Pharmacodynamics
Choline salicylate has analgesic, anti-inflammatory and antipyretic effects. It inhibits the activity of cyclooxygenase, the functions of macrophages and neutrophils, the production of interleukin-1 and inhibits the synthesis of PG. It also has antimicrobial and antifungal effects (in acidic and alkaline environments).
The analgesic effect appears within 2–3 minutes and lasts 2–8 hours.
Cetalkonium chloride has an antiseptic effect on bacteria, fungi and viruses.
Cholisal does not contain sugar, does not have a local irritating effect and is well tolerated by patients.
Pharmacology and pharmacodynamics
The medication has an antimicrobial effect and also has anti-inflammatory and analgesic effects.
The active ingredient choline salicylate relieves pain and inflammation at the site of application of the gel. The analgesic effect lasts for an average of 4-7 hours.
The second active element has a powerful antiseptic effect. Effectively copes with harmful bacteria.
The structure of the ointment promotes its rapid absorption into tissues, reaches the nerve endings in a short time and remains on the oral mucosa for a long time. Almost does not enter the blood.
Indications for the drug Cholisal®
Infectious-inflammatory, ulcerative-necrotic, trophic diseases of the oral mucosa: stomatitis of various etiologies, gingivitis, periodontitis, damage to the mucous membrane when wearing dentures, trauma to the oral mucosa, pain during teething in children, glandular cheilitis, thrush, small surgical interventions, lichen planus, exudative erythema multiforme (including Stevens-Johnson syndrome) - as part of complex therapy.
Adverse reactions and overdose
In some cases, after direct contact of the oral mucosa and the ointment, undesirable reactions may occur in the form of a burning sensation and tingling sensation. Such reactions are normal and disappear on their own after a few minutes. In rare cases, allergies may occur.
If serious side effects occur, you should stop using the gel and tell your doctor.
There are no cases of drug overdose. The ointment should not be swallowed; it is intended for external use only. If part of the medicine gets inside, then you need to rinse the stomach and, if necessary, begin symptomatic treatment.
Special instructions for the use of the drug Cholisal
The drug is used only locally. No study has been conducted regarding the duration and extent of absorption of choline salicylate after topical application of the gel to the mucous membranes of the oral cavity. During pregnancy, use with caution, taking into account the risks/benefits. Salicylic acid derivatives are contraindicated in the third trimester of pregnancy. The substances pass into breast milk, so it is not recommended to use them during breastfeeding. Cholisal does not affect the ability to drive vehicles or operate complex machinery.
Cholisal 10 g dental gel
Instructions for medical use of the drug CHOLISAL® Trade name Cholisal® International nonproprietary name No Dosage form Dental gel Composition 1 g of gel contains active substances: choline salicylate 87.10 mg, cetalkonium chloride 0.10 mg, excipients: hydroxyethylcellulose, methyl parahydroxybenzoate, propyl parahydroxybenzoate, glycerol, oil anise, ethyl alcohol 96%, purified water to 1.0 g. Description Transparent, colorless, homogeneous mass with the smell of anise oil. Pharmacotherapeutic group Antimicrobial drugs for local treatment of oral diseases. Other. ATX code A01AB11 Pharmacological properties Pharmacokinetics Choline salicylate is rapidly absorbed from the mucous membranes (approximately 2 times faster than acetylsalicylic acid). Salicylates easily penetrate most tissues and body fluids. They exhibit high affinity for blood proteins and tissues, binding to blood plasma albumin in the range from 50 to 80%. The half-life of salicylates ranges from 2 to 4 hours. The biotransformation of salicylates to salicylic acid occurs in organs and tissues, mainly the liver, with the formation of salicylic acid, glucuronides, acetal, and gentisic acid. The resulting biotransformation products are excreted in the urine (75% is salicylic uric acid). About 10% of salicylates are excreted unchanged in the urine. Elimination is slow: about 50% of the dose is eliminated within 24 hours. Pharmacodynamics The drug uses the synergistic effect of the components: anti-inflammatory, analgesic and local disinfectant. The main active ingredient in the drug, choline salicylate, has a local anti-inflammatory and mild analgesic effect. The mechanism of the analgesic, antipyretic and anti-inflammatory action of salicylates is associated with inhibition of the activity of prostaglandin cyclooxygenase, as well as the activity of thromboxane synthetase. As a result of this action, the synthesis of prostanoids, primarily E and F, in inflammatory tissues, in the wall of the gastrointestinal tract and in the kidneys is inhibited. Applied topically, in normal doses the drug does not exhibit a general effect. Cetalkonium chloride is an antiseptic acting on bacteria, fungi, and viruses. The bacteriostatics included in the gel base, methylhydroxybenzoate and propylhydroxybenzoate, exhibit a disinfectant effect in concentrations of 0.15% and 0.08%, respectively. The analgesic effect is observed after 2-3 minutes, the duration of action is 2-8 hours. Indications for use - inflammatory processes of the oral mucosa - erosive and ulcerative lesions of the oral mucosa - gingivitis - periodontitis Method of administration and dosage A small amount of gel is squeezed onto a clean finger and rubbed with light massaging movements onto the affected area of the oral mucosa. Use 2-3 times a day before meals and before bed. For periodontal diseases, the gel is injected into the pockets or applied in the form of compresses, or rubbed gently into the gums 1-2 times a day. The course of treatment is determined by the doctor. Side effects A brief, transient burning sensation and allergic reactions may occur at the site of application. Contraindications - hypersensitivity to salicylates and other components of the drug - third trimester of pregnancy, lactation period - children under 3 years of age Drug interactions When using the drug topically in accordance with the recommended dosage, there is no risk of interaction with other drugs. Only in case of a significant overdose and the development of symptoms of systemic action of choline salicylate, it should be taken into account that it acts synergistically with other anti-inflammatory, antipyretic and analgesic drugs. Special instructions No studies have been conducted to determine the duration and degree of absorption of choline salicylate into the body after topical application of the gel to the mucous membranes of the oral cavity. Pregnancy In the first and second trimesters of pregnancy, Cholisal® is used only in cases where the expected therapeutic effect for the mother exceeds the potential risk for the fetus. Effect on the ability to drive vehicles and maintain moving mechanisms No effect Overdose Theoretically, an overdose of the drug is impossible. Symptoms: increased sweating, tinnitus, nausea, vomiting, dizziness, skin manifestations (erythema or urticaria). These symptoms may appear in case of hypersensitivity to salicylates, after an overdose of the gel and the absorption of significant quantities of choline salicylate into the body. Treatment: the patient should rinse the mouth with plenty of water and, if necessary, induce vomiting. Release form and packaging 10 g or 15 g of the drug are placed in lithographed aluminum tubes, varnished inside. One tube, along with instructions for medical use in the state and Russian languages, is placed in a cardboard pack. Storage conditions Store at a temperature not exceeding 25 oC. Do not freeze! Keep out of the reach of children! Shelf life: 3 years Shelf life after first opening: 2 weeks. Do not use after the expiration date. Conditions for dispensing from pharmacies Without a prescription Manufacturer Jelfa Pharmaceutical Plant A.O. 58-500, Jelenia Gora, st. V.Polya, 21, Poland. Owner of the registration certificate OOO "Valeant", Russia Address of the organization that accepts claims from consumers regarding product quality in the territory of the Republic of Kazakhstan Representative office of OOO "Valeant" in the Republic of Kazakhstan Kazakhstan, 050059, Almaty, Al-Farabi Avenue, 17, Business - Block 4B, office 1104 Phone +7 727 3 111 516 Fax +7 727 3 111 517 Email
Use of the drug Cholisal
Cholisal is used topically 2-3 times a day (for pain relief) or after meals and before bedtime. A column of gel 1 cm long for adults and 0.5 cm for children is carefully rubbed into the affected area of the mucous membrane for several minutes. When treating periodontal diseases, the gel should be placed in the gum pockets 1–2 times a day, and also applied in the form of compresses or gently rubbed into the gums 1–2 times a day. The duration of treatment is determined depending on the clinical situation. For 30 minutes after using the gel, do not rinse your mouth with water or eat food.
Pharmacological properties of the drug Cholisal
The drug uses the synergistic effect of components: anti-inflammatory, analgesic and antiseptic. The main active ingredient of the drug, choline salicylate, has a local anti-inflammatory and mild analgesic effect. The mechanism of the analgesic, antipyretic and anti-inflammatory action of salicylates is associated with inhibition of COX activity, as well as thromboxane synthetase activity. As a result, the synthesis of prostaglandins is inhibited, primarily prostaglandins E and F in tissues altered by inflammation, in the wall of the gastrointestinal tract and kidneys. Applied topically, in normal doses it does not have a systemic effect. Cetalkonium chloride enhances the analgesic and anti-inflammatory effects. The antiseptics included in the gel base, methyl parahydroxybenzoate and propyl parahydroxybenzoate (in concentrations of 0.15 and 0.08%, respectively), have an antibacterial effect. Choline salicylate quickly penetrates the mucous membranes (approximately 2 times faster than acetylsalicylic acid). Salicylates easily penetrate most tissues and body fluids. They have a high affinity for blood proteins and tissues, binding (50–80%) to blood plasma albumins. The half-life of salicylates is 2–4 hours. The biotransformation of salicylates occurs in tissues, mainly in the liver to salicylic acid, from which salicylamic acid, glucuronides, acetal, and gentisic acid are formed. Biotransformation products are excreted in the urine (75% is salicylic uric acid). Approximately 10% of salicylates are excreted unchanged in the urine. Excretion occurs slowly, approximately 50% of the dose is eliminated within 24 hours.
Reviews about Cholisal
Most reviews about the use of the drug by adults and children are positive. The gel is able to quickly and effectively eliminate pain and inflammation and cools the affected area. If you use the medicine at night, the effect will last almost until the morning. Also has an antipyretic effect. For many, the advantage is that the composition does not contain lidocaine, to which many have adverse reactions and allergies.
There are many rave reviews from patients who had stomatitis. Within 3-5 minutes after application, you can notice a significant improvement in the condition, pain disappears, and after 15-20 minutes the inflammation is relieved. If you apply compresses before bed, then after a couple of days the signs of stomatitis will almost completely disappear.
The gel is sold in pharmacies. It can be bought without a doctor's prescription.
