pharmachologic effect
Some of the natural components of the drug in the form of senna sennosides are capable of being transformed in the intestinal area and acquiring a different active form (reinanthrone) due to microorganisms in this part of the gastrointestinal tract.
This transformation of the substance can be an irritating factor for the nerve endings of the mucous wall.
Due to this, stimulation of peristalsis occurs - intestinal motility increases, the process of absorption of electrolytes is slowed down, and the amount of water in the intestinal lumen increases significantly.
Also, this active form of the substance is a catalyst for the secretion of chlorine.
The therapeutic effect is observed in the time interval from 10 to 12 hours after using the drug. In some clinical situations, the result may occur after 8 hours.
Release forms
This medicine is presented in the form of drops for oral administration.
The medicinal substance is located in a bottle, which is equipped with a dropper cap. The volume of such a bottle is 20 ml.
Compound
For 1 milliliter of medication there is:
- The main component is presented in the form of sodium picosulfate monohydrate in the amount of 7.5 ml;
- Excipients in the form of propylene glycol, sorbitol, and water.
Indications for use
Experts advise using the drug in the following clinical cases:
- For signs of hemorrhoids, when it is necessary to soften feces that have accumulated in conglomerates;
- With signs of proctitis;
- When will the patient undergo surgery?
- For symptoms of constipation, which is a consequence of intestinal atony;
- Before diagnostic manipulations on internal organs. X-ray examination also falls into this category;
- For pathologies affecting the gallbladder, when constipation is present;
- When cracks are observed in the anus;
- When there is irritable bowel syndrome and constipation is observed;
- For constipation of various origins. For example, with irregular nutrition or intestinal dysbiosis.
Directions for use and dosage
The medicine in the form of drops is used for oral administration. Experts advise combining the intake with a night's rest.
Dosages, time of administration, and amount of medication are prescribed by a medical specialist for each patient individually, taking into account the existing pathology. Practice shows that the size of the initial dosage during therapy can either increase or decrease.
For adult patients, the initial dosage will be 13 drops. In cases where the patient suffers from chronic constipation, the maximum dosage should reach 26 drops of the medicine.
In pediatric practice, doctors prescribe about 5 drops of the drug to a small patient.
On average, therapy with this laxative drug in patients does not take more than 7 days.
Regulax Picosulfate (vial 7.5 mg/ml 20 ml)
A country
Germany
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Sodium picosulfate
Compound
Active substance: sodium picosulfate monohydrate 7.5 mg.
pharmachologic effect
Laxative. Reduces the absorption of electrolytes and water, enhances intestinal motility. The active form of the drug, formed by hydrolysis under the influence of intestinal microorganisms, directly excites the nervous structures of the intestinal wall, resulting in accelerated movement of intestinal contents. The action occurs 10-12 hours after administration. Pharmacokinetics. After oral administration, it is not absorbed from the gastrointestinal tract and is not subjected to hepatic-intestinal circulation.
Indications for use
Atonic constipation. Regulation of stool (hemorrhoids, proctitis, anal fissures). Preparation for surgical operations, instrumental and x-ray examinations.
Mode of application
Inside, before bedtime. Depending on the effect obtained, the dose at subsequent doses is increased or decreased. Adults: initial dose - 13 drops, for persistent constipation - up to 26 drops. For children over 4 years old, the initial dose is 5-8 drops. The course of treatment is 7 days.
Interaction
Increased sensitivity to cardiac glycosides is possible. Glucocorticosteroids and diuretics increase the risk of developing electrolyte disturbances. Broad-spectrum antibiotics reduce the laxative effect. Possible increased sensitivity to cardiac glycosides.
Side effect
Diarrhea, abdominal pain, dehydration, water and electrolyte imbalance, weakness, cramps, decreased blood pressure.
Contraindications
Hypersensitivity, intestinal obstruction, strangulated hernia, acute inflammatory diseases of the abdominal organs. Peritonitis, abdominal pain (of unknown origin), severe dehydration, bleeding from the gastrointestinal tract, metrorrhagia, cystitis, spastic constipation, children (up to 4 years), pregnancy (1st trimester).
Overdose
Symptoms: see section "Side effects". In addition, with chronic overdose, ischemia of the colon mucosa, secondary hyperaldosteronism, urolithiasis, and damage to the renal tubules may develop. Treatment: gastric lavage, correction of water-electrolyte imbalance, antispasmodics.
special instructions
With caution: lactation period. Use during pregnancy. Contraindicated in the first trimester of pregnancy. Repeated use of the drug during the second and third trimesters should be carried out only after a thorough assessment of the need and risks, since there is not enough information on the use of the drug during pregnancy. It should not be taken without medical supervision for more than 7 days. Long-term use often leads to increased intestinal hardening. Should be used in children only in consultation with a doctor.Instructions for patients with diabetes.Suitable for patients with diabetes; contains sugar substitutes.
Side effects
Taking the drug can negatively affect the body, causing the following unpleasant consequences:
- Discomfort and pain in the abdominal area;
- Symptoms of dehydration will appear;
- Electrolyte balance will be disrupted;
- Signs of flatulence;
- Symptoms of diarrhea;
- Passivity, fatigue and general weakness;
- Blood pressure will drop sharply;
- The appearance of seizures in various parts of the body.
Contraindications
Doctors ask not to use Regulax if you have 1 or more of the following pathological abnormalities:
- There are signs of a strangulated hernia of various localization;
- There are inflammatory processes in one or another abdominal organ;
- When there is pain in the abdominal area of unknown etiology;
- With signs of intestinal obstruction;
- If there are signs of internal bleeding;
- With inflammatory phenomena in the peritoneum;
- For inflammatory phenomena in the bladder area;
- For symptoms of metrorrhagia;
- For constipation, spastic origin;
- Age restrictions: for children under 4 years of age;
- When there is hypersensitivity to 1 or more components of the drug on the part of the patient’s body.
Interaction with other medications
When using Regulax with other drugs, the following manifestations are possible:
With cardiac glycosides – increased influence from the latter;- With antiarrhythmic drugs - an increase in the abilities of the latter;
- With antibacterial substances – reducing the effectiveness of Regulax;
- With thiazide diuretic substances, there is a guaranteed likelihood of dehydration and electrolyte imbalance;
- With glucocorticoids – there is a risk of dehydration;
During pregnancy
Prohibited for use in pregnant women (2-3 trimester). Not recommended for use in women who are breastfeeding.
Overdose
When using dosages that are higher than prescribed by a specialist, you can get the following consequences:
- Diarrhea;
- Collapse;
- Metabolic acidosis.
Indications for use of the drug Regulax picosulfate drops
Intestinal atony, constipation (except for spastic constipation), caused by changes in the nature and diet, prolonged immobilization, fever, severe general condition, diseases of the cardiovascular system and metabolic disorders; used in the pre- and postoperative periods, in obstetric and gynecological practice, to facilitate defecation in case of hemorrhoids, anal fissures, inoperable hernias, myocardial infarction, severe hypertension (arterial hypertension), to cleanse the intestines before instrumental examination.
Price
The average price of medicine in Russia is about 210 rubles.
The average cost of medicine in Ukraine is about 70 hryvnia.
Let's present a brief conclusion on the medicinal substance "Regulax":
- A laxative that comes in the form of drops for oral administration;
- It is used for various types of constipation, and for hemorrhoids of various origins;
- It is not recommended for use in persons with inflammation of the peritoneum or internal bleeding;
- Not used in pregnant women and women during the lactation period;
- Side effects occur, but they are rare (low blood pressure, abdominal pain);
- In pediatric practice it is used in children from 4 years of age.
Pharmacological properties of the drug Regulax picosulfate drops
Sodium picosulfate is a contact laxative that irritates receptors in the intestinal mucosa. Activated in the large intestine under the influence of bacterial sulfatases; the substance that is released stimulates the sensitive nerve endings of the intestinal mucosa, enhancing its motility. The laxative effect of sodium picosulfate is not accompanied by tenesmus and intestinal spasms. In infants, the effectiveness of sodium picosulfate may be insufficient due to the small amount of bacterial flora that produces sulfatases. Regulax Picosulfate drops are a drug that regulates intestinal function, increasing the volume of stool and enhancing peristalsis (natural rhythmic movement), promoting timely, painless bowel movements. The laxative effect occurs after 10–12 hours. Sodium picosulfate is absorbed in the small intestine only in limited quantities and has virtually no systemic effect. After the sulfate ester is broken down by bacteria in the large intestine, a diphenolic laxative is formed, which is partially absorbed and, after conjugation, is excreted in the bile. A small portion is excreted in the urine as a glucuronide; most of it is in the feces, both in the form of free diphenol and in the form of picosulfate itself.
Special instructions for the use of Regulax picosulfate drops
The drug Regulax Picosulfate drops is intended for short-term use. During pregnancy, the use of the drug is possible only under strict indications and under the supervision of a doctor. While using the drug, you should stop breastfeeding. The drug can be used for diabetes mellitus, since it contains a sugar substitute (1 ml of drops contains 0.03 XE). The drug should be used with caution after operations on the gastrointestinal tract or in case of dehydration. No addiction was observed with long-term use.
