Omez is a drug for the treatment of serious gastric pathologies

To reduce the production of hydrochloric acid by the stomach glands, the drug omez is used. With its use, it is possible to achieve a rapid positive effect in the treatment of gastritis, gastric or duodenal ulcers, as well as many other pathologies.

Omez and omeprazole are identical medications with the same active ingredient. They have the same indications and, if contraindications are violated, cause similar adverse reactions in the body. The main difference between the drugs is different auxiliary ingredients.

The active ingredient in the drug Omez is omeprazole. The drug is produced in two forms: capsules and powder. When they say “omez tablets,” they mean transparent capsules filled with white granules. The coating may be coated with hypromellose, enteric coating, or gelatin.

A medicinal solution for internal consumption is prepared using Omez Insta powder. An additional ingredient in it is anhydrous sodium carbonate. A solution for infusion is prepared from lyophilized powder in bottles.

pharmachologic effect

As the abstract indicates, this medicine is an antiulcer drug that belongs to the group of proton pump inhibitors. The active substance omeprazole, which the capsules contain, inhibits the secretion of hydrochloric acid, having a specific effect on the enzyme H+-K+-ATPase of stomach cells. As a result, under its influence the last stage of hydrochloric acid synthesis is blocked. As a result, regardless of the type of stimulus, the level of basal and stimulated secretion decreases.

Release form and composition

The product is based on a substance that affects the synthesis of hydrochloric acid - omeprazole. The main effect is to restore the processes of juice secretion, reduce acidity, and prevent negative effects on the stomach receptors from the outside.

Another active component - domperidone - is aimed at increasing the tone of the lower gastrointestinal sphincter, normalizing the process of bowel movements and restoring intestinal motility. The drug is available in 3 forms - capsules, powders for suspensions and infusions. Based on this, they have different auxiliary components.

Capsules

There are 3 types, depending on the content of the active substance omeprazole - 10, 20, 40 mg. They are also divided into types based on the capsule shell:

• the usual coating consists of hypromellose 6 cps;
• enteric coating - sodium hydroxide, methacrylic acid, macrogol 6000, methyl methacrylate copolymer, titanium dioxide, talc;
• gelatin capsules: gelatin, E122 (azorubine coloring), methyl parahydroxybenzoate, water, propyl parahydroxybenzoate.

Auxiliary components of internal filling:

• sodium hydrogen phosphate;
• mannitol;
• sodium lauryl sulfate;
• sucrose;
• lactose;
• hypromellose 6 cps.

Inside the capsules there are white granules, the body is colorless, the cap is pink or purple. Each part of the capsule is marked in black with the name of the drug in English (OMEZ). Capsule tablets are packaged in aluminum strips of 10 units. One cardboard package may contain 1 or 3 blisters, 10 and 30 capsules, respectively.

Insta powder

Purpose: preparation of a suspension for oral administration (orally). The powdery mixture has a white color, a mint smell, and is packaged in bags of 5, 10, 20, 30 pieces per package. The content of the active substance omeprazole is 20 mg. Additional Ingredients:

• sodium bicarbonate;
• mint flavor;
• sucrose;
• xylitol;
• gum.

Before consumption, the powder is diluted with purified water.

Powder lyophilisate

Purpose: preparation of an infusion solution for intravenous drip administration. It is produced in the form of a powder, packaged in colorless glass bottles, and packaged in cardboard boxes. The content of the active substance is 40 mg. Auxiliary components:

• sodium hydroxide;
• edetate disodium.

Before use, add a 5% glucose (dextrose) solution to the contents of the bottle (the drug should not contain preservatives).

Pharmacodynamics and pharmacokinetics

The use of the medicine internally leads to a rapid development of the effect: it manifests itself within 1 hour. Then Omez tablets are valid for 24 hours.

After the medication is stopped, the secretory activity of the exocrine glands of the stomach is restored after about 3-5 days. Omeprazole is characterized by rapid absorption from the intestine. Since the active substance in the drug is contained in acid-resistant granules, they dissolve only in the intestines. In plasma, the highest concentration is observed after 30-60 minutes. The level of bioavailability of omeprazole is 40%. The binding of the drug to plasma proteins is 90%. Metabilized in the liver. Excreted through the kidneys.

When administered intravenously, dose-dependent inhibition of gastric secretion is observed. The half-life of omeprazole after intravenous administration is approximately 40 minutes.

Interaction

Omez does not interact with all dosage forms, so you should consult a doctor before consuming it. You need to pay attention to the following facts:

1. Products based on substances with pH-dependent absorption, as the level of absorption of beneficial substances decreases. These are the active ingredients: itraconazole, ketoconazole, cyanocobalamin, iron, erlotinib, posaconazole.
2. When taking Omez and Digoxin simultaneously, the bioavailability of the latter drug increases, which will require adjustment of the daily dosage.
3. When using Clopidogrel, there is a decrease in the level of inhibition of platelet aggregation and a decrease in exposure to clopidogrel metabolites.
4. Antiretroviral drugs. Omeprazole increases the pH value, so these drugs are poorly absorbed by the body. In addition, the concentration of the active substances of the group decreases and the duration of action of omeprazole slows down. These are drugs such as Nelfinavir, Atazanavir, Saquinavir.
5. Omeprazole increases the amount of the active substance of the drug Tacrolimus and Methotrexate, so adjustment of the dose taken is necessary.
6. Drugs whose metabolism depends on the CYP2C19 isoenzyme: Hexobarbital, Warfarin, Diazepam, Disulfiram, Phenytoin, Imipramine, Cilostazol, Citalopram, Clomipramine. As in the previous case, the concentration of substances in the blood plasma increases significantly and the elimination time increases.
7. Drugs with inhibitors of the isoenzyme CYP2C19, CYP3A4: Clarithromycin, Erythromycin, Variconazole. The metabolism of Omez slows down, the concentration of the active substance in the blood plasma increases.
8. When taking Omez simultaneously and inducers of the CYP2C19 and CYP3A4 isoforms, metabolic processes are accelerated, increasing the amount of omeprazole. Preparations: Rifampicin, products based on St. John's wort.
9. There is no interaction with the following medications: Diclofenac, Propranolol, Theophylline, Metronidazole, Amoxicillin, Quinidine, Lidocaine, Estradil.

Indications for use of Omez

Indications for use of Omez are as follows:

• peptic ulcers of the duodenum and stomach;
• erosive and ulcerative esophagitis;
• ulcerative processes that are associated with treatment with non-steroidal anti-inflammatory drugs;
• stress-related ulcers;
• peptic recurrent ulcers of the gastric or duodenal localization;
• Zollinger-Ellison syndrome;
• pancreatitis;
• gastroesophageal reflux disease;
• systemic mastocytosis .

If it is not possible to take the drug orally, but there are indications for use, the drug can be administered intravenously.

The list of other things Omez is used for can be expanded by the attending physician.

Side effects of Omez

In general, side effects during treatment with this drug are rare. The following side effects are possible:

• Digestive system : abdominal pain, nausea, flatulence , taste disturbances, increased activity of liver enzymes.
• Hematopoietic organs: thrombocytopenia, leukopenia , agranulocytosis.
• Nervous system: headache, dizziness, depression.
• Musculoskeletal system : myasthenia gravis, arthralgia , myalgia .
• Skin : rash, itchy skin, photosensitivity.
• Allergic manifestations : urticaria , fever, bronchospasm.
• In addition, in rare cases, visual disturbances, malaise, and severe sweating may occur.

Instructions for use of Omez (Method and dosage)

The patient should swallow the capsules without opening or chewing. When to take Omez tablets? In the morning, before meals.

If Omez tablets are prescribed for peptic ulcers or reflux esophagitis , the instructions for use stipulate that the medicine is used at a dose of 20 mg per day, in the morning, on an empty stomach. The drug should be taken for 14 days. If the peptic ulcer does not heal during the treatment period, treatment can continue for another two weeks. As a rule, when taking the drug, scarring of a peptic ulcer of the duodenum occurs after 4 weeks.

Treatment of Zollinger-Ellison syndrome involves taking 60 mg of the drug per day. The instructions also indicate how to drink it - before or after meals: the drug is taken before meals. Maintenance doses are then prescribed by the doctor.

For gastritis , treatment lasts from 1 to 2 weeks. Treatment for gastritis is aimed at eliminating the symptoms of an irritable stomach. In this case, 1 capsule per day is prescribed. In addition, your doctor will tell you how to take Omez for gastritis after making a diagnosis.

For pancreatitis, it is prescribed as part of complex treatment. It is assumed that this treatment helps relieve the patient of heartburn, reduce pain and stress on the pancreas. The duration of treatment depends on the severity of symptoms. Initially, two capsules are prescribed per day, then maintenance therapy is practiced - 1 capsule per day. For heartburn, it should not be used without prior approval from a physician.

Intravenous administration, depending on the disease, is carried out in a dose of 40 mg to 80 mg per day. If the dose is 60 mg or more, it can be divided into two administrations. After the acute symptoms are relieved, switching to oral administration of the drug is practiced. The prepared solution is good for 24 hours.

With alcohol

The components of Omez are inhibitors, and alcoholic beverages are ethanol-based catalysts. Alcohol substances participate in metabolism, releasing toxic products. When ethanol and toxic residues combine with the contents of Omez, a negative reaction occurs, as a result of which omeprazole ceases to inhibit hydrochloric acid. In simple terms, the effect of the drug is significantly reduced. In addition, CYP2C19 enzymes activate blocking metabolites, which increases the amount of toxic substances in the body, resulting in severe intoxication.

A person experiences the following symptoms:

• severe pain in the head;
• tremors in the arms and legs;
• nausea and vomiting;
• allergic reaction;
• hyperemia;
• nervous excitement;
• violation of movement coordination;
• diarrhea, constipation;
• bone pain;
• muscle aches;
• confusion.

Based on the above, we can conclude that alcohol is not compatible with Omez. If you have taken an alcohol-containing drink, then before drinking Omez, you must remove ethanol and its breakdown products from the body. This takes time: after drinking beer you need to wait from an hour to six, depending on the dose of alcohol taken. Wine is removed within 2 hours minimum, 17 hours maximum, vodka, cognac - 6-30 hours. You need to know that long-term use of the drug contributes to the accumulation of the active substance, so it is better to completely abstain from alcohol.

special instructions

It is possible to take capsules simultaneously with food, from which the medicine does not lose its effectiveness.

Before you start taking capsules or administering Omez intravenously, you should rule out malignant processes, since therapy can mask symptoms, thereby delaying diagnosis.

Sometimes there are circumstances when it is necessary to avoid swallowing a whole capsule, for which the drug is used in the following way: the capsule is opened and its contents are mixed with soft apple puree (1 tablespoon). You cannot take the contents of the capsule in any other way.

The drug is unlikely to affect the ability to drive vehicles and operate precision equipment.

Omez's analogs

Level 4 ATC code matches:
Khairabesol

Noflux

Lancid

Barol

Beret

Ontime

Gastrozol

Omeprazole

Pantoprazole

Proxium

Lansoprazole

Zulbex

Ultop

Epicurus

Pariet

Losek MAPS

Losek

Sanpraz

Emanera

Omez Insta

There are imported and Russian analogues of Omez, but it is not recommended to select a substitute yourself. Omeprazole , Demeprazole , Chrismel , Zerotsid , Omecaps , Omezol , Gastrozol , Ultop , etc. have a similar effect on the body

Nolpaza or Omez - which is better?

Nolpaza has a similar effect, reducing the level of hydrochloric acid and relieving the symptoms of gastrointestinal diseases . Nolpaz contains the active component Pantoprazole . This medicine sometimes works more quickly.

Omez or Ranitidine – which is better?

Ranitidine contains the active ingredient ranitidine hydrochloride and is used for the same conditions and diseases as Omez. Which drug is preferred depends on the doctor's prescription.

Which is better - Omez or Ultop?

Ultop contains the active ingredient omeprazole. Its action is based on inhibition of gastric juice activity. Which drug should be chosen should be asked by a specialist and the diagnosis taken into account.

Orthanol or Omez - which is better?

Orthanol is another drug whose active ingredient is omeprazole. Like Omez, this drug is prescribed for peptic ulcers, hypersecretory conditions, etc.

Which is better - Omez or Pariet?

Pariet contains the active ingredient rabeprazole sodium. However, the indications for use of this medicine are the same as those of Omez capsules.

Which is better - Omez or De Nol?

De Nol is an antiulcer agent that contains bismuth subcitrate. How to take Omez and De Nol depends on the severity and characteristics of the disease. But this should be done according to the scheme prescribed by the doctor.

Which is better - Omez or Omez D?

Many patients are interested in the difference between Omez and Omez D. The difference between these drugs is that Omez D contains not only omeprazole, but also domperidone as an active substance.

For children

A few years ago, Omez was prohibited for use by children under 12 years of age. Later, scientific research was carried out, thanks to which the drug in capsules and suspensions was allowed to be used from 2 years. Lyophilisate is prescribed from the age of 18. Feature - the child’s body weight should not be less than 20 kg.

Specifics of taking Omez:

1. Starting from 2 years of age, the drug is prescribed for GERD (gastroesophageal reflux disease). The daily dosage per 1 kg of baby's weight ranges from 0.7 to 3.3 mg. On average, 20 mg of active substance per day is allowed. It is recommended to take the drug once for 1-2 months.
2. At 4 years of age, Omez is prescribed for ulcerative lesions and the presence of Helicobacter pylori. The daily norm is 20-40 mg.
3. Omez Insta is mixed with water or natural juice.
4. It is difficult for a child to swallow the capsule, so it is opened, the granules are poured into a cup, and combined with an acidified component (juice, fruit puree).
5. It is strictly prohibited to use dairy and fermented milk products, carbonated water and drinks as liquids.

Reviews about Omez

There are numerous positive reviews about Omez. Reviews from those taking this remedy indicate that it effectively treats peptic ulcers, helps overcome attacks of heartburn , and eliminates the symptoms of acute gastritis. Reviews of Omez on the forms are also positive; people note that it can be taken at any time, and it works equally effectively. In addition, the drug improves the condition of the gastrointestinal tract during treatment with other drugs that irritate the stomach and intestines. The disadvantage is often mentioned that the product is quite expensive.

Omez price, where to buy

The price of Omez 10 mg tablets is on average 70 rubles for 10 capsules. Price Omez 20 mg – from 160 rubles per pack of 30 capsules. The price of Omez in Moscow and other Russian cities is similar.

You can buy Omez 20 mg in Ukraine (Kyiv, Kharkov, other cities) for an average of 80 UAH. (pack of 30 pcs.) Cost of 10 mg - on average 52 UAH. How much the drug costs can be found out more accurately directly at the place of sale.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Omez capsules 20 mg 30 pcs. Dr.
  Reddy's lab. RUB 167 order
• Omez caps. intestinal 40 mg 28 pcs. Dr. Reddy's lab.

  RUB 249 order

Pharmacy Dialogue

• Omeprazole (Omez)-Akrikhin (caps. intestinal 20 mg No. 30) Akrikhin JSC

  72 RUR order

• Omeprazole (Omez)-Teva (caps. 40 mg No. 28)Teva

  135 rub. order

• Omeprazole (Omez)-Akrikhin capsules 20 mg No. 30Akrikhin OJSC

  65 rub. order

• Omez capsules 20 mg No. 30Dr. Reddy's

  RUB 163 order

• Omeprazole (Omez)-OBL (caps. 20 mg No. 28) Obolenskoye pharmaceutical pred.

  83 RUR order

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Pharmacy24

• Omez 40 mg N28 capsules Dr. Reddy's Laboratories Ltd., India
  105 UAH.order
• Omez D No. 30 capsules Torrent Pharmaceuticals Ltd., India

  111 UAH order

• Omez DSR No. 30 capsules Dr. Reddy's Laboratories Ltd., India

  144 UAH order

• Omez 20 mg No. 30 capsules Dr. Reddy's Laboratories Ltd., India

  77 UAH order

• Omez 10 mg N30 capsules Dr. Reddy's Laboratories Ltd., India

  46 UAH order

PaniPharmacy

• Omez capsule Omez caps. 20mg No. 30 India, Dr. Reddy's

  80 UAH order

• Omez bottle Omez Liof. d/p r-ra d/in. 40mg fl. No.1 India, Naprod Life Sciences

  138 UAH order

• Omez capsule Omez caps. 10mg No. 30 India, Dr. Reddy's

  52 UAH order

• Omez capsule Omez caps. 40 mg No. 28 India, Dr. Reddy's

  118 UAH order

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Manufacturer

Omez is produced by Indian Pharmaceuticals. In Moscow there is a representative office of the organization at the address: Moscow, Ovchinnikovskaya embankment, 20/1, index 115035.

The drug Omez is considered safe for the gastrointestinal tract, but only in cases of increased acidity of gastric juice. Before use, you should undergo a comprehensive examination to determine the exact level of acidity. The dosage and duration of therapeutic measures depend on this.