A whole line of medicines is produced under the name “Hepatrombin”. To treat hemorrhoids, Hepatrombin G is used, which is available in the form of ointments and suppositories for rectal administration. The drugs can be used simultaneously: treat external manifestations of varicose veins of the rectum and anus with ointment, and insert suppositories into the rectum.
Compound
The ointment contains the main substances: sodium heparin, prednisolone acetate and lauromacrogol 600 .
Additional components: solid and liquid paraffin, silicon dioxide, lanolin .
Rectal suppositories include the following active ingredients: sodium heparin, prednisolone acetate and lauromacrogol 600.
Additional components: medium chain triglycerides, solid fat, colloidal silicon dioxide, glyceryl tristearate.
Pharmacological composition of the drug
Gepatrombin suppositories contain three active components that provide a large-scale therapeutic effect:
- sodium heparin;
- hormone prednisolone;
- lauromacrogol.
Additional ingredients designed to maintain the shape and improve the effect of medicinal substances include: colloidal silicon dioxide, solid fat, medium chain triglycerides, glyceryl tristearate.
Each suppository has a white color without inclusions, a homogeneous structure and a conical shape for ease of administration.
Packaged in five pieces in plastic blister packs. One box contains 10 suppositories and instructions for use.
Pharmacodynamics and pharmacokinetics
This combined drug is actively used in proctology, exhibiting antithrombotic, anti-inflammatory and venosclerotic effects.
Its main component, heparin , is a well-known direct-acting anticoagulant. It is also characterized by increasing the ability to regenerate connective tissue and preventing blood in the area of hemorrhoids.
As for prednisolone , which belongs to GCS, it exhibits anti-inflammatory, antiexudative and antiallergic effects, reducing itching and burning sensations, pain in the anorectal area.
Lauromacrogol 400 or polidocanol has a local anesthetic effect, providing sclerosis in the area of hemorrhoids .
Penetrating into the body, Hepatrombin G ointment, like suppositories, undergoes biotransformation in the liver and reticuloendothelial system. Plasma protein binding can reach at least 95%. The drug is excreted through the kidneys in several stages.
How do Gepatrombin G suppositories work?
The drug belongs to a combination drug and has the following effects:
- relieves inflammation and pain in the rectal area;
- reduces the formation of blood clots;
- relieves obsessive itching;
- relieves swelling of the mucous membrane of the anus and rectum;
- promotes the resorption of hemorrhoids.
Therapeutic effects are achieved through:
- heparin, which has antithrombotic, anti-edematous and anti-inflammatory effects, improves the regeneration of damaged tissue;
- glucocorticosteroid prednisolone with powerful anti-inflammatory and antipruritic effects;
- lauromacrogol, which helps relieve pain and reduce swollen veins.
The medicinal composition of the suppositories affects the course of the pathology: it reduces the severity and relieves acute symptoms, thereby making it possible to lengthen the period of remission and effectively prepare for surgery to eliminate the disease.
Contraindications
This drug in any form is not prescribed for:
- bacterial, viral and fungal skin lesions;
- tuberculosis;
- syphilis;
- skin tumors;
- reactions to vaccination;
- early pregnancy ;
- predisposition to bleeding;
- sensitivity to the drug.
Contraindications and unwanted effects
The instructions for Gepatrombin suppositories contain a list of pathologies and conditions for which the medication is not prescribed:
- excessive sensitivity to the substances included in the product;
- skin infections of a bacterial, viral or fungal nature;
- neoplasms of the skin;
- tuberculosis;
- local reactions to vaccination;
- syphilis;
- tendency to bleed;
- initial stages of pregnancy.
Side effects do not exclude local manifestations of allergies, redness of the skin and burning. Use longer than recommended carries the risk of unwanted systemic manifestations of glucocorticoid hormones.
Instructions for Gepatrombin G (Method and dosage)
Gepatrombin G ointment instructions for use recommend applying a thin layer to the affected areas until the symptoms of the disease disappear and some more time to consolidate the result. During the main therapy, the ointment can be applied 3 times a day, and then 1 time throughout the week.
The ointment can also be used rectally - inserted into the rectum using the tip, lightly pressing on the tube and squeezing out a little of the drug.
Gepatrombin G suppositories instructions for use recommend administering rectally 1-2 times a day, preferably after defecation.
For what diseases is Hepatrombin G prescribed?
Suppositories are prescribed for external and internal localization of hemorrhoids, as well as in the treatment of:
- inflammatory process in the veins of the anus and rectum with the formation of blood clots;
- defects and wounds of the anal mucosa - cracks and fistulas.
Proctologists recommend Hepatrombin G at the preparatory stage for surgery on the rectum or anus, in the complex therapy of hemorrhoidal thrombosis, and when monitoring hemorrhoids after surgery.
Gepotrombin suppositories are a powerful drug, therefore they are used in the treatment of advanced hemorrhoids, as well as those complicated by thrombosis of the rectal veins.
Analogs
Level 4 ATC code matches:
Girudoproct
Heparoid Zentiva
Heparin ointment
Heparin
Lyoton
Trombless
Venolife
Hepatrombin
The main analogues of this drug: Proctosedyl, Proctosan and Girudoproct.
How does Gepatrombin G work?
The drug is used in proctology to eliminate the main signs of exacerbation of hemorrhoids: irritation, swelling, pain, itching and burning. The effectiveness of the medicine is based on the components it contains:
- heparin reduces platelet activity, prevents the formation of blood clots in hemorrhoids, stimulates the regeneration of connective tissue, and promotes the healing of damage;
- prednisolone reduces inflammation, helps eliminate swelling, prevents the accumulation of exudate in the affected area, reduces pain and itching;
- lauromacrogol quickly relieves the burning sensation and helps in the regeneration of damaged epithelium.
The effect of the drug develops quickly. Within 10–15 minutes after application, acute pain and burning subsides. There is a pleasant feeling of coolness. On the first day of use, false urges to defecate and itching disappear. As treatment continues, swelling and unpleasant symptoms in the anorectal area decrease and then gradually disappear. At the same time, the risk of blood clots in the venous nodes is reduced, and they themselves decrease in size.
The components of Gepatrombin G are partially absorbed through the mucous membranes into the bloodstream. Their concentration in the body is insignificant to lead to systemic changes or health problems. The remains of the drug are transformed in the liver tissues, then excreted throughout the day through the kidneys.
Reviews of Gepatrombin G
It should be noted that reviews of Gepatrombin G ointment are mainly related to the treatment of hemorrhoids. Usually the drug is used for the resorption of hemorrhoidal cones . This therapy turns out to be very effective and helps to quickly get rid of unwanted symptoms.
You can also find reviews about Hepatrombin G suppositories, but this form of the drug is used by patients somewhat less frequently, although it is no less effective.
In addition, reviews of Gepatrombin G ointment for hemorrhoids report that sometimes it is not used entirely for its intended purpose. For example, this external remedy can be used to resolve hematomas that form after injections. There are cases when the ointment was used by women to eliminate swelling and bags under the eyes.
In addition to reports of the effectiveness of this drug, one can find stories about the development of side effects during improvement. Usually these are allergic reactions in the form of itching, rashes and swelling.
Despite the fact that this drug helps well in some off-label cases, it should not be used on its own. This is especially true during pregnancy, when any treatment requires maximum caution.
Price, reviews of Gepatrombin G candles
The price of Gepatrombin G suppositories depends on the pricing policy of the pharmacy chain; the average cost for 10 suppositories is 320 rubles. You can buy the product without a prescription.
Reviews about Gepatrombin G suppositories online are positive. Patients note the rapid action of the composition and help in solving a delicate problem. For some, the medication helped cure chronic hemorrhoids, which developed due to the ineffectiveness of other topical medications. The advantages include an affordable price, as well as the ability to treat hemorrhoids located inside the rectum.
Doctors often prescribe suppositories as monotherapy, or as part of a complex therapy for a complicated course of the disease. Most proctologists recommend using suppositories together with ointment for external use. The product copes well with swelling and discomfort.
Price Gepatrombin G, where to buy
The price of Gepatrombin G in suppositories varies between 220-300 rubles.
You can buy ointment for 180-250 rubles.
The price of Gepatrombin G ointment in Ukraine starts from 50 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Gepatrombin G rectal suppositories.
10 pcs. Hemofarm A.D. Vršac, branch Production site Šabac RUR 308.order - Gepatrombin G ointment 20g Hemofarm A.D. Vršac, branch Production site Šabac
RUB 293 order
Pharmacy Dialogue
- Hepatrombin G suppositories (sup. rect. No. 10) Hemofarm
RUB 349 order
- Gepatrombin G ointment 20g Hemofarm
RUB 333 order
- Hepatrombin gel (tube 50000 units 40 g)Hemofarm
RUB 259 order
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Composition and dosage forms
Hepatrombin G contains several active components that complement each other’s effectiveness:
- heparin sodium: a direct anticoagulant that prevents the formation of blood clots;
- lauromacrogol 600: anesthetic agent with sclerosing effect;
- prednisolone: a glucocorticoid hormone with anti-inflammatory and antiallergic effects.
Gepatrombin G is produced in forms for topical use:
- Ointment: a viscous, homogeneous substance of light cream color with a waxy texture; in addition to active substances, it contains auxiliary and formative substances: paraffin, silicon dioxide. The ointment also contains lanolin, which accelerates tissue healing. The drug is packaged in 20 ml metal tubes equipped with special elongated tips for ease of use.
- Suppositories: torpedo-shaped rectal suppositories on a fat basis. Contains hard wax, triglycerides, silicon dioxide, glycerol and other form-building neutral substances. The drug is packaged in plates with individual cells, each containing 5 suppositories. There are 10 doses in one package of the drug.
When is it prohibited to use Gepatrombin G?
It is necessary to refuse therapy with suppositories and ointments:
- with reduced blood clotting, bleeding from the anus;
- oncological benign and malignant intestinal tumors;
- with infectious lesions of the rectum, the presence of parasites;
- for tuberculosis, syphilis;
- fungal, bacterial lesions of the skin and mucous membranes;
- in case of individual intolerance to the components of the drug.
Signs of a possible allergic reaction to Hepatrombin G: increased itching and severe burning a few hours after administration of the drug, sensation of a foreign object in the rectum, increased dryness of the mucous membrane.
How to use Gepatrombin G: instructions
It is necessary to use suppositories or a remedy in the form of an ointment at the first signs of exacerbation of the disease, choosing whichever is more convenient. In case of extensive damage to the rectum: deep fissures, internal and external hemorrhoids, it is recommended to use both types of drug simultaneously.
The product should be applied to a cleaned surface, preferably after defecation. Before using the ointment externally, it is recommended to wash the anal passage. If the disease is complicated by constipation, empty the intestines with an enema or laxative.
- The ointment should be applied to the affected areas in a thin layer. In case of deep inflammation, you can insert the tip of the tube into the rectum, squeezing out a little of the drug. In the first 1–2 days, the procedure should be repeated 2–3 times a day. When the symptoms of exacerbation subside, it is enough to use the ointment once a day.
- The suppositories must be inserted into the anus to a depth of 2–4 cm, without wetting them with anything. To ensure that the effect of the medicine lasts as long as possible, it is recommended to lie down for 15–20 minutes. You can use suppositories before bed. Treatment should be repeated 2-3 times a day until the symptoms of the disease decrease.
The course of use of the drug Gepatrombin G is about a week. Longer treatment is undesirable, as it can cause hormonal imbalance.
For what diseases is Hepatrombin G indicated?
The drug is prescribed in the complex treatment of proctological pathologies:
- for internal, external and combined hemorrhoids;
- cracks in the anus of the rectum;
- thrombophlebitis of the anal veins;
- for eczema in the anal area, fistulas, itching and irritation of the mucous membrane.
According to user reviews, the drug Hepatrombin G in the form of an ointment helps well in resolving bruises and hematomas on the skin after injections. Before starting treatment, it is important to undergo diagnostics, eliminating possible contraindications.
