Composition and release form
The medicine is dispensed in the following forms:
- The tablets are round, light white or cream in color, with minor inclusions possible. Packaged in cardboard packaging with 1-2 blisters, each containing 10 pieces.
- Syrup - presented as a liquid base with the taste of thyme. Available in 50, 100 and 125 ml volumes. Sold in a glass bottle and secondary cardboard packaging with attached instructions for use.
Active ingredients, regardless of type: ambroxol hydrochloride, sodium glycyrrhizinate. Also dry thermopsis extract and sodium bicarbonate in tablets; liquid thyme extract in syrup.
Auxiliary components: starch, cellulose, talc, nipazole, pure water, sorbitol, stearic acid.
pharmachologic effect
The medicine is intended to treat cough symptoms of any origin. It has a pronounced expectorant and mucolytic effect, and a weak anti-inflammatory effect.
Thanks to the main substances in the composition, the drug promotes the dilution of bronchial secretions and its good discharge.
Due to glycyrrate, there is a decrease in the inflammatory process, the fight against viral agents, and antioxidant properties.
Thermopsis extract stimulates expectoration of sputum, normalizing the secretion in the bronchopulmonary system due to some irritation of the gastric mucosa.
Sodium bicarbonate has an alkaline effect, reduces the viscosity of mucus and stimulates the motility of the epithelial tissue of the bronchopulmonary apparatus.
Thyme plant extract contains a number of essential oils, which contributes to an expectorant, anti-inflammatory and antispasmodic effect.
The pharmacological activity of the drug is aimed at suppressing dry cough, wheezing in the lungs and respiratory failure. In addition, Codelac Broncho reduces the time of intoxication and helps to quickly relieve a runny nose.
Pharmacodynamics
A combined drug for the treatment of cough, it has a mucolytic and expectorant effect, and also has anti-inflammatory activity. The effect of the Codelac® Broncho elixir with thyme is due to the pharmacological properties of its components.
Ambroxol has a secretomotor, secretolytic and expectorant effect, normalizes the disturbed ratio of serous and mucous components of sputum, and increases the secretion of surfactant in the alveoli. Reduces the viscosity of sputum and promotes its removal.
Glycyrrhat (glycyrrhizic acid and its salts) has anti-inflammatory and antiviral effects. It has a cytoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous corticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, it helps reduce the inflammatory process in the respiratory tract.
Thyme herb extract contains a mixture of essential oils that have an expectorant and anti-inflammatory effect. In addition, thyme herb extract has weak antispasmodic and reparative properties.
Contraindications
The following conditions are absolute contraindications to taking Codelac Broncho:
- Carrying a child and breastfeeding.
- Allergic reaction to the components of the drug.
- Children's age - syrup up to 2 years and tablets up to 12 years.
Use the medicine with caution in case of an attack of bronchial asthma, ulcerative lesions of the gastrointestinal tract and disorders of the liver and kidneys.
Elixir Codelac Broncho with thyme: instructions for use
Where can I buy
Registration number: LSR-006772/09
Trade name: CODELAC® BRONCHO WITH THYME
Dosage form : elixir
Composition per 5 ml of elixir:
Active ingredients:
- ambroxol hydrochloride – 10 mg,
- sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) – 30 mg,
- creeping thyme herb extract (thyme liquid extract) – 500 mg.
Excipients:
- methyl parahydroxybenzoate – 3.75 mg,
- propyl parahydroxybenzoate – 1.25 mg,
- sorbitol (sorbitol) – 3000 mg,
- purified water - up to 5 ml.
Description: transparent liquid from light brown to brown. During storage, sediment may form.
Pharmacotherapeutic group: combined expectorant.
ATX code : [R05CA10]
Pharmacological properties
Pharmacodynamics
A combined drug for the treatment of cough, it has a mucolytic and expectorant effect, and also has anti-inflammatory activity. The effect of the elixir CODELAC® BRONCHO WITH THYME is due to the pharmacological properties of its components:
- Ambroxol has a secretomotor, secretolytic and expectorant effect, normalizes the disturbed ratio of serous and mucous components of sputum, and increases the secretion of surfactant in the alveoli. Reduces the viscosity of sputum and promotes its removal. On average, when taken orally, the effect of ambroxol occurs within 30 minutes, the duration of action is 6–12 hours, depending on the dose taken.
- Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) has anti-inflammatory and antiviral effects. It has a cytoprotective effect due to its antioxidant and membrane-stabilizing activity. Enhances the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, it helps reduce the inflammatory process in the respiratory tract.
- Creeping thyme (thyme) herb extract contains a complex of biologically active substances that have expectorant, anti-inflammatory, and antimicrobial effects. In addition, the extract of the herb creeping thyme (thyme) has weak antispasmodic and reparative properties.
Pharmacokinetics
Ambroxol
After oral administration, ambroxol is quickly and almost completely absorbed from the gastrointestinal tract. The maximum concentration (Cmax) in blood plasma after oral administration is reached after 1–3 hours. The volume of distribution is 552 l. In the therapeutic concentration range, binding to plasma proteins is 80-90%. The highest concentrations of the active component of the drug are observed in the lungs. Ambroxol penetrates the placental and blood-brain barriers and is excreted in breast milk. Approximately 30% of an oral dose is subject to first pass effects through the liver. Studies on human liver microsomes have shown that CYP3A4 is the predominant isoform responsible for the metabolism of ambroxol to dibromoantranilic acid. The remainder of ambroxol is metabolized in the liver by conjugation to form pharmacologically inactive metabolites. The terminal half-life (T1/2) of ambroxol from blood plasma is 10 hours. The total half-life of ambroxol and its metabolites is about 22 hours. Excreted by the kidneys: 90% in the form of metabolites, 10% unchanged. No clinically significant effect of age and gender on the pharmacokinetics of ambroxol was found, so there is no basis for selecting the dosage based on these characteristics.
Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid)
After oral administration, in the intestine, under the influence of the enzyme β-glucuronidase, produced by bacteria of normal microflora, the active metabolite β-glycyrrhetic acid is formed from glycyrrhizic acid, which is absorbed into the systemic circulation. In the blood, β-glycyrrhetic acid binds to albumin and is almost completely transported to the liver. The excretion of β-glycyrrhetic acid occurs predominantly in bile, with residual amounts in urine.
Creeping thyme herb extract (thyme)
The effect of the drug is the result of the combined action of the active substances of the creeping thyme herb extract (thyme), so pharmacokinetic studies are not possible; Collectively, the components cannot be traced using markers or bioassays.
Indications for use
Diseases of the respiratory tract with the formation of viscous sputum:
- acute and chronic bronchitis,
- pneumonia,
- chronic obstructive pulmonary disease (COPD),
- bronchiectasis.
Contraindications
Hypersensitivity to the components of the drug, children under 2 years of age, pregnancy, breastfeeding.
Carefully
For liver and/or kidney failure, gastric and duodenal ulcers, bronchial asthma, diabetes mellitus. For liver diseases, alcoholism, traumatic brain injury, brain diseases, children over 2 years of age.
Use during pregnancy and breastfeeding
The use of ELIXIR KODELAK® BRONCHO WITH THYME is contraindicated during pregnancy. If it is necessary to take the drug during breastfeeding, breastfeeding should be discontinued.
Directions for use and doses
Inside, during meals, with a small amount of water.
- adults and children over 12 years old: 10 ml 4 times a day;
- children from 2 to 6 years old are prescribed 2.5 ml of elixir 3 times a day;
- children from 6 to 12 years old: 5 ml 3 times a day.
The maximum duration of treatment without consulting a doctor is 5 days.
If there is no improvement during treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.
Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.
Side effect
Allergic reactions. Rarely - weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With long-term use in high doses - gastralgia, nausea, vomiting.
If you experience the side effects indicated in the instructions, or they get worse, or you notice any other side effects not listed in the instructions. Tell your doctor about this.
Overdose
Symptoms: nausea, vomiting, diarrhea, dyspepsia.
Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug.
Interaction with other drugs
Combined use with antitussive drugs leads to difficulty in sputum discharge.
special instructions
Do not combine with antitussives. Patients with diabetes can use the drug, taking into account the sorbitol content in the amount of 0.18 XE per 5 ml of elixir.
The content of absolute ethyl alcohol in the maximum single dose of the drug is 0.24 grams, in the maximum daily dose of the drug – 0.96 grams.
Impact on the ability to drive vehicles and machinery
During the period of use of the drug, care must be taken when performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).
Release form
Elixir. 50, 100, 125 and 200 ml in dark glass bottles. One bottle with instructions for use and a measuring spoon is placed in a cardboard pack.
Storage conditions
At a temperature not higher than 25 °C. Keep out of the reach of children.
Best before date
3 years. Do not use after the expiration date.
Vacation conditions
Available without a prescription.
Marketing authorization holder/organization receiving consumer complaints:
PJSC OTCPharm, Russia, 123317, Moscow, st. Testovskaya, 10
Tel.
Fax
www.otcpharm.ru
, 305022, Russia, Kursk, st. 2nd Aggregatnaya, 1a/18, tel./fax, www.pharmstd.ru
Side effects
If the course of therapy is not followed, side effects may occur in the form of:
- Headache and dizziness.
- Weakness and fatigue.
- Rhinorrhea.
- Dryness of the mucous surface of the respiratory tract.
- Dyspeptic manifestations - nausea followed by vomiting, dry mouth, pain in the epigastrium, abnormal stool.
Skin rashes and problems with urination are less common.
