Buy Tsitovir-3 powder for oral solution 20g/50ml in pharmacies

Ingredients: per capsule

Active ingredients: alpha-glutamyl-tryptophan sodium (Timogen® sodium) 0.5 mg, ascorbic acid 50 mg, bendazole hydrochloride (Dibazol) 20 mg; Excipients: Lactose monohydrate 97.8 mg, calcium stearate 1.7 mg;

Composition of the capsule shell:

Body: titanium dioxide 2%, gelatin up to 100%. Cap: titanium dioxide 2%, sunset yellow dye 0.2190%, azorubine dye 0.0328, gelatin up to 100%.

Description:

Hard gelatin capsules No. 3 with a white body and an orange cap. The contents of the capsules are odorless, white to yellow powder.

Pharmacotherapeutic group:

Immunostimulating agent.

ATX code: L03AX

Pharmachologic effect:

Pharmacodynamics:

The drug is a means of etiotropic and immunostimulating therapy, has an indirect antiviral effect against influenza A and B pathogens, as well as other viruses that cause acute respiratory diseases.

In in vitro studies, the drug specifically suppresses (inhibits) the reproduction (replication) of the SARS-CoV-2 virus, which is the causative agent of the new coronavirus infection (COVID-19).

The degree of inhibition of the pathogen increases with increasing concentration of the drug (the linearity of the dose-effect relationship is shown). Reduces the severity of the main clinical symptoms of influenza and ARVI, and also shortens the duration of the disease and contributes to its uncomplicated course.

Increases the content of secretory immunoglobulin A (slgA) in the mucous membrane of the nasopharynx - the entrance gate of infection, increasing the local immunoresistance of the body to respiratory infections of a viral and bacterial nature.

With a preventive effect, the drug increases the potential metabolic activity of innate immune cells (neutrophil granulocytes and monocytes), which, in the event of infection, increases their ability to absorb and destroy bacterial and viral agents due to increased enzymatic (oxidative) activity, synthesis of cationic proteins and increased number of phagocytic cells. In this case, the initial state of metabolic activity of innate immune cells, in the absence of infectious agents, does not change, being within normal values.

Bendazole induces the body's production of endogenous interferon and has an immunomodulatory effect (normalizes the body's immune response to various infectious agents). Enzymes, the production of which is induced by interferon in the cells of various organs, inhibit viral replication.

Alpha-glutamyl-tryptophan (thymogen) is a synergist for the immunomodulatory effect of bendazole, normalizing the T-cell component of immunity.

Ascorbic acid activates the humoral component of the immune system, normalizes capillary permeability, thereby reducing inflammation, exhibits antioxidant properties, neutralizing oxygen radicals that accompany the inflammatory process, and increases the body's resistance to infection.

Pharmacokinetics:

When taken orally, the drug is completely absorbed from the gastrointestinal tract. The bioavailability of bendazole is about 80%, alpha-glutamyl tryptophan is no more than 15% and ascorbic acid is 90%. Metabolites of ascorbic acid and bendazole are excreted in the urine. Alpha-glutamyl-tryptophan, under the influence of peptidases, is broken down into L-glutamic acid and L-tryptophan, which are used by the body in peptide synthesis.

Indications for use:

Prevention and complex therapy of influenza and acute respiratory viral infections in adults and children over 6 years of age.

Contraindications:

Hypersensitivity to the components of the drug, pregnancy, children under 6 years of age.

Carefully:

during breastfeeding, use is possible if the expected benefit to the mother outweighs the potential risk to the child.

Directions for use and dosage:

Inside, 30 minutes before meals. Single dose for adults and children over 6 years of age – 1 capsule. For treatment: one capsule 3 times a day for 4 days. For prevention: - in direct contact with a patient with influenza and other acute respiratory viral infections, one capsule 3 times a day for 4 days. — during the period of epidemic rise in the incidence of influenza and other acute respiratory viral infections, one capsule 1 time per day for 12 days. Preventive courses, if necessary, are repeated after 3 weeks (until the epidemic situation normalizes).

Side effects:

Allergic reactions, short-term decrease in blood pressure.

Overdose:

Symptoms: short-term decrease in blood pressure in elderly patients with vegetative-vascular dystonia. Monitoring of kidney function, blood pressure and blood glucose concentrations is necessary.

Interaction with other drugs:

No interaction of alpha-glutamyl-tryptophan with drugs has been identified.

Bendazole prevents the increase in total peripheral vascular resistance caused by the use of non-selective beta-blockers. Strengthens the hypotensive (lowering blood pressure) effect of antihypertensive and diuretic drugs. Phentolamine enhances the hypotensive effect of bendazole.

Ascorbic acid increases the concentration in the blood of antibacterial drugs of the tetracycline series and benzylpenicillin. Improves the absorption of iron (Fe) preparations in the intestines. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce its absorption and absorption. When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Ascorbic acid increases the risk of developing crystalluria when using drugs containing acetylsalicylic acid (ASA) and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration in the blood of oral contraceptives. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Possible simultaneous use with antiviral drugs and symptomatic treatment of influenza and ARVI.

Consult your doctor if you are taking the medications listed in this section or other medications.

Special instructions:

The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form:

Capsules. 12 capsules each in a blister pack made of PVC/PCTFE/PVC film (polyvinyl chloride/polychlorotrifluoroethylene/polyvinyl chloride) or PVC/PVDC/PVC (polyvinyl chloride/polyvinylidene chloride/polyvinyl chloride) and printed varnished aluminum foil. One, or two, or four blister packs with instructions for use in a cardboard pack.

Storage conditions:

At a temperature not higher than 25 oC. Keep out of the reach of children.

Best before date:

3 years. Do not use after the expiration date stated on the packaging.

Vacation conditions:

Over the counter.

Legal entity in whose name the registration certificate was issued: Joint Stock Company Medical-Biological Research and Production Complex Cytomed, Russia. (Cytomed Oy). Production site address: Finland, 55300 Rauha, Laastitie 1 Cytomed Oy. Finland, 55300 Rauha, Laastitie 1. Name and address of the organization authorized by the holder (owner) of the registration certificate of a medicinal product for medical use to accept claims from the consumer: JSC MBNPC Cytomed, Russia. 194356, St. Petersburg, Orlovo-Denisovsky prospect, 14, building 1, tel., cytomed.ru.

Buy Tsitovir-3 powder for oral solution 20g/50ml in pharmacies

Read these instructions carefully before you start taking this medicine.

Save the instructions, you may need them again.

This medicine is available without a prescription. To achieve optimal results, it should be used strictly following all recommendations outlined in the instructions.

If you have any questions, consult your doctor.

Contact your doctor if your condition worsens or does not improve after 3 days.

The medicine you are using is intended for you personally and should not be given to others as it may cause harm to them even if they have the same symptoms as you.

Trade name of the drug:

Tsitovir-3

Group name:

Alpha glutamyl tryptophan + Ascorbic acid + Bendazole

Dosage form:

powder for oral solution [for children] [unflavored, orange, strawberry, cranberry]

Compound:

1 ml of the prepared solution contains:

Active ingredients:

Alpha-glutamyl-tryptophan (Thymogen sodium in terms of thymogen) - 0.15 mg Ascorbic acid - 12 mg Bendazole hydrochloride [Dibazol] - 1.25 mg

Excipients: Lactose monohydrate - 20 mg

In the preparation without flavoring: Fructose - 366.6 mg

In the preparation with flavoring: Fructose - 366.2 mg

Food flavoring “Orange”, or “Strawberry”, or “Cranberry” - 0.4 mg

Description:

white or white powder with a yellowish tint.

An aqueous solution, odorless or with a characteristic odor of orange, cranberry, or strawberry.

Pharmacotherapeutic group:

immunostimulant

Pharmacological properties:

Pharmacodynamics:

the drug is a means of etiotropic and immunostimulating therapy, has an indirect antiviral effect against influenza A and B pathogens, as well as other viruses that cause acute respiratory diseases.

In in vitro studies, the drug specifically suppresses (inhibits) the reproduction (replication) of the SARS-CoV-2 virus, which is the causative agent of the new coronavirus infection (COVID-19).

The degree of inhibition of the pathogen increases with increasing concentration of the drug (the linearity of the dose-effect relationship is shown).

Reduces the severity of the main clinical symptoms of influenza and ARVI, and also shortens the duration of the disease and promotes its uncomplicated course.

Increases the content of secretory immunoglobulin A (sIgA) in the mucous membrane of the nasopharynx - the entrance gate of infection, increasing the local immunoresistance of the body to respiratory infections of a viral and bacterial nature.

With a preventive effect, the drug increases the potential metabolic activity of innate immune cells (neutrophil granulocytes and monocytes), which, in the event of infection, increases their ability to absorb and destroy bacterial and viral agents due to increased enzymatic (oxidative) activity, synthesis of cationic proteins and increased number of phagocytic cells. In this case, the initial state of metabolic activity of innate immune cells, in the absence of infectious agents, does not change, being within normal values.

Bendazole induces the body's production of endogenous interferon and has an immunomodulatory effect (normalizes the body's immune response). Enzymes, the production of which is induced by interferon in the cells of various organs, inhibit viral replication.

Alpha-glutamyl-tryptophan (thymogen) is a synergist for the immunomodulatory effect of bendazole, normalizing the T-cell component of immunity.

Ascorbic acid activates the humoral component of the immune system, normalizes capillary permeability, thereby reducing inflammation, and exhibits antioxidant properties, neutralizing oxygen radicals that accompany the inflammatory process, and increases the body's resistance to infection.

Pharmacokinetics:

When taken orally, the drug is completely absorbed from the gastrointestinal tract. The bioavailability of bendazole is about 80%, alpha-glutamyl-tryptophan is no more than 15%, ascorbic acid is up to 70%. Ascorbic acid is absorbed in the gastrointestinal tract (mainly in the jejunum). Communication with plasma proteins – 25%. Tmax after oral administration – 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues, penetrates the placenta.

Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, impaired intestinal motility, helminthic infestation, giardiasis), consumption of vegetable and fruit juices, and alkaline drinking reduce the binding of ascorbic acid in the intestine. Ascorbic acid is metabolized primarily in the liver into deoxyascorbic acid, then into oxaloacetic and diketogulonic acids. It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites. The products of bendazole biotransformation in the blood are two conjugates formed as a result of methylation and carboethoxylation of the imino group of the imidazole ring of bendazole: 1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2benzylbenzimidazole. Bendazole metabolites are excreted in the urine. Alphaglutamyl-tryptophan, under the influence of peptidases, is broken down into L-glutamic acid and L-tryptophan, which are used by the body in protein synthesis.

Indications for use:

prevention and complex therapy of influenza and acute respiratory viral infections in children over one year of age.

Contraindications

Hypersensitivity to the components of the drug, lactase deficiency, lactose intolerance, sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, pregnancy, children under 1 year of age. If necessary, please consult your doctor before taking the drug.

Carefully

Consult your doctor before taking the drug if you have diabetes, intolerance to certain sugars, or arterial hypotension.

Use during pregnancy and breastfeeding:

During pregnancy, taking the drug is not recommended due to insufficient clinical data. During breastfeeding, use is possible if the expected benefit to the mother outweighs the potential risk to the child. If you need to take the drug during breastfeeding, please consult your doctor.

Directions for use and doses

Orally 30 minutes before meals.

For treatment:

Children aged 1 to 3 years – 2 ml 3 times a day; children aged 3 to 6 years – 4 ml 3 times a day; children aged 6 to 10 years – 8 ml 3 times a day; children over 10 years of age – 12 ml 3 times a day.

Course of application is 4 days. If after 3 days of treatment there is no improvement or the symptoms worsen or new symptoms appear, you should consult your doctor.

For prevention:

In direct contact with patients with influenza and other acute respiratory viral infections:

Children aged 1 to 3 years – 2 ml 3 times a day; children aged 3 to 6 years – 4 ml 3 times a day; children aged 6 to 10 years – 8 ml 3 times a day; children over 10 years of age – 12 ml 3 times a day.

Course of application is 4 days.

Preventive courses, if necessary, are repeated after 3 weeks (until the epidemic situation normalizes).

Rules for preparing the solution: add 40 ml of water (boiled, cooled to room temperature) to the bottle with the powder and shake well. The contents should completely dissolve. The volume of the solution after adding water is 50 ml.

Take the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before taking the drug.

Use the drug only according to the indications indicated in the instructions.

Side effect:

a short-term decrease in blood pressure is possible. Possible allergic reactions: urticaria. In these cases, the use of the drug is stopped and symptomatic treatment and antihistamines are prescribed.

Consult your doctor if you experience any of the side effects mentioned or other side effects not listed in the instructions.

If the side effects listed in the instructions get worse, tell your doctor.

Overdose:

cases of overdose have not been described.

Interaction with other drugs

No interaction of alpha-glutamyl-tryptophan with drugs has been identified.

Bendazole prevents the increase in total peripheral vascular resistance caused by the use of non-selective beta-blockers. Strengthens the hypotensive (lowering blood pressure) effect of antihypertensive and diuretic drugs. Phentolamine enhances the hypotensive effect of bendazole.

Ascorbic acid increases the concentration in the blood of antibacterial drugs of the tetracycline series and benzylpenicillin. Improves the absorption of iron (Fe) preparations in the intestine. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce its absorption and absorption. When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Ascorbic acid increases the risk of developing crystalluria when using drugs containing acetylsalicylic acid (ASA) and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration in the blood of oral contraceptives. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Possible simultaneous use with antiviral drugs and symptomatic treatment of influenza and ARVI.

Consult your doctor if you are taking the medications listed in this section or other medications.

Special instructions:

The drug contains fructose; taking it for more than 2 weeks can cause dental damage.

After a repeated course, monitoring of blood glucose concentrations is recommended.

Information for patients with diabetes mellitus: 1 ml of drug solution contains 20 mg of lactose and 366.6 mg of fructose (in a preparation without flavoring or 366.2 mg of fructose in a preparation with flavoring), which corresponds to 0.032 bread units (XU).

Sugar content in single and daily doses of the drug, in XE:

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to drive vehicles, operate moving machinery, or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form:

powder for oral solution [for children] [unflavored, orange, strawberry, cranberry]. 20 g in a dark glass bottle. The bottle is sealed with a plastic cap with a first opening control in the form of a safety ring and/or a membrane made of aluminum foil, child-resistant. Self-adhesive labels or multi-page labels are placed on the bottles.

One bottle is placed in a cardboard pack. Instructions for use are placed in a pack or in the form of a folded sheet placed under the opening part of the label.

A dosing device is placed in the pack: a measuring cup.

Storage conditions

Store at a temperature not exceeding 25C. Keep out of the reach of children.

Store the prepared solution in a place protected from light at a temperature from 2 °C to 8 °C.

Best before date:

3 years.

The shelf life of the prepared solution is 10 days.

Do not use after the expiration date stated on the packaging.

Vacation conditions:

available without a prescription.