"Givalex" - an effective remedy for sore throat

Composition and release form

• Spray 50 ml in bottles with a sprayer, 1 bottle in a cardboard box.
• Solution 125 ml in bottles, 1 bottle in a cardboard package.

100 ml of Givalex solution contains:

• Hexetidine – 100 mg;
• Choline salicylate – 500 mg;
• Chlorobutanol hemihydrate – 250 mg;
• Excipients, including ethyl alcohol.

100 ml of Givalex spray contains:

• Hexetidine – 100 mg;
• Choline salicylate – 500 mg;
• Chlorobutanol hemihydrate – 250 mg;
• Excipients, including ethyl alcohol.

Price

Average price in Russia:

• spray (50ml bottle with dispenser) – 230 rubles;
• rinse solution (125 ml bottle with measuring cup) – 190 rubles.

You can purchase Givalex without a prescription in all stationary and online pharmacies in the country.

In Ukrainian pharmacies the spray can be purchased for 85 hryvnia. You will be offered a rinse solution for an average of 102 hryvnia.

PHARMACOLOGICAL PROPERTIES

A remedy used for diseases of the oral cavity and pharynx. The effect of the drug is due to three active ingredients.

Antibacterial and antifungal activity

Hexetidine (INN - hexetidinum) exhibits antibacterial activity against both gram-positive and gram-negative strains of microorganisms - both aerobes and anaerobes. It should be noted that it acts mainly bacteriostatically on strains of aerobic microorganisms; the bactericidal effect is weak. Hexetidine has a pronounced bactericidal effect on strains of anaerobic microorganisms. The mechanism of action is based on the competitive replacement of thiamine (the structure of hexetidine is similar to the structure of thiamine), which is necessary for the growth of microorganisms.

Anti-inflammatory activity

Choline salicylate is used due to its analgesic, antipyretic and anti-inflammatory effects.

Analgesic activity

Chlorobutanol is used in otolaryngological (nasal drops, rinses) and dental practice (applications and irrigations) mainly as an anesthetic. Classically used as an anesthetic.

The active substances are fixed on the oral mucosa, from where they are gradually released.

Givalex oral spray 50 ml No. 1

Interaction with other drugs and other types of interactions

Do not use together with medications containing antiseptics.

Hexetidine can be inactivated by alkaline solutions.

Application Features

When using the drug, do not swallow and avoid contact with eyes, since the drug contains ethanol.

The drug should be used with caution in patients with epilepsy. The drug may reduce the epileptic threshold and cause seizures in children.

Use with caution in patients prone to allergic reactions, including bronchial asthma, especially in patients allergic to acetylsalicylic acid.

If signs of hypersensitivity to the drug appear, its use should be stopped immediately.

Since the drug contains ethanol, it should therefore be administered with caution to patients with liver disease.

Long-term use is not recommended as it may alter the natural microbial balance of the mouth and throat, where there is a risk of bacterial and fungal spread.

If general clinical signs of a bacterial infection appear, general antibacterial therapy should be prescribed.

If symptoms persist for more than 5 days and/or body temperature is elevated, treatment strategies should be reconsidered.

If inflammation worsens, treatment should be discontinued.

Use during pregnancy or breastfeeding

There are no data from human studies on the possibility of hexetidine crossing the placenta and excretion into breast milk, therefore the drug should not be used during pregnancy and lactation.

The ability to influence the reaction rate when driving vehicles or other mechanisms

The drug contains ethanol. Drivers are not recommended to drive for 30 minutes after using the drug.

Directions for use and doses

Use as a local remedy for irrigation of the oral cavity and oropharynx.

Adults and children over 15 years of age: 1 spray 4-6 times a day.

Children aged 6 to 15 years: 1 spray 2-3 times a day.

The course of treatment is no more than 5 days.

Children

Do not use in children under 6 years of age.

Overdose

There have been no reports of drug overdose.

If a sufficient amount of solution is absorbed into the oral cavity, alcohol intoxication may occur due to the ethyl alcohol content.

The concentration of hexetidine in the drug is not toxic if the drug is used as directed.

The occurrence of acute alcohol intoxication is unlikely. If a child swallows a large dose of the drug, alcohol intoxication may occur due to the ethyl alcohol content.

There have been no cases of excessive use of hexetidine, which led to allergic reactions.

Treatment of overdose is symptomatic but rarely necessary. If a child swallows the contents of the bottle, consult a doctor immediately. It is necessary to consider the possibility of performing gastric lavage within 2:00 after swallowing and take measures to eliminate signs of alcohol intoxication.

Side effects

From the immune system:

hypersensitivity reactions, including urticaria, angioedema, laryngospasm, bronchospasm.

From the nervous system:

ageusia, dysgeusia, change in taste sensations within 48 hours (the sensation of “sweet” can change twice to the sensation of “bitter”).

From the respiratory system, chest and mediastinal organs:

cough, shortness of breath.

From the digestive system:

dry mouth, dysphagia, enlarged salivary glands, pain when swallowing. If the drug is accidentally ingested, gastrointestinal disorders may occur, primarily nausea and vomiting.

From the skin and subcutaneous tissue:

allergic contact dermatitis, skin reactions (rash).

General disorders and condition of the application site:

local reactions - reversible change in the color of teeth and tongue; sensitivity of the mucous membrane, namely burning, numbness; irritation (pain, feeling of heat, itching) of the tongue and/or oral mucosa; decreased sensitivity; paresthesia of the mucous membrane; inflammation; bubbles; the occurrence of ulcers on the mucous membrane, a sore throat, swelling at the site of contact, dryness of the mucous membrane of the nose/throat.

Best before date

18 months.

Storage conditions

Store in original packaging at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Package

50 ml in a spray bottle.

Vacation category

Over the counter.

Manufacturer

Norzhin Pharma / Norgine Pharma.

Address

st. Ethe Virton 29 28100 m. Dreux, France / 29 rue Ethe Virton 28100 Dreux, France.

APPLICATION

Topically for irrigation and rinsing of the mouth and pharynx.

Givalex spray:

• adults and children over 15 years of age - 1 spray 4-6 times a day;
• children aged 12 to 15 years - 1 spray 2-3 times a day.

Givalex solution:

For one mouth rinse for adults and children over 6 years of age: place the drug in a measuring cup to the 10 ml mark and add warm water to the 50 ml mark or dissolve 2 teaspoons of the drug in ¼ glass of warm water. Do not swallow. The course of treatment is 5 days.

Analogs

There are many analogues of this drug, but you should not make an independent decision about a replacement. A doctor’s advice in this matter will not be superfluous.

Substitutes for Givalex:

1. Stopangin. This antiseptic is also available in the form of a spray and rinse solution. Can be used by children from 8 years of age.
2. Inhalipt is available in the form of a spray. The effect of treatment with this drug is much lower, due to the fact that the active substance included in Ingalipt (sulfanilamide) belongs to the 1st generation of antibiotics.
3. Strepsils is a local antiseptic. Oral lozenges. Can be used during pregnancy and lactation.
4. Falimint is an antiseptic drug produced in the form of lozenges. Well tolerated by patients of all ages. Recommended for use during pregnancy and breastfeeding.
5. Angilex is a spray for topical use for irrigation of the oral cavity.
6. Hepilor is an analgesic and antiseptic. Effective for the treatment of sore throat, pharyngitis, stomatitis, tonsillitis, laryngitis. Often prescribed as a hygienic oral care product.

SPECIAL INSTRUCTIONS

When using Givalex, do not swallow and avoid contact with eyes as it contains ethanol.

Long-term use is not recommended as the natural microbial balance of the mouth and throat may be altered and there is a risk of bacterial and fungal spread.

If general clinical signs of a bacterial infection occur, general antibacterial therapy should be provided.

If symptoms persist for more than 5 days and/or elevated body temperature, it is necessary to reconsider treatment tactics.

During pregnancy and breastfeeding. During pregnancy and lactation, the drug is used only as prescribed by a doctor and only when the benefit of its use for the mother outweighs the risk to the fetus.

Children. The drug should not be used in children under 6 years of age (solution) and under 12 years of age (spray).

The ability to influence reaction speed when driving vehicles and working with other mechanisms. Unknown.

Interaction with other drugs

Doctors do not recommend using Givalex together with similar topical antiseptic drugs. This may lead to increased irritation of the oral mucosa.

If the disease is complex, Givalex can be combined with antibacterial drugs in the form of tablets and injections. Due to the low percentage of absorption of the substance and the low concentration of its components in the blood plasma, this medicine combines well with other drugs.

Cases of allergic reactions are very rare. This should serve as a reason to cancel this drug.

Note!

The description of the drug Givalex on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use. Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug).

Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.