before or after meals, up to 2-3 times a day.

Attention! Taking arginine should not be combined with eating fatty foods.

The amino acid is also not recommended to be taken for a long time. The course of taking arginine is 30 days. You can repeat it after 2 weeks.

Reception depending on the form of release

Arginine in capsules and tablets should be taken 2-3 times a day, 1-2 pieces. The liquid form should be diluted with water and taken 30 minutes before a meal or workout. The powder must be mixed with liquid (200 ml). The daily dose is 3 g, it should be divided into 2 or 3 doses.

How to take arginine?

Most bodybuilders find it beneficial to take supplements containing arginine. If you are not one of them, then most likely you are using them incorrectly.

It is important to consume archi an hour before training. After this time, the level of nitric oxide in the body begins to rise. Expansion of the vascular lumen leads to abundant saturation of muscle fibers with oxygen, amino acids, monosaccharides (glucose) and anabolic hormones. Increased blood flow gives a powerful pump. At the same time, somatotropin is increted. Therefore, advice: take the amino acid not only before the training process, but also in the evening. This way you will increase the formation of growth hormone at night. Experts advocate taking arginine in the morning in combination with protein or BCAA. This will help keep your growth hormone levels high throughout the day.

Do not start taking the drug with large doses. Usually take 3-5 g per dose. The dosage is calculated based on your own weight: 115 mg of arginine per calculated unit (kilogram) of body weight. Some athletes recommend using the drug with 150 mg of ginseng root.

In the morning the supplement is taken on an empty stomach, at other times an hour before eating or an hour after it. When taken simultaneously with food, absorption will be weak. And further. If the diet contains foods rich in fats, then at least 4-6 hours should pass before taking. Before training, first take arginine and then a protein shake.

Pure L-arginine in powder form is poorly absorbed, and the taste leaves much to be desired. If you do not see results from taking amino acids, use other forms, for example, drinking ampoules or lightly carbonated drinks containing arginine, taurine and L-carnitine. Their bioavailability is quite high.

Side effects

Side effects after taking arginine occur when the dose is exceeded, as well as individual intolerance. They are accompanied by the following symptoms:

• nausea, vomiting, diarrhea;
• dizziness, headache;
• tinnitus;
• weakness;
• decreased blood pressure (BP);
• fever;
• numbness of the limbs;
• increased excitability.

If you take the amino acid for a long time, this will lead to a decrease in immunity and activation of herpes infection.

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What foods contain arginine?

Sufficient amounts of arginine can be obtained from food. Its highest concentration is found in nuts, pumpkin seeds, as well as meat and fish. It is found in peas, cottage cheese, eggs. It is worth noting that after heat treatment the level of amino acids in food decreases. In order for arginine to enter the body in sufficient quantities, such foods must be consumed in large quantities. For example, you need to consume six chicken eggs a day or 350 grams of pork. It is not always possible to follow such a meal plan. The menu, of course, needs to be varied, and for athletes who adhere to sports nutrition, it is advisable to include special supplements in the diet in the form of pure arginine, or in combination with other amino acids.

Reviews about the application

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L-arginine

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Based on the reviews, the following advantages were identified:

• amino acid-based preparations provide a pumping effect after training;
• help build muscles;
• tone and speed up recovery after physical activity;
• charge with energy.

Buyers consider the only drawback to be the bitter aftertaste of the powder.

Arginine for athletes

This amino acid is widely used among weightlifters and bodybuilders for three main reasons:

1. It promotes internal secretion of growth hormone;
2. Involved in the synthesis of creatine;
3. It is a donor of nitric oxide.

A study of twenty weightlifters who were prescribed three grams of L-arginine for 8 weeks showed the amino acid's effects on muscle growth, with all participants experiencing significant gains in mass and muscle mass compared to the control group.5

Alcohol compatibility

The amino acid should not be taken at the same time as alcohol, as ethanol destroys this substance. However, arginine is a hepatoprotector and protects the liver from the negative effects of alcoholic beverages. It can be taken during alcohol intoxication to quickly cleanse the organs of ethanol breakdown products.

Under conditions of intense physical and emotional stress, the body experiences a deficiency of L-arginine. To avoid deficiency, you can take a supplement containing this amino acid. But it is better to consult a doctor first, since only he can accurately develop a dosage regimen for the drug.

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Why should you take L-arginine?

Arginine synthesis is ensured only by a young, healthy body. With age, this ability decreases, but the need for it continues to remain high. After 50 years, the natural production of this amino acid practically stops. Unfortunately, today, according to doctors, low levels of arginine are observed in very young people. This leads to the formation of an insufficient amount of oxidized nitrogen, which today scientists see as the main cause of the “diseases of the century.” They associate this with poor quality products, bad habits, stress and poor lifestyle. Be that as it may, L-arginine deficiency can be compensated for by eating foods containing it: all types of meat, eggs, beef liver, caviar; milk and fermented milk products (whey, cottage cheese, homemade cheeses); fish (preferably from the salmon family); nuts, seeds; the entire legume family; mushrooms.

All of these foods can be included in the diet, but there is an easier and more effective way - taking supplements that include arginine.