Pain in the abdominal cavity is often associated with disorders of intestinal motility. Spasms of the muscles of both the small and large intestines lead to difficulty passing stool and abdominal pain. Trimedat successfully relieves unpleasant symptoms by normalizing intestinal muscle tone.
pharmachologic effect
Myotropic antispasmodic that regulates the motility of the digestive system. The active substance affects the enkephalinergic system of the intestine and regulates peristalsis. Trimebutine has an antispasmodic effect in hyperkinesis of smooth muscle tissue of the digestive tract, and in hypokinetic conditions it stimulates intestinal function.
The drug enhances peristalsis and promotes gastric emptying, reduces pressure on the esophageal sphincter, acts throughout the intestine, enhances the response of the smooth muscle tissue of the large intestine to various food irritants.
For diseases of the digestive tract associated with impaired motility, trimebutine helps restore the physiological activity of the intestine.
Trimedat
Trimedat ®
(
Trimedat
®),
Trimedat ® Valenta
(
Trimedat Valenta
) are antispasmodic drugs that regulate gastrointestinal motility.
Dosage forms and composition of the drug Trimedat
The active substance
of the drug Trimedat is trimebutine maleate.
International nonproprietary name
:
trimebutine
.
The drug is produced on the Russian pharmaceutical market.
The medicine was initially registered in 2007 under the name Trimedat.
and was produced by a Russian company from a foreign-made finished dosage form (Dae Han New Pharm Co. Ltd., Korea).
In 2014, the drug was registered in Russia by Valenta Pharmaceuticals OJSC as Trimedat Valenta.
. At the moment, all stages of production, including the production of the finished dosage form, are Russian.
Like Trimedat, Trimedat Valenta is available in the form of white tablets containing the active ingredient trimebutine maleate 100 mg
and
200 mg
.
There are some differences in the appearance of the tablets. The Korean tablets were marked with embossed alphabetic and geometric symbols, different for 100 and 200 mg dosages. Domestic-produced Trimedat is made in the form of round flat-cylindrical tablets with a chamfer and two intersecting marks on one side for a dosage of 100 mg, with a chamfer and a score on one side for a dosage of 200 mg.
The composition of the excipients included in the Trimedat and Trimedat Valenta tablets also differs. In addition to lactose monohydrate, starch (corn and potato, respectively), colloidal silicon dioxide, magnesium stearate and talc, Russian-made tablets include povidone (improves the dissolution and bioavailability of medicinal substances).
Indications for use of Trimedat
In the instructions for the drug Trimedat Valenta
is recommended for the treatment of irritable bowel syndrome and postoperative paralytic ileus.
In the instructions for the previous version of the drug, which received permission for distribution in the Russian Federation ( Trimedat
), in addition to the purposes mentioned above, the following are indicated:
- motor disorders in functional diseases of the gastrointestinal tract
- gastroesophageal reflux disease (GERD)
- dyspeptic disorders in gastroduodenal diseases (abdominal pain, digestive disorders, nausea, vomiting)
- preparation for x-ray and endoscopic examinations of the gastrointestinal tract
The report by O. N. Minushkin, made at the conference “Practical Gastroenterology 2015,” emphasized that the prescription of drugs for the treatment of functional disorders of the gastrointestinal tract, such as Trimedat, should be monitored by instrumental examination methods. In particular, peripheral electrogastroenterography makes it possible to determine the motility of the stomach, small and large intestines before prescribing a drug, during administration and after the end of drug therapy. The slides from the report presented below show that after treatment with Trimedat, the electrical activity of the jejunum and duodenum is leveled out, motor activity improves and the rhythmicity coefficient of the colon increases.
| Slides from the report by O.N. Minushkina “Functional dyspepsia” | |
Trimedat and gastrointestinal motility
Trimebutine regulates intestinal motility by influencing its enkephalinergic system.
The drug has no effect on the central nervous system. Being an agonist of peripheral opiate receptors of various types (δ-, μ- and k-), located on neurons of the enteric nervous system and on smooth muscle cells throughout the gastrointestinal tract, it has a stimulating effect in hypokinetic conditions of the latter and acts as an antispasmodic in case of its excessive tone . Trimedat acts throughout the gastrointestinal tract. The figures below show changes in gastrointestinal motility parameters during treatment of GERD in children with Trimedat. To assess the nature of gastrointestinal motility, the method of peripheral electrogastroenterography (PEGEG) was used (Akobyan A.N., Belmer S.V., Vykhristyuk O.F. et al.). Not only was the basal indicators closer to normal, but also the postprandial response was restored. Note for fig. 1, 2: A - before meals, B - after meals
Rice. 1. Dynamics of relative electrical activity indicators (Pi/Ps) in children with gastroesophageal reflux before and after meals during treatment
Rice. 2. Dynamics of rhythmicity coefficient indicators in children with gastroesophageal reflux before and after meals during treatment. *P<0.05
Trimebutine normalizes visceral sensitivity and thus has an analgesic effect in abdominal pain syndrome.
Trimebutin affects the humoral regulation of gastrointestinal motility, increasing the secretion of motilin and reducing the levels of gastrin, glucagon, pancreatic polypeptide, insulin and vasoactive intestinal peptide (Akopyan A.N., Belmer S.V., Vykhristyuk O.F. et al. with reference to Delvaux M., Wingate D.
).
Procedure for use and dosage of the drug Trimedat
| Old packaging of Trimedat |
Trimedat tablets are taken orally.
Adults and children over 12 years of age are prescribed 100-200 mg 3 times a day. For the treatment of irritable bowel syndrome during an exacerbation, 600 mg of Trimedat per day is prescribed for 4 weeks. To prevent relapse of the disease, further administration of the drug at a dose of 300 mg per day for 12 weeks is recommended.
For children 3-5 years old, Trimedat is prescribed 25 mg 3 times a day, for children 5-12 years old - 50 mg 3 times a day.
Contraindications to the use of Trimedat
Hypersensitivity to trimebutine maleate and other components included in the drug.
Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Children under 3 years of age - for dosage forms of Trimedat Valenta; children under 12 years of age - for dosage forms of Trimedat.
Pregnancy.
Use of Trimedat during pregnancy and lactation
Experimental studies have not revealed data on the teratogenicity and embryotoxicity of Trimedat. However, due to the lack of necessary clinical data, the use of the drug during pregnancy is contraindicated. It is also not recommended to prescribe Trimedat during lactation due to the lack of reliable clinical data confirming the safety of its use during this period. If it is necessary to use Trimedat during lactation, breastfeeding should be stopped.
Side effects of Trimedat
During treatment with the drug, the following side effects may occur:
- from the digestive system - dry mouth, unpleasant taste, diarrhea, dyspepsia, nausea, constipation
- from the nervous system - drowsiness, fatigue, dizziness, headache, anxiety
- allergic reactions - skin rash
- others - urinary retention, in women - menstrual irregularities, painful enlargement of the mammary glands
general information
According to the pharmacological index, Trimedat belongs to the group “Anspasmolytics”. According to ATC - to the group “A03 Drugs for the treatment of functional gastrointestinal disorders”, subgroup “A03AA Synthetic anticholinergic blockers - esters with a tertiary amino group” and has the code “A03AA05 Trimebutine”.
Other medicines containing the active ingredient trimebutine
Other medicines with the active ingredient trimebutine, registered (or having been registered in the past) in Russia: Neobutin, Neobutin Retard, Trimebutin SZ, Trimedat Forte.
Patient Materials
The GastroScan.ru website contains materials for patients on various aspects of gastroenterology:
- “Advice from doctors” in the “Patients” section of the site
- “Popular gastroenterology” in the “Literature” section
- “Popular gastroenterology” in the “Video” section
Materials for healthcare professionals regarding the use of Trimedat
Printed publications
- Akopyan A.N., Belmer S.V., Vykhristyuk O.F. and others. Gastroesophageal reflux and motility disorders of the gastrointestinal tract // Doctor.ru. Pediatrics. Gastroenterology. 2014. No. 11 (99). pp. 45-49.
- Tropskaya N.S., Popova T.S. Trimebutine in the correction of disturbances in the electrical activity of the gastrointestinal tract during experimental endotoxemia // RZHGGK. – 2009. – T.19. – No. 2. – pp. 37–42.
- Belmer S.V., Gasilina T.V., Kovalenko A.A., Karpina L.M. Modern ways of correcting functional disorders of the digestive organs in children // Questions of children's dietology. – 2011. – T. 9. – No. 2. – p. 10–14.
- Minushkin O.N. Combined functional gastrointestinal disorders. Their diagnosis and treatment approaches // Medical Council. 2015. No. 13. pp. 20-25.
- Khavkin A.I., Komarova O.N. Clinical and pathogenetic variants of antroduodenal motility disorders in children and their drug correction // Russian Bulletin of Perinatology and Pediatrics. 2015. No. 4. 119–124..
On the GastroScan.ru website in the “Literature” section there are subsections “Anspasmodics” and “Prokinetics”, containing publications for healthcare professionals that address the use of these classes of drugs in the treatment of diseases of the gastrointestinal tract.
Video
Still from video: Minushkin O.N. Functional dyspepsia - a look at the problem, diagnosis, treatment
Still from video by E.S. Vyuchnova
Tactics for managing patients with duodenogastric/biliary reflux On the GastroScan.ru website in the “Video” section there is a subsection “For doctors”, containing video recordings of reports, lectures, webinars in various areas of gastroenterology for healthcare professionals.
Trimedat has contraindications and side effects. Before use, you should consult a specialist. Back to section
Indications for use of Trimedat
What Trimedat tablets are used for:
- motility disorder in functional gastrointestinal pathology;
- gastroesophageal reflux disease;
- dyspeptic disorders due to gastroduodenal pathology (vomiting, epigastric pain, nausea, digestive disorders);
- paralytic intestinal obstruction after surgery;
- irritable bowel syndrome , accompanied by pain, stool disorders, spasms, colic;
- preparation for examination of the digestive tract (endoscopic manipulations, x-ray examination).
The use of the drug in pediatric practice makes it possible to successfully relieve dyspeptic disorders in gastrointestinal motility disorders.
How to take Trimedat: before or after meals
The drug begins to work an hour after it enters the gastrointestinal tract. To prevent food intake from causing pain, belching, bloating and other unpleasant symptoms, Trimedat should be taken 20-30 minutes before the intended meal. When the food is processed by gastric juice and enters the duodenum, the drug will already begin to act and will not allow the food to stagnate, which will reduce the risk of developing rotting processes, which cause flatulence, nausea and belching.
Instructions for Trimedat (Method and dosage)
How to take: orally, without chewing and with water. Instructions for use of Trimedat recommend a standard treatment regimen: 100-200 mg three times a day. The maximum dose is 600 mg per day.
In order to prevent relapse of irritable bowel syndrome, the drug is prescribed at 300 mg per day. The medicine can be taken for 4 months.
Instructions for the use of tablets in pediatric practice
25 mg three times a day for children 3-5 years old. Children 5-12 years old are prescribed 50 mg three times a day. How to take Trimedat: before or after meals? Taking medication is not associated with food intake.
How to take Trimedat for constipation
The causes of constipation and its nature determine the duration of medication use. In case of one-time stool retention due to poor nutrition and low mobility, it is enough to take the drug three times a day in a standard dosage until the intestines can empty. Most often this takes a day, less often – up to 5 days. In this case, the absence of relapse can be guaranteed by the patient himself by changing eating habits and adjusting daily physical activity.
In case of constipation that occurs due to intestinal obstruction caused by circulatory disorders in the inferior vena cava, Trimedat is taken over a long course, starting from 4 weeks. To avoid relapse and worsen the situation, the patient is prescribed a diet high in fiber-rich plant products. This approach to nutrition will ensure softness of the stool, which will significantly facilitate its passage through the intestines, and will eliminate cases of injury to the walls by hard lumps of feces.
Trimedat's analogs
Level 4 ATC code matches: Aprofen
Meverin
Niaspam
Sparex
Duspatalin
- trimebutine
- Tribudate
- Debridat
- Neobutin
The price of analogues in Ukraine is less than the original drug. For example, the analogue of Trimedat Tribudat can be bought for 40 UAH.
Reviews for Trimedat
The drug is well tolerated, acts quickly enough, relieving spasms, pain, and stabilizing intestinal function. For constipation , the medication enhances peristalsis, ensuring quick, painless emptying of the large intestine.
Reception by children, reviews from parents
In case of irritable bowel syndrome, the drug stabilizes motility, restoring the full functioning of the digestive system.
Reviews from doctors about Trimedat
An effective, affordable drug, widely used for pathologies of the digestive system.
Trimedat price, where to buy
The cost depends on the country, region and pharmacy chain. The price of 200 mg tablets No. 30 in Russia is 600-700 rubles.
You can buy it in Ukraine at an average price of 300 UAH.
- Online pharmacies in RussiaRussia
ZdravCity
- Trimedat Forte tablets p.p.o.
with prolonged release 300 mg 20 pcs. JSC Valenta Pharmaceuticals 553 rub. order - Trimedat por. d/prig. susp. for oral administration 152.5 mg vial. with measure stack 250mlAbdi Ibrahim Ilyach Sanayi ve Tij A.Sh.
RUR 617 order
- Trimedat tablets 200 mg 30 pcs. JSC Valenta Pharm
RUR 527 order
- Trimedat tablets 100 mg 10 pcs. JSC Valenta Pharm
RUR 348 order
- Trimedat forte tablets with prolong. release p.o.p 300mg 60pcs JSC Valenta Pharmaceuticals
RUB 1,164 order
