Amoxil tablets: instructions for use, price and reviews

pharmachologic effect

Antibiotic , belongs to the group of aminopenicillins , has a wide spectrum of action. By inhibiting the synthesis of cell walls, it has a bactericidal effect. Active against staphylococci , streptococci , corynebacteria diphtheria , enterococci, Escherichia coli and Haemophilus influenzae , Neisseria gonorrhea and meningitis , Proteus , Salmonella and Shigella; and anaerobes - clostridia , peptostreptococci and peptococci.

When used simultaneously with metronidazole, it is effective against Helicobacter pylori. Microorganisms capable of producing penicillinase are resistant to the drug.

Amoxil is inactive against mycoplasmas , mycobacteria , fungi , rickettsia , plasmodium , amoebas , viruses , as well as Pseudomonas aeruginosa and Proteus.

Pharmacological properties of the drug Amoxil

Pharmacodynamics . Amoxicillin is a broad-spectrum antibiotic of the aminopenicillin group. It has a bactericidal effect, inhibiting the synthesis of the cell wall of bacteria sensitive to the drug. Active against gram-positive cocci - Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp. , anaerobic streptococci ( Peptostreptococcus , Peptococcus ), microaerophilic streptococci ( Streptococcus faecalis ), as well as gram-positive bacilli - Bacillum anthracis , most strains of Corynebacterium diphtheriae , Clostridium perfringens , Clostridium tetani , Listeria monocytogenes , Erysepelothrix rhusiopathia e and Eubacterium . Acts on gram-negative aerobic microorganisms: cocci - Neisseria gonorrhoeae , Neisseria meningitidis ; sticks - Escherichia coli , Shigella spp. , Salmonella spp. , Proteus mirabilis , most strains of Klebsiella spp. , Haemophilus influenazae , Moraxella catarrhalis ; spirochetes - Treponema pallidum , Treponema pertenue , Leptospira spp. , Borrelia burgdorferi ; chlamydia - Chlamydia trachomatis . In combination with metronidazole, it is active against Helicobacter pylori . Microorganisms that produce penicillinase are resistant to the drug. Inactive against mycobacteria, mycoplasmas, rickettsia, fungi, amoebas, plasmodia, viruses, as well as Pseudomonas aeruginosa and Proteus spp. (except for P. mirabillis ). Pharmacokinetics. After oral administration, amoxicillin is well absorbed, reaching maximum serum concentrations 2 hours after administration. The half-life is 1.5 hours. It is excreted unchanged from the body by the kidneys (60-70%).

Side effects

Allergic reaction in the form of itching , urticaria , fever , hyperemia , Stevens syndrome , hyperkeratosis , epidermal necrolysis , eczema , bullous dermatitis , angioedema , vasculitis , serum sickness , anaphylactic shock .

Digestive tract: decreased appetite, nausea, dry mouth, vomiting, diarrhea, flatulence , colitis, upward changes in liver enzymes, hepatitis and jaundice.

Nervous system: insomnia, anxiety, loss of consciousness, dizziness , hyperkinesis , headache. If kidney function is affected, seizures may occur.

Hematopoietic organs: thrombocytopenia , leukopenia , hemolytic anemia , increased prothrombin index.

Urinary system: interstitial nephritis .

Other reactions may include superinfections, candidiasis , general weakness, false-positive reactions to the determination of glucose in the urine and urobilinogen.

Amoxil tablets 500 mg No. 10x2

Name

Amoxil.

Description

Tablets are white with a yellowish tint, flat-cylindrical with a chamfer and a score. The risk is intended only for breaking to facilitate swallowing, and not for dividing into equal doses.

Main active ingredient

Amoxicillin.

Release form

Pills.

Dosage

500 mg.

special instructions

No studies have been conducted on the effect on the ability to drive vehicles and other machinery. However, adverse reactions may occur (for example, allergic reactions, dizziness, convulsions), which may affect the ability to drive vehicles or use other machinery (see section "Side effects").

pharmachologic effect

Amoxicillin is a semisynthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often called penicillin-binding proteins, PBPs) in the biosynthetic pathway of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to weakening of the cell wall, which is usually accompanied by lysis and cell death. Amoxicillin is inactivated by beta-lactamases produced by resistant bacteria, and therefore the spectrum of activity of amoxicillin alone does not include organisms that produce these enzymes.

Indications for use

Amoxil is indicated for the treatment of the following infections in adults and children (see sections “Dosage and Administration” and “Precautions” and “Pharmacodynamics”): • Acute bacterial sinusitis • Acute otitis media • Acute streptococcal tonsillitis and pharyngitis • Exacerbation of chronic bronchitis • Community-acquired pneumonia • Acute cystitis • Asymptomatic bacteriuria during pregnancy • Acute pyelonephritis • Typhoid and paratyphoid fever • Dental abscess with spreading cellulitis • Infections of joint prostheses • Helicobacter pylori eradication • Lyme disease Amoxil is also indicated for the prevention of endocarditis. Official guidelines for the appropriate use of antibacterial agents should be considered.

Directions for use and doses

The dose of Amoxil is determined by the doctor taking into account: • The expected pathogen and its likely susceptibility to antibacterial agents (see section “Precautions”) • the severity and location of the infectious process • the patient’s age, weight and renal function The duration of treatment should be determined by the type of infection and the patient’s response for treatment and, as a rule, should be as short as possible. Some infections require longer treatment (see Precautions section regarding long-term treatment).

Use during pregnancy and lactation

Pregnancy Animal studies do not indicate direct or indirect reproductive toxicity. Limited data on the use of amoxicillin during pregnancy in humans do not indicate an increased risk of congenital malformations. Amoxicillin may be used during pregnancy when the potential benefits outweigh the potential risks associated with treatment. Breastfeeding Amoxicillin is excreted in small quantities into breast milk with a possible risk of sensitization. Consequently, a breastfed baby may develop diarrhea and fungal infections of the mucous membranes, so breastfeeding may have to be stopped. The use of amoxicillin during breastfeeding is possible only after a benefit/risk assessment by a doctor. Fertility There are no data on the effects of amoxicillin on fertility in humans. Reproductive toxicity studies in animals have shown no effects on fertility.

Precautionary measures

Hypersensitivity reactions Before starting amoxicillin therapy, previous hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam drugs should be carefully reviewed (see sections "Contraindications" and "Side Effects"). Serious and sometimes fatal hypersensitivity reactions (including anaphylactoid and severe cutaneous adverse reactions) have been reported in patients receiving penicillin therapy. These reactions are more common in people with a history of penicillin hypersensitivity and in people with atopy. If an allergic reaction occurs, treatment with amoxicillin should be discontinued and appropriate alternative therapy should be instituted. Non-susceptible organisms Amoxicillin is not suitable for the treatment of some types of infections unless the pathogen is already documented and known to be susceptible, or there is a very high likelihood that the pathogen will be suitable for treatment with amoxicillin (see Pharmacodynamics section). This is especially true when considering the treatment of patients with urinary tract infections and severe ear, nose and throat infections. Seizures Seizures may occur in patients with impaired renal function, or in patients receiving high doses of amoxicillin, or in patients with predisposing factors (for example, a history of seizures, epilepsy or meningeal disorders (see section "Side effects")). Renal failure patients with renal failure, the dose should be adjusted depending on the degree of impairment (see section "Dosage and Administration").Skin reactions The occurrence at the beginning of treatment of febrile generalized erythema, with pustules, may be a symptom of acute generalized exanthemal pustulosis (AGEP, see section "Side effect") If this reaction occurs, stop taking amoxicillin and subsequent use is contraindicated. Amoxicillin should be avoided if infectious mononucleosis is suspected, since the occurrence of a morbilliform rash has been associated with this disease after the use of amoxicillin. Jarisch-Herxheimer reaction Jarisch-Herxheimer reaction Herxheimer's disease has been described following treatment with amoxicillin for Lyme disease (see. section "Side effects"). This is directly related to the bactericidal activity of amoxicillin against the causative agent of Lyme disease, the spirochete Borrelia burgdorferi. Manifested by increased temperature, chills, decreased blood pressure, tachycardia, nausea, headache, muscle pain, aggravation of existing symptoms or the appearance of new symptoms of the underlying disease. The patient should be warned that this is a common occurrence and is usually self-limiting and is considered a normal consequence of antibiotic treatment for Lyme disease. Overgrowth of non-susceptible organisms Prolonged use may sometimes result in overgrowth of non-susceptible organisms. Antibiotic-associated colitis has been reported with almost all antibiotics and can range in severity from mild to life-threatening (see Side Effects section). Therefore, it is important to consider this diagnosis in patients with diarrhea during or after taking any antibiotics. If antibiotic-associated colitis occurs, amoxicillin should be stopped immediately, consult a physician, and initiate appropriate therapy. Medicines that slow down peristalsis are contraindicated in this situation. Long-term therapy During long-term therapy, periodic assessment of the functions of certain organs and systems is recommended: including renal, hepatic and hematopoietic function. Increased levels of liver enzymes and changes in blood counts have been reported (see section "Side effects"). Anticoagulants There are isolated reports of prolongation of prothrombin time in patients receiving amoxicillin. When used together with anticoagulants, proper monitoring is necessary. To maintain the desired level of anticoagulation, dose adjustment of oral anticoagulants may be necessary (see sections "Interaction with other drugs and other types of interactions" and "Side effects"). Crystalluria Crystalluria is observed very rarely, mainly during parenteral therapy, in patients with reduced urine output. During administration of high doses of amoxicillin, it is advisable to maintain adequate fluid intake and urination to reduce the likelihood of amoxicillin crystalluria. In patients with bladder catheterization, patency should be checked regularly (see Section "Side effects" and "Overdose"). Effect on Diagnostic Tests Elevated levels of amoxicillin in serum and urine may interfere with some laboratory tests. Due to the high concentration of amoxicillin in urine, false-positive results are possible when using chemical methods. When testing for the presence of glucose in urine during treatment with amoxicillin, it is recommended to use the enzymatic glucose oxidase method. The presence of amoxicillin may distort the results of the test for the presence of estriol in pregnant women. Excipients Amoxil contains less than 1 mmol (23 mg)/dose of sodium, that is, it is practically free of sodium.

Interaction with other drugs

Probenecid Concomitant use of probenecid is not recommended. Probenecid reduces renal tubular secretion of amoxicillin. Concomitant use of probenecid may increase and prolong the level of amoxicillin in the blood. Allopurinol Concomitant use of allopurinol during treatment with amoxicillin may increase the likelihood of allergic skin reactions. Tetracyclines Tetracyclines and other bacteriostatic drugs may reduce the bactericidal effect of amoxicillin. Oral anticoagulants Oral anticoagulants and penicillin antibiotics have been widely used in practice without reports of interaction. However, the literature has described cases of increased international normalized ratio in patients receiving acenocoumarol or warfarin concomitantly with amoxicillin. If coadministration is necessary, carefully monitor prothrombin time or international normalized ratio with amoxicillin dosage adjustments. In addition, dose adjustment of oral anticoagulants may be necessary (see sections "Precautions" and "Side Effects"). Methotrexate Penicillins may decrease the excretion rate of methotrexate, potentially causing increased toxicity.

Contraindications

Hypersensitivity to the active substance, to any of the penicillins or to any of the excipients included in the drug. History of severe immediate hypersensitivity reactions (eg, anaphylaxis) to another beta-lactam drug (eg, cephalosporin, carbapenem, or monobactam).

Compound

Symptoms: dysfunction of the gastrointestinal tract - nausea, vomiting, diarrhea, which may result in water and electrolyte imbalance. Cases of crystalluria have been reported, sometimes leading to renal failure. Patients with impaired renal function or those who have received high doses of amoxicillin may experience seizures (see Precautions and Side Effects sections). Treatment: induce vomiting or rinse the stomach, then take activated charcoal and an osmotic laxative. Water and electrolyte balance should be maintained. Amoxicillin is removed from the blood using hemodialysis. A specific antidote is unknown.

Overdose

Side effect

The most frequently reported adverse reactions were diarrhea, nausea and skin rash. Undesirable adverse reactions recorded during clinical trials and post-marketing surveillance of amoxicillin are presented according to systemic organ classes and frequency of occurrence. Infections and infestations: Very rare: Candidiasis of the skin and mucous membranes. Blood and lymphatic system disorders: Very rare: Reversible leukopenia (including severe neutropenia or agranulocytosis), reversible thrombocytopenia and hemolytic anemia. Prolongation of bleeding time and prothrombin time (see section "Precautions"). Immune system disorders: Very rare: Severe allergic reactions including angioedema, anaphylaxis, serum sickness and allergic vasculitis (see Precautions section). Frequency unknown: Jarisch-Herxheimer reaction (see Precautions section). Nervous system disorders: Very rare: Hyperkinesia, dizziness and convulsions (see section "Precautions"). Gastrointestinal disorders: Common: Diarrhea and nausea. Uncommon: Vomiting. Post-marketing data: Very rare: Antibiotic-associated colitis (including pseudomembranous colitis and hemorrhagic colitis, see Precautions section). Coloring the tongue black. Liver and biliary tract disorders: Very rare: Hepatitis and cholestatic jaundice. Moderate increase in AST and/or ALT. Skin and subcutaneous tissue disorders: Common: Skin rash. Uncommon: Urticaria and itching. Post-marketing data: Very rare: Skin reactions such as erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous and exfoliative dermatitis, acute generalized exanthematous pustulosis (AGEP) (see Precautions section) and drug reactions with eosinophilia and systemic symptoms (DRESS). From the kidneys and urinary tract: Very rarely: Interstitial nephritis. Crystalluria (see section “Precautions” and “Overdose”). *The incidence of these adverse reactions was obtained from clinical studies of approximately 6,000 adults and children taking amoxicillin. Reporting of adverse reactions It is important to report suspected adverse reactions after registration of a medicinal product to ensure continuous monitoring of the benefit/risk profile of the medicinal product. Health care professionals are encouraged to report any suspected adverse drug reactions through national adverse reaction and drug failure reporting systems. If the patient experiences any adverse reactions, he is advised to consult a doctor. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the Adverse Drug Events Information Database, including reports of drug failure. By reporting adverse reactions, you can help provide more information about the safety of the drug.

Storage conditions

To protect from light and moisture, store in original packaging at a temperature not exceeding 25°C. Keep out of the reach of children.

Buy Amoxil tab. 500 mg per bl. in pack No. 10x2 in the pharmacy

Price for Amoxil tablet. 500 mg per bl. in pack №10x2

Instructions for use for Amoxil tab. 500 mg per bl. in pack №10x2

Instructions for use of Amoxil (Method and dosage)

Take the tablets as prescribed by your doctor, regardless of food.

Dosage for diseases of moderate and mild severity:

adults and children over 10 years old - 500-750 mg 2 times a day;
children from 3 to 10 years: 750 mg per day in 3 divided doses;
from 1 to 3 years 250 mg twice a day.

In the case of chronic recurrent diseases and in severe cases, adults take 3 g per day; children - 60 mg/kg body weight, divided into 3 doses.

The daily dose for adults is a maximum of 6 g.

The course of treatment is continued for another 3 days after the cessation of symptoms. Mild to moderate infections require a course of treatment of about 1 week. In case of infection with beta-hemolytic streptococcus, treatment is for at least 10 days.

For the treatment of acute uncomplicated gonorrhea, a single dose of 3 g is prescribed in combination with probenecid in an amount of 1 g.

For peptic ulcers to eradicate Helicobacter pylori, the instructions for Amoxil 500 mg provide regimens that should be prescribed in combination with other drugs:

Amoxil 2 g per day in two doses in combination with clarithromycin 500 mg twice daily and omeprazole 40 mg per day.
Amoxil 2 g per day with metronidazole 400 mg three times a day and omeprazole 40 mg per day.

The course of treatment is 1 week.

In case of renal failure, it is prescribed taking into account the level of glomerular filtration and the level of creatinine .

Indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

upper respiratory tract infections (tonsillopharyngitis, sinusitis, acute otitis media);
lower respiratory tract infections (acute bacterial bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia);
infections of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, endometritis, cervicitis, gonorrhea);
abdominal infections (cholangitis, cholecystitis);
eradication of Helicobacter pylori
in patients with duodenal or gastric ulcers (always in combination with other drugs);
infections of the skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses);
leptospirosis, listeriosis;
Lyme disease;
infections of the gastrointestinal tract (enterocolitis, typhoid fever, dysentery, salmonellosis (caused by Salmonella typhi
, sensitive to ampicillin), salmonella carriage;
prevention of bacterial endocarditis during surgical procedures in the oral cavity and upper respiratory tract.

Interaction

Amoxil tablets, when taken simultaneously with oral contraceptives, can reduce the effect of contraception and increase the likelihood of bleeding.

of digoxin increases and the toxicity of methotrexate .

When used simultaneously with probenecid, phenylbutazone, sulfinperazone, indomethacin and acetylsalicylic acid, the excretion of Amoxil by the kidneys slows down.

Drugs that have a bacteriostatic effect ( chloramphenicol , macrolides , tetracycline ) neutralize the effect of Amoxil.

Combined use with allopurinol increases the likelihood of allergic skin reactions.

The simultaneous administration of antacids reduces the absorption of Amoxil.

Combination with anticoagulants increases the likelihood of bleeding, so you need to monitor the prothrombin time.

Diarrhea reduces drug absorption.

In pregnant women, the medicine reduces the concentration of estradiol in the urine.

special instructions

The possibility of developing an allergy to cephalosporin and penicillin antibiotics should be excluded before starting treatment.

Repeated and long-term use leads to the development of resistance and superinfections.

Vomiting and diarrhea reduce the absorption of the drug; in these conditions it should not be prescribed.

Prescribed with caution to patients with asthma and allergic diathesis .

Taking the drug in high doses causes the development of crystalluria , so for prevention it is necessary to take a sufficient amount of fluid.

The drug can change the color of tooth enamel in children, so you need to ensure proper dental and oral hygiene.

In case of anaphylactic shock, artificial ventilation of the lungs is performed, epinephrine , antihistamines , glucocorticoids and oxygen .

Amoxil's analogs

Level 4 ATC code matches:
Hiconcil

Ampioks

Ampicillin Trihydrate

Ampicillin

Ospamox

Amoxicar

Penicillin

Flemoxin Solutab

Amoxicillin

Amosin

Ecoball

Ospamox , Flemoxin Solutab , Ampiox , Amoxicillin

Reviews about Amoxil

By studying reviews about Amoxil, you can be sure that it is a fairly affordable and effective drug. There are a lot of good opinions about its use for bronchitis , pneumonia and tonsillitis , both in adults and children. Patients who used the drug noted rapid recovery.

There are also several positive reviews of use for streptoderma and other pustular skin lesions.

The disadvantage is that some patients experience side effects such as skin rashes or gastrointestinal upset.

Another advantage is that, due to its safety, Amoxil tablets are allowed to be used by pregnant and lactating women.

Note!

The description of the drug Amoxil on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Amoxil price, where to buy

In Ukraine, Amoxil is sold at an average price of 19 UAH. for 20 tablets of 250 mg. The price of Amoxil in a dose of 500 mg ranges from 29 to 34 UAH.

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LuxPharma* special offer

Amoxil tablet
No. 20 500 mg 1600 rub. order

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