Pharmacodynamics and pharmacokinetics
The medication has sympathomimetic , antipyretic , immunostimulating and analgesic effects. The features of its action depend on the properties of the components included in the composition.
The active components are excreted mainly in the urine. In addition, some ascorbic acid may be excreted in the bile. The half-life of phenylephrine is 2-3 hours, and that of paracetamol is 1-4 hours.
Side effects
When used according to the instructions, the medicine is well tolerated without side effects. In rare cases, the following negative reactions have been observed:
- digestive system and liver: increased activity of liver enzymes , vomiting, nausea, diarrhea , anorexia , dry mouth;
- nervous system: headache , insomnia , irritability, tinnitus, dizziness , tremor ;
- allergies : skin itching , rash, angioedema , urticaria , Lyell's syndrome , anaphylactic shock ;
- CVS: cardiac arrhythmia, leukopenia , thrombocytopenia , agranulocytosis , arterial hypertension , neutropenia , anemia , pancytopenia ;
- urinary system: oliguria , nephrotoxic effect , renal colic ;
- other: hyperhidrosis blood glucose levels .
Coldrex
Coldrex is a combination drug widely known in our country from a British pharmaceutical company, used for the symptomatic treatment of acute respiratory viral infections (ARVI). The key characteristic of ARVI is the species diversity of their pathogens, including influenza viruses, parainfluenza, rhinoviruses, adenoviruses, etc. Such etiological polymorphism greatly complicates the development of methods for specific treatment of these diseases. In this regard, the main emphasis must be placed on symptomatic therapy, whose action is aimed at eliminating the most unpleasant symptoms of viral infections: runny nose, cough, nasal congestion, headache and sore throat, myalgia, weakness and fever. All these facts make it advisable to use combination drugs in the drug therapy of ARVI, the components of which have different mechanisms of action, but therapeutically complement each other, providing pharmacological synergism. One of these drugs is Coldrex, which includes five active substances: paracetamol, phenylephrine, caffeine, terpene hydrate and ascorbic acid. Its composition is selected in such a way as to influence all parts of the pathological process of ARVI. The main “driving force” of Coldrex is highly purified paracetamol. Its analgesic and antipyretic properties have been mercilessly exploited by doctors for almost four decades. Unlike aspirin, it does not have an ulcerogenic (ulcerating) effect, and, unlike analgin, it does not cause blood side effects (granulocytopenia, granulocytosis). The pharmacological effect of paracetamol is due to the blockade of the synthesis of prostaglandins, mediators of pain and inflammation, however, unlike aspirin and a number of other non-steroidal anti-inflammatory drugs, this effect is not systemic, but is believed to manifest itself mainly at the level of the central nervous system, due to which the drug realizes its antipyretic effect . The analgesic effect of the drug is more complex in its development mechanism and involves not only central, but also peripheral pain pathways.
Phenylephrine is a direct beta-agonist. Causes a decrease in the lumen of arterioles, thereby relieving swelling, reducing excess formation and secretion of mucus, and relieving congestion in the nasal passages. Caffeine reinforces the analgesic potential of paracetamol, has a general tonic effect, invigorates and improves well-being. Terpin hydrate is a time-tested expectorant. It dilutes bronchial secretions and promotes their freer separation, protects the respiratory tract from blockage and makes breathing easier. It has, among other things, a weak anti-inflammatory effect. Ascorbic acid stimulates the immune system, normalizes tissue respiration processes and increases the body’s resistance to invasion by various pathogens (as is known, a bacterial infection is often “layered” on top of a viral infection).
One of the main advantages of Coldrex over its pharmacological “brothers” is the presence “under one roof” of all the medicinal ingredients required for the complex treatment of ARVI, which significantly simplifies the administration of the drug to patients. In addition, a thoughtful combination of active substances in Coldrex allows you to reduce the doses of each of them, and, therefore, reduce the risk of side effects. If you start taking Coldrex in a timely manner, the duration of the manifestation of acute symptoms of ARVI is significantly reduced. In fact, cough and increased secretion of mucus from the nose are eliminated already in the first days of the disease, creating the preconditions for further suppression of the pathological process in the respiratory tract. Taking Coldrex at the first alarming pathogenetic “bells” prevents the development of the acute phase of ARVI, thereby stopping the acute inflammatory reaction at the preclinical stage. As a result, a milder course of the disease is ensured and the negative manifestations of temperature and catarrhal reactions are leveled out. In conclusion, it should be noted that Coldrex is well tolerated by patients and rarely causes clinically significant side effects.
Overdose
The dose of the drug indicated in the instructions cannot be exceeded. In case of overdose, you should definitely consult a doctor, even if there are no pronounced negative symptoms, as there is a possibility of serious liver damage, encephalopathy , coma and metabolic acidosis .
In case of an overdose, nausea, headache, loss of appetite , vomiting, pallor, and pain in the epigastric region . In addition, in severe cases, arterial hypertension and hepatotoxic effects of the drug are possible. Manifestations of toxic reactions due to an overdose of paracetamol usually appear within 12-48 hours. In this case, the use of Acetylcysteine and Methionine .
In case of overdose, gastric lavage and the use of enterosorbents . Treatment is symptomatic.
Mode of application
The drug is taken orally. Pour the contents of one sachet into a 200-300 ml cup and fill up to half the cup with hot water (not boiling water). Stir until completely dissolved. Add cold water if necessary. Take warm.
Adults and children over 12 years of age: 1 sachet every 4-6 hours, if necessary. Do not take more than every 4 hours. The maximum daily dose is 6 sachets. The maximum duration of treatment without consulting a doctor is 7 days.
Exceed the indicated doses. If symptoms do not go away, you should consult a doctor.
The lowest effective dose should be used.
Interaction
When combined with barbiturates , Carbamazepine , Diphenin , Rifampicin , Zidovudine and other inducers of microsomal liver enzymes, taking the drug can cause a hepatotoxic effect .
Coldrex Hotrem should not be taken together with other products containing paracetamol . In addition, use with MAO inhibitors , tricyclic antidepressants and beta-blockers , as well as within 14 days after their discontinuation.
Reviews
Those who leave reviews of Coldrex Hotrem powder report the following advantages of the drug:
- efficiency;
- fast action;
- pleasant taste;
- the presence of various flavoring additives (lemon, currant);
- convenient packaging;
- ease of use;
- possibility to buy individually;
- availability in pharmacies.
Among the disadvantages of the product, reviews indicate the presence of contraindications and side effects, as well as the high price.
Note!
Description of the drug Coldrex Menthol Active por. d/oral. solution No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Coldrex Hotrem powder price, where to buy
The cost of the product in a cardboard pack for 5 sachets is about 160 rubles. And the price of Coldrex Hotrem powder in a package of 10 sachets is approximately 260 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
Pharmacy Dialogue
- Coldrex HotRem for colds and flu, lemon and honey flavor, powder, 5 sachetsSmith Kline Beecham
RUB 199 order - Coldrex HotRem for colds and flu, lemon flavor, powder, 5 sachetsSmith Kline Beecham
RUB 199 order
- Coldrex HotRem Menthol and Honey Lemon for Colds and Flu, powder, 5 sachetsSmith Kline Beecham
RUB 234 order
- Coldrex HotRem for colds and flu, lemon flavor, powder, 10 sachetsSmith Kline Beecham
RUB 333 order
- Coldrex HotRem Menthol and Honey Lemon for Colds and Flu, powder, 10 sachetsSmith Kline Beecham
RUB 356 order
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Pharmacy24
- Coldrex Hotrem No. 10 Lemon powder SmithKleinBeecham S.A., Spain
122 UAH order
Coldrex® hotrem
The patient should be informed that if symptoms of the disease persist after 5 days of using the drug, they should stop taking it and consult a doctor.
The patient should be informed that he should stop taking the drug and contact his doctor immediately if he:
- allergic reactions are observed: itching or redness of the skin, difficulty breathing or swelling of the lips, tongue, throat or face;
- there is a rash or peeling on the skin, the formation of ulcers on the oral mucosa;
- breathing problems have previously been observed when taking acetylsalicylic acid or other NSAIDs;
— hematomas or bleeding appeared;
- visual impairment has occurred. This may be a consequence of increased intraocular pressure. Very rarely, but most likely, this side effect occurs in patients with glaucoma;
- there is a strong heartbeat or he feels an increase in frequency or disturbance in the rhythm of heart contractions;
- there is difficulty urinating. This side effect is most often observed in patients with prostatic hypertrophy.
The drug should be taken only in recommended doses.
With caution and after consulting a doctor, Coldrex® HotRem should be taken simultaneously with metoclopramide, domperidone, cholestyramine and indirect anticoagulants (warfarin).
The drug should not be taken at the same time as other drugs containing paracetamol, decongestants and products to relieve cold and flu symptoms.
Patients taking Coldrex® HotRem should refrain from drinking alcohol to avoid liver toxicity. It is not recommended to prescribe the drug for chronic alcoholism.
Patients on a low-sodium diet should be aware that 1 sachet of Coldrex® HotRem contains 0.12 g of sodium.
Before taking Coldrex® HotRem, you should consult your doctor if the patient is taking:
- warfarin or other indirect anticoagulants;
- antihypertensive drugs, for example, beta-blockers;
- digoxin or other cardiac glycosides;
- drugs to reduce appetite or psychostimulants;
- tricyclic antidepressants (including amitriptyline).
Impact on the ability to drive vehicles and operate machinery
Since the active components of the drug do not have a sedative effect, when taken in recommended doses, there are no restrictions on driving a car or operating machinery.
