Pharmacodynamics and pharmacokinetics
Grammidin for children is a combination drug that is used for the symptomatic treatment of various infectious and inflammatory diseases of the oropharynx, includes an antimicrobial component - gramicidin C and an antiseptic - cetylpyridinium chloride .
gramicidin C based on the ability to increase the permeability of the cytoplasmic membranes of microbial cells (most Gram+ and Gram-), as a result, stability is disrupted and the death of microorganisms occurs.
It is known that cetylpyridinium chloride as an antiseptic suppresses the growth and reproduction of pathogens of various infectious diseases in the mouth and throat.
In addition to the antimicrobial effect, inflammation is reduced, discomfort when swallowing is eliminated, salivation increases ( hypersalivation ), which promotes natural cleansing of the mouth and throat.
Grammidin children's tablets d/diss. 4+ No. 18
A country
Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Gramicidin C + Cetylpyridinium chloride
Compound
Active ingredients: gramicidin C dihydrochloride (in terms of gramicidin C) - 1.5 mg; cetylpyridinium chloride monohydrate (in terms of cetylpyridinium chloride) -1 mg.
pharmachologic effect
A combined drug for the symptomatic treatment of infectious and inflammatory diseases of the throat and oral cavity. The drug contains the antimicrobial agent gramicidin C and the antiseptic agent cetylpyridinium chloride. The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes death. Gramicidin C has an antibacterial (bactericidal) effect against a wide range of gram-positive and gram-negative microorganisms. Cetylpyridinium chloride is an antiseptic that inhibits the growth and reproduction of pathogens that cause infectious diseases in the oral cavity. The drug has an antimicrobial effect, reduces inflammation, softens discomfort in the throat, facilitates swallowing, and when absorbed causes hypersalivation, which contributes to the mechanical cleansing of the oral cavity and pharynx from microorganisms.
Indications for use
Symptomatic treatment of infectious and inflammatory diseases of the oral cavity and throat, accompanied by pain in the throat and oral cavity: pharyngitis, tonsillitis, periodontitis, gingivitis, stomatitis.
Mode of application
Locally. Used after meals, by dissolving in the mouth without chewing. Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours. Dosage for children from 4 to 12 years: 1 tablet 4 times a day. The maximum daily dose is 4 tablets. Dosage for children over 12 years of age and adults: 2 tablets (one after the other for 20-30 minutes) 4 times a day. The maximum daily dose is 8 tablets. If there is no therapeutic effect within 7 days of taking the drug, it is recommended to consult a doctor.
Interaction
Currently, there are no cases of clinically significant interactions with other drugs.
Side effect
Allergic reactions to the components of the drug, gastrointestinal disorders (nausea, diarrhea) are possible.
Contraindications
Hypersensitivity to the components of the drug; phenylketonuria (the drug contains aspartame); lactation period; children up to 4 years of age.
Overdose
Symptoms: taking the drug in doses higher than recommended may cause gastrointestinal disorders due to changes in bacterial microflora: nausea, vomiting, diarrhea. Treatment: You should stop taking the drug and consult a doctor.
special instructions
Use during pregnancy and lactation. Pregnant women should consult a doctor before using the drug. The use of the drug is possible if the potential benefit to the mother outweighs the possible risk to the fetus. Breastfeeding should be stopped during treatment. The drug should not be taken in the presence of open wounds in the mouth, since cetylpyridinium chloride slows down wound healing. Effect on the ability to drive vehicles and control mechanisms: the drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving a car and other vehicles, working with moving mechanisms, the work of a dispatcher and operator, etc.).
Analogs
Level 4 ATC code matches: Grammidin with anesthetic Neo
Grammidin with anesthetic
Grammidin Neo
Grammidin
Bioparox
Gramicidin S
Trachisan
The active components of Grammidin Neo are also gramicidin C and cetylpyridinium chloride , in this analogue the dosage of active components is 2 times greater.
Grammidin children's dosed spray for topical use, 112 doses
Registration Certificate Holder
VALENTA PHARMACEUTICS (Russia)
Dosage form
Medicine – Grammidin® for children (Grammidin for children)
Description
Spray for topical use, dosed
in the form of a colorless or yellowish-tinged, transparent or opalescent solution with a characteristic raspberry odor.
1 dose
gramicidin C dihydrochloride 0.0319 mg, which corresponds to the content of gramicidin C 0.03 mg cetylpyridinium chloride 0.1 mg
Excipients
: ethanol 96% - 9.5 mg, sucralose - 0.2 mg, glycerol - 33.2 mg, raspberry flavor - 0.4 mg, citric acid monohydrate - 0.058 mg, sodium citrate - 0.022 mg, polysorbate 80 - 0.4 mg, methyl parahydroxybenzoate - 0.184 mg, propyl parahydroxybenzoate - 0.02 mg, purified water - up to 0.2 ml.
112 doses - aluminum bottles (1) - cardboard packs.
Indications
Infectious and inflammatory diseases of the oral cavity and pharynx: sore throat; pharyngitis; tonsillitis; periodontal disease; gingivitis; stomatitis.
Contraindications for use
Children under 4 years of age; I trimester of pregnancy; hypersensitivity to the components included in the drug.
pharmachologic effect
Combined drug for local use.
Gramicidin C is an antimicrobial agent. The mechanism of action is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which violates its stability and causes cell death. Gramicidin C has a pronounced antimicrobial effect against pathogens of infectious diseases of the oral cavity and pharynx.
Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity.
The combined drug reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed causes hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms.
Drug interactions
Enhances the effects of other antimicrobial agents of local and systemic action.
Dosage regimen
For resorption or treatment of the oral cavity. Use 1-4 times a day, depending on the indications, the age of the patient and the dosage form.
Immediately after use, you should refrain from eating and drinking for 1-2 hours.
Side effect
Maybe:
in some cases - allergic reactions.
special instructions
If there is no therapeutic effect within 7 days of use, you should consult a doctor.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.
Use is contraindicated in the first trimester of pregnancy.
If it is necessary to use it during lactation, breastfeeding should be stopped during use.
Use in children
Restrictions for children - With caution.
Price Grammidin Children, where to buy
Usually the price per package (18 tables) does not exceed 220 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Grammidin children's tablets for rassas.
1.5mg+1mg 18 pcs. JSC Valenta Pharmaceuticals RUB 315 order - Grammidin children's spray dosage. for local approx. 0.03 mg+0.1 mg/dose vial. 112 doses Delpharm Bladel B.V./JSC Valenta Pharm
RUB 392 order
Pharmacy Dialogue
- Grammidin children's tablets d/diss. 4+ No. 18 Valenta Pharmaceuticals OJSC
RUB 319 order
show more
Grammidin for children 1.5 mg + 1 mg No. 18 tablet/dispens.
Instructions for medical use of the drug Grammidin® for children Trade name Grammidin® for children International nonproprietary name No Dosage form Lozenges 1.5 mg + 1 mg Composition One tablet contains active substances: gramicidin C dihydrochloride (in terms of gramicidin C) - 1.5 mg , cetylpyridinium chloride monohydrate (in terms of cetylpyridinium chloride) – 1 mg, excipients: colloidal silicon dioxide (Aerosil® 200), talc, citric acid monohydrate, aspartame, raspberry flavor, sorbitol (Neosorb®), magnesium stearate Description White or almost white, round, biconvex, with a bevel, the inscription on one side GR and the smell of raspberries. Minor marbling is allowed. Pharmacotherapeutic group Drugs for the treatment of throat diseases. Antiseptics. ATC code R02AA20 Pharmacological properties Combined drug for the symptomatic treatment of infectious and inflammatory diseases of the throat and oral cavity. The drug contains the antimicrobial agent gramicidin C and the antiseptic agent cetylpyridinium chloride. The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes cell death. Gramicidin C has an antibacterial (bactericidal) effect against a wide range of gram-positive and gram-negative microorganisms. Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity. The drug reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed causes hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms. Indications for use Symptomatic treatment of infectious and inflammatory diseases of the oral cavity and throat, accompanied by pain in the throat and oral cavity: - pharyngitis - tonsillitis - periodontitis - gingivitis - stomatitis Method of administration and dosage Locally. It is used after meals, by dissolving in the mouth without chewing. Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours. Dosage for children from 4 to 12 years: 1 tablet 4 times a day. The maximum daily dose is 4 tablets. Dosage for children over 12 years of age and adults: 2 tablets (one after the other for 20-30 minutes) 4 times a day. The maximum daily dose is 8 tablets. If there is no therapeutic effect within 7 days of taking the drug, it is recommended to consult a doctor. Side effects Possible allergic reactions to the components of the drug, gastrointestinal disorders (nausea, diarrhea) Contraindications - hypersensitivity to the components of the drug - phenylketonuria (the drug contains aspartame) - children under 4 years of age - lactation period Drug interactions Currently, there are no clinically described cases significant interactions with other drugs. Special instructions Grammidin® for children should not be taken if there are open wounds in the oral cavity, since cetylpyridinium chloride slows down wound healing. Pregnancy and lactation Pregnant women should consult a doctor before using the drug. The use of the drug is possible if the potential benefit to the mother outweighs the possible risk to the fetus. Breastfeeding should be stopped during treatment. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms. The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving a car and other vehicles, working with moving mechanisms, working as a dispatcher and operator, etc.). Overdose Symptoms: taking the drug in doses higher than recommended may cause disturbances in the gastrointestinal tract due to changes in the bacterial flora: nausea, vomiting, diarrhea. Treatment: you should stop taking the drug and consult a doctor. Release form and packaging Lozenges 1.5 mg + 1 mg. 9 tablets each in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil. 2 blister packs together with instructions for medical use in Russian and state languages are placed in a cardboard pack. Storage conditions Store in a place protected from light at a temperature not exceeding 25° C. Keep out of the reach of children! Shelf life: 2 years Do not use after expiration date. / Conditions for dispensing from pharmacies Without a prescription Manufacturer Open joint-stock company "Valenta Pharmaceuticals", Russian Federation 141101, Shchelkovo, Moscow region, Fabrichnaya str., 2 Registration certificate holder Open joint-stock company "Valenta Pharmaceuticals", Russian Federation 141101, Shchelkovo , Moscow region, Fabrichnaya str., 2 Address of the organization that accepts claims from consumers regarding the quality of products (products) in the Republic of Kazakhstan Representative office of Valenta Pharmaceuticals OJSC in the Republic of Kazakhstan Republic of Kazakhstan, 050009, Almaty, Abay Ave., ug. st. Radostovtsa, 151/115, business, office No. 1102 Telephone/fax Email address
List of main indications and contraindications for prescribing the drug
In therapeutic and otorhinolaryngological practice, Grammidin is used to treat a wide range of diseases, such as:
- Acute pharyngitis. This is an inflammation of the pharyngeal mucosa.
- Acute tonsillitis. Otherwise, this disease is called angina. It is characterized by inflammation of the tonsils.
- Stomatitis (disease of the mucous membranes of the mouth).
- Periodontitis.
- Gingivitis.
- Other inflammatory processes of this localization, caused by infection and other damaging factors.
Conditions that are contraindications to taking Grammidin:
- The entire period of pregnancy.
- Breast-feeding.
- Children's age up to 12 years.
- History of allergic reactions to the main or excipients of the drug.
- Enzyme deficiency (lactase deficiency).
- Malabsorption syndrome (galactose-glucose).
pharmachologic effect
Grammidin is a combination drug that has antimicrobial and antiseptic effects. Therefore, the drug is used in the treatment of infectious and inflammatory diseases localized in the nasal cavity or throat.
The mechanism of the therapeutic effect of the main substance is based on increasing the permeability of the membrane of microorganism cells. In this regard, vital processes in them are disrupted, and microbes die.
Grammidin helps reduce or completely remove the inflammatory process, get rid of discomfort in the throat and make swallowing easier. Resorption of the drug tablets leads to increased secretion of saliva, due to which the oral cavity is cleansed of pathogenic microbes and inflammatory exudate also mechanically.
Reviews about Grammidin
Comments about the drug from patients and doctors are full of variety. There are both positive and negative reviews about it. However, this is typical for any product.
Most experts recommend this remedy, because it has been tested for years, acts quickly and does not have a systemic effect. With its help, you can quickly get rid of a sore throat and suppress the resulting inflammatory process.
There are various variants of Grammidin, intended for children and adults and differing from each other in different tastes and aromas. This will make your treatment as pleasant as possible.
