Corvaltab is a drug. It has the following pharmacological effects: sedative, antispasmodic, vasodilator. Helps reduce excitability of the central nervous system and normalizes sleep. There are a lot of reasons for stress in the world, for example, hard work, or everyday problems, or just a bad day. Unfortunately, we are not able to completely remove stressful situations from our lives, but we can help the body calm down faster and cope with the problem. Korvaltab in this case is used as first aid. Korvaltab for blood pressure. Korvaltab as a sedative is exactly the drug that every person should have in their first aid kit.
Pharmacodynamics and pharmacokinetics
Corvaltab tablets, due to the properties of the active ingredients, have a calming effect , help reduce the excitability of the central nervous system and facilitate the process of falling asleep. Antispasmodic and sedative effects, similar to the effects of valerian extract , are inherent in the ethyl ester of α-bromoisovaleric acid , which is part of Corvaltab, which, when taken in large doses, also exhibits an unexpressed hypnotic effect . The sedative and vasodilating effect of phenobarbital manifests itself in small doses and turns into a hypnotic when taking higher doses. All this is supported by the antispasmodic and reflex vasodilating effects of mint oil.
Corvaltab No. 20 tab.
Instructions for medical use of the drug CORVALTAB Trade name Corvaltab International nonproprietary name No Dosage form Tablets Composition One tablet contains the active substance: α-bromoisovaleric acid ethyl ester - 8.2 mg, phenobarbital - 7.5 mg, peppermint oil - 0.58 mg excipients: β-cyclodextrin, potato starch, tabletose (lactose monohydrate), microcrystalline cellulose, magnesium stearate. Description Tablets are white or almost white, round in shape, with a flat surface, chamfered, with inclusions. Pharmacotherapeutic group: Hypnotics and sedatives. Barbiturates in combination with other drugs. ATC code N05C B02 Pharmacological properties Pharmacokinetics Phenobarbital is well absorbed from the gastrointestinal tract. The distribution of phenobarbital is slower than that of other barbiturates due to its lower lipophilicity. Partially binds to blood plasma proteins (mainly albumin). Metabolized in the liver with the participation of microsomal enzymes by hydroxylation. The half-life (T 1/2) in adults is 2-4 days. Repeated use is characterized by material accumulation. Continuous long-term use of barbiturates leads to the development of addiction. Excreted by the kidneys. Peppermint oil is quickly absorbed from the gastrointestinal tract. The main component of peppermint oil, menthol, is transformed in the liver to form a conjugate with glucuronic acid, which is excreted from the body through the kidneys. α-bromoisovaleric acid ethyl ester is metabolized by deesterification to form isovaleric acid. Pharmacodynamics Corvaltab helps reduce the excitability of the central nervous system, has a calming effect and facilitates the onset of natural sleep. The ethyl ester of a-bromoisovaleric acid included in the drug has a sedative and antispasmodic effect, similar to the effect of valerian extract; in large doses it also has a mild hypnotic effect. Phenobarbital has a vasodilating, sedative and hypnotic effect in appropriate doses. Peppermint oil has reflex vasodilating and antispasmodic effects. Indications for use - neuroses with increased irritability - increased excitability - insomnia, including difficulty falling asleep - neurocircular dystonia (including tachycardia, coronary vasospasm) - arterial hypertension of the first degree - spasms of the digestive tract caused by neurovegetative disorders Method of administration and doses. The drug is taken orally. The dosage and duration of treatment are determined by the doctor individually for each patient. Adults are usually prescribed 1-2 tablets of the drug 2-3 times a day before meals. For tachycardia and spasms of coronary vessels, the single dose can be increased to 3 tablets. Side effects - daytime drowsiness - dizziness - allergic skin reactions that disappear when the dose is reduced or the drug is stopped Contraindications - hypersensitivity to the components of the drug - severe renal and liver dysfunction - hepatic porphyria - pregnancy and lactation Drug interactions With simultaneous taken with sedatives – enhances the effect of the drug. The drug may increase the toxicity of methotrexate. Simultaneous use with neuroleptics and anxiolytics enhances, and with stimulants of the central nervous system, weakens the effect of the drug. Ethanol (alcohol) enhances the effects of the drug and may increase its toxicity. Phenobarbital reduces the antibacterial activity of antibiotics and sulfonamides, the antifungal effect of griseofulvin (reduces absorption), the effectiveness of indirect anticoagulants, HSC, doxycycline, estrogens metabolized in the liver through oxidation (accelerates their destruction). Special instructions The drug contains lactose, therefore patients with hereditary lactose-galactose intolerance are not recommended to use Corvaltab. You should not drink alcohol while taking the drug. Use in pediatrics There is no experience of use in the treatment of children, therefore the drug is not used in pediatric practice. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms During treatment with the drug, it is not recommended to engage in activities that require increased attention, rapid mental and motor reactions. Overdose Symptoms: drowsiness, weakness, dizziness. Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy. There is no specific antidote. Release form and packaging 10 tablets each in a blister pack made of orange polyvinyl chloride film and printed varnished aluminum foil. 2 or 10 contour packages together with an insert sheet and/or instructions for medical use in the state and Russian languages are placed in a cardboard pack. Storage conditions Store in original packaging at a temperature not exceeding 25 ºС. Keep out of the reach of children! Shelf life 2 years Do not use after the expiration date Dispensing conditions Without a prescription Manufacturer LLC “Pharma Start” Ukraine, Kiev, blvd. I. Lepse, 8 Address of the organization that accepts claims from consumers regarding product quality on the territory of the Republic of Kazakhstan: LLC “Pharma Start” Ukraine, 03124. Kiev, blvd. I. Lepse, 8 Tel/fax: 404-58-36, 404-85-05 E-mail
Indications for use
Indications for taking Corvaltab are:
- increased excitability ;
- neuroses with symptoms of increased irritability;
- insomnia , as well as disturbances in the process of falling asleep;
- tachycardia;
- cardiopsychoneurosis;
- spasm of coronary vessels (mild);
- arterial hypertension at an early stage of development;
- spasms of the gastrointestinal tract, provoked by disorders of the neurovegetative system.
Corvaltab tablets No. 20
Compound
active ingredients:
ethyl ester of α-bromoisovaleric acid, phenobarbital, mint oil;
1 tablet contains α-bromoisovaleric acid ethyl ester - 8.2 mg; phenobarbital - 7.5 mg; peppermint oil - 0.58 mg;
Excipients:
β-cyclodextrin, potato starch, lactose, microcrystalline cellulose, magnesium stearate.
Dosage form
Pills.
Basic physical and chemical properties:
tablets are white or almost white with inclusions, round in shape, with a flat surface and a line, with a specific odor.
Pharmacotherapeutic group
Sleeping pills and sedatives. ATX code N05C B02.
Pharmacodynamics
Sedative, vasodilator, antispasmodic. Helps reduce the excitability of the central nervous system, has a calming effect and facilitates the onset of natural sleep. The ethyl ester of α-bromoisovaleric acid, which is part of the drug, has a sedative and antispasmodic effect, similar to the effect of valerian extract; in large doses it also causes a mild hypnotic effect. Phenobarbital has a sedative and moderate antispasmodic effect. Peppermint oil has a reflex vasodilator and antispasmodic effect.
Indications
- neuroses with increased irritability;
- insomnia;
- in complex therapy of hypertension and vegetative-vascular dystonia;
- not pronounced spasms of the coronary vessels, tachycardia;
- intestinal spasms caused by neurovegetative disorders (as an antispasmodic drug).
Contraindications
- hypersensitivity to the components of the drug;
- severe dysfunction of the liver and/or kidneys;
- hepatic porphyria;
- severe heart failure.
Medicines containing phenobarbital are contraindicated in cases of severe arterial hypotension, acute myocardial infarction, diabetes mellitus, depression, myasthenia gravis, alcoholism, drug and drug addiction, respiratory diseases with shortness of breath, obstructive syndrome.
Interaction with other drugs and other types of interactions
When used simultaneously with other drugs that depress the central nervous system, mutual enhancement of the effect is possible. The effect of the drug is enhanced by the use of valproic acid and alcohol.
Phenobarbital induces liver enzymes and, accordingly, may accelerate the metabolism of certain drugs that are metabolized by liver enzymes (including indirect anticoagulants, cardiac glycosides, antimicrobial, antiviral, antifungal, antiepileptic, anticonvulsant, psychotropic, oral hypoglycemic, hormonal, immunosuppressive, cytostatic, antiarrhythmic, antihypertensive medicines, etc.).
Phenobarbital enhances the effect of analgesics and local anesthetics.
MAO inhibitors prolong the effect of phenobarbital. Rifampicin may reduce the effect of phenobarbital.
With the simultaneous use of phenobarbital with gold preparations, the risk of kidney damage increases.
With long-term simultaneous use of phenobarbital with non-steroidal anti-inflammatory drugs, there is a risk of gastric ulcers and bleeding.
The simultaneous use of phenobarbital with zidovudine increases the toxicity of both drugs.
Increases the toxicity of methotrexate.
Features of application
During treatment, it is not recommended to engage in activities that require increased attention, rapid mental and motor reactions.
While taking the drug, you should avoid drinking alcohol.
The presence of phenobarbital in the drug can lead to the development of Stevens-Johnson syndrome and Lyell's syndrome, which is most likely in the first weeks of treatment. Long-term use is not recommended due to the risk of developing drug dependence, possible accumulation of bromine in the body and the development of bromine poisoning.
In cases where pain in the heart area does not go away after taking the drug, you should consult a doctor to rule out acute coronary syndrome. It should be prescribed with caution in case of arterial hypotension, hyperkinesis, hyperthyroidism, adrenal hypofunction, acute and persistent pain, acute drug intoxication.
Penapam contains lactose, therefore, Corvaltab is not recommended for patients with hereditary lactose-galactose intolerance.
The ability to influence reaction speed when driving a vehicle or operating machinery
Corvaltab may cause drowsiness and dizziness, therefore, during the treatment period, patients are not recommended to work with dangerous machinery or drive vehicles.
Use during pregnancy or breastfeeding
The drug should not be prescribed during pregnancy and breastfeeding.
Directions for use and doses
The dosage and duration of treatment is determined by the doctor individually for each patient.
Adults are usually prescribed 1-2 tablets of the drug 2-3 times a day before meals.
For tachycardia and spasms of coronary vessels, the single dose can be increased to 3 tablets.
Children
There is no experience of use in children, so the drug should not be used in pediatric practice.
Overdose
Overdose is possible with frequent or long-term use of the drug, which is associated with the accumulation of its components. Long-term and constant use can lead to dependence, withdrawal symptoms, and psychomotor agitation.
Overdose symptoms:
respiratory depression, until it stops; depression of the central nervous system, up to coma; depression of cardiovascular activity, including rhythm disturbances, decreased blood pressure, up to a collapsed state; nausea, weakness, decreased body temperature, decreased diuresis.
Treatment
: symptomatic.
Adverse reactions
Corvaltab is generally well tolerated.
In some cases, the following side effects may occur:
from the digestive system:
constipation, feeling of heaviness in the epigastric region, with prolonged use - impaired liver function, nausea, vomiting
from the nervous system:
weakness, ataxia, incoordination, nystagmus, hallucinations, paradoxical arousal, decreased concentration, fatigue, slow reactions, headache, cognitive impairment, confusion, drowsiness, mild dizziness
from the hematopoietic organs:
anemia, thrombocytopenia, agranulocytosis
from the cardiovascular system:
arterial hypotension, bradycardia
from the immune system:
hypersensitivity reactions, including angioedema, allergic reactions (including skin rash, itching, urticaria)
from the skin and mucous membranes:
Stevens-Johnson syndrome, toxic epidermal necrolysis;
from the musculoskeletal system:
with long-term use of drugs containing phenobarbital, there is a risk of impaired osteogenesis;
Other
: labored breathing.
Long-term use of drugs
containing bromine can lead to bromine poisoning, which is characterized by the following symptoms: central nervous system depression, depressed mood, confusion, ataxia, apathy, conjunctivitis, rhinitis, lacrimation, acne or purpura.
These phenomena disappear after the dose is reduced or the drug is discontinued.
Best before date
2 years.
Storage conditions
Store out of the reach of children, in the original packaging at a temperature not exceeding 25 ° C.
Package
10 tablets in a blister, 2 and 10 blisters in a cardboard box.
Vacation category
Without a prescription - No. 10 and No. 10 × 2. With a prescription - No. 10 × 10.
.
Manufacturer's location and address of place of business
Ukraine, 03124, Kiev, blvd. Vaclav Havel, 8.
In case of side effects and safety issues regarding the use of the medicinal product, please contact the pharmacovigilance department of Asino UKRAINE LLC at the address: Vaclav Havel Boulevard, 8, Kiev, 03124, tel/fax: +38 044 281 2333.
© Translation into Russian by the editorial team of apteka24.ua.
Source: “State register of medicinal facilities of Ukraine”, 2020.
Side effects
As a rule, the drug is quite well tolerated by patients.
drowsiness , mild dizziness allergic skin reactions may occur .
These phenomena are not permanent and usually disappear when the dose is reduced; it is extremely rare that a temporary cessation of taking pills is required.
In the case of taking high doses for a long time, the development of bromism .
Corvaltab tablets, instructions for use
The instructions for Corvaltab recommend taking the tablets orally before meals.
The selection of daily doses, as well as the duration of the treatment itself, should be determined only by a doctor and carried out individually.
As a rule, adults (over 18 years of age) are recommended to take 1-2 tablets two or three times (preferably with equal intervals) throughout the day.
In the case of treatment of spasms of coronary vessels, as well as treatment of tachycardia , the single dose can be increased to 3 tablets.
Note!
The description of the drug Corvaltab on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Interaction
When taken in combination with other drugs that depress the central nervous system , a two-way increase in effects is observed.
The effect of the drug, when taken together with alcohol and valproic acid , increases.
Against the background of the action of Corvaltab, it is possible to weaken the effects of Griseofulvin , glucocorticoids , coumarin derivatives, oral contraceptives and increase the toxicity of Methotrexate .
Analogs
Level 4 ATC code matches:
Corvalol
Belloid
Corvaldin
Bellaspon
Bellataminal
Reladorm
Valocordin
- Barboval;
- Valocordin;
- Valecard;
- Corvaldin;
- Corvalcaps , etc.
Reviews about Corvaltab
In almost all cases of using Corvaltab, reviews of its effectiveness are positive. The drug copes well with its intended purpose and, in very rare cases, leads to minimal side effects. The undoubted advantage of this drug is its price and dosage form in the form of tablets, which, along with drugs of similar action, such as Valocordin or Barboval in the form of drops, sets it apart in terms of speed and ease of administration.
KORVALTAB TAB No. 20
Instructions
Composition
Active substances: one tablet contains 8.2 milligrams of bromoisovaleric acid ester, 7.5 milligrams of phenobarbital, 0.58 milligrams of mint oil. Other components: cyclodextrin, lactose monohydrate, potato starch, microcrystalline cellulose, magnesium stearate.
Dosage form
Available in the form of: tablets. Vacation category
Manufacturer Direct production: Pharma Start LLC, Ukraine, Kyiv, Lepse Boulevard, 8.
Pharmacotherapeutic group
Drugs used to produce a hypnotic and sedative effect.
Pharmacological properties
The drug Corvaltab has a sedative effect, dilates blood vessels, and relieves spasms. With the help of the product, the activity of the nervous system decreases and natural sleep occurs.
Indications for use
Corvaltab tablets are prescribed for overexcitation of the nervous system, for the treatment of insomnia, and as an adjuvant for VSD and the treatment of high blood pressure. Used as a remedy that relieves spasms.
Contraindications
Hypersensitivity of the body to one of the components of the product. Disturbances in the functioning of the kidneys, liver and heart muscle.
Not prescribed for treatment for people who have chronically low blood pressure and people with alcohol or drug addiction, diabetes mellitus and diseases of the respiratory system.
Proper safety precautions for use
During treatment with Corvaltab tablets, it is necessary to avoid consuming alcohol-containing substances. It should be borne in mind that if the drug is used for a long period of time, drug dependence on the drug may occur. Also, during the treatment period, the following situation is possible: bromine will accumulate in the body. This may in turn lead to poisoning with this substance. The auxiliary composition includes lactose, which makes the drug unsuitable for use by people with lactose intolerance.
Use during pregnancy or breastfeeding
Corvaltab should not be used by pregnant women or women who are breastfeeding.
The ability to influence reaction speed when driving vehicles
The use of Corvaltab tablets may cause drowsiness and dizziness, which may affect activities requiring alertness.
Directions for use: Corvaltab tablets are taken orally before meals for adults. The duration of administration and quantity are determined by a specialist.
The usual dose for 24 hours is: one or two tablets two or three times.
Overdose
If the drug is taken for a long time, overdose symptoms may occur due to the accumulation of active substances in the body. All symptoms are associated with severe depression of the nervous system, expressed in depression of respiratory function, central nervous system, cardiovascular system, decreased temperature and depression of all vital functions. Treatment is aimed at eliminating symptoms.
Side effects
Sometimes side effects are observed after taking Corvaltab, which manifest themselves in disturbances in the gastrointestinal tract, general weakness of the body, hallucinations may occur, a decrease in hemoglobin, and difficulty breathing.
Drug interactions
If you simultaneously use medicinal substances that act similarly to Corvaltab, the activity of both drugs increases. Phenobarbital, which is part of the main composition of Corvaltab, increases the effect of substances that analgesize and local anesthetize. When Corvaltab is used together with aurum preparations, nephrotoxicity increases. Not compatible for a long course with NSAIDs. Increases the toxicity of zidovudine and methotrexate.
Best before date
Suitable for treatment two years from the date of manufacture.
Storage conditions
Keep out of reach of children at temperatures not exceeding 25 degrees Celsius.
Release form / packaging
Tablets are packaged in blisters of 10 pieces, 2 or 10 blisters in a cardboard package.
Vacation category
To obtain the drug for 20 tablets, you do not need a prescription. To obtain the drug for 100 tablets, you must have a prescription.
Corvaltab price, where to buy
The price of the drug in Ukraine is No. 20 - 16 hryvnia and No. 100 - 75 hryvnia.
The estimated cost of the medicine in Russia is 60 rubles for 20 tablets.
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
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