Buy Rinzasip powder for preparing an oral solution Lemon/Vit. With 5g No. 10 in pharmacies


Rinzasip®

In case of overdose, consult a doctor immediately.

Prompt medical attention is critical, even if you do not experience any signs or symptoms.

Caffeine

Symptoms of acute overdose

: abdominal pain, vomiting, feeling of heat, facial flushing, fever, chills, agitation, insomnia, irritability, loss of appetite, weakness, tremor, increased muscle tone, state of altered consciousness, delirium, hallucinations, increased blood pressure followed by hypotension, tachycardia , tachypnea, increased diuresis, hypokalemia, hyponatremia, hyperglycemia, metabolic acidosis, convulsions, myoclonus and rhabdomyolysis, supraventricular and ventricular arrhythmias.

Symptoms of chronic caffeine intoxication, “caffeineism”

: irritability, insomnia, anxiety, emotional lability, chronic abdominal pain.

Pheniramine

Symptoms

: central nervous system depression, hyperthermia, anticholinergic syndrome (mydriasis, flushing, fever, dry mouth, urinary retention, intestinal paresis), tachycardia, arterial hypotension, arterial hypertension, nausea, vomiting, agitation, disorientation, hallucinations, psychosis, convulsions , arrhythmias. Rarely, patients with agitation, seizures, or comatose patients develop rhabdomyolysis and renal failure.

Phenylephrine

Symptoms

: nausea, vomiting, irritability, agitation, insomnia, psychosis, convulsions, palpitations, tachycardia, increased blood pressure, reflex bradycardia.

Paracetamol

Symptoms appear after taking more than 7.5-10 g

: during the first 24 hours after administration - pallor of the skin, nausea, vomiting; anorexia, abdominal pain; increased prothrombin time, impaired glucose metabolism, hypokalemia and metabolic acidosis (including lactic acidosis).

Symptoms of liver dysfunction may appear 12-48 hours after overdose

: increased activity of “liver” transaminases, hepatonecrosis. In severe cases - liver failure with progressive encephalopathy, coma. Rarely, liver failure develops rapidly and can be complicated by renal failure (tubular necrosis).

Treatment

: gastric lavage, administration of activated charcoal in the first 6 hours after an overdose, administration of SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after an overdose and acetylcysteine ​​after 12 hours. The need for additional therapeutic measures (further administration of methionine and acetylcysteine ) is determined by the concentration of paracetamol in the blood, as well as the time elapsed after taking it. Symptomatic therapy.

The threshold for overdose may be lowered in elderly patients and children, in patients taking certain medications (eg, liver microsomal enzyme inducers), alcohol, or who are malnourished.

Description of the drug RINZASIP®

Paracetamol

Enhances the effects of MAO inhibitors, sedatives, ethanol.

The risk of hepatotoxic action of paracetamol increases with simultaneous use of barbiturates, phenytoin, phenobarbital, carbamazepine, rifampicin, isoniazid, zidovudine and other inducers of microsomal liver enzymes.

With long-term regular use of paracetamol, the anticoagulant effect of warfarin and other coumarins may be enhanced, and the risk of bleeding increases. A single use of paracetamol does not have a significant effect.

Metoclopramide increases the rate of absorption of paracetamol and reduces the time to reach its Cmax in the blood plasma. Likewise, domperidone may increase the rate of absorption of paracetamol.

Paracetamol may lead to an increase in T1/2 of chloramphenicol.

Paracetamol can reduce the bioavailability of lamotrigine, which may reduce the effectiveness of lamotrigine due to the induction of its metabolism in the liver.

Absorption of paracetamol may be reduced when used concomitantly with cholestyramine, but the reduction in absorption is not significant if cholestyramine is taken one hour later.

Regular use of paracetamol concomitantly with zidovudine may cause neutropenia and increase the risk of liver damage.

Probenecid affects the metabolism of paracetamol. In patients concomitantly using probenecid, the dose of paracetamol should be reduced.

The hepatotoxicity of paracetamol increases with prolonged excessive consumption of ethanol (alcohol).

Paracetamol may interfere with the results of the uric acid test using the phosphotungstate precipitating reagent.

Pheniramine

The effect of other substances on the central nervous system (for example, MAO inhibitors, tricyclic antidepressants, alcohol, antiparkinsonian drugs, barbiturates, tranquilizers and narcotic drugs) may be enhanced. Pheniramine may inhibit the action of anticoagulants.

Phenylephrine

Phenylephrine can potentiate the effect of MAO inhibitors and cause a hypertensive crisis.

Concomitant use of phenylephrine with other sympathomimetic drugs or tricyclic antidepressants (eg, amitriptyline) may lead to an increased risk of adverse cardiovascular reactions.

Phenylephrine may reduce the effectiveness of beta blockers and other antihypertensive drugs (eg, debrisoquine, guanethidine, reserpine, methyldopa). There may be an increased risk of hypertension and other cardiovascular side effects.

Concomitant use of phenylephrine with digoxin and cardiac glycosides may increase the risk of cardiac arrhythmias or myocardial infarction.

Concomitant use of phenylephrine with ergot alkaloids (ergotamine and methysergide) may increase the risk of ergotism.

When used simultaneously with barbiturates and primidone, the excretion of ascorbic acid in the urine increases.

Caffeine

Caffeine accelerates the absorption of ergotamine.

Buy Rinzasip powder for preparing an oral solution Lemon/Vit. With 5g No. 10 in pharmacies

Powder for colds Rinzasip® with a pleasant lemon flavor is a drug that helps relieve the main symptoms of colds, ARVI and flu.

The increased (1) content of paracetamol and the complex of active components included in the composition help reduce temperature, reduce pain in the throat, muscles and joints, fight chills, nasal congestion and runny nose. Caffeine, which is part of the composition, enhances the effect of paracetamol (2), and Vitamin C increases the body's resistance to various adverse environmental factors and strengthens the immune system.

Approved for use from 15 years of age.

1. Compared with preparations containing less than 750 mg of paracetamol. 2. Caffeine accelerates absorption and enhances the analgesic effect of acetaminaphen. B. Renner, D. Clark. Journal of Clinical Pharmacology, 04/18/2007.

Composition per 1 sachet (5 g)

Active ingredients: Ascorbic acid (Vitamin C) - 200 mg, Caffeine - 30 mg, Paracetamol - 750 mg, Phenylephrine hydrochloride - 10 mg, Pheniramine maleate - 20 mg.

Excipients:

- orange: citric acid 200.0 mg, sodium saccharinate 40.0 mg, sodium citrate 500.0 mg, sucrose 3062.5 mg, sunset yellow dye (E110) 7.5 mg, orange flavor 150.0 mg; - citric: citric acid 200.0 mg, sodium saccharinate 40.0 mg, sodium citrate 500.0 mg, sucrose 3136.0 mg, quinoline yellow dye (E104) 1.0 mg, lemon flavor 83.0 mg; — blackcurrant: citric acid 200.0 mg, sodium saccharinate 40.0 mg, sodium citrate 500.0 mg, sucrose 2915.0 mg, azorubine dye (E122) 4.0 mg, fruit flavor (Tutti Frutti) 166.7 mg , raspberry flavor 66.7 mg, blackcurrant flavor 66.7 mg.

Indications for use:

symptomatic treatment of colds, flu, ARVI (fever syndrome, pain syndrome, rhinorrhea).

Directions for use and doses

Inside. Pour the contents of 1 sachet (bag) into a glass, add hot water, stir until completely dissolved and drink (you can add sugar or honey if desired). Taking the drug is recommended 1-2 hours after eating. Adults and children over 15 years of age: take one sachet 3-4 times a day with intervals between doses of 4-6 hours. The maximum daily dose is 4 sachets. The course of treatment without consulting a doctor is no more than 5 days.

Contraindications

Severe atherosclerosis of the coronary arteries, portal hypertension, simultaneous use of tricyclic antidepressants, beta-blockers, monoamine oxidase inhibitors (MAO) and discontinuation of their use less than 2 weeks ago; sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption; hypersensitivity to individual components of the drug, as well as to sympathomimetic drugs; simultaneous use of medications containing substances included in the drug; pregnancy, lactation period, children under 15 years of age, alcoholism.

Side effect

Allergic reactions: skin rash, itching, urticaria, angioedema, hypersensitivity reaction, anaphylactic reaction. From the nervous system: headache, dizziness, difficulty falling asleep, insomnia, drowsiness, increased excitability. From the cardiovascular system: increased blood pressure, tachycardia, palpitations. From the digestive system: nausea, vomiting, pain in the epigastric region, dryness of the oral mucosa, increased activity of liver enzymes, hepatotoxic effect. From the senses: mydriasis, accommodation paresis, increased intraocular pressure. From the hematopoietic organs: anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia. From the urinary system: nephrotoxicity (renal colic, glycosuria, interstitial nephritis, papillary necrosis), difficulty urinating. Other: bronchospasm, dry nasal mucosa. Serious skin reactions: Very rare: - Acute generalized exanthematous pustulosis (AGEP). Acute condition with the development of pustular rashes. It is characterized by fever and diffuse erythema, accompanied by burning and itching. Swelling of the face, hands and mucous membranes may occur; — Stevens-Johnson syndrome (SJS) (malignant exudative erythema). A severe form of erythema multiforme, in which blisters appear on the mucous membrane of the mouth, throat, eyes, genitals, and other areas of the skin and mucous membranes. - Toxic epidermal necrolysis (TEN, Lyell's syndrome). The syndrome is a consequence of extensive apoptosis of keratinocytes, which leads to the peeling of large areas of skin at the dermoepidermal junction. The affected skin looks like it has been scalded by boiling water. If you notice one of the side effects described above, you should stop taking the drug and consult a doctor immediately!

Overdose

In case of overdose, consult a doctor immediately. Prompt medical attention is critical, even if you do not notice any signs or symptoms. Ascorbic acid: Symptoms of acute overdose: diarrhea and other gastrointestinal disorders. Symptoms of chronic intoxication with ascorbic acid: impaired excretory function of the kidneys, formation of kidney stones, decreased capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies, impaired iron metabolism), erosion of tooth enamel. Caffeine: Symptoms of acute overdose: abdominal pain, nausea, vomiting, fever, chills, headache, agitation, insomnia, irritability, loss of appetite, weakness, tremor, anxiety, altered consciousness, delirium, hallucinations, increased blood pressure followed by hypotension, tachycardia, tachypnea, hypokalemia, hyponatremia, hyperglycemia, metabolic acidosis, epileptic seizures, convulsions, myoclonus and rhabdomyolysis, supraventricular and ventricular arrhythmias. Symptoms of chronic caffeine intoxication (“caffeineism”): irritability, insomnia, anxiety, emotional lability, chronic abdominal pain. Pheniramine: Symptoms: central nervous system depression, hyperthermia, anticholinergic syndrome (mydriasis, flushing, fever, dry mouth, urinary retention, intestinal paresis), tachycardia, hypotension, hypertension, nausea, vomiting, psychomotor agitation, disorientation, hallucinations, psychosis , convulsions, arrhythmias. Rarely, patients with agitation, seizures, or comatose patients develop rhabdomyolysis and renal failure. Phenylephrine: Symptoms: headache, nausea, vomiting, irritability, agitation, insomnia, psychosis, convulsions, palpitations, tachycardia, increased blood pressure, reflex bradycardia. Paracetamol: Symptoms that appear after taking more than 7.5-10 g: during the first 24 hours after taking - pallor of the skin, nausea, vomiting, anorexia, abdominal pain, increased prothrombin time, impaired glucose metabolism, hypokalemia, metabolic acidosis (in including lactic acidosis). Symptoms of liver dysfunction may appear 12-48 hours after an overdose: increased activity of “liver” transaminases, hepatonecrosis. In severe cases - liver failure with progressive encephalopathy, coma. Rarely, liver failure develops rapidly and can be complicated by renal failure (tubular necrosis). The threshold for overdose may be lowered in elderly patients and children, in patients taking certain medications (eg, liver microsomal enzyme inducers), alcohol, or who are malnourished. Treatment: gastric lavage, administration of activated charcoal in the first 6 hours after an overdose, administration of SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after an overdose and acetylcysteine ​​- 12 hours later. The need for additional therapeutic measures (further administration of methionine and acetylcysteine) depends on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration. Symptomatic therapy.

Interaction with other drugs

Enhances the effects of monoamine oxidase inhibitors (MAO), sedatives, ethanol. When taken with digoxin or other cardiac glycosides, the risk of arrhythmia and myocardial infarction may increase. Antidepressants, antiparkinsonian drugs, antipsychotic drugs, phenothiazine derivatives increase the risk of developing urinary retention, dry mouth, and constipation. Glucocorticosteroids increase the risk of developing glaucoma. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity. Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. Paracetamol reduces the effectiveness of diuretic and uricosuric drugs. When administered simultaneously with barbiturates, diphenin, carbamazepine, rifampicin and other inducers of microsomal liver enzymes, the risk of developing the hepatotoxic effect of paracetamol increases. In most patients taking warfarin long-term, infrequent use of paracetamol usually has little or no effect on the international normalized ratio (INR). However, with prolonged regular use, paracetamol enhances the effect of indirect anticoagulants (warfarin and other coumarin derivatives), which increases the risk of bleeding. A single dose of caffeine increases lithium excretion by the kidneys. Abrupt cessation of caffeine may result in increased serum lithium concentrations. When taken simultaneously with monoamine oxidase inhibitors (MAOIs), furazolidone, pheniramine can lead to hypertensive crisis, agitation, and hyperpyrexia. When taken with MAO inhibitors, phenylephrine may increase blood pressure. Phenylephrine reduces the effectiveness of beta blockers and antihypertensive drugs. It also reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenomimetic activity of phenylephrine. Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine; simultaneous administration of halothane increases the risk of developing ventricular arrhythmia.

special instructions

During the treatment period you should refrain from drinking alcohol. If symptoms worsen or persist for more than 5 days, or if new symptoms appear, you should consult your doctor. The drug may cause drowsiness. The drug contains sucrose, which must be taken into account by patients suffering from diabetes mellitus, as well as those on a hypocaloric diet. 1 single dose of the drug contains from 2915.0 to 3136.0 mg of sucrose, which corresponds to 0.24-0.26 XE. Keep out of the reach of children. If the drug is swallowed by a child, seek immediate medical attention. If the medicine has become unusable or has expired, do not throw it into wastewater or onto the street! Place the medication in a bag and place it in the trash. These measures will help protect the environment!

Vacation:

over the counter

Expiration date, days:

1080

Age:

over 15 years old

Storage conditions

Store in a dry place at a temperature not exceeding 25 °C. Keep out of the reach of children.

Rinza / Rinzasip

Name: Rinza / Rinzasip Pharmacological action: Combined drug used for respiratory diseases. Contains paracetamol, phenylephrine hydrochloride, chlorpheniramine maleate, caffeine. Paracetamol is a non-steroidal analgesic-antipyretic. It is capable of inhibiting the enzyme cyclooxygenase (both isomers in equal parts), reduces the synthesis of prostaglandins, and reduces the excitability of the thermoregulation center in the brain. Since paracetamol is blocked by cellular peroxidases in inflamed tissues, the blocking of COX-1 and COX-2 in them is insignificant, this explains the insignificant anti-inflammatory effect. At the same time, paracetamol completely blocks the synthesis of prostaglandins in the spinal cord and brain, has a pronounced antipyretic effect, unlike drugs with a hypothermic effect, it only reduces febrile temperature and does not affect normal body temperature. Paracetamol has virtually no negative effect on the mucous membrane of the gastrointestinal tract, since it has no activity in peripheral tissues. Taking paracetamol in therapeutic doses does not affect water-salt and other types of metabolism in the body. Paracetamol is rapidly absorbed, mainly from the small intestine, has a high degree of binding to plasma proteins, and does not participate in the formation of methemoglobin (a hemoglobin compound in the blood that is not capable of binding to oxygen and carbon dioxide). The maximum concentration of the substance in the blood is reached within 30-60 minutes after ingestion; paracetamol penetrates the blood-brain and placental barrier.

Phenylephrine hydrochloride is an alpha1-adrenergic agonist. By binding to postsynaptic adrenergic receptors of the vascular wall, the substance causes vasoconstriction. Thus, blood pressure increases slightly. As a vasoconstrictor, it has an anticongestive effect: it reduces swelling and hyperemia of the nasal mucosa, the severity of exudative manifestations, and restores free breathing; lowers pressure in the paranasal sinuses and middle ear. With long-term use of phenylephrine hydrochloride, the phenomenon of tachyphylaxis (a gradual decrease in the strength of the effect with a constant dosage) is possible.

Chlorpheniramine (pheniramine) maleate is an H1 histamine receptor blocker. The drug inhibits H1 histamine receptors, leads to the elimination of the effects of histamine activity, including: relieves spasm of bronchial smooth muscles, reduces capillary permeability, prevents and eliminates swelling of soft tissues (including nasopharyngeal tissue). Reduces mucus secretion in the nasopharynx and has a mild sedative effect.

Caffeine has a stimulating effect on the central nervous system. Reduces symptoms of drowsiness, leads to increased mental and physical performance. In addition, it enhances the analgesic effect of paracetamol and accelerates its onset.

Indications for use: Used to relieve febrile syndrome in acute respiratory diseases of various origins. For pain syndromes of various origins: headache and toothache, myalgia, neuralgia, arthralgia, pain from injuries and burns, migraine. For acute rhinitis, sinusitis, rhinopharyngitis of various etiologies, including allergic forms of diseases. In complex therapy of the inflammatory process of the paranasal sinuses.

Directions for use: Rinza tablets: Adults are prescribed 1 tablet 3-4 times a day. The maximum single dose is 2 tablets, daily dose is 4 tablets. The course of treatment is no more than 5 days.

Powder for the preparation of a solution for oral use Rinzasip: Adults are prescribed 1 sachet 3 times a day. The contents of the sachet must be dissolved in a glass of hot water. The course of treatment is no more than 5 days.

Side effects: Allergic reactions: skin rash, itching, urticaria, angioedema, broncho-obstruction. From the side of the central nervous system: dizziness, disturbance of sleep and wakefulness, absent-mindedness, increased fatigue, increased excitability, anxiety, tremor. From the gastrointestinal tract: dry mouth, nausea, vomiting, pain in the epigastric region, liver dysfunction, exacerbation of gastric and intestinal ulcers, diarrhea. From the cardiovascular system: increased blood pressure, tachycardia, arrhythmia. From the organ of vision: increased intraocular pressure, mydriasis. From the hematopoietic system: anemia, thrombocytopenia, agranulocytosis. From the urinary system: urinary retention, papillary necrosis of the kidneys.

Contraindications: Increased individual intolerance to the components of the drug. Organic diseases of the cardiovascular system, including acute myocardial infarction, atherosclerosis. Glaucoma, tendency to vascular spasms, sleep disturbance, increased excitability, epilepsy or tendency to seizures, severe forms of diabetes mellitus, thyrotoxicosis, dysfunction of the thyroid gland, impaired liver and kidney function, children under 15 years of age, prostate hypertrophy. Pregnancy and lactation period. Prescribe with caution to patients with angina pectoris, arrhythmia, hypertension, inflammatory diseases of the gastrointestinal tract, gastric and duodenal ulcers, and bronchial asthma.

Pregnancy: Use of the drug during pregnancy and lactation is contraindicated.

Interaction with other drugs: When taken simultaneously, the drug reduces the effect of sleeping pills, sedatives, and narcotics. Increases the effect of anticoagulant drugs. Concomitant use with hepatotoxic drugs increases the risk of developing severe liver intoxication. Simultaneous use with ethanol contributes to the development of acute pancreatitis. Concomitant use with other non-steroidal anti-inflammatory drugs increases the risk of developing renal papillary necrosis and nephropathy. Concomitant use with diuretics, phenothiazines and alpha-blockers can lead to the development of a hypertensive crisis. Beta blockers reduce the cardiac stimulating activity of the drug.

Overdose: In case of acute overdose of the drug, gastrointestinal disorders (nausea, vomiting, diarrhea), increased sweating are possible. In case of chronic overdose of the drug, the result may be severe liver dysfunction. In case of overdose, gastric lavage and enterosorbents are prescribed. Specific therapy is the introduction of SH-group donors and precursors for the synthesis of glutathione-methionine and N-acetylcysteine.

Release form: Rinza tablets in blister packs of 10 pieces, 1, 2 or 10 blisters per package. Powder for the preparation of a solution for oral use with orange/lemon/blackcurrant flavor Rinzasip in 5g bags, 10 or 25 bags in a carton.

Storage conditions: In a dry place, protected from light at a temperature of 15-25 degrees Celsius. Shelf life – 3 years.

Composition: Tablets 1 tablet of Rinza contains: Paracetamol – 500 mg; Caffeine – 30 mg; Phenylephrine hydrochloride – 10 mg; Chlorpheniramine maleate – 2 mg; Additional substances.

Powder for preparing a solution for oral use, 1 sachet of Rinzasip contains: Paracetamol – 750 mg; Pheniramine maleate – 20 mg; Phenylephrine hydrochloride – 10 mg; Caffeine – 30 mg; Additional substances.

Attention! The description of the drug “ Rinza / Rinzasip ” on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

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