Novalgin® (Novalgin)
Symptoms
: (due to paracetamol) during the first 24 hours after an overdose - nausea, vomiting, pain in the epigastric region, pallor of the skin, loss of appetite. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of microsomal liver enzymes). Possible development of carbohydrate metabolism disorders and metabolic acidosis.
In adult patients, liver damage develops after taking 10 g of paracetamol.
If there are factors that influence the toxicity of paracetamol to the liver, liver damage is possible after taking 5 or more grams of paracetamol. In severe cases of overdose, encephalopathy and coma, acute renal failure with tubular necrosis (including in the absence of severe liver damage), arrhythmia, and pancreatitis may develop as a result of liver failure.
Treatment
: within 1 hour after an overdose, gastric lavage, administration of activated charcoal, and symptomatic therapy are recommended.
The administration of acetylcysteine is most effective during the first 8 hours after an overdose; over time, the effectiveness decreases; if necessary, intravenous administration of SH-group donors and precursors for the synthesis of glutathione - methionine is possible over the next 24 hours after an overdose; treatment of such patients is carried out in a specialized department of liver diseases .
High doses of caffeine cause the following symptoms: headache, tremor, irritability, gastralgia, agitation, restlessness, confusion, tachycardia, arrhythmia, hyperthermia, dehydration, increased tactile and pain sensitivity, frequent urination, headache, nausea, vomiting, sometimes with blood, ringing in the ears, convulsions (in case of acute overdose - tonic-clonic).
Treatment
: gastric lavage, taking activated charcoal, laxatives, for hemorrhagic gastritis - administration of antacids, gastric lavage with ice-cold 0.9% sodium chloride solution, maintaining pulmonary ventilation and oxygenation, for convulsions, intravenous diazepam, phenobarbital, maintaining water-electrolyte balance. It should be borne in mind that the appearance of clinically significant symptoms of caffeine overdose when taking this drug is always associated with severe liver damage caused by an overdose of paracetamol.
Oral tablets Novalgin (Novalgin)
Instructions for medical use of the drug
Description of pharmacological action
A combined drug, the effect of which is determined by the components included in its composition. Caffeine has a psychostimulant (stimulates the psychomotor centers of the brain), analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance. Paracetamol and propyphenazone have analgesic and antipyretic effects.
Indications for use
Pain syndrome of moderate severity: headache, toothache, myalgia, post-traumatic pain; febrile syndrome: colds, flu.
Release form
pills; packaging contour charunkova 12, cardboard pack 1; pills; polymer container 30, cardboard pack 1;
Pharmacodynamics
Paracetamol is an analgesic (pain-relieving), antipyretic and antipyretic drug. This is due to the significant influx on the center of thermoregulation in the hypothalamus (in the perineal cord) and the less pronounced inhibition of synthesis (suppressing the creation in the body) of prostaglandins (bi logically active substances that vibrate in the body, which are responsible for the appearance of pain and swelling in burning place). Propiphenazone exhibits analgesic action. Caffeine stimulates the respiratory and vascular centers, increases the tone of the blood vessels in the brain, promotes dilation of the blood vessels of the skeletal muscles, heart, and lowers the aggregation (gluing) of platelets. Relieves changes in sleepiness, increased mental and physical performance.
Pharmacokinetics
The drug should be added quickly and easily absorbed into the shkt. The skin of the three components of the combination binds very weakly to blood plasma proteins. After oral administration, a small part of paracetamol is converted into the highly reactive intermediate product N-acetyl-benzo-quinone imine with further inactivation through the cell glutathione system.
Use during pregnancy
The drug is contraindicated before use during pregnancy and breastfeeding.
Contraindications for use
Individual sensitivity to the components of the drug and other drugs in the group of non-steroidal anti-inflammatory drugs has been increased. The drug is not suitable for the treatment of wives during pregnancy and lactation, as well as for the treatment of children up to 12 years of age. The drug is contraindicated for patients who suffer from impaired liver function, impaired hematopoietic function, as well as patients with glucose-6-phosphate dehydrogenase deficiency, lactase deficiency, etc. and the urinary tract and duodenum. The drug should be used with caution in patients who suffer from liver disease and/or mild hyperbilirubinemia. In addition, caution should be exercised when administering the drug Revalgin to elderly patients. When the drug was administered in recommended doses, there was no indication that it would be necessary to control potentially unsafe mechanisms and drive a car.
Side effects
When taking the drug, patients experienced the development of the following side effects: On the side of the intestinal tract: nausea, vomiting, pain in the epigastric region. On the side of the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, methemoglobinemia, hemolytic anemia. Allergic reactions: skin visip, itching, kropiv'yanka, Quincke's stain.
Directions for use and doses
The drug is taken orally, it is recommended to crush the tablet whole, without chewing or crushing it, with plenty of water. It is recommended to take the drug after taking it. The validity of the course of treatment and dose of the drug depends on the medicine individually for each patient. As we grow older, take 1-2 tablets of the drug 1-3 times per dose. It is also possible to take the drug one-time for acute pain. Children aged 12 to 16 years are usually prescribed 1 tablet of the drug 1-3 times per day. The maximum dosage for adults is 6 tablets. The maximum dosage for children aged 12 to 16 years is 3 tablets. It is not recommended to take the drug more than 10 days after sleep. In cases where the duration of the course of treatment exceeds 5 days, liver function and peripheral blood patterns are monitored.
Overdose
When increasing doses of the drug are administered, patients experience the development of leukopenia, agranulocytosis, hemolytic anemia, as well as liver and liver disorders up to liver failure. With further increased doses, the development of methemoglobinemia is possible. In case of overdose, rinsing the tube, taking enterosorbents and carrying out symptomatic therapy is indicated. In case of paracetamol withdrawal, administration of N-acetylcysteine and methionine is indicated.
Interactions with other drugs
When left to stand for one hour, the drug potentiates the effects of oral antidiabetic drugs, sulfonamides and anticoagulants. With one-hour administration of the drug with corticosteroids, the remaining ulcerogenic effect was strengthened. Cholestyramine, anticholinergic drugs, antidepressants and antidepressants when taken overnight with the drug Novalgin reduce its therapeutic effect. When the drug is administered simultaneously with anti-drug drugs, ethyl alcohol and barbiturates, the hepatotoxic effect is enhanced.
Special instructions for use
Excessive consumption of caffeine-containing products (kava, tea) against the background of a bath may cause symptoms of overdose. In case of trival (more than 1 week) leakage, it is necessary to control the peripheral blood picture and the functional state of the liver. Without consulting a doctor, take no more than 3 days for treatment of fever syndrome and no more than 5 days for pain syndrome. You can change the results of doping control analyzes for athletes. It complicates the diagnosis of acute gastrointestinal tract. Patients who suffer from atopic bronchial asthma have polynoses and are at risk of developing allergic reactions. During the hour of bathing, there may be a risk of ingestion of ethanol (increasing the risk of hepatotoxicity).
Storage conditions
For the stolen one, the place is bright.
Best before date
36 months
ATX classification:
N Nervous system
N02 Analgesics
N02B Analgesics and antipyretics
N02BE Anilides
N02BE71 Paracetamol in combination with psychotropic drugs
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Novalgin, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Novalgin is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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NOVALGIN
Interaction
Paracetamol reduces the effectiveness of uricosuric drugs.
The simultaneous use of paracetamol in high doses increases the effect of anticoagulants (decreased synthesis of procoagulant factors in the liver).
Inducers of microsomal liver enzymes, ethanol and hepatotoxic agents increase the production of: hydroxylated. metabolites of paracetamol, which makes it possible to develop severe intoxications even with a slight overdose.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
When used simultaneously with ethanol, it improves. risk of developing acute pancreatitis.
Myelotoxic drugs enhance the hematotoxicity of paracetamol.
Caffeine is an adenosine antagonist (larger doses of adenosine may be required).
When used simultaneously; caffeine and inducers of microsomal liver enzymes may enhance metabolism and increase caffeine clearance; inhibitors, microsomal liver enzymes - decreased metabolism of caffeine in the liver.
Mexiletine reduces caffeine excretion by up to 50%; Nicotine increases the rate of caffeine elimination.
Monoamine oxidase inhibitors; furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure.
Caffeine reduces the absorption of calcium from the gastrointestinal tract; reduces the effect of narcotic and sleeping pills; increases the excretion of lithium drugs in the urine; accelerates absorption and enhances the effect of cardiac glycosides, increasing their toxicity.
Concomitant use of caffeine with p-blockers may lead to mutual suppression of therapeutic effects; with β-adrenergic agonists - to additional stimulation of the central nervous system and other additive toxic effects.
Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects.
Propyphenazone can enhance the effect of oral hypoglycemic agents, sulfonamide drugs, anticoagulants, the ulcerogenic effect of glucocorticosteroids, and reduces the effectiveness of potassium-sparing diuretics.
Absorption of the drug components may be reduced when used simultaneously with cholestyramine; m-anticholinergics, antidepressants.
Novalgin tablets 50 mg+200 mg+200 mg 10 pcs.
Paracetamol reduces the effectiveness of uricosuric drugs. The simultaneous use of paracetamol in high doses increases the effect of anticoagulants (decreased synthesis of procoagulant factors in the liver). Inducers of microsomal liver enzymes, ethanol and hepatotoxic drugs increase the production of hydroxylated metabolites of paracetamol, which makes it possible to develop severe intoxications even with a small overdose. Long-term use of barbiturates reduces the effectiveness of paracetamol. When used simultaneously with ethanol, the risk of developing acute pancreatitis increases. Myelotoxic drugs enhance the hematotoxicity of paracetamol. Caffeine is an adenosine antagonist (larger doses of adenosine may be required). With the simultaneous use of caffeine and inducers of microsomal liver enzymes, it is possible to enhance metabolism and increase the clearance of caffeine; inhibitors of microsomal liver enzymes - decreased metabolism of caffeine in the liver. Mexiletine reduces caffeine excretion by up to 50%; Nicotine increases the rate of caffeine elimination. Monoamine oxidase inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or severe. increased blood pressure. Caffeine reduces the absorption of calcium from the gastrointestinal tract; reduces the effect of narcotic and sleeping pills; increases the excretion of lithium drugs in the urine; accelerates absorption and enhances the effect of cardiac glycosides, increasing their toxicity. Concomitant use of caffeine with β-blockers may; lead to mutual suppression of therapeutic effects; with β-adrenomimetics - to additional stimulation of the central nervous system and other additive: toxic effects. Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects. Propyphenazone may enhance the effect of oral hypoglycemic agents, sulfonamide drugs, anticoagulants, the ulcerogenic effect of glucocorticosteroids, and reduce the effectiveness of potassium-sparing diuretics. Absorption of the components of the drug may be reduced when used simultaneously with cholestyramine, m-anticholinergics, and antidepressants.
