pharmachologic effect
What kind of substance is lysine?
Lysine is an amino acid (aliphatic), which acts as a basis for the construction of proteins. The amino acid Lysine is necessary for the human body for tissue repair, normal growth and development. The substance is responsible for the production of enzymes , antibodies and hormones . Contained in the following foods: lentils, wheat germ, soybeans, yogurt, meat protein, fish, potatoes, egg whites, pork. Quite often, amino acids are added to the diet of athletes in order to quickly gain muscle mass. In agriculture, Lysine Sulfate is contained in feed additives to enrich and balance the diet of animals. Lysine formula: HO2CCH(NH2)(CH2)4NH2.
What is Lisina Escinat?
Lysine Escinate is able to suppress the activity of lysosomal hydrolases, which leads to a decrease in the rate of breakdown of mucopolysaccharides in connective tissue and the walls of small capillaries. The drug has an analgesic effect and has an anti-edema (anti-exudative) effect. During treatment, vascular tone and vascular-tissue permeability increase. The medication has a moderate hypoglycemic effect .
Indications for use
L-Lysine in ampoules is prescribed for swelling of any origin (after surgery, injury):
- swelling of the spinal cord and brain;
- displacement of the midline structures of the brain;
- intracranial hematomas;
- subarachnoid hematomas;
- edema-swelling syndrome;
- edema-painful vertebral syndromes;
- swelling of soft tissues with damage to the musculoskeletal system;
- swelling and pain syndromes of the trunk and limbs;
- disturbances of venous outflow in the lower extremities in acute thrombophlebitis.
Note!
Description of the drug L-lysine escinate solution d/in. 0.1% amp. 5ml No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Side effects
Allergic responses:
- fever;
- hyperemia and itching of lips, facial skin;
- skin rashes (erythema, petechiae, papules);
- anaphylactic shock;
- hives;
- Quincke's edema.
Nervous system:
- short-term loss of consciousness;
- dizziness;
- ataxia;
- tremor of the limbs;
- migraine headache.
Digestive tract:
- increased ALT, AST, bilirubin ;
- diarrhea syndrome;
- vomit;
- nausea.
The cardiovascular system:
- instability of blood pressure ;
- chest pain;
- cardiopalmus.
Respiratory tract:
- bronchial obstruction;
- dyspnea;
- feeling of lack of air;
- dry non-productive cough.
Other reactions:
- chills;
- severe weakness;
- phlebitis at the injection site;
- burning during the procedure;
- feeling of heat;
- hand pain.
If other negative reactions are registered, it is recommended to discontinue the drug.
special instructions
In some patients with hepatocholecystitis, when using the drug, a short-term increase in the activity of transaminases and bilirubin (direct fraction) in the blood plasma is possible, which does not pose a danger to the patient and does not require discontinuation of the drug.
During pregnancy and breastfeeding. The use of the drug during pregnancy and breastfeeding is contraindicated. During treatment you should stop breastfeeding.
Children. The drug is contraindicated in children under 1 year of age.
The ability to influence reaction speed when driving vehicles and working with other mechanisms. At the moment there are no reports, however, when using the drug, the possibility of developing suspected adverse reactions from the nervous system should be taken into account.
Instructions for use (Method and dosage)
L-Lysine Escinat can only be administered intravenously slowly. Intra-arterial administration of the drug is unacceptable. Daily dose – 5-10 ml. The infusion solution is prepared by mixing Na chloride (50-100 ml of 0.9% solution) and medication. In rare cases, a jet infusion of the drug at a slow speed is allowed. Instructions for the use of L-lysine for life-threatening conditions (head injury, spinal cord edema, etc.): double administration of a 20 ml solution (total daily dose). The course lasts 2-8 days. Lysine solution can only be stored in ampoules.
L-lysine escinate concentrate d/p solution for intravenous injection 1 mg/ml amp 5 ml N10
Registration Certificate Holder
PHARMACEUTICAL BALKANS (Serbia)
Dosage form
Medicine - L-lysine aescinat® (L-lysine-aescinat)
Description
Concentrate for the preparation of a solution for intravenous administration
in the form of a transparent, colorless or slightly colored liquid.
1 ml
L-lysine escinate 1 mg
Excipients
: ethanol 96% - 200 mg, propylene glycol - 200 mg, liquid water - up to 1 ml.
5 ml - colorless glass ampoules (5) - contour cell packaging (2) - cardboard packs.
Indications
- post-traumatic and postoperative swelling of soft tissues of various localizations;
- swelling of the brain or spinal cord of traumatic or postoperative origin;
- disorders of peripheral venous circulation, accompanied by edema.
Contraindications for use
- severe renal dysfunction;
- severe liver dysfunction;
- bleeding;
- children under 18 years of age;
- pregnancy;
- lactation period;
- hypersensitivity to L-lysine escinate and/or other components of the drug.
pharmachologic effect
L-lysine escinate reduces the activity of lysosomal hydrolases, which prevents the breakdown of mucopolysaccharides in the walls of capillaries and in the connective tissue that surrounds them, and thus normalizes increased vascular-tissue permeability and has an antiexudative (decongestant) and analgesic effect. The drug increases vascular tone and has a moderate hypoglycemic effect.
Drug interactions
The drug should not be used simultaneously with aminoglycosides due to the possibility of increasing their nephrotoxicity.
In the case of recent, prior to the administration of L-lysine aescinate, long-term therapy with anticoagulants, or if simultaneous administration of L-lysine aescinate and anticoagulants is necessary, it is necessary to adjust the dose of the latter under the control of the prothrombin index.
The binding of escin to plasma proteins is complicated by the simultaneous use of cephalosporin antibiotics, which can increase the concentration of free escin in the blood with the risk of developing side effects of the latter.
The composition of the drug includes ethyl alcohol 96%. It is necessary to take into account the possible interaction of alcohol with other drugs.
Dosage regimen
The drug is administered strictly IV slowly, usually by drip (intra-arterial administration is not allowed) in a daily dose of 5-10 ml. To prepare an infusion solution of L-lysine, escinate is diluted in 50-100 ml of 0.9% sodium chloride solution.
If necessary, the drug can be administered intravenously very slowly. For IV jet administration of L-lysine escinate is diluted in 10-15 ml of 0.9% sodium chloride solution. The drug should not be used without prior dilution.
In conditions that threaten the life of the patient (traumatic brain injury, postoperative edema of the brain and spinal cord with symptoms of edema-swelling, large swelling due to extensive soft tissue injuries),
the daily dose is increased to 20 ml, divided into 2 doses. The duration of treatment is from 2 to 8 days, depending on the patient’s condition and the effectiveness of therapy.
Overdose
Symptoms:
fever, tachycardia, nausea, heartburn, epigastric pain.
Treatment:
symptomatic therapy.
Side effect
With individual hypersensitivity to escin in some patients, the following are possible:
Allergic reactions:
skin rash (papular, petechial, erythematous), itching, flushing of the skin of the face, lips, fever, urticaria; in isolated cases - Quincke's edema, anaphylactic shock.
From the side of the central nervous system:
headache, dizziness, tremor; in isolated cases - ataxia, short-term loss of consciousness.
From the liver and biliary system:
increased activity of transaminases and bilirubin.
From the digestive system:
nausea; in isolated cases - vomiting, diarrhea.
From the cardiovascular system:
decreased blood pressure, increased blood pressure, tachycardia, chest pain.
From the respiratory system:
isolated cases - a feeling of lack of air, shortness of breath, broncho-obstruction, dry cough.
Local reactions:
burning along the vein during insertion, phlebitis, pain in the arm.
Other:
general weakness, chills, fever.
special instructions
In some patients with hepatocholecystitis, when the drug is prescribed, a short-term increase in the activity of transaminases and bilirubin (direct fraction) is possible, which does not pose a threat to patients and does not require discontinuation of the drug.
The concentrate for the preparation of a solution for intravenous administration contains 23.8% ethanol by volume, that is, up to 2.4 ml of ethanol in a single dose and a maximum of 6.1 ml/day, which corresponds to 122 ml of beer or 50.8 ml of wine per day.
The drug should be prescribed with caution in cases of alcoholism, as well as in patients with liver disease and epilepsy.
Effect on the ability to drive vehicles and operate machinery
The use of the drug may affect the ability to drive vehicles and operate machinery, but due to the severity of the injuries for which use is indicated, this factor is usually not significant.
Storage conditions
Store in a place protected from light at a temperature of 15°C to 25°C. Keep out of the reach of children.
Best before date
Shelf life: 2 years. Do not use the drug after the expiration date indicated on the package.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.
Contraindicated during pregnancy and lactation.
Use for renal impairment
Restrictions for impaired renal function - Contraindicated.
Contraindicated in severe renal impairment.
Use for liver dysfunction
Restrictions for liver dysfunction - Contraindicated.
Contraindicated in severe liver dysfunction. Prescribe with caution in case of liver diseases.
Use in children
Restrictions for children - Contraindicated.
Contraindicated in children under 18 years of age.
Terms of sale
The drug is available with a prescription.
Price of L-Lysine Escinata, where to buy
The price of L-Lysine in Ukraine is 203 UAH. In Russia, you can buy Lysine at a pharmacy for 1,200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- L-lysine escinate concentrate for preg.
solution for intravenous injection. 1 mg/ml ampoules 5.0 ml 10 pcs. PJSC Galichfarm RUB 1,803 order
Pharmacy Dialogue
- L-lysine escinate 0.001/ml 5ml No. 10 ampoules GalichPharm
RUB 1,754 order
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Pharmacy24
- L-lysine escinate 5 ml N10 solution for injection
362 UAH. order
PaniPharmacy
- L-Lysine escinate ampoule L-lysine escinate 0.1% amp. 5ml No. 10 Ukraine, Galichfarm JSC
372 UAH. order
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Interactions
When treating l-lysine escinate, it is possible to prescribe other drugs (anti-inflammatory, analgesics, antimicrobials) for appropriate indications.
The drug should not be used simultaneously with aminoglycosides due to the possibility of increasing their nephrotoxicity. In the case of long-term therapy with anticoagulants, which was carried out before the prescription of L-lysine aescinate, or if it is necessary to use L-lysine aescinate and anticoagulants simultaneously, it is necessary to adjust the dose of the latter (reduce the dose) and monitor the prothrombin index.
The binding of escin to plasma proteins is reduced with simultaneous use of cephalosporin antibiotics, which can increase the concentration of free escin in the blood with the risk of developing side effects of the latter.
