Instructions for use UNIDOX SOLUTAB®

Pharmacodynamics and pharmacokinetics

Is Unidox Solutab an antibiotic or not?

The active ingredient of the drug doxycycline is an antibiotic from the tetracycline group. It inhibits the activity of pathogenic bacteria, affecting the ribosomal membranes in the cell. It does not allow the processes of RNA synthesis of some organisms to occur.

The medicine is active against such gram-positive bacteria as Streptococcus haemolyticus, Streptococcus viridans, Listeria spp., Streptococcus faecalis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis.

The drug inhibits the vital activity of gram-negative bacteria: Bacillus anthracis, Neisseria meningitidis, Brucella spp., Escherichia coli, Neisseria gonorrhoeae, Haemophilus influence, Clostridium spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Entamoeba., Shigella spp. etc.

Doxycycline is also used to treat diseases caused by Mycoplasma spp., Rickettsia spp., Chlamydia spp. and Spirochaeta spp. .

Doxycycline is absorbed from the gastrointestinal tract. Within 2 hours after administration, it can be detected in almost all tissues of the body (teeth, saliva), with the exception of cerebrospinal fluid. About half of the drug is excreted by the kidneys, the rest through the gastrointestinal tract. The drug can be detected in blood plasma after 19 hours with a single dose and after 48 hours during a course.

Indications for use

What are Unidox Solutab tablets for?

The drug is prescribed for the treatment of diseases caused by microorganisms sensitive to doxycycline:

• ENT diseases: otitis media, tonsillitis , etc.;
• respiratory tract diseases: pharyngitis , tracheitis , lung abscess , acute and chronic bronchitis ;
• cystitis , prostatitis , pyelonephritis , urethritis , endometritis ;
• PPI: for ureaplasmosis , syphilis , gonorrhea , chlamydia ;
• gastrointestinal tract infections: cholera , cholecystitis , gastroenterocolitis , diarrhea , yersiniosis ;
• trachoma , sepsis , peritonitis , osteomyelitis ;
• prevention of malaria and postoperative suppuration.

What else does Unidox Solutab treat?

Yaws , rickettsiosis , legionellosis , Q fever , , first stage Lyme disease, Rocky Mountain spotted fever , tularemia , actinomycosis , plague , malaria , psittacosis , leptospirosis psittacosis, bartonellosis , anthrax , whooping cough , granulocytic ehrlichiosis , brucellosis , acne .

Possible body reactions

While taking Solutab tablets, the instructions for use indicate this, health-threatening symptoms may occur. The most common problems occur in the digestive system. When taking the medicine the following is noted:

• Nausea.
• Vomit.
• Diarrhea.
• Dysbacteriosis.

The drug may cause:

• Anorexia, characterized by refusal to eat due to a neuropsychiatric disorder.
• Dysphagia, which is associated with disorders of the swallowing process.
• Enterocolitis, against the background of which inflammatory processes occur in the intestines.
• Pseudomembranous colitis, which provokes acute inflammation in the large intestine.

After taking Unidox Solutab tablets, allergies or dermatological problems of varying severity may occur. Very often there is urticaria and rash in various manifestations and places. If the patient suffers from autoimmune diseases, for example, lupus erythematosus, then the risks of developing exacerbations increase significantly. Sometimes treatment with the drug leads to the development of pericarditis and exfoliative dermatitis.

When therapy is carried out for a long time, the risks of malfunctions in the liver and kidneys increase. The drug poses an increased danger to patients with renal or liver failure.

Also, the instructions for the drug focus on other side effects. Malfunctions may occur:

• Hematopoietic systems.
• Nervous system.
• ·Endocrine system.

Side effects

• nausea , vomiting , loss of appetite , enterocolitis , inflammation in the genital area due to increased growth of the Candida fungus, stomatitis ;
• dermatitis , urticaria , anaphylaxis , pericarditis and erythema ;
• renal and liver failure, albuminuria , lack of potassium in the blood, increased nitrogen levels in the blood plasma;
• anemia , porphyria , thrombocytopenia ;
• tinnitus , hallucinations ;
• fragility of bones and teeth, discoloration of enamel;
• hyperemia , anaphylactic shock , decreased blood pressure, tachycardia , difficulty breathing.

Instructions for use Unidox Solutab (Method and dosage)

The duration of use and dosage of the drug should be prescribed by a doctor, depending on the disease and its course. The tablets are swallowed whole or crushed into powder and mixed with water.

According to the instructions for Unidox Solutab, adults are prescribed 0.2 g of doxycycline per day (the first day), in one or two doses. In subsequent days, the dosage can be reduced to 0.1 g, at the discretion of the attending physician.

For gonorrhea , syphilis and other serious STDs, the daily dose is usually 0.3 g. Tablets are taken for 5-10 days.

For children over 8 years old, if their weight is less than 50 kg, the calculation is based on the principle of 0.004 g of antibiotic per 1 kg. Or half as much at the end of the first day of use.

Form of the medicinal product

The antimicrobial agent Unidox Solutab contains the active substance - doxycycline monohydrate. The release form of the drug is tablets. Various substances are additionally used for their production. Their list is given in the instructions for use of the drug.

Biconvex tablets have certain external signs that can be used to exclude counterfeit. They have a grayish-yellow or brownish tint. Blotches are visible on their surface. In addition, there is an engraving “173” and a risk on different sides. Tablets are packaged in blisters of 10 pieces.

Interaction

Taken together with magnesium-containing laxatives, iron preparations, sodium bicarbonate , calcium, magnesium and aluminum should occur at least 3 hours after the antibiotic.

The drug reduces the effectiveness of antibiotics such as penicillin and cephalosporin .

The medicine may cause a decrease in the prothrombin index and the effectiveness of hormonal contraceptives . Also, when taken simultaneously with retinol, in intracranial pressure may be observed .

The concentration of doxycycline in the blood will decrease if you combine the drug with ethanol , rifampicin , phenytoin , barbiturates and carbamazepine .

Nosological classification (ICD-10)

• A49.3 Mycoplasma infection, unspecified
• A53.9 Syphilis, unspecified
• A54 Gonococcal infection
• A55 Chlamydial lymphogranuloma (venereal)
• A69.2 Lyme disease
• A70 Chlamydia psittaci infection
• A75 Typhus
• H60 Otitis externa
• H66 Suppurative and unspecified otitis media
• H70 Mastoiditis and related conditions
• J01 Acute sinusitis
• J02.9 Acute pharyngitis, unspecified
• J03.9 Acute tonsillitis, unspecified (angina agranulocytic)
• J04 Acute laryngitis and tracheitis
• J06 Acute upper respiratory tract infections of multiple and unspecified localization
• J22 Acute respiratory infection of the lower respiratory tract, unspecified
• J31 Chronic rhinitis, nasopharyngitis and pharyngitis
• J32 Chronic sinusitis
• J35.0 Chronic tonsillitis
• J37 Chronic laryngitis and laryngotracheitis
• K62.8.1* Proctitis
• L08.9 Local infection of skin and subcutaneous tissue, unspecified
• L70 Acne
• M60.0 Infectious myositis
• M65 Synovitis and tenosynovitis
• M65.0 Tendon sheath abscess
• M71.0 Abscess of bursa
• M71.1 Other infectious bursitis
• M86 Osteomyelitis
• N30 Cystitis
• N34 Urethritis and urethral syndrome
• N39.0 Urinary tract infection without established location
• N41 Inflammatory diseases of the prostate gland
• N49 Inflammatory diseases of the male genital organs, not elsewhere classified
• N71 Inflammatory diseases of the uterus, except the cervix
• N73.9 Inflammatory diseases of the female pelvic organs, unspecified
• N74.2 Inflammatory diseases of the female pelvic organs caused by syphilis (A51.4+, A52.7+)
• N74.3 Gonococcal inflammatory diseases of the female pelvic organs (A54.2+)

Analogues of Unidox Solutab

Level 4 ATC code matches:
Vibramycin

Doxycycline hydrochloride

Doxycycline

The most common analogues:

• Doxycycline
• Vidoccin
• Vibramycin
• Doxibene
• Doxa-M-Ratiopharm
• Tigacil

The price of analogues differs significantly from the original, most often it is lower.

Doxycycline or Unidox Solutab - which is better?

The main difference between the drugs is the fact that Unidox does not have such a strong effect on the stomach and does not cause side effects characteristic of Doxycycline ( stomach ulcer , gastritis ). Absorption of the active substance occurs in the intestines and almost 100% of the medicine is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.

What is the difference between Unidox and Unidox Solutab?

The prefix “Solyutab” in the name of the drug means that the tablet can be crushed and dissolved in water to prepare a suspension for administration. This method of taking the medicine is preferable for children.

special instructions

An overdose of a medicine poses a health risk and can increase negative side reactions of the body. First of all, serious problems occur in the liver. Typically, severe vomiting and fever begin. Jaundice appears, azotemia also develops, the level of transaminases increases, and the prothrombin time increases.

If an overdose is suspected, you should urgently induce repeated vomiting, removing a large amount of water. After gastric lavage, absorbents should be taken. If necessary, you can take an additional laxative. After this, you should drink plenty of clean water for several days.

Actibiotic Unidox Solutab is available only by prescription. The shelf life of the drug is 5 years. The medicine should be stored at a temperature below +25°C out of the reach of children.

Reviews about Unidox Solutab

Reviews in gynecology. The drug has good reviews in the treatment of gynecological diseases, for example chlamydia . Patients who were prescribed the drug for chlamydia note that the antibiotic is easily tolerated and effective. Although sometimes side effects occur in the form of headaches and disruption of the digestive system.

Reviews for use against ureaplasma are also good, many are of the opinion that the drug is almost the only effective way to get rid of the disease.

Reviews of Unidox Solutab for acne. a dermatologist may prescribe antibiotics to treat acne For most patients, acne medication helps, but then other problems arise due to the medication's side effects. For many, following a therapeutic diet helped better than those taking an antibiotic.

Unidox Solutab price, where to buy

The average price of tablets in Russia is about 300 rubles. per pack 10 pcs.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Unidox Solutab dispersible tablets 100 mg 10 pcs. ZiO-Zdorovye ZAO
  315 rub. order
• Unidox solutab dispersant tablets. 100 mg 20 pcs. ZiO-Zdorovye ZAO

  RUR 595 order

Pharmacy Dialogue

• Unidox Solutab (table dispersant 100 mg No. 10) ZiO-Zdorovye CJSC/Astellas Pharma Europe B.V.

  RUB 314 order

• Unidox Solutab (table dispersant 100 mg No. 20)Astellas Pharma/ZiO-Zdorovye CJSC

  RUR 597 order

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Pharmacy24

• Unidox Solutab 100 mg N10 tablets Astellas Pharma Europe B.V., Netherlands
  141 UAH.order

PaniPharmacy

• Unidox solutab tablets Unidox salutab tablets. 100 mg No. 10 Netherlands, Astellas Pharma Europe

  152 UAH order

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Release form, composition and packaging

Dispersible tablets
are round, biconvex, from light yellow to gray-yellow in color, with a score on one side and engraving “173” (tablet code) on the other.

Excipients:

microcrystalline cellulose, saccharin, hyprolose (low-substituted), hypromellose, colloidal silicon dioxide (anhydrous), magnesium stearate, lactose monohydrate.

10 pieces. - blisters (1) - cardboard packs.