Pharmacodynamics and pharmacokinetics
According to Wikipedia, nandrolone is an anabolic steroid with a prolonged action. The androgenic effect of the substance is weakly expressed. Nandrolone is a derivative of testosterone , the anabolic effect of which is more pronounced.
The drug stimulates erythropoiesis , the number of red blood cells in the body increases, the level of hemoglobin and hematocrit , and the rate and intensity of protein synthesis increases. It is noteworthy that the product does not contain a C17-alpha-alkyl group, which can cause disturbances in the liver and affect the development of cholestasis .
The anabolic and androgenic indices in the product are successfully combined, so the drug is often used in bodybuilding to gain muscle mass. It does not cause problems with spermatogenesis and skin rashes, and has low toxicity to the liver.
Retabolil is smoothly released from the injection site and enters the bloodstream. The half-life from the body is 6 days. metabolism in the liver. The main metabolites - 19-norandrosterone , 19-norepiandrosterone and 19-noretiocholonolone are excreted in the urine. The therapeutic effect occurs on the 3rd day after taking the first dose.
Pharmacological properties of the drug Retabolil
Nandrolone (17β-hydroxyestr-4-en-3-one decanoate) is a testosterone derivative. Unlike testosterone, it has a more pronounced androgenic effect (data obtained during studies on receptors, as well as in preclinical and clinical studies). Nandrolone stimulates human erythropoiesis, as indicated by an increase in the number of red blood cells, an increase in the level of hematocrit and hemoglobin. This effect is used therapeutically to treat anemia caused by bone marrow hypoplasia or decreased erythropoietin production as a result of chemotherapy. If the recommended doses are observed, androgenic effects (for example, virilization) are rarely observed. Nandrolone does not contain a C17 α-alkyl group, which is associated with impaired liver function and the development of cholestasis. Pharmacokinetics. Nandrolone decanoate is slowly released from the injection site and enters the bloodstream. The half-life is 6 days. The ester is quickly converted in the blood to nandrolone with a half-life of ≤1 hour. The total time of hydrolysis of nandrolone decanoate, its distribution and excretion is 4.3 hours. Nandrolone is metabolized in the liver. Nandrolone metabolites (19-norandrosterone, 19-noretiocholanolone and 19-norepiandrosterone) are detected in urine. Their pharmacological activity is unknown.
Indications for use
The drug is prescribed:
- with progressive muscular dystrophy ;
- for osteoporosis of various origins;
- to restore normal protein metabolism after burns , injuries , radiation therapy , severe infections and operations;
- with cachexia ;
- for the treatment of disseminated breast cancer in women;
- for spinal amyotrophy of Werdnig-Hoffmann ;
- with glomerulonephritis ;
- for gaining muscle mass (in bodybuilding);
- for diabetic retinopathy .
The medicine can be combined with cytostatics , glucocorticosteroids , tuberculostatics .
Contraindications
Retabolil is contraindicated:
- during pregnancy and during breastfeeding ;
- children under 18 years of age;
- for carcinoma of the prostate and mammary glands in men;
- after the occurrence of nephrotic syndrome after prolonged therapy with anabolic steroids ;
- for metastases in cancer patients ;
- if the patient is allergic to the components of the product;
- with porphyria ;
- for severe liver diseases.
The medicine is prescribed with caution for cardiac disorders, epilepsy , liver and kidney diseases, diabetes mellitus , high blood pressure , migraine and glaucoma .
Retabolil 50 mg/ml No. 1 solution for intravenous oil.
Instructions for medical use of the drug RETABOLIL Trade name Retabolil International nonproprietary name Nandrolone Dosage form oil solution for injection Composition One 1 ml ampoule contains the active substance - nandrolone decanoate 50 mg excipients: benzyl alcohol, isopropyl alcohol, sunflower oil for injection Description Yellow transparent oil particle-free solution. Pharmacotherapeutic group Anabolic steroid drugs - esters ATC code A14AB01 Pharmacological properties Pharmacokinetics Nandrolone decanoate is slowly released from the injection site and enters the blood. The half-life is 6 days. The ester is quickly converted in the blood to nandrolone with a half-life of ≤ 1 hour. The total time for hydrolysis of nandrolone decanoate, distribution and excretion of nandrolone is 4.3 hours. Nandrolone is metabolized in the liver. Nandrolone metabolites - 19-norandrosterone, 19-noretiocholanolone and 19-norepiandrosterone, are determined in the urine. Their pharmacological activity is unknown. Pharmacodynamics Retabolil is a synthetic derivative of testosterone. Unlike testosterone, it has a more pronounced anabolic and less pronounced androgenic effect. Promotes the synthesis of nucleic acids, proteins, causes retention of nitrogen, calcium, sodium, potassium, chloride and phosphate. Activates reparative processes in epithelium, bone and muscle tissues. Retabolil stimulates the production of erythropoietin and stimulates erythropoiesis, provides protection of the bone marrow from the inhibitory effects of cytotoxic agents, which, with the simultaneous use of iron supplements, manifests itself as an antianemic effect. When recommended doses are followed, androgenic effects (eg, virilization) are rare. Indications for use - convalescence after severe injuries, intoxication, infectious diseases, extensive surgical interventions - anemia as a result of chronic renal failure (as part of complex therapy) Method of administration and dosage Anemia: weekly, intramuscularly - women 100 mg - men 200 mg. The therapeutic effect is individual. Treatment should be discontinued if there is no therapeutic effect after 3-6 months. applications. After a corresponding improvement in the blood picture or its normalization, the dose should be gradually reduced under regular monitoring of hematological parameters. Deterioration in performance during dose reduction or after completion of treatment may be an indication for resumption of treatment. Convalescence: 50 mg every 3-4 weeks, intramuscularly, deep into the muscle. Side effects - burning sensation in the tongue, heartburn, loss of appetite, nausea, vomiting - cholestasis, jaundice - suppression of gonadotropin secretion - peripheral edema - increased vascularization of the skin - hypercalcemia - virilization in women (acne, hirsutism, male pattern baldness, irreversible decrease in tone voices, menstrual irregularities, clitoral hypertrophy) - in men - suppression of testicular function, oligospermia, gynecomastia - hypocoagulation with a tendency to bleeding - slowing or cessation of growth - hypertrophy and/or prostate carcinoma Contraindications - children and adolescents under 18 years of age - pregnancy , lactation period - prostate hypertrophy or carcinoma - breast carcinoma in men - hypersensitivity to any of the components of the drug - edema syndrome Drug interactions When prescribed simultaneously with antidiabetic drugs, indirect anticoagulants - coumarin derivatives, antiplatelet agents, caution should be exercised due to the possible enhancing the effect of these drugs. When used simultaneously with glucocorticoids, mineralocorticoids, corticotropin, sodium-containing saline solutions; Food rich in sodium increases fluid retention in the body. Special instructions Do not exceed recommended doses. When prescribing the drug, women should weigh the benefits and harms of treatment due to the androgenic effect of the drug. The drug is prescribed with caution for myocardial dysfunction, hypertension, impaired liver and kidney function, epilepsy, migraine and glaucoma (including a history of it). During treatment, it is recommended to monitor intraocular pressure due to possible retention of sodium and water in the body. Changes in liver function (for example, bromsulfthalein levels) are possible, so after a 4-week course of treatment it is recommended to monitor its function. Before starting treatment and further, during it, a rectal examination of the prostate should be performed regularly. In case of diabetes mellitus, the dosage of antidiabetic drugs should be reconsidered. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms. The effect of the drug on the abilities necessary to drive vehicles and working machines has not been studied. Overdose Symptoms: severe endocrine, metabolic and mental adverse reactions develop. Treatment: symptomatic. Release form and packaging 1 ml of oil solution for injection in a colorless glass ampoule. 1 ampoule in plastic form, in a cardboard box with attached instructions for use. Storage conditions Store at temperatures from +15 °C to +25 °C, protected from light. Keep out of the reach of children! Shelf life: 5 years. Do not use the drug after the expiration date. Conditions for dispensing from pharmacies By prescription 1103 Budapest, st. Gemrei 19-21, Hungary
Side effects
If the drug is taken as recommended in recommended therapeutic doses, adverse reactions are rare.
With long-term use, the following may occur:
- hypersensitivity reactions ;
- nausea, burning sensation on the tongue, vomiting;
- disturbances in the functioning of the ovaries (hypo- or hyperfunction);
- acne , skin rashes ;
- jaundice , liver disease;
- water, sodium, nitrogen retention and edema ;
- decreased level of gonadotropin .
With insufficient physical activity and in women with breast cancer, hypercalcemia .
Also, in women, the timbre of the voice may decrease, the menstrual cycle , the clitoris will become enlarged, hirsutism , and hair will begin to fall out.
Men sometimes develop oligospermia , the penis and frequency of erections , and the mammary glands become inflamed.
Side effects of the drug Retabolil
in male and female patients: heartburn, loss of appetite, vomiting, burning sensation of the tongue, suppression of gonadotropin secretion, cholestasis, jaundice; retention of nitrogen, sodium and water in the body; swelling, increased vascularization of the skin, hypercalcemia (especially in patients on bed rest and women with metastatic breast cancer). In women: symptoms of virilization (acne, hirsutism, male pattern baldness, irreversible decrease in voice tone, menstrual irregularities, clitoral hypertrophy). In men: suppression of testicular function, oligospermia, gynecomastia.
Instructions for use of Retabolil (Method and dosage)
The drug is prescribed to both inpatient and outpatient patients.
The medicine is administered intramuscularly, deeply.
The dosage is determined by the attending physician, depending on the disease. As a rule, adults are prescribed 25 to 50 mg of the drug once a month. The dosage for children (in case of urgent need, if the drug was prescribed by a doctor) is calculated at 400 mcg per kg of the child’s weight, the frequency of administration is the same as for adults.
Instructions for Retabolil for anemia
Men are prescribed 200 mg once a week, women – 100 mg once every 7 days. If six months have passed since the start of treatment with the drug, and there has been no improvement, the drug should be discontinued.
For severe renal failure , take 50 mg every week.
Patients with oncology are prescribed 50 mg, once every 5 days.
Use of the drug Retabolil
Anemia. Adults: intramuscularly, men 200 mg once a week, women 100 mg once a week. The therapeutic effect is individual. Treatment should be discontinued if there is no therapeutic effect after 3-6 months of use. After a corresponding improvement in the blood picture or its normalization, the dose should be gradually reduced, regularly monitoring hematological parameters. Deterioration in performance during dose reduction or after completion of treatment may be an indication for resumption of treatment. The period of convalescence. Adults: 50 mg every 3-4 weeks, IM deep into the muscle.
special instructions
It is forbidden to exceed the recommended dosage.
If the drug is prescribed to women, then it is necessary to carefully evaluate the balance of benefit and harm from the drug, due to its androgenic effect on the body.
For diabetes mellitus, it is necessary to adjust the dosage of insulin and other medications.
If the patient has a malignant neoplasm , then the dosage of the drug must be adjusted, taking into account the results of renal tests and the patient's condition.
While taking the drug, it is necessary to monitor blood counts and intraocular pressure .
Persons under 18 years of age may develop hypercalcemia and hypercalciuria .
Retabolil price
The price of Retabolil in pharmacies is about 250 rubles per ampoule.
Where to buy Retabolil in Moscow?
It can sometimes be difficult to purchase a drug in pharmacies, especially if there is no prescription for it. However, the medicine has a sufficient number of synonyms and analogues containing the same active substance. If you couldn’t buy the product without a prescription at the pharmacy, you can purchase it in the online store. Beware of fakes.
- Online pharmacies in KazakhstanKazakhstan
