Purified fish oil for internal use 50 ml

Fish oil

Suction

Retinol is absorbed from the gastrointestinal tract (mainly the duodenum and jejunum) after emulsification with bile acids. Retinol entering the intestinal microvilli undergoes esterification. The resulting retinyl palmitate binds to specific lipoproteins, penetrates the lymphatic pathways and, as part of chylomicrons, enters the liver, where it is captured by stellate reticuloendotheliocytes, and then by hepatocytes, where the chylomicrons are cleaved, releasing retinyl palmitate, retinol and retinal and the retinoic acid formed from it. Retinol binds to a specific protein, enters the blood, combines with albumin and is transported to various organs.

Absorption of vitamin D occurs in the proximal small intestine, necessarily in the presence of bile. Part of vitamin D is absorbed in the middle sections of the small intestine and a small part in the ileum. After absorption, cholecalciferol is found in chylomicrons in free form and only partially in ester form. In the blood, most of it is bound to gamma globulins and albumins.

Distribution

Retinol is distributed unevenly in the body: the largest amount is in the liver and retina, the smaller amount is in the kidneys, heart, lungs, lactating mammary gland, and adrenal glands. Retinol is deposited in the form of retinol palmitate, its reserves are slowly but constantly renewed. In tissues, retinol is localized mainly in the microsomal fraction, mitochondria, lysosomes, and in the membranes of cells and organelles.

Vitamin D accumulates in large quantities in bones, in smaller quantities in the liver, muscles, blood, and small intestines, and is stored especially long in adipose tissue. Passes into breast milk in small quantities.

Metabolism and excretion

Retinol binds to glucuronic acid: β-glucuronate undergoes hepatic circulation and oxidation to retinal and retinoic acid. Retinoic acid undergoes decarboxylation and binds to glucuronic acid, subsequently excreted in bile and feces. The half-life of retinol is very long and is measured from several weeks to several months. Retinoic acid and other water-soluble metabolites are also excreted in urine and feces.

The main processes of vitamin D biotransformation occur in the skin, liver and kidneys. In the skin, under the influence of ultraviolet irradiation, vitamin D3 is formed from precursors. In the liver, vitamin D is hydroxylated and converted into 25-hydroxycholecalciferol (25-OH-D3). The latter in the kidneys, with the participation of parathyroid hormone, is converted into the most active metabolite of vitamin D - calcitriol, or 1,25-dihydroxycholecalciferol (l,25(OH)2-D3). The half-life of vitamin D from the body is about 19 days. It is excreted through bile excretion, initially into the intestine (15-30% of the administered dose during the day), where it undergoes enterohepatic circulation (reabsorption). The remaining part is excreted in the feces.

How to choose Omega-3

Articles

“Lack of strength, depression and apathy towards everything, poor sleep and appetite, heart palpitations or high blood pressure - take vitamins with Omega-3!” Is this popular drug really a panacea? How to choose and take Omega-3 correctly? What can you expect from regularly consuming extra fatty acids? Read on!

What are the benefits of fish oil?

Among the numerous types of fatty acids (Omega-3, 6, 9), the “three” is the most deficient for the human body. Its main source is fish oil, which contains useful and essential eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The benefits of these polyunsaturated fatty acids are difficult to overestimate. After all, they:

• restore and strengthen the immune system;
• help the body resist diseases;
• prevent the formation of blood clots and inflammation;
• have a positive effect on reproductive function and the vascular system;
• normalize the functioning of the nervous system;
• reduce stress, give strength and energy;
• improve memory, appetite and mood;
• strengthen the skeletal system, alleviate arthritis;

Omega-3 preparations are indicated for young and mature people, men and women, pregnant and lactating women, teenagers and pensioners. There are benefits for everyone, the main one of which is maintaining the immune system and the body’s defenses.

What is fish oil combined with?

First of all, with fat-soluble vitamin E, which is a strong antioxidant, takes an active part in metabolism, and has a beneficial effect on reproductive function. Fish oil is also useful in combination with turmeric, whose biologically active component curcumin has a positive effect on the functioning of the heart, blood vessels, and gastrointestinal tract.

You need to drink fish oil capsules with clean water, not juice, since they do not combine with an acidic environment. You can also drink them with warm, unsweetened green tea, since its catechins successfully combine with fat and complement its beneficial effects.

What is the best way to take fish oil?

The main rule is that this drug should not be taken on an empty stomach! First of all, because it is less digestible and also gives an unpleasant “aftertaste” to the fish. Therefore, it is best to take capsules during meals, with water, warm tea, and eating them. Then fatty acids will dissolve in food and will evenly enter the esophagus without causing discomfort. Should you take fish oil with breakfast? Yes, you can do this in the morning or afternoon, at lunch. Don't wait to take your vitamins for dinner. So, let's summarize the main recommendations for taking fish oil:

• better with food than on an empty stomach;
• better for breakfast, lunch than in the evening;
• drink water, you can and should eat;
• do not exceed the recommended dose;

In addition, it is important to take it regularly, and not from time to time, so that the effect is noticeable and permanent.

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How many fatty acids do you need daily?

For preventive purposes, the daily recommended dose is about 1000 mg of a mixture of EPA and DHA fatty acids. With weak immunity, cardiovascular problems, high physical activity and stress, the daily dose can be increased to 2000-3000 mg. The same applies to pregnant women. But it is important for them to consult their doctor before starting treatment.

What to look for and how to choose Omega-3?

To choose a truly effective and worthwhile drug, you need to pay attention not to the bright, tempting packaging, but to the information it contains. Here's what you might be interested in:

1. Compound. It is important to read which Omega-3 is in these capsules (DHA, EPA or ALA). The first two are very indicated for those suffering from cardiovascular and other diseases.
2. Manufacturer Omega-3. Which ones are the best? Usually these are large foreign manufacturers who guarantee the purity and quality of marine raw materials. In addition, pay attention to the certification of the drug. Choose Omega-3s made from fish muscle rather than liver. In this case, the usefulness will be greater.
3. Dosage and packaging. It is more convenient and practical to use fish oil in capsules, which quickly dissolve in the stomach. They are easily digestible and do not have a specific taste or smell of fish. They are easy to take with plenty of water. The dosage of the drug may vary from manufacturer to manufacturer. So, it can be 1 to 3 capsules daily dose.
4. Best before date. Do not ignore this parameter when choosing Omega-3! What are the best drugs? With a “fresh” production date, since in expired preparations the fat may already be spoiled. To assess freshness and quality, it is useful to break one capsule and smell it - the specific smell of fish oil should not be rancid, sour or too smelly.

Your doctor may also recommend a fish oil supplement. It is important to follow his recommendations, especially if you are expecting a child or are undergoing post-operative rehabilitation.

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Basic preparations based on Omega-3 acids

Are you wondering how to choose Omega-3 from a large selection? We recommend paying attention to the following drugs:

• Solgar. A well-known American brand, a popular, high-quality drug. It is offered in different concentrations: 1300, 950, 700 mg. Dosage: 1 capsule daily. The raw materials for obtaining this fish oil are anchovy and mackerel. The manufacturer guarantees a high degree of purification of raw materials and the absence of harmful, toxic impurities.
• Carlson Labs Super Omega. Available in 1200 mg dosages and containing DHA and EPA. The raw material for the production of this high-quality fish oil is deep-sea fish. The manufacturer emphasizes that the drug does not contain preservatives, cholesterol, or gluten. You need to take 1 capsule daily.
• Doppelhertz Omega-3 Active. Another popular drug made in Germany, which, unlike others, has a combined composition. In addition to fish oil, it also contains olive and flaxseed oils. The composition also contains glycerin, gelatin, vitamin E and iron oxide. Salmon fish species are used as raw materials. This drug is useful for both the immune system, the cardiovascular system, and for hair, skin, and the general condition of the body. You need to take 1 capsule daily.
• Omega-3 from Orihiro. A very famous drug from a Japanese company. Available in soft capsule form, it contains fish oil high in Omega-3 fatty acids: docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). A high-quality, pure, certified drug that is indicated for people of any age. Does not cause allergies! Dosage regimen: 4 capsules per day with water.
• Country Life Omega-3. Which are the best among budget brands? Exactly these! The drug is made from cold-loving sea fish. The raw materials are thoroughly cleaned from harmful impurities and heavy metal salts. The content of EPA and DHA in the capsule is low, especially in comparison with the above products. Dosage: 1 capsule daily.
• Madre Labs Omega-3. Another budget drug containing EPA and DHA, as well as vitamin E (tocopherol). The raw materials for its production are sea fish, mackerel, anchovies and sardines. The manufacturer also indicates that the composition contains soy derivatives.

Omega-3 preparations. Which ones are better?

The most popular drugs are from the manufacturers Solgar, Orihiro, and Doppelgerts. Despite the rather high cost, this is a guaranteed high-quality, pure and very effective fish oil, presented in the optimal dosage. Good reviews can also be found on Carlson Labs Super Omega, which is considered a suitable drug for active people and athletes.

Now you know how to choose Omega-3 and what to pay special attention to. Take this useful drug correctly, and it will give you strength, activity and health for many years!

You can buy Omega-3 dietary supplements using the link.

Marking deadlines

The oil solution obtained from fish liver can be produced in solution or in gelatin capsules of various shapes. Capsules can be in a blister or in a common jar. The solution is available in a bottle with a box.

The primary packaging always indicates the production date and shelf life. This marking is present on the lid or side seam. The shelf life after opening is usually only indicated on the secondary packaging. There are also detailed recommendations on storage conditions:

• temperature;
• humidity;
• the most optimal place.

We talked more about how to understand the indicated expiration date of a medicine here.

Duration of use of the additive

For a dietary supplement, this depends on the form of release and the concentration of the active substance. This period of time is influenced by the microclimate of the room in which the product is stored. When exposed to light and heat, fatty acids begin to rapidly oxidize.

In capsules

The oil solution in the capsules is protected from oxidation after opening . Therefore, for this form of release, only the expiration date from the date of production is taken into account. It usually lasts 2-3 years.

In a bottle

This value depends on the manufacturer. But usually the shelf life is a year, and after opening the bottle 3 months.

Does the biological additive have expiration and storage dates?

Fish oil is a product of natural origin . This additive has an oily consistency and a yellow to transparent color. This product contains unsaturated fatty acids, as well as fat-soluble vitamins. Can be used for various forms of vitamin deficiency, for the prevention of certain diseases and a poor diet.

This product is obtained from the liver of ocean fish. The production uses technologies that exclude heat treatment. These production methods help preserve all active substances, but this shortens the period suitable for consuming all forms of biological additives.

An expiration date is set for the product . This concept is often confused with shelf life. But these are not identical terms. Shelf life is the period during which a supplement is considered fit for use. It is calculated from the moment of production. You can learn more about the shelf life and storage of medications here.

Detailed storage rules for this product are specified in SanPiN 2.3.2.1290-03, in GOST GOST 8714-2014, as well as in technical regulations of enterprises and pharmacopoeial monographs.

Composition and release forms

The active substance is fish oil from the liver of cod fish.

One 1000 mg capsule or 1 teaspoon of liquid form of the drug contains:

1. Eicosapentaenoic acid (EPA) not less than 16%.
2. Docosahexaenoic acid (DHA) at least 18%.
3. Polyunsaturated fatty acids (PUFAs) at least 40%.
4. 1000 IU Vitamin A.
5. 100 IU Vitamin D.

The mineral composition is presented:

• Zinc.
• Calcium.
• Iodine.
• Magnesium.
• Phosphorus.
• Sodium.
• Iron.
• Potassium.

For the convenience of consumers, manufacturers have taken care of producing several forms of the drug: capsules and liquid substance.

The first is a transparent gelatinous shell filled with a light oily liquid with a faint odor. The volume of the capsule is determined by the manufacturer. Packaged in blisters or glass/plastic containers. Available without a prescription. Taking the drug does not imply any restrictions on driving a car or performing potentially dangerous actions.

The liquid version of the natural additive looks like a thick, straw-colored oil mass placed in tinted glass containers with a high level of tightness. It has similar properties as the previous form. Meanwhile, their aftertaste is completely different - liquid fish oil is less pleasant.

Also in pharmacies you can find combination preparations that, in addition to fish oil, include vegetable oil.

Storage rules at home

The dietary supplement in capsules must be stored in a cool, dry place , protected from direct sunlight. This helps prevent damage to the gelatin shell of the capsule. You can store the product in the refrigerator, this will extend the shelf life. Do not allow the product to freeze or heat above +25C.

Bottles with an oily solution are also stored in a cool place. The packaging has tinted glass that protects from exposure to sunlight. After opening the bottle, the solution is stored in the refrigerator for about three months. This time is enough to consume the product.

Why is oxidation dangerous?

After oxidation, fish oil in liquid form has a pungent odor and bitter taste. Capsules lose their natural yellowness. Clinical studies show that the oxidized product does not cause lipid peroxidation in healthy individuals. However, during photolysis the concentration of DHA and EPA decreases. Since these types of PUFAs are the most beneficial of the Omega-3 family for the human body, the benefits of the dietary supplement will be reduced if stored incorrectly or for a long time. Then how to store fish oil to maintain maximum benefits?