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Manufacturers: Akrikhin
Active ingredients
- Sucralfate
Disease class
- Stomach ulcer
- Duodenal ulcer
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antiulcer
Pharmacological group
- Gastroprotectors
Pharmacodynamics and pharmacokinetics
The composition of the drug includes the active substance - sucralfate - a disaccharide, including aluminum hydroxide and sucrose sulfate. When taking the drug, rapid healing of peptic ulcers , prevention of the development of gastric and duodenal , and protection of the gastric mucous membranes from the influence of pepsin and hydrochloric acid .
Treatment with Venter can reduce pepsin by 30%, without having any particular effect on the acidity of gastric juice. In this case, the mechanism of action of the drug is based on the binding of sucralfate to the proteins of the affected tissues of the mucous membranes, causing the formation of a protective film on the surface of the ulcer. The drug accelerates the regeneration of damage, scarring of ulcers, prevents the development of relapses of ulcers and the formation of stress ulcers . The absorption of phosphates in the gastrointestinal tract also decreases.
When taken orally, the substance is slightly absorbed into the systemic circulation. In the body, the drug does not form clinically significant concentrations in plasma and does not exhibit a systemic effect. The substance is not metabolized inside the body. Partial excretion of the drug occurs through the kidneys, the rest - unchanged through the intestines.
Venter oral tablets
Instructions for medical use of the drug
Description of pharmacological action
Gastroprotective agent. By interacting with the proteins of necrotic ulcer tissue, it forms a protective layer that prevents the further destructive effect of pepsin, hydrochloric acid and bile salts. Increases prostaglandin synthesis, reduces pepsin activity and binds bile salts. Inhibits pepsin activity by 30%. Has a weak antacid effect. Being in the stomach and duodenum, it is transformed into a polyanion with many free negative charges, which form strong bonds with positive radicals of protein-like exudate (albumin, fibrinogen) of the mucous membrane. Interaction with unchanged mucous membrane is insignificant.
Indications for use
Peptic ulcer of the stomach and duodenum.
Release form
tablets 1 g; blister 10, cardboard pack 5; tablets 0.5 g; contour packaging 10, cardboard pack 10; tablets 0.5 g; contour packaging 20, cardboard pack 5;
Pharmacokinetics
Absorption is low - 3-5% of the administered dose (up to 5% of the disaccharide component and less than 0.02% of aluminum). Excreted through the intestines - 90% unchanged; a small amount of sulfate disaccharide that enters the bloodstream is excreted by the kidneys.
Use during pregnancy
Use with caution during pregnancy and lactation.
Contraindications for use
Severe renal dysfunction, dysphagia or gastrointestinal obstruction, gastrointestinal bleeding, hypersensitivity to sucralfate.
Side effects
From the digestive system: constipation, diarrhea, nausea, dry mouth, gastralgia. From the central nervous system: drowsiness, dizziness, headache. Dermatological reactions: skin itching, rash, urticaria. Other: pain in the lumbar region.
Directions for use and doses
Orally for adults, 0.5-1 g 4 times a day. or 1 g morning and evening, or 2 g 2 times a day. 1 hour before meals and before bedtime. The maximum daily dose is 12 g. The average duration of treatment for peptic ulcer is 4-6 weeks, if necessary - up to 12 weeks. Children - 0.5 g 4 times a day. In patients with hyperphosphatemia, when plasma phosphate concentrations decrease, the dose of sucralfate may be reduced.
Overdose
Not described.
Interactions with other drugs
When used simultaneously with indirect anticoagulants, their anticoagulant activity (including warfarin) may decrease. With simultaneous use, the absorption of antimicrobial agents of fluoroquinolone derivatives is reduced. With simultaneous use, the absorption of amitriptyline is reduced, which may lead to a decrease in its clinical effectiveness. It is believed that with simultaneous use, the formation of chelate complexes with amphotericin B sucralfate, colistin sulfate, and tobramycin is possible, which can lead to a decrease in their antimicrobial activity. When used simultaneously with digoxin, the absorption of digoxin may be reduced. It is believed that with simultaneous use there may be a slight decrease in the absorption of ketoconazole and fluconazole. When used simultaneously with levothyroxine, the effectiveness of levothyroxine is noticeably reduced. When used concomitantly with sucralfate, slight changes in the pharmacokinetics of theophylline were observed. It is also believed that there may be a significant reduction in the absorption of theophylline from sustained release dosage forms. It is believed that with simultaneous use, a decrease in the absorption of tetracycline is possible. With simultaneous use, the absorption of phenytoin and sulpiride decreases. A case has been described of a decrease in the concentration of quinidine in the blood plasma when used simultaneously with sucralfate. With simultaneous use, a slight decrease in the bioavailability of cimetidine, ranitidine, and roxatidine cannot be ruled out.
Special instructions for use
If simultaneous use of antacids is necessary, they should be taken 30 minutes before or 30 minutes after taking sucralfate. In case of renal failure, monitoring of serum aluminum and phosphate concentrations is necessary. The appearance of drowsiness and convulsions may indicate manifestations of the toxic effects of aluminum. Short-term treatment can lead to complete scarring of the ulcer, but does not change the frequency and severity of relapses of peptic ulcer disease after scarring. The administration of sucralfate through a nasogastric tube may lead to the formation of a bezoar (a stone formed in the digestive tract and shaped like a ball) with other drugs or enteral nutrition solutions, because. sucralfate can bind protein.
Storage conditions
List B: In a dry place, protected from light, at a temperature not exceeding 25 °C.
Best before date
36 months
ATX classification:
A Digestive tract and metabolism
A02 Drugs used for conditions associated with acidity disorders
A02B Antiulcer agents and drugs used for gastroesophageal reflux
A02BX Other antiulcer drugs
A02BX02 Sucralfate
Side effects
During treatment with Venter, the following may develop: constipation , nausea , flatulence, vomiting , diarrhea , dry mouth, headache, drowsiness , dizziness, gastralgia , lower back pain, allergic reactions and so on.
Venter granules and tablets, instructions for use (Method and dosage)
According to the instructions for use of Venter, the drug in tablets or granules is taken orally. In this case, the tablets are swallowed whole with the required amount of water. When the whole tablet is difficult to swallow, it can be dissolved in water and then drunk. The granules must be pre-dissolved in water.
The prepared solution should be taken 30-60 minutes before meals. The duration of therapy is determined by a specialist, taking into account the complexity of the disorder and the individual characteristics of each patient.
For adult patients, the daily dosage is 2 tablets or 2 sachets - one taken before lunch, the second before bed.
If the patient is diagnosed with hyperphosphatemia , then the dosage is reduced. The presence of peptic ulcers allows the daily dose to be increased by 2 times. The therapeutic course for patients with peptic ulcers of the stomach and duodenum is about 12 weeks. The disappearance of symptoms is not a signal to discontinue the drug; as a rule, treatment is continued until a diagnostic examination that confirms scarring of the ulcers.
Prevention of stress ulcers is carried out by prescribing for adult patients one tablet or a bag of granules to be taken 6 times a day. To prevent relapse of peptic ulcers, take one tablet or sachet 2 times a day. The maximum permissible daily dosage is 8 tablets or sachets. In case of renal dysfunction, patients have a reduced therapeutic course.
Children over 4 years old are recommended to take 0.5-1 tablet no more than 4 times a day. It is not recommended to take the drug in the form of granules in childhood.
Special instructions for the use of the drug Venter
The small amount of aluminum contained in sucralfate is absorbed in the digestive tract and subsequently excreted in the urine. In case of severe renal dysfunction, aluminum may accumulate in the body with the development of its toxic effect. The risk of accumulation increases with simultaneous administration of other drugs containing aluminum (for example, some antacids). The safety and effectiveness of sucralfate in children under 4 years of age have not been sufficiently studied, so it is not recommended to prescribe the drug to children in this age group. The drug can be used during pregnancy only when the expected benefit to the expectant mother outweighs the potential risk to the fetus. There is no evidence that sucralfate passes into breast milk, so it should be used with caution during breastfeeding.
Overdose
This drug is generally well tolerated by patients, so the risk of overdose is minimized
However, when taking Venter in high doses, intolerance reactions or allergy symptoms may worsen. In this case, the following may develop: nausea, vomiting, abdominal pain, irritation and skin rashes. Such cases require symptomatic therapy.
If patients have renal failure, then with long-term treatment aluminum intoxication encephalopathy or osteomalacia . This requires urgent discontinuation of treatment, hemodialysis, hemofiltration, peritoneal dialysis and deferoxamine.
Interaction
Concomitant use with antacids requires an interval between doses of at least 30 minutes.
Combination therapy can reduce the absorption of tetracyclines , cimetidine, ciprofloxacin, ranitidine, norfloxacin, digoxin , indirect anticoagulants, ofloxacin and theophylline . In this case, it is also necessary to maintain an interval that should be more than 2 hours.
The combination of Venter and Phenytoin reduces the absorption and normal concentration of phenytoin , which can cause resumption of seizures. Therefore, it is important to maintain a 2-hour interval.
Venter drug interactions
Antacids can be prescribed during treatment with sucralfate, but they should be taken at least 30 minutes before taking sucralfate or 1.5 hours after taking it. Medicines containing aluminum compounds (for example, some antacids) may cause aluminum to accumulate in the body in patients with kidney failure. Sucralfate may reduce the absorption of certain drugs, such as tetracycline, cimetidine, ranitidine, fluoroquinolones, digoxin, theophylline, warfarin, ketoconazole, levothyroxine, quinidine and phenytoin. These medications should be taken at least 2 hours before taking sucralfate. Sucralfate may bind to some food proteins. For patients being fed by gastric tube, sucralfate should be administered separately from food and other medications.
Venter's analogues
Level 4 ATC code matches:
Ventrisol
Novobismol
Vis-Nol
De-Nol
Gastrocepin
Dalargin
Vikair
Omez DSR
Omez D
Gastrofarm
Gaviscon
Vikalin
The main analogues of Venter are represented by the following drugs: Alsukral, Ankrusal, Sucralfate, Sukrat and Ulgastran.
Also, a similar effect is typical for: De-Nol, Maalox, Almagel and Rennie.
Reviews about Venter
Various forms of disorders of the digestive system and gastrointestinal tract bother many people. At the same time, for some, these may be minor deviations caused by overeating or other malnutrition, while for others, more complex and aggravated forms in the form of ulcers and gastritis . In any case, there are a lot of reviews about Venter and drugs that have a similar effect on the Internet.
Users report that this medicine affects different people differently and does not always help get rid of problems in the gastrointestinal tract. At the same time, they say that they started taking Venter after recommendations from friends, random people on the Internet, or pharmacy employees. It should be noted that in addition to this drug, they also took Omez, Phosphalugel, Rennie, and so on at different times.
Thus, it may take a long time to independently select a drug until the stomach pain increases significantly. Only after this do patients turn to a specialist who diagnoses them with a serious disorder. However, most people do not blame themselves for this, but the pills, which turned out to be useless and did not help them recover. Therefore, there is no need to prolong the pain until it worsens, but you should immediately consult a doctor.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Venter, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Venter is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Venter price, where to buy
The price of Venter in tablets in Russian pharmacies varies between 200-250 rubles.
It is quite difficult to buy the drug in granules in Russian pharmacies. In Ukraine, its cost is 133 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Venter granules 1g No. 50
RUB 4,880 order - Antepsin (analogue of Venter) 1 g tablet No. 60
2700 rub. order
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Pharmacy24
- Venter 1 g No. 50 tablets KRKA, Slovenia
206 UAH. order
