Gelarium Hypericum - description of the drug, instructions for use, reviews

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Manufacturers: Bionorica AG

Active ingredients

  • Not indicated. See instructions

Disease class

  • Not indicated. See instructions

Clinical and pharmacological group

  • Not indicated. See instructions

Pharmacological action

  • Anxiolytic
  • Antidepressant

Pharmacological group

  • Not indicated. See instructions

Pharmacodynamics and pharmacokinetics

The active component of the drug, St. John's wort extract , prevents the development of neurotransmitter transmission disorders, modulates the secretion of interleukin-6 and inhibits catechol-O-methyltransferase and monoamine oxidase. At the same time, manifestations of emotional lability, depressed mood, anxiety and tension disappear.

There are no data available on the pharmacokinetics of Gelarium Hypericum.

Pharmacological properties of the drug Gelarium hypericum

Antidepressant of plant origin. A standardized extract from the herb St. John's wort prevents the development of neurotransmitter transmission disorders (norepinephrine, serotonin), inhibits MAO and catechol-O-methyltransferase, modulates the secretion of interleukin-6, which determines the mechanism of its antidepressant and anxiolytic action (eliminates feelings of anxiety, tension, improves mood). Due to the presence of the drug, in addition to its own antidepressant effect, adaptogenic and anxiolytic properties, its use is advisable for complex (comorbid) anxiety-depressive conditions. The drug is indicated for neurotic depression. After oral administration, the maximum concentration of active substances in the blood plasma is achieved after 5 hours for hypericin and 3 hours for pseudohypericin. Compared to pseudohypericin, hypericin enters the blood with some delay, which is obviously due to their different lipophilic properties. The half-life of hypericin and pseudohypericin has a high level of variability and is 10–37 and 6–30 hours, respectively.

Contraindications for use

It is not recommended to take Gelarium Hypericum if:

  • individual hypersensitivity to it;
  • children under 12 years of ;
  • lactase deficiency, lactose and fructose intolerance, glucose-galactose malabsorption, sucrase or isomaltase deficiency;
  • the presence of photosensitivity of the skin to UV radiation;
  • simultaneous use with Cyclosporine , Tacrolimus , indinavir , amprenavir and other HIV protease inhibitors, for example, in the treatment of HIV-positive patients, as well as with warfarin, irinotecan and MAO inhibitors. In such cases, it is necessary to maintain an interval of at least 14 days;
  • lactation, pregnancy.

Aerosol Helarium Hypericum

Instructions for medical use of the drug

Description of pharmacological action

Gelarium Hypericum is a drug that has antidepressant and anxiolytic effects. The drug contains a standardized extract of St. John's wort, which prevents disturbances in neurotransmitter transmission, modulates the secretion of interleukin-6 and inhibits monoamine oxidase and catechol-O-methyltransferase. Gelarium Hypericum eliminates the phenomena of emotional lability, depressed mood, tension and anxiety. Standardized St. John's wort extract induces enzymes of the cytochrome P450 system, in particular CYP 3A4.

Indications for use

Psychovegetative disorders, neurotic reactions (conditions expressed by increased anxiety, tension and restlessness), mild to moderate depression.

Release form

Film-coated tablets/dragees, Gelarium Hypericum in blister packs of 15 pieces, 2 or 4 blister packs are included in a cardboard box.


The use of the drug improves mood, increases mental and emotional stability. The drug has an anxiolytic and antidepressant effect.


The pharmacokinetics of Gelarium Hypericum are not presented.

Use during pregnancy

Gelarium Hypericum is not recommended for pregnant women. Standardized St. John's wort extract can be taken during lactation only if breastfeeding is interrupted.

Contraindications for use

Children under 12 years old. Established hypersensitivity to light. Individual hypersensitivity to the components of the drug. When treating HIV-positive patients with cyclosporine, indinavir, and other protease-inhibiting substances, the use of Gelarium® Hypericum is contraindicated.

Side effects

Allergic reactions, gastrointestinal complaints, fatigue, and anxiety are possible. Photosensitivity may occur, especially in fair-skinned individuals.

Directions for use and doses

Adults and children over 12 years of age, take 1 tablet 3 times a day with meals with liquid, without chewing, for a course of at least 4 weeks.


There have been no reports of cases of overdose of Gelarium Hypericum. When taking high doses of the drug, ultraviolet radiation should be avoided for at least 2 weeks to prevent the development of severe photosensitivity reactions.

Interactions with other drugs

Gelarium Hypericum, when used in combination, may reduce the effectiveness of coumarin anticoagulants, simvastatin, amitriptyline, digoxin, theophylline, nortriptyline and antihypertensive drugs of the beta-adrenergic blocker group. When used simultaneously, the drug may reduce the effectiveness of oral estrogen-containing contraceptives; in addition, with this combination, intermenstrual bleeding may develop. The combined use of St. John's wort extract with nefazodone, paroxetine and sertraline is prohibited due to an increased risk of developing serotonergic effects. An interval of at least 2 weeks should be observed between taking these drugs. A mutual enhancement of the photosensitizing effect is possible with the combined use of drugs that cause photosensitivity and the drug Gelarium Hypericum.

Special instructions for use

It is not recommended to use together with antidepressants (MAO inhibitors), coumarin anticoagulants (phenprocoumon, warfarin), cyclosporine, digoxin, indinavir, amitriptyline, nortriptyline, theophylline, as well as with oral contraceptives. The medicine does not affect the ability to drive. Do not use during pregnancy and lactation.

Storage conditions

Store for no more than 3 years after production in rooms with a temperature not exceeding 25 degrees Celsius. The drug should be protected from exposure to direct sunlight.

Best before date

24 months

Side effects

During treatment with Gelarium Hypericum, allergic reactions may develop: rashes, itching, eczema, skin pigmentation , sensitivity to UV rays, and so on.

anxiety , severe fatigue and headaches are also possible .

The digestive system often suffers, which is manifested by nausea , abdominal pain , dryness oral mucosa , flatulence, diarrhea or constipation, and anorexia .

In addition, disorders of the hematopoietic organs, for example, iron deficiency anemia, .

Instructions for Gelarium Hypericum (Method and dosage)

The tablets are intended for oral administration in their entirety. According to the instructions for use of Gelarium Hypericum, in order to obtain the maximum therapeutic effect and reduce the risk of side effects, the medicine should be taken simultaneously with food .

The duration of treatment and permissible dosages of the drug are determined by the attending physician, taking into account the nature of the disease and the individual characteristics of the patient. For adults and adolescents, the standard dose is usually one tablet 3 times a day . As a rule, the duration of the therapeutic course should not be less than 4 weeks. When patients do not notice an improvement in their condition within one month from the start of treatment, the diagnosis needs to be clarified and the treatment regimen adjusted.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Gelarium Hypericum, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Gelarium Hypericum is provided for informational purposes only and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Simultaneous use of Gelarium Hypericum with indirect anticoagulants - phenprocoumon, warfarin, imatinib and other cytostatics, midazolam, digoxin, amitriptyline, fexofenadine, benzodiazepine, nortriptyline, theophylline, methadone, verapamil, simvastatin and finasteride can significantly reduce their effectiveness.

Combination therapy with antidepressants , for example: nefazodone, paroxetine, sertraline, Buspirone, triptans, often leads to an increase in their effect, as well as the development of undesirable symptoms: nausea, vomiting, fear, anxiety, confusion .

Sometimes, when taken together, Gelarium Hypericum enhances the photosensitizing effect of a number of drugs: tetracyclines, thiazide diuretics, sulfonamides, quinolones and piroxicam.

Also, this drug may prolong the sleep caused by general anesthesia or narcotic analgesics, but shortens the sleep caused by barbiturates. A decrease in the hypotensive effect of reserpine and a decrease in the concentration of cyclosporine and indinavir in the blood were noted.

Concomitant use with desogestrel and ethinyl estradiol increases the risk of bleeding and metabolic rate. of digoxin in the blood and its effectiveness decrease

oral contraceptives are taken during treatment , then patients need to take care of additional methods of contraception.

Drug interactions Gelarium hypericum

Simultaneous use with a number of drugs can lead to a decrease in their effectiveness: anticoagulants of coumarin derivatives (phenprocoumon, warfarin), indinavir, verapamil, cyclosporine, theophylline, digoxin. Simultaneous use with oral hormonal contraceptives in some cases may be accompanied by intermenstrual bleeding, and with other photosensitizing drugs - an increase in their effect. Concomitant use with antidepressants - MAO inhibitors can enhance the serotonergic effect, so there should be an interval of at least 14 days between taking these drugs.


Level 4 ATC code matches:




















The main analogues of Gelarium Hypericum are the following drugs: Deprim, Cipralex, Rexetine and Fluoxetine .

Reviews of Gelarium Hypericum

As reviews of Gelarium show, it is taken by patients who are concerned about a wide variety of disorders associated with the activity of the nervous system. Many users say that before they were prescribed this drug, they were prescribed other medications. However, it is taking Gelarium Hypericum that really helps eliminate unpleasant symptoms.

The drug is often prescribed to patients with nervous breakdowns, panic attacks, anxiety, fears and rapid heartbeat . It is also actively used in the form of maintenance therapy for patients with vegetative-vascular dystonia . Most people note a long-lasting and sustainable effect.

As for the specialists, they are sure that for such patients one dose of the drug will not be enough. Therefore, doctors’ reviews often contain additional recommendations for psychological work on oneself in the form of consultations with a psychologist, pleasant communication with loved ones, meditation, listening to soothing music and maintaining a harmonious mood. Only this approach helps strengthen a person’s physical and moral condition.

Helarium® hypericum

Manufacturer: BIONORICA AG (Germany)

◊ dragees: 30, 60 or 100 pcs. Reg. No.: P N014575

Clinical and pharmacological group:

Herbal medicine with antidepressant activity

Release form, composition and packaging


covered with a greenish-yellow shell, round, biconvex.

1 dragee
dry extract of St. John's wort herb285 mg,
 which is resp. content of the sum of hypericins in terms of hypericin 900 mcg


highly dispersed silicon dioxide, potato starch, lactose, magnesium stearate.

Shell composition:

shellac, talc, calcium carbonate, titanium dioxide (E171), sucrose, kaolin, macrogol, gum acacia, yellow quinoline (E104), green varnish-forming agent (E104/E132).

15 pcs. — contour cell packaging (2) — cardboard packs. 20 pcs. — cellular contour packages (3) — cardboard packs. 25 pcs. — contour cell packaging (4) — cardboard packs.

Description of the active components of the drug "Gelarium® hypericum"

pharmachologic effect

Herbal medicine. It has an antidepressant and anxiolytic effect (relieves anxiety, tension, improves mood).


— psychovegetative disorders (decreased mood, apathy);

- depressive states of mild to moderate severity;

- neurotic reactions.

Dosage regimen

Adults and children over 12 years old

Prescribe 1 tablet 3 times a day.

The course of treatment is at least 4 weeks. The patient should be informed that if symptoms persist for more than 4 weeks, consultation with a physician is necessary.

The pills should be taken with food, without chewing, with water.

Side effect

Dermatological reactions:

photosensitivity (especially in people with fair skin).


rarely - allergic skin reactions, dyspepsia, fatigue, anxiety.


- simultaneous treatment with cyclosporine, indinavir and other protease inhibitors in HIV-positive patients;

- children under 12 years of age;

- established photosensitivity of the skin to ultraviolet radiation;

- hypersensitivity to the components of the drug.

Pregnancy and lactation

Gelarium® Hypericum should not be prescribed during pregnancy and lactation (breastfeeding) due to the lack of sufficient experience in using the drug during these periods.

Application for children

Contraindicated in children under 12 years of age.

special instructions

Do not take the drug simultaneously with antidepressants - MAO inhibitors. The interval between taking these medications should be at least 14 days.

When prescribing the drug to patients with diabetes, it should be taken into account that 1 single dose of the drug contains less than 0.03 XE.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive a car or operate machines.


Cases of acute poisoning with the drug are still unknown. In case of significant overdose, patients should avoid sun exposure and UV exposure for 1-2 weeks.

Drug interactions

With the simultaneous use of Gelarium Hypericum with anticoagulants such as coumarin (phenprocoumon, warfarin), cyclosporine, theophylline, indinavir, digoxin, amitriptyline, nortriptyline, methadone, verapamil, their effectiveness may decrease.

With the simultaneous use of Gelarium Hypericum with nefazodone, paroxetine, sertraline, their effect may be enhanced.

When Gelarium Hypericum is used simultaneously with oral hormonal contraceptives, their effect may be weakened.

The drug enhances the photosensitizing effect of tetracyclines, sulfonamides, thiazide diuretics, quinolones, piroxicam.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored in a dry place, protected from light, at a temperature not exceeding 25°C. Shelf life: 3 years.

Drug interactions

With the simultaneous use of Gelarium Hypericum with anticoagulants such as coumarin (phenprocoumon, warfarin), cyclosporine, theophylline, indinavir, digoxin, amitriptyline, nortriptyline, methadone, verapamil, their effectiveness may decrease.

With the simultaneous use of Gelarium Hypericum with nefazodone, paroxetine, sertraline, their effect may be enhanced.

When Gelarium Hypericum is used simultaneously with oral hormonal contraceptives, their effect may be weakened.

The drug enhances the photosensitizing effect of tetracyclines, sulfonamides, thiazide diuretics, quinolones, piroxicam.

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