Mode of application
Enisamium iodide tablets are swallowed without chewing 2 hours before meals.
The maximum single dose is 1000 mg (1 g), the maximum daily dose is 2000 mg (2 g).
Treatment. For adults, enisamium iodide is prescribed at a dose of 500 mg (0.5 g) 3 times or 1000 mg (1 g) 2 times a day.
For children over 12 years of age, enisamium iodide is prescribed at a dose of 500 mg (0.5 g) 3 times a day.
Children aged 6 to 12 years are prescribed 125 mg (0.125 g) 2-3 times a day.
The duration of treatment is 7 days.
Prevention. Adults and children over 16 years old - 250 mg (0.25 g) for 3-5 days, then - 250 mg (0.25 g) once every 2-3 days for 2-3 weeks for children 6 -12 years - 125 mg (0.125 g) every other day for 2-3 weeks; children aged 12 to 16 years - 250 mg (0.25 g) every other day for 2-3 weeks.
Amizon tablets p/o 0.25g No. 20x1
Name
Amizon tablet p/o 0.25g in blister pack No. 20x1
Description
Tablets are round, biconvex, yellow or yellow-green in color, coated with a transparent film coating. Minor inclusions are allowed on the surface of core tablets
Main active ingredient
amizon
Release form
pills
Dosage
1 tablet contains amizon® (enisamium iodide) 125 mg (0.125 g) or 250 mg (0.25 g);
Pharmacodynamics
Amizon® is an isonicotinic acid derivative with antiviral activity. In animal experiments, it suppresses the effect of influenza viruses and other pathogens of acute respiratory viral infections due to a direct inhibitory effect on the process of penetration of viruses through the cell membrane. It has interferonogenic properties, helps to increase the concentration of endogenous interferon (interferon alpha and interferon gamma) in the blood plasma. Increases the body's resistance to viral infections. Reduces acute clinical manifestations of viral intoxication and helps reduce the duration of the disease.
Pharmacokinetics
After oral administration, Amizon® quickly enters the bloodstream, its maximum concentration in the blood is observed 2-2.5 hours after administration. The half-life is 13.5-14 hours, metabolized in the liver, but quickly eliminated from tissues (half-life is 2-3 hours). 90-95% is excreted from the body in the form of metabolites.
Indications for use
Treatment and prevention of diseases: influenza and other acute respiratory viral infections in adults and children over 6 years of age.
Directions for use and doses
Amizon® should be taken orally after meals without chewing. The maximum single dose is 1000 mg, daily dose is 2000 mg. The recommended course of treatment, depending on the severity and etiology of the disease, is from 5 to 30 days. Influenza and other respiratory viral infections Treatment. Adults and children over 12 years of age are prescribed 250-500 mg 2-4 times a day for 5-7 days; Children from 6 to 12 years old are prescribed 125 mg 2-3 times a day for 5-7 days. Prevention. Adults and children over 16 years old - 250 mg per day for 3-5 days, then - 250 mg once every 2-3 days for 2-3 weeks; children 6-12 years old - 125 mg every other day for 2-3 weeks; children from 12 to 16 years old - 250 mg every other day for 2-3 weeks.
Use during pregnancy and lactation
The drug is contraindicated for use in the first trimester of pregnancy. Use in the second and third trimester of pregnancy is possible only as prescribed by a doctor. There are no data regarding use in breastfeeding women.
Precautionary measures
The drug should be prescribed with caution to patients with thyroid diseases, especially hyperthyroidism. The drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug. Use during pregnancy or breastfeeding. The drug is contraindicated for use in the first trimester of pregnancy. Use in the second and third trimester of pregnancy is possible only as prescribed by a doctor. There are no data regarding use in breastfeeding women. Children. The drug in this dosage form is not used to treat children under 6 years of age. The ability to influence reaction speed when driving a vehicle or operating other mechanisms. Taking Amizon® does not affect the ability to drive vehicles or operate other mechanisms.
Interaction with other drugs
Amizon® enhances the effect of antibacterial and immunomodulatory agents. It is advisable to combine this drug with ascorbic acid and other vitamins. Amizon® can also be prescribed simultaneously with the use of recombinant interferon.
Contraindications
– Hypersensitivity to any of the components of the drug; – Lactase deficiency, lactose intolerance, glucose-galactose malabsorption; – Pregnancy; – Lactation period; – Severe organic damage to the liver and kidneys. – Children's age (up to 6 years).
Compound
active ingredient: amizon® (enisamium iodide); 1 tablet contains amizon® (enisamium iodide) 125 mg (0.125 g) or 250 mg (0.25 g); excipients: lactose monohydrate, microcrystalline cellulose, povidone, croscarmellose sodium, calcium stearate; shell: OPADRY II Clear 85F19250 (polyvinyl alcohol, talc, polyethylene glycol, polysorbate 80).
Overdose
No cases of overdose with Amizon® have been reported. In case of overdose, it is possible to increase the manifestations of adverse reactions: brown staining of the mucous membranes, vomiting, abdominal pain and diarrhea. The development of edema, erythema, acne-like and bullous rashes, and fever may occur. Treatment: gastric lavage, symptomatic treatment.
Side effect
Allergic reactions: hypersensitivity reactions, including skin rashes, urticaria, angioedema, itching. From the digestive system: dryness and bitter taste in the mouth, swelling of the oral mucosa, hypersalivation, yellow tongue, nausea, vomiting, heartburn, abdominal pain, heaviness in the right hypochondrium, diarrhea, bloating. From the respiratory system: shortness of breath, throat irritation. In the post-registration period, the following adverse reactions were observed in isolated cases: headache, dizziness, weakness, fluctuations in blood pressure.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C. Keep out of the reach of children.
Features of application
Taking enisamium iodide leads to an increase in plasma iodide levels. A secondary increase in the level of circulating iodide triggers a mechanism of self-regulation of thyroid function, in which the uptake of inorganic iodide into thyrocytes is suppressed, which helps prevent excess formation of thyroid hormones; at the same time, the level of thyroid-stimulating hormone increases transiently (Wolff-Chaikov phenomenon). This effect lasts for several days; after cessation of treatment, thyroid function returns to normal. In some cases, a transient increase in thyroid-stimulating hormone was observed over several weeks.
Pregnant
The use of the drug during pregnancy is contraindicated, since clinical studies of enisamium iodide in pregnant women have not been conducted.
Children
The drug in this dosage form should not be used in children under 6 years of age.
Drivers
Taking Amizon® does not affect the ability to drive vehicles or operate machinery.
Amizon Kids syrup 10 mg/ml bottle 100 ml No. 1
Name
Amizon Kids syrup 10 mg/ml in bottle. 100ml per pack. No. 1
Description
Transparent, slightly yellowish-greenish liquid with a specific odor.
Main active ingredient
amizon
Release form
syrup
Dosage
1 ml of syrup contains amizon® (enisamium iodide) 10 mg
Pharmacodynamics
Enisamium iodide is a derivative of isonicotinic acid. It has an inhibitory effect on influenza viruses, exhibits interferonogenic properties, increases the body's resistance to viral infections, and has anti-inflammatory, antipyretic and analgesic effects. The antiviral effect of Amizon® Kids is associated with its direct effect on the hemagglutinins of the influenza virus, as a result of which the virion loses the ability to attach to target cells for further replication. The anti-inflammatory effect is the result of stabilizing cellular and lysosomal membranes, slowing down basophil degranulation, antioxidant action, normalizing the level of prostaglandins, cyclic nucleotides and energy metabolism at the site of inflammation. The antipyretic properties of this remedy are due to its effect on the thermoregulatory centers of the brain. Enisamium iodide enhances persistent immunity by increasing the level of endogenous interferon in the blood plasma by 3-4 times, lysozyme and increasing the titer of antibodies to infectious agents, as well as cellular immunity by stimulating the functional activity of T-lymphocytes and macrophages. This drug is a powerful inducer of endogenous interferon.
Pharmacokinetics
After oral administration, enisamium iodide quickly enters the blood; its maximum concentration in the blood is observed 2-2.5 hours after administration. The half-life is 13.5-14 hours. The drug is metabolized in the liver, but is quickly eliminated from tissues (half-life is 2-3 hours). 90-95% is excreted from the body in the form of metabolites.
Indications for use
Treatment of influenza and ARVI.
Directions for use and doses
The drug is recommended for the treatment of children over 3 years of age. The syrup is taken orally, preferably after meals, with a small amount of water. Children from 3 to 4 years old - 5 ml (50 mg) 3 times a day. Children from 4 to 5 years old - 6 ml (60 mg) 3 times a day. Children from 5 to 6 years old - 7 ml (70 mg) 3 times a day. For children aged 6 to 12 years, the drug is prescribed in tablet form. If the child cannot swallow tablets, the drug is taken 12 ml (120 mg) 2-3 times a day. Do not exceed recommended doses. To dispense the syrup, a syringe dispenser with a volume of 5 ml with a division value of 1 ml is included. If you need to measure a dose of more than 5 ml, measure out the first 5 ml of syrup first, and then the rest of the dose. The course of treatment is 5-7 days, depending on the severity of the disease and the therapeutic effect.
Use during pregnancy and lactation
The drug is not intended for use in these categories of patients. Children. The drug is used to treat children over 3 years of age. The ability to influence reaction speed when driving a vehicle or operating other mechanisms. The drug is not intended for use in this category of patients.
Precautionary measures
The drug should be prescribed with caution to patients with thyroid diseases, especially with hyperthyroidism. The syrup contains sorbitol, so patients with rare hereditary fructose intolerance should not take this drug. Sorbitol may also have a slight laxative effect.
Interaction with other drugs
Amizon® Kids enhances the effect of antibacterial and immunomodulatory agents. It is advisable to combine this drug with ascorbic acid and other vitamins. Amizon® Kids can also be prescribed simultaneously with recombinant interferon preparations.
Contraindications
– Hypersensitivity to the components of the drug and iodine preparations. – The presence of allergic reactions, regardless of the nature of the allergen in the anamnesis. – Severe organic damage to the liver and kidneys.
Compound
active ingredient: amizon® (enisamium iodide); 1 ml of syrup contains amizon® (enisamium iodide) 10 mg; excipients: sodium hydrogen phosphate, dodecahydrate; citric acid, monohydrate; flavoring "Tutti-Frutti"; “Peach” flavor; purified water; sorbitol solution, non-crystallizing (E 420).
Overdose
In case of overdose, it is possible to increase the manifestations of adverse reactions: brown staining of the mucous membranes, vomiting, abdominal pain and diarrhea. The development of edema, erythema, acne-like and bullous rashes, and fever is possible. Treatment: gastric lavage, symptomatic treatment.
Side effect
Allergic reactions: hypersensitivity reactions, including skin rashes, urticaria, angioedema, itching. From the digestive system: dryness and bitterness in the mouth, swelling of the oral mucosa, hypersalivation, yellow tongue, nausea, vomiting, heartburn, abdominal pain, heaviness in the right hypochondrium, diarrhea, bloating. From the respiratory system: shortness of breath, burning sensation in the throat. Others: headache, dizziness, weakness, fluctuations in blood pressure.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °. Keep out of the reach of children.
Note!
Description of the drug Amizon table. p/o 0.25g No. 20 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
