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Fluimucil®

A mucolytic agent that thins sputum, increases its volume, and facilitates the separation of sputum.

The action is associated with the ability of free sulfhydryl groups of acetylcysteine to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity.

In addition, it reduces induced hyperplasia of mucoid cells, enhances the production of surfactants by stimulating type II pneumocytes, and stimulates mucociliary activity, which leads to improved mucociliary clearance.

Remains active against purulent sputum, mucopurulent and mucous sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs.

It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins.

Acetylcysteine easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized.

Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that traps endogenous and exogenous free radicals and toxins.

Acetylcysteine prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus promoting the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning.

Paracetamol exerts its cytotoxic effect through the progressive depletion of glutathione. The main role of acetylcysteine is to maintain proper levels of glutathione concentration, thereby providing protection to cells.

Protects alpha 1-antitrypsin (elastase inhibitor) from the inactivating effects of HOC1, an oxidizing agent produced by myeloperoxidase of active phagocytes.

It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Fluimucil (tab. spike. 600 mg No. 10)

A country

Italy, Switzerland
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Acetylcysteine

Compound

1 tablet contains: acetylcysteine 600 mg.
Excipients: citric acid, sodium bicarbonate, aspartame, lemon flavor. Effervescent tablets are white, round, with a rough surface. With a lemony, slightly sulfuric odor. The solution prepared by reconstituting the tablets in water should be slightly opalescent, with a characteristic odor and taste of lemon flavor.

pharmachologic effect

Mucolytic drug. Liquefies mucus, increases its volume and facilitates its separation. The action of acetylcysteine is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in sputum viscosity. Remains active in the presence of purulent sputum. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Acetylcysteine easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning. Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Indications for use

- diseases of the respiratory system, accompanied by impaired sputum discharge (including bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, pulmonary emphysema, laryngotracheitis, interstitial lung diseases, pulmonary atelectasis /due to blockage of the bronchi by mucus plug/) ; - catarrhal and purulent otitis media, sinusitis, incl. sinusitis (to facilitate the passage of secretions); - to remove viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

Mode of application

The drug in the form of effervescent tablets is prescribed to adults at 600 mg (1 tablet) 1 time/day. Before use, the effervescent tablet is dissolved in 1/3 glass of water. Granules for the preparation of a solution for oral administration are prescribed to adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day; children aged 1 to 2 years - 100 mg 2 times a day. In newborns, the drug is used only for health reasons at a dose of 10 mg/kg body weight under the strict supervision of a physician. Before use, the required amount of granules is dissolved in 1/3 glass of water. Children of the first year of life are given the resulting solution to drink from a spoon or feeding bottle. The duration of treatment is determined individually. For acute diseases, the duration of treatment is from 5 to 10 days, for chronic diseases - up to several months.

Interaction

The simultaneous use of Fluimucil with antitussives may increase sputum stagnation due to suppression of the cough reflex. When used simultaneously with antibiotics, such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, their interaction with the thiol group of acetylcysteine is possible, which leads to a decrease in the activity of both drugs, therefore the interval between taking acetylcysteine and antibiotics should be at least 2 hours. Simultaneous taking Fluimucil and nitroglycerin can lead to an increase in the vasodilatory and antiplatelet effects of the latter. Acetylcysteine reduces the hepatotoxic effect of paracetamol.

Side effect

From the digestive system: - rarely - heartburn, nausea, feeling of fullness in the stomach, vomiting, diarrhea; — cases of stomatitis development are described. Allergic reactions: - rarely - skin rash, itching, urticaria; — cases of bronchospasm development have been described. Other: - rarely - nosebleeds, tinnitus; — cases of collapse development and decreased platelet aggregation have been described.

Contraindications

- peptic ulcer of the stomach and duodenum in the acute phase; - lactation period; - children under 2 years of age (for granules for the preparation of a solution for oral administration); - children and adolescents up to 18 years of age (for effervescent tablets); - hypersensitivity to acetylcysteine. The use of the drug in the form of granules for the preparation of a solution for oral administration in children under 2 years of age is possible only if there are vital indications and under strict medical supervision. Prescribed with caution for peptic ulcers of the stomach and duodenum, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, phenylketonuria, bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension.

Overdose

Fluimucil® when taken at a dose of 500 mg/kg/day does not cause signs and symptoms of overdose.

special instructions

For patients with bronchial asthma and obstructive bronchitis, Fluimucil® can be prescribed with caution under systematic monitoring of bronchial conduction. The drug contains aspartame, so it should not be prescribed to patients with phenylketonuria. When dissolving the drug, you must use glass containers and avoid contact with metal and rubber surfaces. When opening a bag of granules, there may be a smell of sulfur, which is the smell of the active substance.

Storage conditions

Room temperature

Buy Fluimucil granules for the preparation of solution Orange 200 mg No. 20 in pharmacies

Brief description Mucolytic drug with antioxidant properties

Composition One sachet contains: active substance: acetylcysteine - 200 mg; excipients: aspartame 25 mg, betacarotene 12.3 mg, orange flavor 100 mg, sorbitol 662.7 mg.

Pharmacological action Mucolytic drug. Liquefies mucus, increases its volume and facilitates its separation. The action of acetylcysteine is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in sputum viscosity. Remains active in the presence of purulent sputum. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Acetylcysteine easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning. Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Indications : respiratory diseases accompanied by impaired sputum discharge (including bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, pulmonary emphysema, laryngotracheitis, interstitial lung diseases, pulmonary atelectasis /due to blockage of the bronchi by mucus plug/ ); - catarrhal and purulent otitis media, sinusitis, incl. sinusitis (to facilitate the passage of secretions); - to remove viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

Method of administration and dosage The drug in the form of effervescent tablets is prescribed to adults at 600 mg (1 tablet) 1 time/day. Before use, the effervescent tablet is dissolved in 1/3 glass of water. Granules for the preparation of a solution for oral administration are prescribed to adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day; children aged 1 to 2 years - 100 mg 2 times a day. In newborns, the drug is used only for health reasons at a dose of 10 mg/kg body weight under the strict supervision of a physician. Before use, the required amount of granules is dissolved in 1/3 glass of water. Children of the first year of life are given the resulting solution to drink from a spoon or feeding bottle. The duration of treatment is determined individually. For acute diseases, the duration of treatment is from 5 to 10 days, for chronic diseases - up to several months.

Side effects From the digestive system: rarely - heartburn, nausea, feeling of fullness in the stomach, vomiting, diarrhea; Cases of the development of stomatitis have been described. Allergic reactions: rarely - skin rash, itching, urticaria; Cases of bronchospasm have been described. Other: rarely - nosebleeds, tinnitus; Cases of collapse and decreased platelet aggregation have been described.

Contraindications - peptic ulcer of the stomach and duodenum in the acute phase; - lactation period; - children under 2 years of age (for granules for the preparation of a solution for oral administration); - children and adolescents up to 18 years of age (for effervescent tablets); - hypersensitivity to acetylcysteine. The use of the drug in the form of granules for the preparation of a solution for oral administration in children under 2 years of age is possible only if there are vital indications and under strict medical supervision. Prescribed with caution for peptic ulcers of the stomach and duodenum, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, phenylketonuria, bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension.

Overdose of Fluimucil® when taken at a dose of 500 mg/kg/day does not cause signs and symptoms of overdose.

Special instructions For patients with bronchial asthma and obstructive bronchitis, Fluimucil® can be prescribed with caution under systematic monitoring of bronchial conduction. The drug contains aspartame, so it should not be prescribed to patients with phenylketonuria. When dissolving the drug, you must use glass containers and avoid contact with metal and rubber surfaces. When opening a bag of granules, there may be a smell of sulfur, which is the smell of the active substance.

Interaction with other drugs The simultaneous use of Fluimucil with antitussives may increase sputum stagnation due to suppression of the cough reflex. When used simultaneously with antibiotics, such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, their interaction with the thiol group of acetylcysteine is possible, which leads to a decrease in the activity of both drugs, therefore the interval between taking acetylcysteine and antibiotics should be at least 2 hours. Simultaneous taking Fluimucil and nitroglycerin can lead to an increase in the vasodilatory and antiplatelet effects of the latter. Acetylcysteine reduces the hepatotoxic effect of paracetamol.

Storage conditions The drug should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life: 3 years.