Noopept: instructions for use, price, reviews from neurologists, analogues

Noopept is a nootropic drug intended for the treatment of patients with impaired central nervous system functions.

When taken correctly, it can activate a person’s memory and thinking, as well as improve the primary processing of information by brain cells, analysis and consolidation of data, storage and retrieval of images, thoughts, ideas.

Therefore, Noopept is used in neurological and psychiatric practice to inhibit the development of amnesia in patients with traumatic brain injuries, electric shock and other conditions (sleep disorders, concentration problems, memory problems).

Under the influence of the drug, damaged brain cells become more resilient and are destroyed much more slowly, so the degree of their degeneration decreases.

• Noopept is able to stop or significantly slow down the death of nervous tissue during ischemic pathologies in the brain, as well as remove toxic substances formed under the influence of free oxygen, i.e. the medicine has an antioxidant effect.
• In addition, the nootropic has antiplatelet, anticoagulant and fibrinolytic effects, it prevents the formation of blood clots and blockage of brain vessels.

The main effect of Noopept is associated with the production of cycloprolylglycine , a substance that is similar in composition to the natural dipeptide that protects memory processes.

The medicine also has a choline-positive effect, indirectly strengthening the cells of the central nervous system.

Taking Noopept improves the processes of associative connections between neurons, due to which memory, attention, and thinking are restored.

The drug acts in stages, in the first week of administration it has a beneficial effect on the mood and sleep of patients, and from the second week it improves cognitive functions, reducing psycho-emotional stress and anxiety in patients.

The vegetative-normalizing effect of the drug is manifested in the disappearance or minimization of headaches and dizziness, normalization of orthostatic functions and heart rate, improvement of muscle tone, the appearance of physical activity and good mood.

The big advantage of the drug is its ability not to accumulate in tissue structures.

Noopept does not cause addiction or withdrawal symptoms, it is safe for the immune and hematopoietic systems, and does not have a mutagenic effect. Therefore, Noopept is well tolerated by patients both at a young age and in the elderly and senile.

Radar

The drug was registered as a pharmacological agent in 2006, it has its own individual number - 001577.

It is a medicine that is sold without a prescription .

The instructions for Noopept were developed and approved by the manufacturer; they contain clear recommendations on how to take the drug and how long the course of treatment lasts.

Noopept has passed all the necessary clinical trials, has a certificate of conformity, is recognized and recorded as a nootropic drug.

Compound

Noopept tablets are produced in a flat-cylindrical form, they have a dividing line and are white in color.

One tablet contains 10 mg of the active substance (N-phenylacetyl-L-prolylglycine ethyl ester), as well as formative and preservative components: cellulose (21.2 mg), milk sugar (55 mg), povidone (0.0008 mg), starch (13.5 mg), magnesium stearate (0.3 mg).

Noopept

Noopept® has nootropic and neuroprotective properties. Improves learning ability and memory, acting on all phases of processing: initial information processing, consolidation, retrieval. Prevents the development of amnesia caused by electric shock, blockade of central cholinergic structures, glutamatergic receptor systems, and deprivation of the paradoxical phase of sleep.

The neuroprotective (protective) effect of the drug Noopept® is manifested in increasing the resistance of brain tissue to damaging influences (trauma, hypoxia, electroconvulsive, toxic) and reducing the degree of damage to brain neurons. The drug reduces the volume of the lesion in a thrombotic stroke model and prevents the death of neurons in cultured tissue of the cerebral cortex and cerebellum exposed to neurotoxic concentrations of glutamate and free radical oxygen.

Noopept® has an antioxidant effect, blocks voltage-dependent calcium channels of neurons, weakening the neurotoxic effect of excess calcium, improves the rheological properties of the blood, having antiplatelet, fibrinolytic, and anticoagulant properties.

The nootropic effect of the drug is associated with the formation of cycloprolylglycine, which is similar in structure to the endogenous cyclic dipeptide, which has antiamnestic activity, as well as the presence of a choline-positive effect.

Noopept® increases the amplitude of the transcallosal response, facilitating associative connections between the cerebral hemispheres at the level of cortical structures.

Promotes the restoration of memory and other cognitive functions impaired as a result of damaging influences - brain injury, local and global ischemia, prenatal damage (alcohol, hypoxia).

The therapeutic effect of the drug in patients with organic disorders of the central nervous system manifests itself starting from the 5-7th day of treatment. Initially, the anxiolytic and mild stimulating effects present in the spectrum of activity of the drug Noopept® are realized, manifested in the reduction or disappearance of anxiety, increased irritability, affective lability, and sleep disturbances. After 14-20 days of therapy, a positive effect of the drug on cognitive functions, parameters of attention and memory is revealed.

Noopept® has a vegetative-normalizing effect, helps reduce headaches, orthostatic disorders, and tachycardia. When you stop taking the drug, no withdrawal syndrome is observed.

Does not have a damaging effect on internal organs; does not lead to changes in the cellular composition of the blood and biochemical parameters of blood and urine; does not have immunotoxic, teratogenic effects, does not exhibit mutagenic properties.

Pharmacokinetics

Suction and distribution

N-phenylacetyl-L-prolylglycine ethyl ester, absorbed from the gastrointestinal tract, enters the systemic circulation unchanged. Penetrates the BBB and is detected in the brain in higher concentrations than in the blood. The average time to reach Cmax is 15 minutes.

Metabolism and excretion

T1/2 from blood plasma - 0.38 hours. Partially stored unchanged, partially metabolized with the formation of phenylacetic acid, phenylacetylproline and cycloprolylglycine. It has high relative bioavailability (99.7%), does not accumulate in the body, and does not cause drug dependence.

Mechanism of action

The product has nootropic and neuroprotective effects.

Therefore, it is advisable to use it to improve brain function, strengthen memory, mental functions, and attention.

• The drug is prescribed to prevent the occurrence of complications as a result of prolonged hypoxia, head injuries, and severe intoxication .
• Experimental studies on animals have shown relief of the lesion in a thrombotic model of stroke .

The bioavailability of Noolept is high; the maximum concentration of the drug, 99.7%, is observed in the blood and brain structures several hours after taking it.

Examples of reviews about Noopept

Reviews of doctors and patients about it help you get an idea of ​​the drug Noopept, its pros and cons.

Neurologists

Most neurologists speak positively about this remedy. They note its effectiveness, safety and almost complete absence of side effects:

Sergeev P., neurologist with 14 years of experience: “This medicine is 100% consistent with its declared effect. My colleagues and I often prescribe Noopept to patients who have developed cognitive impairment. It helps to cope very well with the consequences of traumatic brain injuries. It should be taken in a course that lasts from several weeks to several months. It is important to follow the dosage regimen."

Milova E.G., psychotherapist, candidate of medical sciences: “Noopept is an inexpensive over-the-counter drug, but its effect is more similar to placebo. In case of severe organic disorders of the brain and asthenic disorders, expect a visible effect. One of the side effects is that it often causes headaches.”

Shkolnikov I.A., neurologist: “I 100% confirm the effectiveness of Noopept in reducing intellectual productivity of any kind - many of my patients felt much better after taking it. If compared with the popular Piracetam, this drug is much more effective, undoubtedly.”

Patients taking the drug

Reviews from patients who have previously taken Noopept are also mostly positive:

Andrey, 44 years old: “My father took this medicine when he had memory problems and absent-mindedness. To improve brain activity, a doctor friend recommended Noopept. About 2 months of treatment - and the result is amazing. Now I’m also thinking about taking this medicine, because I also noticed a deterioration in my memory.”

Valentina, 38 years old: “After a head injury and concussion, I started having problems: headaches, dizziness, memory impairment, problems concentrating. My head always feels like the plague. I had to go to a neurologist. He prescribed the nootropic Noopept. I liked everything. Improvement was evident after 2 weeks of use. There are no side effects at all. The only negative is the high price. Everything else is fine."

Noopept is a popular nootropic drug that is widely used in neurological and psychiatric practice. It is used to restore cerebral circulation, saturate it with oxygen, and also to prevent complications associated with injuries, strokes or intoxications.

Indications for use

1. Dysfunctions of memory, thinking, perception, attention.
2. Rehabilitation after traumatic brain injuries.
3. Vascular diseases of the brain.
4. Atherosclerosis.
5. Encephalopathies of various origins.
6. Astheno-neurotic syndrome.
7. Conditions after coma, stroke.
8. Dysfunctions of the cognitive sphere.
9. Neurotic reactions with somatoform disorders.
10. Sleep disorders.
11. Vegetovascular dystonia.
12. Metabolic pathologies leading to changes in the nutrition of nervous tissue.

Indications and restrictions for taking the drug

Many patients cannot figure out what Noopept helps with. This drug is prescribed if there are special indications for use. As a rule, its use is advisable to improve memory, learning ability, motor skills, and eliminate an excitable personality disorder.

Such functions may be impaired due to:

• GM injuries and concussions;
• severe traumatic brain injury (often accompanied by headaches and dizziness);
• encephalopathy of various origins;
• chronic impotence syndrome (asthenia);
• senile dementia.

It is strictly forbidden to take the medicine if there are the following contraindications:

• intolerance to the active substance or auxiliary components (for example, lactose);
• lack of lactase, malabsorption of glucose-galactose;
• severe impairment of kidney or liver function.

It is also not recommended to take the drug for young children and adolescents under 18 years of age, pregnant women and women during lactation. Clinical trials have not been conducted for these categories of patients, so there is no data on the safety and effectiveness of this product for them.

See also:

Instructions for use of Cellex, analogues and reviews of the drug from doctors and patients

Instructions for use

Noopept is prescribed orally after meals.

They start drinking it 10 mg twice a day , morning and evening.

At the discretion of the doctor, according to the condition of the patients, the dose of the drug can be increased to 30 mg per day. In such cases, the medicine is taken three times a day.

As a limitation, Noopept is taken until six o'clock in the evening, this is necessary in order not to disrupt the processes of falling asleep and the depth of sleep.

The standard course of treatment with the drug is 1-3 months.

If therapy needs to be repeated, this is done no earlier than one month after the end of the first course of treatment.

Instructions for use of Noopept tablets

When using the medicine, it is recommended to adhere to the following recommendations:

1. Take the drug orally. The tablets should be swallowed whole with liquid. The best time to take is after a meal.
2. At the beginning of treatment, the patient is prescribed 20 mg of medication (2 tablets) per day. This dosage is divided into 2 doses.
3. If the result does not occur, then the dose is increased to 30 mg. In this case, take 1 tablet three times a day.
4. The last dose should be taken before 6 pm.
5. The treatment course can last from 6 to 12 weeks. It is repeated if necessary, but not earlier than after a month.

Important! If the patient takes doses higher than 20 mg/day for a long time, he should be under the supervision of the attending physician.

If any side effects occur, the need to take other medications, or a general deterioration in the patient’s condition, the patient should seek advice from a medical facility.

Side effects, possibility of overdose

The drug is well tolerated by most patients, so side effects are extremely rare. Basically, people taking Noopept developed allergic manifestations:

• redness of the skin;
• itching, burning;
• hives;
• erythema;
• dermatitis;
• rarely - anaphylactic reactions.

In patients with severe forms of hypertension, blood pressure may increase when taking the drug.

An overdose of the drug is unlikely, and no specific reactions occur. In addition, the drug:

• does not have a damaging effect on internal organs;
• does not cause developmental abnormalities during gestation;
• not able to change the biochemical parameters of urine and blood;
• not capable of toxic damage to the immune system;
• has no mutagenic effect.

Also, if you abruptly stop taking the medication, withdrawal syndrome does not develop.

How to take with other medications

Noopept is not able to interact with most medications, including antihypertensives, hypnotics and drugs that affect the central nervous system. Also, no negative effects of Noopept on the body when combined with alcohol have been established.

See also:

Instructions for use of Cipralex, its analogues and reviews from patients and doctors

Side effects

Those who took Noopept rarely experienced adverse events. They usually manifest themselves in the first days of taking the drug.

Most often these are allergic manifestations in the form of a rash, burning and itching on the skin.

Sometimes patients note a rise in blood pressure, changes in heart rate, and dizziness.

Cases of drug overdose do not have specific signs.

Reviews from neurologists

Taranenko Sergey Alexandrovich, 36 years old:

A mild nootropic drug, I use it in patients with attention and memory disorders. The effect appears gradually, after 10-14 days.

The drug is easily tolerated by patients, the price in Moscow and the regions for Noopept is reasonable and affordable, it can be purchased at any pharmacy, no prescription is needed.

Shirokov Pavel Maksimovich, 45 years old:

According to reviews from my patients and my observations, the drug is effective, helps to recover from ischemic strokes, head injuries, and decreased intellectual resources.

Korobeinikov Viktor Sergeevich, 54 years old:

My impressions of Noopept were mixed. Many patients noted improvement after it, but for others it did not help. The advantages are the price, lack of side effects, high bioavailability.

Reviews from patients who took the drug

Vostrikova Dina, 34 years old

My mother was prescribed Noopept after a stroke. She drank for three months and she felt better. In general, my mother began to sleep calmer and sleep better, and also remember information.

Good medicine at a reasonable price, we did not notice any shortcomings.

Kimber Arseniy, 34 years old

My work involves high intellectual costs. It happens that I completely fall apart - my memory deteriorates, attention drops and the results of my work are reduced to almost zero. It is Noopept that helps out; it worked best for me, as it has virtually no side effects.

A course of the drug restores the activity of the nervous system, with Noopept I can work more productively and get less tired.

Analogs

Vinpocetine

The drug facilitates blood flow through the vessels, the drug reduces inflammatory changes in them and cleanses them of toxic substances, improves trophic processes in the brain.

Available in tablet form, take 5-10 mg per day. Indications for use include trauma, encephalopathy, and neurocirculatory dystonia.

Vinpocetine has several more contraindications than Noopept.

Piracetam

A metabolic drug that has a beneficial effect on nutrition and blood supply to the central nervous system. Similar analogues of the drug are designed to improve glucose absorption and capillary tone, as well as thin the blood.

It helps well with long-term intoxication, poisoning, and electrical injuries.

Piracetam can be used in childhood, the initial dose of the drug is 30-50 mg.

Vinpotropil

A combined nootropic that can stimulate neurons.

Combines the advantages of Vinpocetine and Piracetam and is prescribed for parkinsonism, microcirculation disorders, and organic brain lesions.

Nootropil

An imported piracetam-based product that activates thought processes and memory, improving concentration and learning abilities.

The drug is prescribed for dizziness, migraine headaches, and organic changes in the structure of neural tissue.

Aminalon

Made on the basis of gamma-aminobutyric acid, it improves metabolic reactions, accelerates the absorption of nutrients, and renews blood gas exchange.

There are also cheaper analogues of Noopept, similar in action. These are Glycine and Tanakan.

Glycine

It is an amino acid that accelerates metabolism in the central nervous system.

The drug normalizes sleep, mood, and relieves psycho-emotional stress.

Tanakan

A herbal product based on Ginkgo biloba extract, it has a beneficial effect on brain function.

General information about Noopept

Noopept is a medication that is used to improve blood circulation in the brain. It is produced in Russia by several pharmaceutical companies (ZAO Lekko FF, Pharmstandard-Leksredstva-Ros, OTCPharm).

Drug group, INN, scope of use

The drug belongs to a special medicinal group - nootropics or neurometabolic stimulants. They have a specific effect on higher mental functions.

The international nonproprietary name of the drug depends on the content of the active component in it, which determines the mechanism of its action.

In this case, the INN of the drug coincides with the trade name - Noopept. The scope of application of this remedy is neurology or psychiatry. It is prescribed to patients who have problems with memory and mental activity.

Pharmacological form, cost

The medicine Noopept is presented in the form of tablets that are intended for oral administration. They are white in color and round in shape. The tablets are packaged in cellular blisters made of aluminum foil, 25 pieces each. In total, the cardboard box contains 50 tablets.

The price of a medicine depends on its manufacturer and place of purchase. The table shows examples of how much the drug costs in different pharmacies in large Russian cities:

Composition and pharmacological properties

The medicine contains the active substance noopept. It is N-phenylacetyl L-prolylglycine ethyl ester. 1 tablet contains 10 mg.

The composition also includes auxiliary components - potato starch, milk sugar, cellulose, magnesium stearate and povidone.

The pharmacodynamics of the drug is determined by the effect of its active component on the central nervous system. When taking Noopept the following effects are observed:

Nootropic. It is provided by the following processes:

• blocking central cholinergic and glutamatergic receptor systems;
• cholinergic effect;
• the formation of cycloprolylglycine, which has an identical structure to the endogenous cyclic dipeptide, which has antiamnestic activity.

At the same time, there is an improvement in memory and learning ability. Noopept also prevents the development of memory loss associated with electric shock and eliminates the paradoxical sleep phase.

1. Protective or neuroprotective. The action is based on increasing the resistance of brain tissue to external and internal damaging factors (oxygen starvation, injury, exposure to electric current, toxic substances). Another substance reduces the amount of damage and death of nerve cells due to stroke, thrombosis, preventing the negative effects of glutamate and free radicals.
2. Antioxidant. This effect is associated with a weakening of the neurotoxic effects of excess calcium (blocking calcium neuronal channels). The drug helps improve blood flow, having anticoagulant, antiaggregation and fibrinolytic properties.
3. Vegetative normalizing. It manifests itself in the following effects:

• reduction of headaches;
• preventing the development of tachycardia;
• reduction of manifestations of orthostatic disorders.

The active substance helps facilitate associative connections between the right and left hemispheres of the brain at the level of cortical structures. This leads to the restoration of memory and cognitive functions that were damaged due to stroke, traumatic brain injury, oxygen deprivation, alcohol or other poisoning.

Pharmacokinetic features of noopept:

• absorbed through the organs of the digestive system;
• enters the general bloodstream unchanged;
• penetrating the blood-brain barrier and entering the brain structures;
• the content of the substance in GM is significantly higher than in blood plasma;
• the highest concentration is observed 15 minutes after ingestion;
• has high bioavailability (more than 99%);
• the substance is partially stored unchanged in the body, partially metabolized with the release of cycloprolylglycine, phenylacetic acid and phenylacetylproline;
• half-life from blood plasma takes about 40 minutes.

This substance is not able to accumulate in the body, and also does not cause drug dependence.

The first results after using the drug are observed after 5 days. In this case, an anxiolytic and stimulating effect occurs, which is manifested by a decrease in anxiety, irritability and affective lability. Sleep also improves. After 2 or 3 weeks of therapy, a positive effect on cognition, memory and attention develops.

Similar means

Most often, drugs that belong to the same drug group are used to replace Noopept. The best nootropics:

1. Piracetam (Nootropil). This is the most commonly used remedy in neurological and psychiatric practice. It improves cerebral circulation, protects neurons from damage, including due to oxygen starvation, injury, improves cognitive functions (memory, attention, motor skills, learning ability).
2. Noben. Product based on idebenone. This medicine, in addition to being neuroprotective, has a psychoactivating and antidepressant effect.
3. Phenotropil. The drug has a neuroprotective effect, improves blood circulation and metabolic processes in the brain, and stimulates cognitive functions. It also has antianorexic and antiepileptic properties.

Medicines that have a similar mechanism of action to nootropics are also used. Particularly popular are Glycine or products containing extract of the ginkgo biloba plant (Tanakan and others).

See also:

Instructions for use of the Nootropic drug, indications, contraindications and reviews