Pharmacy No. 84. Delivery of medicines to your home and office.

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Lactobacterin

Lactobacterin is used orally for intestinal diseases, and intravaginally in obstetric and gynecological practice.

Dissolve the contents of the bottle with boiled water at room temperature at the rate of 5 ml (teaspoon) of water per 1 dose of the drug.

Dissolution is carried out as follows: pour the required amount of water into a glass (in accordance with the number of doses indicated on the bottle); open the bottle by removing the cap and stopper; transfer a small amount of water from the glass into the bottle; after dissolution (the drug dissolves in no more than 5 minutes to form a homogeneous suspension of yellowish-beige or whitish-gray color), transfer the contents of the bottle into the same glass and mix. One teaspoon of the drug dissolved in this way is 1 dose. For children, the contents of the bottle are dissolved at the rate of 1 ml per 1 dose of the drug.

For intestinal diseases, the drug should be taken 40-60 minutes before meals and preferably washed down with milk. Treatment is recommended to be accompanied by the use of vitamins.

The daily dose and duration of treatment is determined by the doctor depending on the clinical form of the disease and the severity of dysbacteriosis.

For intestinal diseases, Lactobacterin is used in the following daily doses:

Age	Dose
Up to 6 months	3 doses 2 times a day
From 6 months to 1 year	3 doses 3 times a day
From 1 to 3 years	5 doses 2 times a day
Over 3 years and adults	5 doses 2-3 times a day

The course of treatment with Lactobacterin for various diseases is

a) in case of prolonged and chronic course of dysentery, post-dysenteric colitis, after-treatment of convalescents after acute intestinal infections, as well as in case of long-term intestinal dysfunction of unknown etiology - at least 4 weeks;

b) for nonspecific ulcerative colitis, as well as chronic colitis and enterocolitis - up to 2 months;

c) for dysbacteriosis of various etiologies - 3-4 weeks.

If there is no effect from using the drug for 2 weeks, it is necessary to re-examine the microflora of the gastrointestinal tract and correct it with other drugs, depending on the result obtained.

To consolidate the obtained clinical effect or in the absence of complete normalization of the microflora after the end of the course of treatment, for diseases that occur with relapses, repeated courses of treatment are advisable. In these cases, before prescribing the drug, a repeated study of the microflora is necessary.

For inflammatory diseases of the genitals

Lactobacterin is prescribed 5 doses 2 times a day intravaginally for 10-12 days, starting from the 10-12th day of the menstrual cycle.

For prenatal preparation of pregnant women at risk

Lactobacterin is prescribed 5 doses 1 time per day for 5-8 days.

For intravaginal use, dissolve the contents of the bottle in 5-10 ml of boiled water at room temperature, soak a sterile tampon with the dissolved drug, insert the tampon into the vagina and leave for 2-3 hours.
In adolescents and young children, douching (irrigation) can be used. Treatment is carried out under the control of restoration of the purity of vaginal secretions to the I-II degree, the appearance of lactoflora and the disappearance of clinical symptoms of the disease.

In what cases is Lactobacterin prescribed?

The instructions for Lactobacterin contain an extensive list of indications. First of all, these are pathologies of the digestive system associated with an imbalance in the intestinal microflora in patients without age restrictions. The drug is also successfully used in the treatment of diseases of the female reproductive system caused by an imbalance in the vaginal microflora.

For gastrointestinal diseases Lactobacterin is used for:

normalizing the intestinal microflora after an acute intestinal infection or food poisoning in cases where there are symptoms of intestinal malfunction or pathogenic or conditionally pathogenic flora is released in the biomaterial;
therapy for intestinal dysbiosis resulting from long-term use of antibiotics, hormones, or undergoing a course of treatment for cancer;
treatment of chronic colitis;
treatment of infectious and non-infectious diseases, which are accompanied by intestinal dysbiosis and skin manifestations, in children whose body is weakened.

In gynecology, Lactobacterin is prescribed to restore the microflora of the external genitalia after a course of antibiotics for bacterial vaginosis, in the treatment of inflammation of a non-infectious nature. Suppositories are also indicated for:

preparation for surgical interventions or special diagnostics of gynecological pathologies;
carrying out infection prevention after childbirth or after gynecological operations;
prenatal preparation of women at risk and having 3 or 4 degrees of smear purity.

Dosage forms and composition of the drug

Lactobacterin is available in two forms: lyophilisate for making a suspension and suppositories for use in gynecology.

The lyophilisate is a crystalline powder or porous mass of pale yellow or grayish color, with a specific odor. The dry substance is packaged in bottles, each containing three or five doses. The bottles are placed in cardboard boxes complete with annotation.

One dose contains approximately 2 × 109 CFU of lactobacilli, excipients are gelatin, sucrose and milk.

One suppository contains about 10 million CFU of lactobacilli acidophilus. Candles are packaged in boxes with cells of 5 pieces; they go on sale in 10 pieces in boxes equipped with instructions.

How the drug works

Lactobacterin has a detrimental effect on pathogenic and conditionally pathogenic microbes, including staphylococcus, E. coli, Proteus, and Shigella. Thanks to this, the medicine restores the imbalance in the microbiocenosis of the digestive system and vagina.

Also this drug:

help improve metabolic processes;
serve to prevent the transition of intestinal diseases to a chronic form;
increases the body's innate resistance to the invasion of infectious agents.

After entering the body, lactobacilli:

promote the formation of lactic acid and hydrogen peroxide;
trigger the production of lysozyme and other substances that resemble antibiotics in their activity;
help the absorption of vitamins;
normalize and help maintain the balance of the bacterial flora of the vagina.

How to use Lactobacterin suppositories

The regimen for using suppositories depends on the indications for use:

to normalize vaginal microflora after taking antibiotics, treat non-infectious inflammations - five doses twice a day for 10-12 days;
to prevent the development of infections after childbirth or gynecological operations, during prenatal preparation - 5 doses once a day for a course of 7-8 days.

At the end of the course of treatment, a smear on the flora to determine the effectiveness of treatment.

Lactobacterin lyof for the preparation of suspension 5 doses fl N 10

Active substance

lactobacilli (Lactobacillus)

ATX code

A07FA01 (Preparations containing microorganisms producing lactic acid)

Release form, packaging and composition of the drug

◊ Pills	1 tab.
Lactobacillus acidophilus	2 billion CFU

20 pcs. — bottles (5) — cardboard packs. 20 pcs. — bottles (10) — cardboard packs.

◊ Pills	1 tab.
Lactobacillus acidophilus	4000000000 CFU

3 doses - bottles (10) - cardboard packs. 5 doses - bottles (10) - cardboard packs.

Clinical and pharmacological group

A drug that regulates the balance of intestinal microflora (probiotic)

Pharmacotherapeutic group

MIBP-eubiotic

Indications for use

For diseases of the gastrointestinal tract:

convalescents who have suffered acute intestinal infections, in the presence of intestinal dysfunction or the release of pathogenic and opportunistic bacteria;
somatic diseases complicated by dysbiosis resulting from the use of antibiotics, chemotherapy and other reasons;
complex treatment of weakened children with diseases of infectious and non-infectious etiology, accompanied by dysbiosis and atopic dermatitis;
chronic colitis of various etiologies, including nonspecific ulcerative colitis.

For diseases of the female genital area:

for sanitization of the genital tract in case of nonspecific inflammatory diseases of the genitals and prenatal preparation of pregnant women at risk with violations of the purity of vaginal secretions up to the III-IV degree.

Dosage

Lactobacterin is used orally for intestinal diseases, and intravaginally in obstetric and gynecological practice.

Dissolve the contents of the bottle with boiled water at room temperature at the rate of 5 ml (teaspoon) of water per 1 dose of the drug.

Dissolution is carried out as follows: pour the required amount of water into a glass (in accordance with the number of doses indicated on the bottle); open the bottle by removing the cap and stopper; transfer a small amount of water from the glass into the bottle; after dissolution (the drug dissolves in no more than 5 minutes to form a homogeneous suspension of whitish-gray or yellowish-beige color), transfer the contents of the bottle into the same glass and mix. One teaspoon of the drug dissolved in this way is 1 dose.

For intestinal diseases, the drug should be taken 40-60 minutes before meals and preferably washed down with milk. Treatment is recommended to be accompanied by the use of vitamins.

For intestinal diseases, Lactobacterin is used in the following daily doses:

Age	Dose
Up to 6 months	3 doses 2 times a day
From 6 months to 1 year	3 doses 3 times a day
From 1 to 3 years	5 doses 2 times a day
Over 3 years and adults	5 doses 2-3 times a day

The course of treatment with Lactobacterin for various diseases is:

a) for protracted and chronic dysentery, post-dysenteric colitis, after-treatment of convalescents after acute intestinal infections, as well as for long-term intestinal dysfunction of unknown etiology, treatment - at least 4-6 weeks;

b) for nonspecific ulcerative colitis, as well as chronic colitis and enterocolitis - up to 2 months;

c) for dysbacteriosis of various etiologies - 3-4 weeks.

If there is no effect from using the drug for 2 weeks, it is necessary to re-examine the microflora of the gastrointestinal tract and correct it with other drugs, depending on the result obtained.

For inflammatory diseases of the genitals, Lactobacterin is prescribed 5 doses 2 times a day intravaginally for 10-12 days, starting from the 10-12th day of the menstrual cycle. For prenatal preparation of pregnant women at risk, Lactobacterin is prescribed 5 doses once a day for 5-8 days.

Treatment is carried out under the control of restoration of the purity of vaginal secretions to the I-II degree, the appearance of lactoflora and the disappearance of clinical symptoms of the disease.

Contraindications

vulvovaginal candidiasis.

Overdose

Not registered.

Side effects

No reaction to the drug was detected.

Overdose

Due to the high antibiotic resistance of lactobacilli, the use of dry lactobacterin during antibiotic therapy is allowed.

Storage conditions

In accordance with SP 3.3.2.1248-03 at a temperature not exceeding 10 °C. Keep out of the reach of children. The shelf life of the drug is 1 year (if one dose contains at least 2 × 109 live lactobacilli); 2 years (with at least 4 × 109 live lactobacilli contained in one dose).

Conditions for dispensing from pharmacies

Over the counter.

Special Instructions

Precautions for use.

The dissolved drug cannot be stored. A drug whose packaging integrity is damaged (cracked bottles), a drug without labeling, a drug with altered physical properties (discoloration, wrinkling of biomass), or in the presence of foreign inclusions is unsuitable for use.

Impact on the ability to drive vehicles and operate machinery

None.