Compound
1 tablet contains: long-leaved astercanth seeds - 19 mg, compass lettuce seeds in powder form and dry pearl parmelia thallus extract 10 mg each, male orchis tubers - 39 mg, mosaic gold (tin disulfide) and velvet itchy bean seed powder - 10 mg each mg, extract of the roots of beautiful argyrea, creeping Tribulus fruits and stems of reticulate leptadenia - 19 mg each, roots of snake rauwolfia in the form of a dry extract - 18.75 mg.
The tablet contains the following excipients: carmellose sodium, microcrystalline cellulose, crospovidone, silicon dioxide, magnesium stearate.
Description of the drug SILAMEN
The drug for the treatment of erectile dysfunction is a reversible selective inhibitor of the specific PDE5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by tadalafil results in increased cGMP levels in the corpus cavernosum of the penis. The consequence of this is relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.
In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the corpus cavernosum, in the smooth muscles of the vessels of internal organs, in skeletal muscles, platelets, kidneys, lungs, and cerebellum.
The effect of tadalafil on PDE5 is more active than on other phosphodiesterases. Tadalafil is 10,000 times more active against PDE5 than against PDE1, PDE2, PDE4, which are localized in the heart, brain, blood vessels, liver and other organs. Tadalafil is 10,000 times more potent at blocking PDE5 than PDE3, an enzyme found in the heart and blood vessels. This selectivity for PDE5 over PDE3 is important because PDE3 is an enzyme involved in cardiac muscle contraction. In addition, tadalafil is approximately 700 times more active against PDE5 than against PDE6, which is found in the retina and is responsible for phototransmission. Tadalafil is also 10,000 times more active against PDE5 compared to its effect on PDE7-PDE10.
Effective for 36 hours. The effect appears within 16 minutes after ingestion in the presence of sexual arousal.
Tadalafil in healthy individuals does not cause significant changes in systolic and diastolic blood pressure, compared with placebo, in the supine position (average maximum decrease is 1.6/0.8 mmHg, respectively) and standing (average maximum decrease is 0.2/4.6 mmHg. respectively). Tadalafil does not cause a significant change in heart rate.
Tadalafil does not cause changes in color recognition (blue/green), which is explained by its low affinity for PDE6. In addition, there was no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size.
There were no clinically significant effects on sperm characteristics in men taking tadalafil in daily doses for 6 months.
Analogs
Level 4 ATX code matches: Renel
Samprost
Lingonberry leaves
Uriflorin
Gentos
Bioprost
Bearberry leaves
Testis compositum
Birch buds
Lespefril
Prostopin
Lespeflan
Phytonephrol
Lespenefril
Canephron N
Vitaprost Forte
Vitaprost Plus
Vitaprost
Brusniver
Speman
There are many analogues with different active ingredients: Speman , Vezilut , Viagra, Vigrande , Vuka Vuka , Impaza , Cialis , Tentex Forte , Veromax , Levitra , Sealex .
Drug interactions and special instructions
If a pathology such as oligospermia is detected, doctors recommend the simultaneous use of Tentex Forte and Speman. This significantly increases the effectiveness of the treatment used.
Additional intake of vitamin E can help increase blood pressure, increase serum triglycerides, and reduce the need for insulin in insulin-dependent diabetes. Therefore, it is necessary to regularly monitor blood sugar.
Speman should be prescribed with caution if the patient has certain disorders.
Such pathologies are:
- Myocardial infarction.
- Severe cardiosclerosis.
- Increased risk of thromboembolism.
- Signs of hypervitaminosis.
If the patient takes additional vitamin E, he may experience nausea and some other dyspeptic symptoms.
Taking the drug together with alcohol has a negative effect on the body and reduces the therapeutic effectiveness of the drug.
Reviews of Speman Forte
Available reviews from doctors about the drug indicate an ambiguous attitude of official medicine towards the use of the drug. Some doctors consider it a good remedy for treating reduced potency , especially against the background of prostatitis , since when taken it improves blood circulation and reduces stagnation in the prostate. Another part of doctors prescribe medicine, but only as part of a complex treatment, as an auxiliary drug. There is also an opinion that you can do without this medicine, since there is no reliable evidence of its effectiveness.
Numerous reviews of Speman Forte from men who have experience in its use indicate that the drug is quite effective for the treatment of premature ejaculation , since it prolongs sexual intercourse.
Also, everyone points to the safety of the drug, since it is made from natural herbal raw materials.
Speman No. 100 tab.
Instructions for medical use of the drug SPEMAN™ Trade name of the drug Speman™ International nonproprietary name No Dosage form Tablets Composition 1 tablet contains active substances: Powders: mg Orchis male tubers 65 Astercanthus longifolia seeds 32 Compass lettuce seeds 16 Velvet beans itchy seeds 16 Mosaic gold (suvarnavang) 16 Extracts: Argyrea beautiful roots 32 Tribulus creeping fruits 32 Leptadenia reticulate stems 32 Parmelia pearl thalli 16 excipients: magnesium stearate, crospovidone, microcrystalline cellulose, sodium carboxymethylcellulose, colloidal silicon dioxide Pharmacotherapeutic group Genitourinary system and sex hormones. Other drugs for the treatment of urological diseases. ATC code G04BX Description Round, biconvex, uncoated tablets of light brown color interspersed with lighter and darker colors Pharmacological properties Pharmacokinetics The pharmacokinetic effect of the drug Speman is the combined effect of its components, so kinetic observations are not possible; Collectively, the components cannot be traced using markers or bioassays. Pharmacodynamics The active ingredients of the plants included in the tablets stimulate spermatogenesis, increase sperm activity, reduce viscosity, increase the volume of sperm produced, reduce congestion in the prostate gland, and reduce the severity of dysuric disorders in benign prostate enlargement. Male orchis, pearl parmelia, beautiful argyrea have a tonic effect for sexual impotence and prolong sexual intercourse. Tribulus creeping fruits, itchy velvet beans, leptadenia reticularis increase the volume and reduce the viscosity of sperm, increase testosterone levels without disturbing the hormonal balance of the body, increase the frequency, intensity and duration of erections, and increase sexual desire. Compass lettuce seeds and Tribulus terrestris fruits increase sperm activity and reduce congestion in the prostate gland. Indications for use - benign prostatic hyperplasia - chronic prostatitis (as part of complex therapy) - oligospermia - decreased sperm motility - to enhance libido and potency Method of administration and dosage Benign prostatic hyperplasia: initially 2 tablets 2-3 times a day, followed by reduction to a maintenance dose: 1 tablet 3 times a day. The course of treatment is 4-6 months. Chronic prostatitis: 2 tablets 3 times a day in combination with antibiotics Oligospermia: 2 tablets 3 times a day for 4-6 months. With simultaneous use of the drug Speman with the drug Tentex forte for oligospermia, the effectiveness of therapy increases. Side effects Allergic reactions are possible. Contraindications Hypersensitivity to individual components of the drug. Drug interactions unknown. Special instructions Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms. The drug does not affect the ability to drive vehicles and potentially dangerous machinery. Overdose No cases of overdose have been reported. Release form and packaging 100 tablets in plastic bottles with a screw cap. The neck of the bottle is additionally covered with aluminum foil with the company logo printed on it. Each bottle, along with instructions for use in the state and Russian languages, is placed in a cardboard box. Storage conditions Store in a dry place, at a temperature from 10 to 30o. Keep out of the reach of children. Shelf life: 3 years Do not use after expiration date. Order of dispensing from pharmacies Without a prescription Manufacturer Himalaya Drug Company Makali, Bangalore 562123, India www.himalayahealthcare.com
Analogues of the drug
If a patient experiences side effects or an allergic reaction during therapy, the doctor may recommend Speman analogues.
Substitutes for Speman are:
- Vitaprost is a modern medicine that contains only natural ingredients. It has a positive effect on the gland in any disease and a number of complications. The drug Vitaprost contains an active ingredient - prostate extract. Vitaprost is available in several dosage forms - in the form of tablets and rectal suppositories. The medicine can be purchased without a prescription. The medicine must be stored at a temperature not exceeding 20 degrees in a place protected from direct sunlight. The shelf life of Vitaprost is 2 years. The cost of the medicine is from 625 to 880 rubles.
- Bioprost is a drug of combined action that has a bacteriostatic, analgesic and anti-inflammatory effect on the body. The drug Bioprost is produced in the form of suppositories for rectal use, 10 pieces in a cardboard pack. You can buy Bioprost suppositories on the open market without presenting a prescription at a pharmacy. Preserving all the medicinal qualities of suppositories requires compliance with the temperature range of 2-8 °C. The cost of candles ranges from 400 to 500 rubles.
Also, drugs such as Tamsulosin, Prostatilen, Ranel, Samprost, Rowatinex, Solidago compositum S, Superlymph, Tentex forte, Testis compositum, Uroprost, Flaronin, Himcolin and some others can be used as substitutes.
Pharmacological properties of the drug Speman
Pharmacodynamics. Speman is a combined herbal preparation, the effect of which is determined by the properties of the components included in its composition. Orchis male acts as an aphrodisiac and is used for disorders characterized by sexual weakness. Astercantha longifolia - bitterness, diuretic, aphrodisiac. Wild lettuce is a remedy that has a weak sedative, diuretic and expectorant effect. Dolichos pruriens is an effective remedy for the prevention of oligospermia, acts as a tonic and helps prevent infertility in men and women. Gold mosaic acts as a rejuvenating and tonic, improves memory and appetite. It is used in the complex treatment of spermatorrhea and sexual weakness. Argyrea branchata is used as an aphrodisiac, diuretic, and a remedy for the treatment of gonorrhea and nervous system disorders. Acts as a tonic, anabolic and androgenic agent. Tribulus terrestris is a general tonic that increases the body's immunity to infectious diseases. Leptadenia reticularis has a stimulating, tonic and anti-inflammatory effect. Parmelia pearl - bitterness, mild sedative. Used to treat amenorrhea. Speman increases spermatogenesis by improving the functioning of testicular vesicles, as well as increasing the function of the epididymis. The drug increases the number of sperm and also improves the quality of the latter by increasing the number of basophilic cells that produce LH and FSH. Speman has antiseptic, anti-inflammatory, antispasmodic and diuretic effects, which is especially important in the treatment of prostate hypertrophy. Speman's action is manifested in stimulating spermatogenesis, increasing the number of sperm, improving their morphological structure, increasing sperm motility and sperm viscosity. The drug eliminates congestion in the hypertrophied prostate gland, reduces its size, promotes complete emptying of the bladder, thus reducing the number of urinations in patients, especially at night. Pharmacokinetics. The effect of the drug is the combined effect of all its components, so kinetic studies are impossible; the totality of action of the components cannot be monitored using markers or biostudies. For the same reason, the metabolites of the drug cannot be determined.
