Pharmacodynamics and Pharmacokinetics
The drug contains large quantities of conjugated double bonds. They are characterized by a high level of tropism for sterol formations in the plasma membrane of fungi.
When interacting with them, double bonds contribute to increased membrane permeability, due to which cytosolic components are exchanged with the external environment, which stimulates cell lysis.
Maximum activity is observed against Candida albicans and a number of protozoa such as Trichomonas .
After entering the body, the components of the drug are almost not absorbed from the gastrointestinal tract and are excreted through the intestines.
Price
To clarify the price, you need to contact a specific pharmacy or online store. The instructions provide an approximate cost.
In Russia and Ukraine the price will differ significantly. This is due to the exchange rate and currency.
Russia
For the drug Levorin you will have to pay up to 129 rubles.
Ukraine
The medicine Levorin costs on average 59 hryvnia.
Video on the topic: Cleansing the body, treating intestinal candidiasis, dysbacteriosis, worms, Helicobacter pylori, stomach ulcers
Indications for use
Levorin is indicated for the treatment of diseases caused by the yeast-like fungus Candida. These include:
- gastrointestinal candidiasis;
- trichomoniasis;
- fungal infections of the mucous membranes;
- fungal infections of the epidermis;
- fungal infections of the female genital organs.
In addition, Levorin is used as a prophylactic for the so-called candidiasis - a condition when parasitic fungi are present in the body, but the disease itself does not develop.
Contraindications
Levorin is contraindicated in:
- high susceptibility to the components included in the drug;
- liver or kidney failure;
- acute gastrointestinal diseases;
- pancreatitis;
- pregnancy and lactation ;
- peptic ulcer;
- stomach ulcer.
Side effects
The patient’s body can give a response, which is usually expressed in diseases and conditions such as:
- Vomiting, headache, diarrhea, dizziness, nausea, as well as pain in the abdomen, loss of appetite;
- Hives, itching, redness of the skin, swelling of the face.
Overdose
In the event of an overdose, a person experiences symptoms such as:
- Head pain, dizziness;
- Diarrhea, vomiting, constipation;
- Decreased appetite;
- Fever, chills, heat;
- Severe itching, redness of the skin;
- Irritation.
If you have signs of an overdose, you need to stop taking the drug. Next, the patient is advised to go to the hospital to receive medical care.
Contraindications
A drug belonging to the group of polyenes.
It is not recommended to take this medicine if you have such concomitant diseases and conditions as:
- Severe form of liver or kidney failure;
- Pancreatitis;
- Stomach ulcer;
- Acute diseases of the gastrointestinal tract;
- Duodenal ulcer.
Caution: Levorin can be prescribed for mild to moderate renal or liver failure. In addition, the medicine is carefully prescribed for the treatment of young patients under 2 years of age.
Pregnancy period
If it is impossible to stop the drug, then taking it is allowed, however, the girl must always be under the supervision of a doctor, i.e. stay in hospital. Only such a measure will allow monitoring the negative impact on the fetus.
During breastfeeding you should refrain from taking the medicine. If it is not possible to replace the drug Levorin with a safe analogue, then taking the drug is allowed, however, before starting treatment, the issue of stopping breastfeeding must be decided.
Side effects
Levorin in all forms can cause adverse reactions. Tablets and injection solution can cause various types of dyspeptic reactions, headaches , and dizziness .
The use of ointment rarely provokes allergic reactions - severe itching, local redness, irritation .
Instructions for use of Levorin (Method and dosage)
For paronychia, interdigital erosions and damage to skin folds caused by yeast-like fungi, it is recommended to use ointment. It is necessary to lubricate problem areas one to two times a day for seven to ten days.
For diseases of the oral cavity, inflammation of the mucous membrane caused by yeast-like fungi, Levorin is prescribed (for adults) as a solution (1: 500) for rinsing. You need to rinse your mouth with the solution up to three times a day for three weeks.
For fungal infections of the mucous membrane of the genital organs in women, Levorin solution is also used, where a tampon is moistened and then inserted into the vagina. Treatment is carried out for fifteen to twenty days. For uterine bleeding, this method is not recommended.
Levorin tablets, instructions for use
For candidiasis of the gastrointestinal tract and intestines, Levorin is prescribed orally to adults, one tablet or capsule up to four times a day for ten days. If the form of the disease is severe, then treatment can be prescribed for a course of twelve days.
For children under two years of age with relevant diseases, the drug is prescribed in dosages of 25,000 - 30,000 ED / kg per day, for children from two to six years old - 20,000 - 25,000 ED / kg / day, for children after six years of age the drug is prescribed in a dosage of 250,000 ED up to four times in a day. The course of treatment is one week. At the discretion of the specialist, the course of treatment can be extended to two weeks.
For oral candidiasis , damage to the mucous membrane, and gastrointestinal candidiasis, tablets of 500,000 ED can be used. Adults are prescribed one tablet up to four times a day, children from three to ten years old - 1/4 tablet up to four times a day, children from ten to fifteen years old - half a tablet up to four times a day, children over fifteen years old are prescribed an adult dosage up to four times a day.
The duration of treatment can be two weeks. In the standard course of the disease, the course of treatment is one week.
Application of the suspension
Children are most often prescribed the drug in the form of a suspension, which is prepared from powder. The bottle contains 2,000,000 or 4,000,000 ED of Levorin. To prepare the suspension, pour cooled clean water into the bottle exactly up to the mark on the bottle, then shake thoroughly until a homogeneous mass is formed.
Shake the bottle of suspension thoroughly before each use. One teaspoon (5 ml) contains 100,000 ED. The suspension is taken in the same doses as the tablets.
Storage
The drug Levorin must be placed in a room where the temperature is from 0 to 5 degrees. In addition, this room should be dark and dry. The room should also be cool (the drug is usually stored in the refrigerator).
If these conditions are met, Levorin can be taken for two years. After the expiration date, further use of the medicine is strictly prohibited. The medicinal product must be disposed of by placing it in the trash.
Analogues of Levorin
Level 4 ATC code matches:
Sangviritrin
Ersefuril
Stopdiar
Nifuroxazide
Analogues of this drug on the pharmaceutical market are represented by the following drugs:
- Allylchep – drops for internal use;
- Bacteriophage – solution for internal and local use;
- Bacteriophage – rectal suppositories;
- Bacteriophage – suspension;
- Bacteriophage - tablets;
- Enterofuril – capsules, suspension;
- Ersefuril - capsules;
- Stopdiar – tablets, suspension;
- Bevisal - tablets.
Similar drugs:
- Natamycin Substance-powder
- Lamisil Uno Topical solution
- Levorin Oral tablets
- Livarol Vaginal suppositories
- Lamisil Oral tablets
- Mycocet Ointment for external use
- Loceryl Solution for local and external use
- Lotrimin Cream for external use
- Fluomisin Vaginal tablets
- Primafungin Vaginal suppositories
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Levorin, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Levorin is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Reviews about Levorin
Reviews about this drug are left not only by patients who have actually used it, but also by specialists who are aware of its features. Both the first and second agree that Levorin in all forms has the expected effect in almost 90% of cases.
There are reviews with a neutral character. Doctors explain the lack of any effect by improper use of the medicine - tablets, suspensions, suppositories and ointments must be taken strictly in accordance with the instructions and recommendations of the doctor.
special instructions
In this section you can find useful information.
Driving
The medicine may affect the driver while driving.
Pregnancy
During pregnancy, you should refrain from using this drug. During pregnancy, it is highly undesirable to take Levolin. This is due to the fact that the active substance can have a detrimental effect on the fetus.
It is also not recommended to take this drug while breastfeeding.
Admission in childhood
This drug can be taken from 2 years of age.
Use for kidney problems
Taking the drug is contraindicated if kidney function is damaged.
Use for liver dysfunction
Taking the medication is contraindicated if the liver function is impaired.
Release from pharmacy
Only by prescription from a doctor.
Medicine and alcohol
Taking medication and alcohol are two incompatible things.
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