Isofra is an antimicrobial (antibacterial), but not vasoconstrictor, drug for topical use in ENT practice. The composition includes the antibiotic framycetin, which belongs to the group of aminoglycosides and has a bactericidal effect. Has activity against gram-positive and gram-negative microorganisms and various strains of bacteria. Isofra inhibits the synthesis of proteins that are necessary for the life of the bacterial cell. Pseudomonas aeruginosa, chlamydia, streptococci, and enterococci show resistance to framycetin.
Pharmacokinetics have not been studied, since Isofra has a low level of absorption by the body.
The drug is a prescription drug and is therefore dispensed from the pharmacy only with a doctor's prescription.
Contraindications
- Susceptibility to the active substance;
- Children under 1 year;
- Pregnancy;
- Breastfeeding period;
- It is forbidden to use Isofra for rinsing the nose.
- Long-term use is not recommended.
You can buy the drug in the 911 pharmacy chain or on the official website apteka911.ua at the most affordable price. On the website you can arrange delivery to a post office convenient for you, thus protecting your health from contact with sick people.
Dosages for Isofra therapy, methods of administration
The instructions recommend adhering to the following standards:
- for adults – from 4 to 6 procedures per day, one injection into each nasal passage;
- babies over 12 months - three times a day, one spray in each nostril.
The duration of therapeutic manipulations does not exceed 1 week. The duration of therapy is prescribed by the attending physician taking into account the indicators of laboratory diagnostic examination, tolerability of Isofra and the results achieved.
The spray is more convenient to use than classic nasal drops. The solution is evenly distributed over the mucous membranes and does not flow down the back wall of the nasopharynx. The volume of administered medication is precisely dosed.
During clinical studies, no cases of drug overdose were recorded. Tests have proven that the active components of the drug can reduce the effectiveness of topical medications aimed at combating fungal infections. No other interactions with medications have been recorded.
Isofra, how to inject?
The bottle with the drug should be held vertically, the head should be slightly tilted forward and sprayed.
Isofra, how often can I use it?
For adults, the drug should be used 4 to 6 times a day, for children over 1 year old - no more than 3 times a day. Isofra should not be used frequently, as resistance to the drug may occur in some strains of microorganisms.
Isofra from what?
Isofra is used for infectious and inflammatory processes of the nasal cavity: rhinitis, sinusitis, sinusitis, nasopharyngitis, and for the prevention of complications after operations.
What is better Isofra or Polydex for adults?
Polydexa is an analogue of Isofra. Both drugs are produced by the same pharmaceutical company, the drugs are indicated for similar diseases, are well tolerated and have a minimum of adverse reactions, both drugs are contraindicated during pregnancy and breastfeeding. The main difference is the composition and principle of action. Isofra is a monocomponent drug and is used only for bacterial infections. Polydexa is a complex remedy that not only has an antibacterial effect, but also decongestant and fights inflammatory diseases.
Indications, adverse reactions, contraindications for Isofra therapy
The instructions indicate that the nasal spray is prescribed for complex therapy:
- sinusitis;
- pharyngitis, sinusitis of bacterial etiology;
- rhinopharyngitis.
Isofra is recommended to prevent the development of infections and inflammations of the ENT organs after surgery. The use of the spray is allowed for patients over 12 months of age.
The drug is contraindicated in children under one year of age and is not used in cases of individual intolerance to the component composition. The drug is not contraindicated in nursing and pregnant women, but treatment should be carried out with the approval of a doctor if the potential risk to the fetus does not outweigh the practical benefit to the mother's body.
During therapeutic manipulations, some patients experienced adverse reactions to Isofra. During therapy the following may occur:
- allergic reactions;
- toxicerma - an acute inflammatory process of the skin that forms in response to allergens that have entered the body;
- Quincke's edema and anaphylaxis.
The appearance of signs of allergies or other non-standard reactions requires consultation with your doctor. The specialist will change the treatment regimen and select suitable analogues. In case of adverse reactions, taking the medication should be stopped immediately.
Note!
The description of the drug Isofra on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Features of the composition and release form
The active component of the colorless solution of Isofra is framycetin sulfate. Additional drops ingredients are:
- sodium chloride;
- sodium salt and citric acid monohydrate;
- purified water;
- preservative E218.
The medicine is available in 15 ml bottles made of opaque white polyethylene. Each package contains instructions for use and a bottle of medication.
Isofra 1.25% 15ml nasal spray
pharmachologic effect
An antibiotic from the aminoglycoside group.
Composition and release form Isofra 1.25% 15ml nasal spray
Spray - 100 ml:
- Active ingredient: Framycetin sulfate - 1.25 g, which corresponds to 800,000 units;
- Excipients: methyl parahydroxybenzoate, sodium chloride, sodium citrate, citric acid monohydrate, purified water.
Nasal spray 1.25%. 15 ml in light-proof polyethylene bottles with a spray tip and a polyethylene screw cap.
1 bottle along with instructions for use is placed in a cardboard box.
Description of the dosage form
Transparent colorless or almost colorless liquid.
Directions for use and doses
Adults: one spray into each nostril 4-6 times a day.
Children: one spray into each nostril 3 times a day.
The duration of treatment is no more than 7 days.
When used, the bottle should be kept in an upright position.
Pharmacodynamics
Antibiotic from the group of aminoglycosides for topical use in otolaryngology. Acts bactericidal. Active against most gram-positive and gram-negative bacteria (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae), causing the development of infectious processes in the upper respiratory tract.
Indications for use Isofra 1.25% 15ml nasal spray
As part of combination therapy for infectious and inflammatory diseases of the upper respiratory tract, including:
- rhinitis;
- rhinopharyngitis;
- sinusitis (in the absence of damage to the septum).
Prevention and treatment of inflammatory processes after surgery.
Contraindications
Hypersensitivity to framycetin and other aminoglycoside antibiotics. The drug should not be used to rinse the paranasal sinuses. Pregnancy and breastfeeding period.
Use of Isofra 1.25% 15ml nasal spray during pregnancy and breastfeeding
Contraindicated during pregnancy and breastfeeding.
special instructions
It should be remembered that during treatment, resistant strains of microorganisms may appear.
Overdose
Due to the low degree of absorption into the systemic circulation, an overdose is unlikely.
Side effects of Isofra 1.25% 15ml nasal spray
Allergic reactions are possible.
Drug interactions
No clinically significant interactions of the drug with other drugs have been identified.
Patient reviews
According to buyers, the product acts quickly in the early stages of a bacterial disease and suppresses the activity of pathogenic microflora in a few days. With sinusitis, the clinical manifestations of the disease disappear within 72 hours, but if no changes occur, then the therapeutic procedures are stopped, and a more suitable analogue is selected.
In childhood, the appointment is prescribed by the attending physician. Attempts at self-medication without determining the source of the disease do not bring the expected results and may cause pathogen resistance to the active ingredients of the solution. The medicine works well in the treatment of rhinitis, sinusitis, and adenoids.
Special instructions and analogues of Isofra
The manufacturer focuses on the following nuances:
- violation of the rules of use from the instructions attached to the drug, uncontrolled use can cause bacterial resistance to the active components of the solution;
- before starting therapy, the patient must attend a consultation with a local doctor;
- after completion of treatment procedures, the bottle of medicine is disposed of - the problem is associated with a high risk of contamination of the packaging by bacteria.
The medicine is sold by prescription and should be stored in a dark place at temperatures up to 25 degrees. The spray should be kept away from small children and pets. Isofra retains its properties for 1.5 years; after opening the bottle it must be used within one calendar month.
The appearance of adverse reactions and signs of allergy requires a revision of the treatment regimen, replacing the drug with a suitable analogue. A list of common substitutes is presented:
- Aqua Marisom Strong;
- Aqua Marisome;
- AquaMaster;
- Delufen;
- Marimer;
- Morenasalom;
- Otrivin Baby;
- Pinosol;
- Salin;
- Sinuforte;
- Physiometer;
- Cinnabsin;
- Evamenol;
- Eucaseptum;
- Euphorbium Compositum Nazentropfen S.
The drug does not have a 100% analogue with the same active ingredient. Therapy can be carried out with drugs containing aminoglycosides: Amikacin, Bramitob, Garamycin, Dilaterol, Streptomycin and others.
The cost of substitutes is sometimes lower than the price of the original medicine. Pharmacies offer Isofra from 170 rubles per 15 ml bottle.
Helps ease children's breathing and adult experiences!
1. Patients with acute rhinosinusitis. What to do? Simple answers to complex questions. Effective pharmacotherapy. 2019; thirty
2. Instructions for medical use of the drug Isofra, RU P N015454/01 dated December 15, 2008
3. Kokorina V.E. Analysis of the results of the possibility of local therapy for acute rhinosinusitis as complications of H1N1 influenza in frequently ill children. Materials of the VII St. Petersburg Forum of Otorhinolaryngologists of Russia. 2018
4. Radtsig E.Yu., Zlobina N.V. Topical antibiotics in the treatment of acute adenoiditis in children. Pediatrics. 2015; 5
5. Periodic reports on drug safety submitted to the RZN by Recordati
6. Production is certified according to GMP standards
7. Ryazantsev S.V., Krivopalov A.A., Eremin S.A., Shamkina P.A. Topical antibacterial therapy in the treatment of inflammatory diseases of the nasal cavity, paranasal sinuses and the prevention of complications. RMJ. 2019; 8(I):55–59
8. Lopatin A.S. Rational pharmacotherapy of ear, nose and throat diseases. M: Literra Publishing House, 2019
9. Kryukov A.V., Kunelskaya N.L. et al. Acute sinusitis: wedge. rec. M.: GEOTAR-Media, 2018
10. Acute sinusitis: methodological recommendations of NMAO / ed. S.V. Ryazantsev. St. Petersburg: Polyforum Group, 2018
11. Soldatsky Yu.L., Denisova O.A. Comparative effectiveness of framycetin in the complex therapy of adenoiditis in children. Bulletin of otorhinolaryngology. 2014; 5
12. Svistushkin V.M., Sinkov E.V. Inflammatory diseases of the nasal cavity and paranasal sinuses. The role of local therapy. Medical advice. 2016; 18
13. Karpishchenko S.A., Vereshchagina O.E., Bolozneva E.V., Bibik P.R. Prevention of stenosis of the frontal recess after endoscopic transnasal surgery on the frontal sinus and endoscopic septoplasty for acute and chronic pathology of the frontal sinuses. Bulletin of otorhinolaryngology. 2020; 85(1):105-110.
14. Rusetsky Yu.Yu., Malyavina U.S., Meitel I.Yu., Spiranskaya O.A. Features and effectiveness of endoscopic sinus surgery in children. Bulletin of otorhinolaryngology. 2020; 85(1):89-93
15. Balyasinskaya G.L., Edgem S.R. Experience in the treatment of acute rhinosinusitis in children with topical medications. Effective pharmacotherapy. 2011; 2
16. Karpova E.P., Kharina D.V. Possibilities of rational pharmacotherapy of adenoiditis in children. Bulletin of otorhinolaryngology. 2016; 5
17. Dobretsov K.G. The use of topical antibacterial drugs for acute bacterial rhinosinusitis in children under 1 year of age. 2013; 12(1):190-192
