Oftalmoferon, eye drops, is a highly active antiviral and antiallergic drug for the treatment of viral conjunctivitis (including conjunctivitis caused by herpes viruses, adenoviruses).
Inflammatory eye diseases occupy a leading place among eye diseases (up to 50% of all those who consult ophthalmologists). In clinical practice, for local therapy of diseases such as viral (adenoviral and herpetic) conjunctivitis, keratitis, keratoconjunctivitis, uveitis, human interferon preparations obtained from blood leukocytes have been used with high efficiency.
Currently, interferon preparations of genetically engineered origin are being widely introduced into healthcare practice as the most purified (purification degree up to 99%), guaranteed safe from the point of view of viral contamination and allowing the use of higher concentrations of interferon.
The dosage form in the form of ready-made eye drops based on genetically engineered interferon was developed for the first time in the world by ZAO FIRN M under the leadership of Professor P. Ya. Gaponyuk.
The drug intended for the treatment of eye diseases of viral etiology is called Ophthalmoferon.
pharmachologic effect
Experimental medical, biological and clinical studies were carried out at the Moscow Research Institute of Eye Diseases named after. Helmholtz. In addition to interferon (10,000 IU/ml), Ophthalmoferon contains boric acid with diphenhydramine, which enhances the antiseptic, anti-inflammatory, antiallergic and analgesic effect of the drug.
Compound
1 ml of Oftalmoferon eye drops contains 10,000 IU of human recombinant interferon alpha-2b , as well as an additional active compound – 1 mg of diphenhydramine hydrochloride ( diphenhydramine ).
Auxiliary are: 3.1 mg of boric acid, 0.4 mg of disodium edetate, 2.2 mg of sodium chloride, 7 mg of sodium acetate, 3 mg of hypromellose, 5 mg of povidone 8000, 50 mg of macrogol 4000 and approximately 1 ml of purified water.
Analogs
Oftalmoferon eye drops have several analogues. They have a similar effect, but may differ in composition and degree of effectiveness:
- Albucid. The drug is especially effective in the treatment of bacterial conjunctivitis. The constituent elements penetrate deep into the eye and prevent the appearance and spread of harmful microorganisms.
- Alfarona. The medicine has an immunomodulatory and antiviral effect. Harmful pathogens develop immunity over time, so using the drug for long-term treatment is not recommended.
- Aktipol. Antiviral medicine. Takes an active part in restoring the damaged membrane of the eyeball. Drops relieve swelling and heal wounds that appear as a result of exposure to microbes.
- Poludan. The speed of penetration into the tissues and membrane of the eye is comparable to Oftalmoferon. The main component is polyriboadenylic acid.
Pharmacodynamics and pharmacokinetics
Ophthalmoferon is a combined drug containing an antiviral immunomodulatory antiproliferative substance - human recombinant interferon α-2b , which is supplemented with an active antihistamine - diphenhydramine .
Diphenhydramine acts by blocking H1-histamine receptors, which has an antiallergic effect, reducing swelling and itching in the human conjunctiva.
Pharmacokinetic properties
If you follow the instructions and apply eye drops topically, then systemic absorption does not occur - the concentration of the active substances of the drug in the blood is achieved significantly less than the standard detection limit (for example, for interferon α-2b - approximately 1-2 IU in 1 ml), which does not allows you to identify clinically significant reactions.
Pharmacology
Oftalmoferon is a drug of combined action. The composition contains immunomodulatory interferon. Its effects are increased by the presence of diphenhydramine. With the simultaneous influence of these two components, allergic processes manifested in the form of swelling and redness of the conjunctival membrane begin to gradually disappear.
These drops are intended for local use. They are absorbed into the blood in minimal quantities; their presence is even difficult to detect. The active substances cannot cause serious medical consequences.
Indications for use
- conjunctivitis of various types, including adenoviral , hemorrhagic ( enteroviral ), herpetic ;
- keratitis - adenoviral , herpetic (card-shaped, vesicular, dotted or tree-like);
- herpetic keratitis with stroma, which may be accompanied by corneal ulceration;
- or herpetic keratoconjunctivitis ;
- herpetic uveitis or keratouveitis (ulceration is possible);
- with dry keratoconjunctivitis (dry eye syndrome);
- prophylactic for graft disease , to prevent relapses of herpetic keratitis after keratoplasty ;
- prevention or treatment of complications after excimer laser refractive surgery on the cornea.
special instructions
Oftalmoferon is mainly used in combination with other medications to treat viral diseases.
For conjunctivitis of a viral nature, antibacterial drops or combined agents are prescribed together with it.
For allergic conjunctivitis - glucocorticoids and combination drugs.
After surgical interventions, they complement the effect of anti-inflammatory eye drops.
For corneal ulcerations, drugs that have a regenerating or healing effect (Korneregel, Solcoseryl) are additionally prescribed.
Oftalmoferon eye drops, instructions for use (Method and dosage)
The drug is used conjunctivally until symptoms disappear completely for various eye lesions or for prevention.
For viral diseases
Adults and children in the acute stage are prescribed 1-2 drops to be instilled approximately 6-8 times during the day. When positive dynamics appear and the inflammatory process is stopped, instillation can be reduced to 2-3 times.
For keratoconjunctivitis sicca (dry eye syndrome)
Recommended daily use - 1-2 drops twice a day for 25-30 days.
Instructions for the use of Oftalmoferon for preventive purposes
- Complications after excimer laser refractive surgery on the cornea of the eye: drops should be used daily from the first day of surgery according to the scheme: 1-2 drops. 2 times a day, course – at least 10 days.
- Graft disease or prevention of recurrence of herpetic keratitis that occurs after keratoplasty: the drug should be used daily according to the regimen: 1-2 drops. into the operated eye 3-4 times a day, the course is at least 14 days, starting from the first day after surgery.
Attention! When using contact lenses , drops can be used only after removing the lenses; they can be put on only 15–20 minutes after the instillation procedure.
Interaction with other drugs
Drops do not have a negative effect on other drugs. They can be prescribed together with antibacterial drugs (Tsipromed, Tobrex, etc.), glucocorticoids (Dexamethasone), and combination drugs (Dexa-Gentamicin).
Oftalmoferon is also compatible with local anesthetics and anti-inflammatory drugs (Nevanak, Diclofer, Diclofenac).
The medicine has a therapeutic effect for dry eye syndrome and can be used with drugs that are substitutes for natural and artificial tears. Due to the content of hypromellose, the drops retain other medications on the surface of the eye, increasing the time and effect of their action.
Newborns
Since Ophthalmoferon contains interferon and has an immunomodulatory and antiviral effect, it is more preferable for newborns. In addition, it has an antipruritic effect and restores damaged eye tissue, stopping the inflammatory process.
The drug is not contraindicated for newborns, however, before use, the mother should consult an ophthalmologist who, depending on the child’s age and the course of the disease, will determine the dosage and treatment regimen individually.
Can it be taken by newborns?
Since the composition contains interferon and the drug has an antiviral and immunomodulatory effect, it can be given to newborns. In addition, they have an antipruritic effect and promote the regeneration of eye tissue, blocking inflammatory reactions.
Before applying eye drops to a newborn, parents should come for an examination by a specialist who, taking into account the age and condition of the baby, will be able to establish an individual treatment regimen and acceptable dosage.
Oftalmoferon's analogues
Level 4 ATC code matches:
Florenal
Oksolin
Oxolinic ointment
Zirgan
Oftan I'm coming
Poludan
There are known analogues of eye drops that also have antiviral or immunostimulating effects:
- Aktipol
- Poludan
- Oftan-Idu
Reviews from doctors
Oleg Gennadievich, ophthalmologist: In pediatric practice for conjunctivitis, I often prescribe Oftalmoferon in combination with antibacterial drops and eye ointment. This scheme helps very quickly and well; before use, you need to rinse your eyes with green tea or chamomile decoction. The advantages of the drug are that there are no age restrictions or side effects.
Olga Sergeevna, ophthalmologist: For adults and children with viral eye diseases, I prescribe safe Russian drops Oftalmoferon. The only drawback is the relatively high price. The medicine is well tolerated at any age and can be combined with all types of other eye drops.
Reviews about Oftalmoferon
Today, Oftalmoferon eye drops are quite popular and in demand, reviews and discussions of which can be found on various Internet resources and forums. Most often, the comments are positive, because they can be used both in children and in elderly patients suffering from eye problems - various etiologies of conjunctivitis, “dry eye”, as well as for prevention purposes.
Mothers praise Oftalmoferon, noting its safety of use, availability, lack of itching and allergies.
Side effects
The medicine does not cause unwanted side effects. However, in case of individual intolerance or hypersensitivity to the components of the drug, the following actions may occur:
- increased tearfulness;
- redness, itching of the mucous membrane;
- burning sensation;
- other symptoms of an allergic reaction.
Additional substances included in the composition may cause intolerance reactions. If the symptoms do not go away or get worse, it is advisable to stop using the drops.
In addition to interferon, the drug contains diphenhydramine, which may be poorly tolerated.
Oftalmoferon price, where to buy
Many patients like the easy-to-use and affordable Oftalmoferon eye drops, the price of which does not exceed 350 rubles. for 10 ml. The price of eye drops of a smaller volume - 5 ml is usually up to 200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Oftalmoferon drops hl.
10000 IU/ml 10 ml n1 ZAO Firn M RUB 327 order
Pharmacy Dialogue
- Ophthalmoferon (vial 10 ml eye/drop) Firn M
300 rub. order
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Release form
Oftalmoferon is an antiviral drug in the form of eye drops, produced by the Russian pharmaceutical plant FIRN M. The bottle capacity is 10 ml. Ease of use is ensured by the existing pipette.
When stored correctly and within the expiration dates, the drug has no color or a slightly yellowish tint without sediment or foreign impurities. If there is a change in color, precipitation, or the appearance of suspensions and impurities, the medicine cannot be used.
Storage temperature
The recommended temperature (2-8 degrees Celsius) is maintained in the refrigerator. It is better to put the packaging in a special compartment intended for medications. It is usually located in a suitable temperature zone of the refrigerator and is isolated from the interior with a lid to prevent excess moisture from entering the compartment.
It is necessary to take into account compliance with these requirements when transporting the drug: drops should not be left at room temperature for a long time, especially in the sun. After 4-5 hours at high temperatures, the drops will lose their healing properties.
Contraindications and adverse reactions
Eye drops should not be taken if you have a personal intolerance to at least one of the constituent substances. The drug is also contraindicated for people prone to severe allergic reactions.
Usually the drug is well tolerated by patients. But if there is excessive sensitivity to the constituent elements, then adverse reactions may occur in the form of:
- swelling of the eyelids;
- burning sensation in the eye area;
- redness of the eyes;
- blurred vision.
These side effects do not pose a serious threat and disappear very quickly without medical help. You should not refuse to take drops because of this. If after taking the medicine the eyelids begin to swell and a rash appears in the eye area, then you will need to consult a specialist.
No cases of overdose have been identified.
Shelf life and storage
An unopened dropper bottle can be stored for 2 years from the date of release. Opening the medicine reduces the shelf life to 30 days from the date of first use.
To ensure the safety of the properties stated in the instructions, the drops must be stored in the refrigerator - from 2 to 8 degrees. Fast transportation without cold is allowed. The bottle must also be protected from light.
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Reviews from parents
Anna: My daughter goes to kindergarten - she either rubs her eyes with dirty hands, or puts a soft toy to them. Very often we develop conjunctivitis and the eye becomes sour. The doctor prescribed Oftalmoferon and Tobrex, improvements came on the third day. I have been using antiviral drops for up to a month, as a result the disease has begun to appear less frequently. I didn't notice any side effects.
Anton: After birth, my son’s eyes often festered; doctors tried not to prescribe antibacterial drugs. The pharmacy recommended Oftalmoferon - safe and effective. The only drawback is the need to store in the refrigerator.
