Pharmacodynamics and pharmacokinetics
The drug removes microbes and viruses from the mucous membrane of the nasopharynx, preventing their reproduction and development of the disease.
The effect can be noticeable after the first use. Regular use helps eliminate runny nose and sore throat. This remedy quickly relieves swelling and removes pathogenic mucus.
It consists of a mixture that, after dissolution, forms a solution similar in composition to physiological fluids. The effect of the drug is due to the properties of its components (minerals and plant extracts).
Sodium chloride, rosehip extract and iodine are antiseptics. Trace elements also stimulate the secretion of protective mucus. In addition, the medicine has a regenerating effect. Licorice extract has antiallergic and protective effects.
Rinsing the nose with Dolphin ensures the removal of pathogenic agents that provoke inflammation, and also reduces swelling, restores the patency of the nasal passages, increases the outflow of pus and mucus from the paranasal sinuses, and prevents the development of otitis media .
General information about the drug
The drug Dolphin is a medicinal powder that is included with the device. A similar nasal rinse in question is Aquamaris, which is produced in Croatia. It has a similar effect on the body and is practically the same in cost. However, Dolphin has a number of advantages compared to its counterparts. To obtain the powder, special microelements and mineral salts are used. To obtain them, unique technologies are used that make it possible to preserve ocean water of the Permian period in crystals. This significantly distinguishes the medicine from other medicines, the base for which is sea water.
Among the mineral substances that make up the powder, one can highlight: salt of sulfuric, carbonic and hydrochloric acid, iodine, silicon, phosphorus, bromine, nitrogen, etc. An important component of the drug is table salt, or it is otherwise called sodium chloride. The antiseptic effect is ensured precisely thanks to table salt and iodine. Rinsing the nose with Dolphin will help avoid the formation of crusts in the nose, as it helps moisturize the nasal mucosa and increases the amount of mucus secreted.
Medicinal plants are also used to prepare the powder: licorice and rose hip concentrates. They enhance the positive effect of the drug on the patient’s body due to increased anti-inflammatory effect and better immunomodulation. You can normalize the functioning of the immune system faster with the help of zinc and selenium included in the drug.
Magnesium salt enhances the protective functions of the nose, as it restores the damaged layer of epithelium in the nasal cavity. The entry of infection into the body contributes to the destruction of tissues, their renewal is ensured by organic components.
Dolphin promotes the rapid mechanical removal of pathogenic microorganisms from the patient's body that cause inflammatory processes, significantly reduces nasal swelling, clears the nasal passages, and prevents the appearance of otitis media. Rinsing the nasal cavity with Dolphin does not cause any discomfort. An excellent result can be obtained because a well-chosen concentration of salt in the powder corresponds to its amount in the human body.
The box with a picture of a dolphin contains 30 sachets of powder, 2 g each (for adults), 1 g each for children. The nasal rinsing device is a bottle made of plastic. For adults, its capacity is 240 ml, for children - 120 ml. There is a plastic tube inside the container. A lid with a dispenser is attached to it, which is made as convenient as possible so that during the procedure it fits tightly and provides the best result.
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Patients need to take into account that such a nasal rinsing device is used purely individually. It cannot be used after another subject - this is a violation of personal hygiene rules. Storage conditions for the powder included in the kit: keep in a room with moderate humidity and air temperature, make sure that children cannot use the drug.
Indications for use
Dolphin for rinsing the nose and gargling helps with sinusitis , runny nose , ARVI , allergies , adenoiditis , flu , rhinitis during pregnancy, pharyngitis , sore throat .
This remedy is also used for rhinosinusitis , sinusitis , before and after surgical interventions in the nasal cavity, in case of dryness and crusting in the nasal mucosa, and, in addition, for irritation of the nasal mucosa caused by dust, washing powder or detergents.
Experience in the use of combination drugs in the treatment of rhinitis and sinusitis in children
The incidence of sinusitis is still quite high. According to various authors, diseases of the nose and paranasal sinuses affect from 17 to 22% of the child population. One of the significant factors in the pathogenesis of acute and especially chronic inflammatory diseases of the nose and paranasal sinuses is a violation of the mechanism of mucociliary transport. This is most often associated with swelling of the mucous membrane, excessive formation and increased viscosity of nasal secretions, which entails a disorder of drainage, respiratory, secretory and olfactory functions. The most common treatment for sinusitis is oral or intramuscular antibiotics. Since the supply of antibiotics from the bloodstream to the site of inflammation is limited, the treatment of sinusitis must be comprehensive.
First of all, this should concern improving ventilation, as well as drainage of the paranasal sinuses and nasopharynx.
Until now, otolaryngologists do not always practice prescribing adequate mucoregulating drugs included in the treatment regimen for patients with sinusitis, which, by thinning the thick viscous secretion and improving mucociliary clearance, help remove secretions from the sinuses. Among the drugs that affect mucociliary activity, previously used drugs that stimulate the liquefaction of rhinobronchial secretions, or so-called mucolytics, which change the viscosity of the secretion, affecting its physicochemical properties. We are talking about enzymes (trypsin, chymotrypsin, etc.), which are not currently used due to side effects.
Drugs that reduce surface tension also have a mucolytic effect, i.e., they act on the gel phase of the discharge and dilute both sputum and nasopharyngeal secretions. This group includes fluimucil (N-acetylcysteine), the action of which is associated with the ability of the free sulfhydryl group of N-acetylcysteine to cleave the intermolecular disulfide bonds of mucus glycoprotein aggregates, exerting a strong liquefying effect and reducing viscosity in relation to any type of secretion: purulent, mucopurulent, mucous . The peculiarity of fluimucil is that in addition to the direct mucolytic effect, N-acetylcysteine has powerful antioxidant properties and is able to protect the respiratory system from the cytotoxic effects of inflammatory metabolites, environmental factors, and tobacco smoke.
In the group of mucolytics, combination drugs are of great interest, namely rhinofluimucil, which, in addition to N-acetylcysteine, which dilutes the secretions, includes a sympathomimetic - tuaminoheptane sulfate, which has a mild vasoconstrictor effect and does not cause excessive dryness of the mucous membrane. After the disulfide bridges break, mucus and phlegm lose their viscosity, begin to absorb water and are gently removed when blowing the nose, sneezing, or coughing. Indications for the use of rinofluimucil are:
- prolonged purulent sinusitis with viscous thick secretion;
- chronic rhinitis with the formation of crusts in the nasal cavity and nasopharynx;
- vasomotor rhinitis with thick viscous discharge.
The effectiveness of the drug was assessed in a group of 55 patients aged 6 to 14 years; rinofluimucil was injected one dose into each half of the nose 3-4 times a day, the course was 6-7 days. The condition of the children was assessed by their subjective feelings before and after using the drug, as well as by objective criteria (reduction of hyperemia and congestion in the mucous membrane, improvement of nasal breathing, reduction of mucus, change in its rheological properties).
After 6-8 inhalations of rhinofluimucil, positive dynamics were noted.
The result of using the drug was assessed as follows: 70% of patients - excellent; 20% - good; 10% - satisfactory.
| Drawing. Comparative results of treatment with the antibiotic fluimucil IT and traditional methods |
There were no side effects from the use of the drug. The advantage of rhinofluimucil is that it acts on the surface of the mucous membrane and, by thinning the mucus, reduces its viscosity and promotes the productive physiological act of cleansing the nasal cavity.
The next drug that you should pay attention to is the fluimucil antibiotic IT, which combines two components in one dosage form: N-acetylcysteine and thiamphenicol glycinate (thiamphenicol is a drug from the chloramphenicol group). The spectrum of antimicrobial activity of the drug is presented in table. 1 (Clinical pharmacology of antibacterial drugs/Ed. Yu. B. Belousov, 1988).
The drug has a combined antibacterial and mucolytic effect and is recommended for the treatment of respiratory diseases caused by bacterial infection and accompanied by the formation of a thick viscous secretion. The antimicrobial activity of thiamphenicol is due to its interference with the synthesis of bacterial proteins. Recent studies have shown that the combination of thiamphenicol and N-acetylcysteine allows the drug to retain its unconjugated form and reach the site of inflammation in concentrations sufficient to create a bactericidal effect. The drug exhibits mucolytic activity against any type of secretion - mucous, mucopurulent, purulent. Fluimucil antibiotic IT facilitates the separation of sputum and nasal mucus. The drug is effective when administered into the paranasal sinuses.
We have data on treatment with the drug fluimucil-antibiotic IT in 37 children, of which 17 were diagnosed with acute sinusitis, 10 with exacerbation of chronic sinusitis and 10 with exacerbation of chronic purulent sinusitis. The control group of patients was treated using the traditional method without the use of fluimucil antibiotic. Comparative data is presented in the figure.
The drug was used for washing the paranasal sinuses after punctures or after surgery, including after endonasal opening of the ethmoidal labyrinth cells. Good results were obtained after 2-3 rinses: nasal breathing improved, swelling of the nasal mucosa decreased, the amount of secretion decreased, and its purulent nature disappeared. Indications and methods of use of the drug are presented in table. 2.
The effectiveness of the IT antibiotic fluimucil is determined not only by its antibacterial effect, but also by its ability to ensure rapid and complete removal of exudate, which in turn enhances the antibacterial effect.
Literature
- Ammosova S.P., Chuchalin A.G. et al. The effectiveness of N-acetylcysteine therapy in the treatment of liquidators of the Chernobyl accident with chronic bronchitis.
- Balyasinskaya G. L., Minasyan V. S., Kachkaeva E. D. The use of rinofluimucil in the treatment of rhinitis in children: Collection of works of the department. M., 2001. pp. 162-165.
- Garashchenko T. I., Bogomilsky M. R., Radtsig E. Yu. Mucoactive drugs in the treatment of non-purulent diseases of the middle ear: Collection of works of the department. M., 2001. pp. 157-162.
- Levin A. R., Zaitseva O. V., Vykhristyuk O. F., Kasyanov E. N. Results of the use of acetylcysteine in the complex treatment of children with bronchopulmonary diseases // Pediatrics. 1995. No. 5. P. 66-68.
- Sinopalnikov A.I., Klyachkina I.L. The place of mucolytic drugs in the complex therapy of respiratory diseases // Russian Medical Bulletin. No. 4. pp. 9-10.
- Samsygina G. A. et al. Experience in the use of acetylcysteine in the treatment of acute and chronic respiratory diseases in children // Pediatrics. 1995. No. 3. P. 76.
- Rizzata J. Aerosol antibiotics for the treatment of respiratory infections. The focus is on thiamphenicol glycinate acetylcysteinate. Publishing house "Mattioli", 1985, Therapist, 2001. No. 9. P. 1-6.
Note!
Fluimucil antibiotic IT has the following pharmacological and therapeutic properties:
- High bioavailability of the drug.
- High antibacterial activity, which is achieved thanks to a special dosage form.
- High mucolytic activity, ensuring the restoration of mucociliary clearance and the removal of pathological microorganisms.
- By creating a high therapeutic concentration of both an antibiotic and N-acetylcysteine in the affected organs.
Contraindications
The medicine is prohibited for use:
- children under 4 years old;
- with a predisposition to nosebleeds ;
- in case of deformation of the nasal septum or in the presence of other causes of mechanical obstruction of the nasal passages;
- people with benign and malignant tumors ;
- with complete nasal congestion .
Instructions for use of Dolphin (Method and dosage)
For those who use Dolphin, the instructions for use explain in detail how to use this product.
Approximately 240 ml of boiled water, which is preheated to 35 °C, should be poured into the irrigator bottle. Pour the contents of one sachet into the liquid. Then you need to screw on the endonasal cap and shake the bottle until the powder is completely dissolved.
Leaning over the sink, you need to apply the bottle cap to one nostril, hold your breath and press the bottle (without sudden movements). The fluid should flow out of the other nostril. After this, you need to blow your nose through each nostril one by one.
If the nose is completely stuffy and breathing is difficult, the instructions for use of Dolphin recommend first instilling vasoconstrictor drugs and clearing the nose.
The drug should be used at least 1-2 times a day. Therapy lasts up to 2 weeks.
Mode of application
How to rinse your nose correctly? In order for the effect to be as fast and high-quality as possible, you must follow these rules. Before starting the treatment procedure, you need to stir the contents of 1 packet in 240 ml of boiled water (its temperature should be 36°C). It is important to observe the temperature regime, since fluctuations in water temperature in one direction or another can give a negative result in the form of increased runny nose and other complications of the disease. The resulting solution is used 1 time.
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To prevent the medicine from flowing out when inserting the dispenser into the nostril, it should touch the nasal walls tightly. Rinsing the nasal passages should be done one at a time.
How to rinse your nose without harm? You need to bend over in front of the washstand, slowly squeezing the bottle with the solution. If the medicine quickly enters the nasal cavity, it can be damaged, and this medicine can also enter the Eustachian tube. The drug, if administered correctly, will flow out of the second nostril. If liquid gets into the mouth, it needs to be spat out. After completing the administration of the medication, the pressure on the bottle stops. Cleansing is performed for both moves.
You can rinse your nose at any time of the day. However, this should not be done before the patient is about to go to bed or go somewhere. This limitation is due to the fact that fluid may be released from the nose for a certain time after the procedure.
Analogs
For those looking for Dolphin analogues, the closest option is the Croatian Aqua Maris . These products cost almost the same. However, according to Russian doctors, Dolphin is still, in most cases, somewhat better than the Croatian drug. In addition, Dolphin has the following analogues:
- Delufen
- Sinupret
- Aqualor
- Prevalin
- Pinosol
- Rhinital
- Tsetrilev
- Erespal
- Allergodil
- Erius
- Rhinonorm
- Xymelin Extra
- Aleron
- For the nose
- Sinomarin
- Physiometer
- Salin
- Nazivin
- Nazol
- Isofra
- Rinazolin
- Baconase
- Beclomethasone
- Suprastin
- Grippocitron
- Atomer
- Naso spray
- Rolinosis
Dolphin for children
Dolphin for children can be used from 4 years of age. This natural remedy removes pathological secretions from the nasopharynx and effectively treats adenoiditis . In addition, Dolphin for children is used for acute, allergic and chronic rhinitis , for the prevention of influenza and ARVI , in case of sinusitis , preoperative preparation of the nasal cavity, frontal sinusitis , dry nose syndrome, tonsillitis , ethmoiditis , pharyngitis .
Parents and pediatricians leave reviews about this product, which report that its composition is safe for health and often turns out to be much more effective than other solutions that contain sea salt.
Reviews about Dolphin
Those who use Dolphin to rinse the nose for sinusitis and other diseases have very different opinions. As a rule, they are positive. Reviews about Dolphin report that the product quickly and effectively helps to cope with problems. However, some of them warn about unpleasant consequences in the form of otitis media , sinusitis , etc. Such negative reactions can occur if you use the product for a long time and not according to the instructions. That is why many reviews about Dolphin contain information that you should carefully read the instructions and use the drug strictly according to the recommendations.
For children, this product should also be used with caution. Its natural composition is safe for the body, but you must use the inhaler according to the scheme established by the manufacturer.
Treatment and prevention
There are various preparations for rinsing the nose, but Dolphin has the most beneficial effect in the treatment of various diseases. This remedy is especially good at fighting rhinitis caused by allergies or colds. In addition, Dolphin for sinusitis is often prescribed not only for the treatment of an already existing disease, but also for preventive purposes. The drug helps to quickly and effectively eliminate various types of crusts that form in the nasal cavity during atrophic rhinitis.
It is recommended to rinse your nose with Dolphin if inflammatory processes develop in the nasal sinuses, which lead to swelling and irritation of the mucous membrane. The drug is able to eliminate symptoms characteristic of colds, such as a runny nose and mucus discharge from the nasal passages.
After various operations performed in the nasal cavity, various complications often arise, which the drug in question can combat.
Its use is often carried out as preventive measures aimed against the onset of these complications. It directly affects the mucous membrane, where pathogenic microorganisms can appear. The action of the drug is also aimed at preventing inflammation and swelling that may occur after operations. The use of the medicine makes it possible to gain access to the affected areas and effectively eliminate dried crusts and accumulations in the form of mucus and pus.
When planning surgery in the nasal cavity, Dolphin is prescribed 2 days before the operation, and then used for 2 weeks after. The action of the drug is aimed at ensuring the restoration of the mucous membrane and facilitating the occurrence of inflammatory processes. The attending physician informs the patient how many times a day to use the drug in the case under consideration, depending on his condition.
They resort to using Dolphin when the patient works in harmful conditions (for example, in a large amount of coal dust). It helps clean the nasal passages even before the possible onset of various types of diseases, that is, thanks to the drug, a full range of preventive measures is provided. Diseases that develop in the nasal cavity can also affect the patient’s throat, so the drug in question is in some cases prescribed for gargling to relieve inflammation.
Dolphin price, where to buy
The price of Dolphin for rinsing the nose is considered quite high, however, many people purchase this particular product, as it turns out to be very effective in the fight against a runny nose. You can buy the drug for about 300 rubles. A product specifically for children costs about 400 rubles.
The price of Dolphin in Ukraine is approximately 150-200 hryvnia for the entire set. However, there are sets for a lower cost.
It is believed that one package is enough to carry out a full course of treatment for influenza, allergy symptoms, colds, as well as for a month’s prevention of these diseases. And when the bags run out, they can be purchased separately.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Dolphin nasopharyngeal rinsing agent for allergies package 2g No. 30 Dynamics LLC/Dolphin LLC
344 rub. order - Dolphin nasal rinse for children, 120 ml. + mineral-herbal remedy, 30 packs. Dynamics LLC/Dolphin LLC
RUB 356 order
- Dolphin cleanser. nose for children 1g 30 pcs. Dynamics LLC/Dolfin LLC
RUB 265 order
- Dolphin nasal rinse for adults 240 ml + mineral-herbal remedy 10 packs of 2 g each Dinamika LLC/Dolphin LLC
RUB 253 order
- Dolphin nasal rinse for adults 240 ml + mineral-herbal remedy 30 packs. 2 gDynamika LLC/Dolfin LLC
412 rub. order
Pharmacy Dialogue
- DOLPHIN solution for rinsing the nasopharynx, sachets 2g No. 30 (for allergies) Dolphin LLC
RUB 372 order
- DOLPHIN device for washing the nasopharynx + sachets 2g No. 30 (for allergies) Dolphin LLC
455 rub. order
- DOLPHIN device for washing the nasopharynx for children + sachets 1g No. 30 Dynamics
400 rub. order
- DOLPHIN solution for washing the nasopharynx, sachets 2g No. 30 Dolphin LLC
RUB 373 order
- DOLPHIN solution for rinsing the nasopharynx sachets 1g No. 30 for children Rosehip/LicoriceDolphin LLC
RUB 294 order
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Pharmacy24
- Dolphin otorhinolaryngological system for nasal lavage individual capacity 240 No. 30 + set with system (recipe No. 1) TOV "Zdravnik", Ukraine
192 UAH. order - Dolphin product for otorhinolaryngological device for rinsing the nose, sachet 2g No. 30 (recipe No. 1) LLC "Zdravnik", Ukraine
144 UAH order
PaniPharmacy
- Dolpfin Dolphin Children's Otolaryngological device for rinsing the nose 120ml 1g No. 30 Ukraine, Zdravnik LLC
182 UAH order
- Dolpfin Dolphin Otolaryngol device. for rinsing the nose 240ml + 2g. No. 30 Ukraine, Health resort
265 UAH order
- Dolphin Dolpfin Dolphin Otolaryngological device for rinsing the nose 240ml + 2g. No. 10 Ukraine, Health Resort LLC
165 UAH order
- Dolphin Dolphin for Children Hygienic product for rinsing the nose with plant extracts 1g. No. 30 Ukraine, Health resort
152 UAH order
- Dolphin Dolphin Hygienic product for washing the nose with plant extracts 2g. No. 30 Ukraine, Health resort
195 UAH order
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